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World TB Day Symposium 2023
Friday 24th March 2023
This will be a whole day hybrid event based at LSHTM, with in-person and online access.
Programme
- 10:00 - 11:00 Coffee for in-person attendees
- 11:00-11:15 Opening and welcomes
An overview of the programme and welcome to the event.
- 11:15 - 12:15: Session 1: Early TB - definitions and implications for TB research, policy and care
The spectrum of TB disease is expanding with key stages or phenotypes being recognised. This session will explore the implications of this development for TB research, policy and care
- Language and definitions - update from the Early TB Disease symposium - Dr Asad Zaidi, UCL
- Quantifying the new natural history - Katherine Horton, LSHTM
- Impact of new TB disease phenotypes on product development and policy recommendations - Mikashmi Kohli, FIND
- Implications for treatment - Adam Gray, UCL
Panel discussion and Q&A (15 minutes)
- 12:45 - 13:45: Session 2: Big Data in TB
Technological advances across disciplines in the last few years have resulted in an explosion in the availability of clinical (e.g. pharmacological, radiological and electronic health records) and biological (multi-omics e.g. genomics, metabolomics, transcriptomics) data relevant to TB research. This session focuses on research infrastructure (cloud computing, software engineering etc) and analytical approaches (ML applied statistics) to leverage big data in TB.
- PKPDai: A Pharmacometric Knowledge Repository to support anti-mycobacterial drug development - Frank Kloprogge, UCL
- KZN Public Health Data Centre: effective data use to address initial lost to follow up - Dr. Sadiyya Sheik, AHRI
- A key determinant of predictive value of the CAD score - Thomas Gachie, LSHTM
- Genomic analysis of Mycobacterium tuberculosis in the big data era - Dr. Jody Phelan, LSHTM
Panel discussion and Q&A (15 minutes)
- 13:45-14:45: Lunch break
For in person attendees, lunch will be in LSHTM south courtyard.
- 14:45 - 15:45: Session 3: From bench to bedside: new drugs and regimens against drug-resistant TB (DR-TB)
Antimicrobial resistance is an increasing problem with the currently used interventions becoming outdated. This session focuses on new strategies and compounds from early bench studies to clinical trials for treatment of DR-TB.
- Mtb resistance to pretomanid: unusual mutations and evolution of resistance - Anna Bateson, UCL.
- MDR-TB diagnosis in Western Africa - Schadrac Agbla, LSHTM.
- Swimming against the current: STREAM-2 results - Ruth Goodall, UCL
- Implementation of the TB PRACTECAL regimen -Dr Animesh Sinha, LSHTM
Panel discussion and Q&A (15 minutes)
- 16:15 - 17:00: Session 4: Preventive therapy as a means to curb the TB epidemic
The aim of this session is to discuss the challenges and controversies around the roll out of TB preventive therapy (TPT) for individuals with latent TB, focusing on regimens, targets, evidence-led refinement of guidelines, and whether HIV co-infection needs to be considered separately.
- Population trials of preventive therapy: History and future - Prof Gavin Churchyard, LSHTM
- Diagnostics to guide preventative treatment: are we making progress? - Rishi Gupta, UCL
- Modelling the potential global impact of DR-TB household contact management in children - Finn McQuaid, LSHTM
Panel discussion and Q&A (15 minutes)
- 1700 - 1730 Session 5: Steve Lawn TB-HIV Prize winners - presentation and discussion
The Steve Lawn TB-HIV leadership prize recognises young researchers and upcoming leaders conducting promising work focused on reducing the disease burden of TB and HIV/AIDS in Africa. In this session two of the 2023 awardees, Ruvandhi Nathavitharana and Alberto García-Basteiro) will present their prize winning work and vision in a set of short blitz talks, followed by a moderated discussion.
- 17:30-17:45: Summary and handover to University of California San Francisco
As part of a global day, we will join with researchers in UCSF as they start their World TB Day event.
Admission
Register to attend in person, or join online (no registration needed)
Visit the LSHTM WTBD 2023 webpage
Visit the LSHTM TB Centre webpage
Visit the UCSF WTBD 2023 webpage
