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Miguel Ardid Candel's Webpage

Photo of Miguel Ardid Candel Postgraduate Researcher

Phone: +44 (0)20 7679 3806
Email: m.candel@ucl.ac.uk
Address:
Department of Chemical Engineering
University College London
Torrington Place
London WC1E 7JE
United Kingdom

Miguel Ardid Candel obtained a BEng in Biochemical Engineeering at UCL in 2006 and an MSc at the London School of Pharmacy in 2007. He then worked for a year at the London School of Hygiene and Tropical Medicine carrying out research on novel antimalarial compounds before joining the Department of Chemical Engineering at UCL as a PhD student.

Research project

Title: An experimental and theoretical study of enantiomer separation by diastereomeric salt formation.

Supervisors: Prof Alan Jones and Prof Sally Price (Dept of Chemistry)

The production of enantiomerically pure compounds in the pharmaceutical industry is of paramount importance, as sadly demonstrated by the Thalidomide tragedy in the 1960's. The resolution of racemic mixtures (mixtures of enantiomers) is usually more economical than the synthesis of pure enantiomers. However,normal separation methods, which usually exploit differences in physical or chemical properties, cannot be used as enantiomers share these properties.

One of the preferred techniques in industry is classical resolution, where a resolving agent is used to form a diastereomeric salt pair and the least soluble salt is precipitated out. It is clear that the solubility of the diastereomeric salt depends on the resolving agent. Nonetheless, despite its importance, the choice of resolving agent is still mostly made on a trial and error basis.

This study aims to provide necessary physical and thermodynamic data to validate a computational model developed at the Department of Chemistry at UCL for the prediction of resolution efficiency by crystallisation of diastereomeric salts.

Page last modified on 15 sep 11 09:41