UCL Institute of Cardiovascular Science


Roshni Joshi

PhD Project Title: Triglycerides, triglyceride containing lipoproteins and cardiovascular disease: causal relevance and potential therapeutic targets.

Picture of Roshni Joshi

Supervisors: Professor Aroon Hingorani

Lay summary:

Atherosclerosis is the build-up of fat and inflammatory material in the walls of blood vessels, a process which can lead to blockage of blood vessels which underlies conditions such as heart attacks and stroke. High levels of low-density lipoprotein cholesterol (LDL-C), a particular type of fat circulating in the blood is a definite cause of atherosclerosis. However, it is unclear whether other circulating fats, such as those containing triglycerides are also involved in atherosclerosis disease progression. 

I aim to confirm or refute the causal role of triglycerides in heart disease and stroke using state-of-the art omics tools in a population genetic approach. 


Contact details 

Twitter: @roshnijoshi