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UCL Institute of Cardiovascular Science

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Gavin Paul Raphael Manmathan

PhD Project Title: Extensive Cardiovascular phenotyping in asymptomatic people living with HIV.

Supervisors: Dr Roby Rakhit

Lay summary:

A study looking into people who have lived with HIV for over 10 years. We will compare 50 people who have HIV and 50 people who do not have HIV. They will have blood tests (for inflammation, stickiness of the blood, and evidence of any damage to the heart), CT scans of the heart, ultrasound of the heart and of the arteries in the neck. We aim to find any evidence of heart disease risk early before people are aware of it, to enable positive change to improve cardiovascular outlook. If you are interested in taking part please get in touch, we are looking for Black African women aged 35-55 years old, or White men who have sex with men (MSM) both of whom have no known traditional risk factors for heart related problems (such as high blood pressure, diabetes, smoking or high cholesterol.) 

My Background 

I am cardiology Dr in training from Kent, Surrey and Sussex Deanery. I have been a doctor since 2006 and spent 5 years as a house officer in the NHS and have been a registrar since 2011. I got a national training number in Cardiology in 2014 and have completed my core cardiology training. In 2018, I have been granted time out of training to partake in research.
After working in a busy strained NHS, the opportunity arose for me to work with and perform research in a stigmatised, vulnerable patient group, where huge advances in medicine have occurred, transforming a deadly disease into one where people are being treated with amazing science. People living with HIV are living to a normal life expectancy, with those who are undetectable not transmitting the disease through sexual exposure. However, people living with HIV are at increased cardiovascular risk, so I have the opportunity to study and perform research at the Royal Free Hospital, where we can educate patients and staff, initiate diagnostic and treatment regimes. This has also facilitated an environment for me to register with UCL for a PhD.   

Qualifications

  • 2010 – 2013    Membership of The Royal College of Physicians (Part 1 Sep 2010 Part 2 Nov 2011 PACES Feb 2013)
  • 2004 – 2005    Neuroscience and Neuropsychology Intercalated BSc, King’s College, University of London, UK
  • 2000 – 2006    MBChB, Liverpool University, UK

Awards

  • Apr 19    Scientific Scholarship; 25th Annual Conference, Bournemouth, UK, British HIV Association    
  • Mar 19    Young Investigator Award; 9th International HIV & Women Conference, Seattle, USA     
  • Sep 18    Internal Medicine Research and Audit Day Oral Presentation Winner; Kent, Surrey and Sussex Deanery, Health Education England
  • Sep 16    Cardiology Case Presentation Winner; Kent, Surrey and Sussex Deanery, Health Education England
  • Jan 06    ERASMUS, Maastricht University, European Exchange Scholarship

Publications 

  • G Manmathan, R Ramphul, M Johnson, R Rakhit, F Burns. Reclassification of severe renal failure in people living with HIV using modified KDIGO classification. Journal of the international AIDS Society. 2018.(21)S8:e25187
  • G Manmathan, A Hunter, M Johnson, R Rakhit.  Accelerated Atherosclerosis and Myocardial injury in people living with HIV. Cardiovascular Research. 2018 Sept;144
  • J Stewart, G Manmathan, P Wilkinson. Primary prevention of cardiovascular disease: A review of contemporaryguidance and literature. JRSM Cardiovascular Disease. 2017 Jan(6)1-9.
  • C Young, G Manmathan, J Ward. Perceptions of goal setting in a neurological rehabilitation unit:a qualitative study of patients, carers and staff. Journal of Rehabilitation Medicine. 2008 Mar;40(3):190-4

Appointments 

  • UCL 1st Year Cardiovascular Sciences PhD Representative
  • Cardiology and HIV Research Registrar at the Royal Free Hospital 

Contact details 

rmgpgpr@ucl.ac.uk
@drgprman