Professor Pier Lambiase
Professor Peter Taggart (Emeritus Professor)
Dr Michele Orini (Postdoc)
Dr Stefan van Duijvenboden (MRC Postdoc)
Dr Rui Provdencia
Dr Neil Srinivsan (BHF Clinical Fellow)
Dr Adam Graham
Diogo Santos (MRC CASE Fellow)
Tudor Basleaga (UCL IBME Fellow)
Clinical Postdoctoral Fellows:
Dr Claire Martin
Dr Richard Ang
The focus of our group is the mechanistic basis of arrhythmias and the development of new diagnostic and therapeutic strategies. Mechanistic studies are conducted in ion channelopathies (Long QT & Brugada Syndrome) aswell as cardiomyopathies utilising a combination of high density clinical mapping techniques (Carto, Rhythmia), epicardial sock mapping in cardiac theatres and non-invasive strategies (ECG Imaging and MRI). This is coupled with parallel basic science research investigating the genetic basis of these conditions utilising population data from UK Biobank and clinical cohorts at Barts Heart Centre aswell as cellular (iPSC) and murine models.
We supervise MSc and undergraduate BSc projects and work closely with Industry evaluating new technologies for ablation of arrhythmias & prevention of sudden cardiac death including the Subcutaneous ICD. The group is also developing new algorithms to identify arrhythmogenic regions in sinus rhythm responsible for ventricular tachycardia without having to initiate arrhythmia and technology to identify patients at risk of sudden death with non-invasive techniques. Research is supported by project grants and fellowships from MRC, Welcome Trust, BHF, Heart Research UK, European Union (Marie Curie Action) Barts Charity and UCL CBRC.
Lambiase PD, Ahmed A.K, Ciaccio E.J., Chaubey S., Brugada R., Chow A.W., Lowe M.D., McKenna W.J. (2009). High density substrate mapping in Brugada Syndrome-the role of conduction and repolarization heterogeneities. Circulation 14(2), 106-17. (Impact Factor 14.5). The first study to show how ventricular arrhythmias that lead to cardiac arrest develop in this condition in man. The study demonstrated how conduction slowing in the right ventricular outflow tract precipitates cardiac arrest independent of a previously posited early repolarisation mechanism. This has leant support recent ablation strategies to prevent cardiac arrest in high risk Brugada Syndrome patients who have had multiple cardiac arrests.
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, Tinker A, Lambiase PD. Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J. 2012 Jan 11 (IF 14.7) This manuscript demonstrates how subclinical electrical abnormalities can be detected in patients with preclinical arrhythmogenic cardiomyopathy and has significant implications in the earlier diagnosis of this condition aswell as identifiying higher risk individuals presenting with isolated extra beats (ectopics)
Nunn LM, Bhar-Amato J, Lowe MD, Macfarlane PW, Rogers P, McKenna WJ, Elliott PM, Lambiase PD. Prevalence of J-point elevation in sudden arrhythmic death syndrome families. J Am Coll Cardiol. 2011 Jul 12;58(3):286-90. (Impact Factor 14.5). The first study to demonstrate that this ECG marker is more common in families with a history of premature sudden cardiac death and provides the evidence to support ongoing work to identify novel genes leading to lethal arrhythmias.
Lambiase PD, Barr C, Theuns DAMJ, Knops R, Neuzil P, Johansen JB, Hood M, Pedersen S, Kääb S, Murgatroyd F, Reeve HL, Carter N, Boersma L. Worldwide Experience with a Totally Subcutaneous ICD: Early Results from the EFFORTLESS S-ICD Registry. European Heart Journal 2014;35(25):1657-65 (IF 14.7) This is the first manuscript to publish the clinical outcomes of patients receiving an innovative Internal Cardiac Defibrillator that does not require an intravascular lead avoiding long term ICD lead complications in patients who do not require pacing. It is transforming practice particularly in young patients and has been recognised as a therapy in the recent European Guidelines on the Management of Hypertrophic Cardiomyopathy. I am the Chief Investigator in the EFFORTLESS Registry which is an international Registry gathering prospective data on 1000 patients over 5 years on S-ICD recipients. The creation of such a Registry is recognised as a transformative approach in new technology assessment to obtain real world experience for the Device Industry as opposed to clinical trials alone. It is enabling a number of important publications in the field of which I am lead/co-author.
Taggart P, Orini M, Hanson B, Hayward M, Clayton R, Dobrzynski H, Yanni J, Boyett M, Lambiase PD. Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects. Prog Biophys Mol Biol. 2014;115(2-3):252-60. This manuscript describes the unique integrated approach we undertake utilising high density epicardial sock mapping in cardiac surgical patients to investigation mechano-electric feedback and the molecular basis of cardiac alternans. This experimental approach is being applied in a number of mechanistic and interventional studies by the group.
awarded to the group include:
Michael Davies Early career award (British Cardiovascular Society)
British Heart Rhythm Society Young Investigator Award
European Heart Rhythm Society Young Investigator Award