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Image of the Week

Academic Publications


Selected Publications 2013

  • Zani A, Cananzi M, Fascetti-Leon F, Lauriti G, Smith V V., Bollini S, Ghionzoli M, D’Arrigo A, Pozzobon M, Piccoli M, Hicks A, Wells J, Siow B, Sebire NJ, Bishop C, Leon A, Atala A, Lythgoe MF, Pierro A, Eaton S, De Coppi P Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut:1-10. PDF
  • Yan R, Sander K, Galante E, Rajkumar V, Badar A, Robson M, El-Emir E, Lythgoe MF, Pedley RB, Årstad E (2013) A one-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes. Journal of the American Chemical Society 135:703–709. PDF
  • Kalber TL, Campbell-Washburn AE, Siow BM, Sage E, Price AN, Ordidge KL, Walker-Samuel S, Janes SM, Lythgoe MF (2013) Primed infusion with delayed equilibrium of Gd.DTPA for enhanced imaging of small pulmonary metastases. PloS One 8:e54903. PDF
  • Wells JA, Siow B, Lythgoe MF, Thomas DL (2013) Measuring biexponential transverse relaxation of the ASL signal at 9.4 T to estimate arterial oxygen saturation and the time of exchange of labeled blood water into cortical brain tissue. Journal of Cerebral Blood Flow & Metabolism 33:215–224. PDF
  • Riegler J, Liew A, Hynes SO, Ortega D, O’Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF (2013) Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury. Biomaterials 34:1987–1994. PDF
  • Mitchell N, Kalber TL, Cooper MS, Sunassee K, Chalker SL, Shaw KP, Ordidge KL, Badar A, Janes SM, Blower PJ, Lythgoe MF, Hailes HC, Tabor AB (2013) Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging. Biomaterials 34:1179–1192. PDF

Selected Publications 2012

  • Norris FC, Betts-Henderson J, Wells JA, Cleary JO, Siow BM, Walker-Samuel S, McCue K, Salomoni P, Scambler PJ, Lythgoe MF (2012) Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro-histology. Magnetic Resonance in Medicine:1–9. PDF
  • Kenny GD, Villegas-Llerena C, Tagalakis AD, Campbell F, Welser K, Botta M, Tabor AB, Hailes HC, Lythgoe MF, Hart SL (2012) Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours. Biomaterials 33:7241–7250. PDF
  • Writer MJ, Kyrtatos PG, Bienemann AS, Pugh JA, Lowe AS, Villegas-Llerena C, Kenny GD, White EA, Gill SS, McLeod CW, Lythgoe MF, Hart SL (2012) Lipid peptide nanocomplexes for gene delivery and magnetic resonance imaging in the brain. Journal of Controlled Release 162:340–348. PDF
  • Baker LCJ, Boult JKR, Walker-Samuel S, Chung Y-L, Jamin Y, Ashcroft M, Robinson SP (2012) The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function. British Journal of Cancer 106:1638–1647. PDF
  • Boult JKR, Jamin Y, Jacobs V, Gilmour LD, Walker-Samuel S, Halliday J, Elvin P, Ryan AJ, Waterton JC, Robinson SP (2012) False-negative MRI biomarkers of tumour response to targeted cancer therapeutics. British Journal of Cancer 106:1960–1966. PDF
  • Burrell JS, Walker-Samuel S, Baker LCJ, Boult JKR, Jamin Y, Ryan AJ, Waterton JC, Halliday J, Robinson SP (2012) Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas. International Journal of Cancer 131:1854–1862. PDF
  • Walker-Samuel S, Boult JKR, McPhail LD, Box G, Eccles SA, Robinson SP (2012) Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts. International Journal of Cancer 130:1284–1293. PDF
  • Burrell JS, Bradley RS, Walker-Samuel S, Jamin Y, Baker LCJ, Boult JKR, Withers PJ, Halliday J, Waterton JC, Robinson SP (2012) MRI measurements of vessel calibre in tumour xenografts: Comparison with vascular corrosion casting. Microvascular Research 84:323–329. PDF
  • Campbell-Washburn AE, Zhang H, Siow BM, Price AN, Lythgoe MF, Ordidge RJ, Thomas DL (2012) Multislice cardiac arterial spin labeling using improved myocardial perfusion quantification with simultaneously measured blood pool input function. Magnetic Resonance in Medicine:1–12. PDF
  • Christie IN, Wells JA, Southern P, Marina N, Kasparov S, Gourine AV, Lythgoe MF (2012) fMRI response to blue light delivery in the naïve brain: Implications for combined optogenetic fMRI studies. NeuroImage. PDF
  • Norris FC, Modat M, Cleary JO, Price AN, McCue K, Scambler PJ, Ourselin S, Lythgoe MF (2012) Segmentation propagation using a 3D embryo atlas for high-throughput MRI phenotyping: Comparison and validation with manual segmentation. Magnetic Resonance in Medicine:1–7. PDF
  • Pérez-Medina C, Patel N, Robson M, Badar A, Lythgoe MF, Årstad E (2012) Evaluation of a (125)I-labelled benzazepinone derived voltage-gated sodium channel blocker for imaging with SPECT. Organic & Biomolecular Chemistry 10:9474–9480. PDF
  • Richardson S, Siow B, Batchelor AM, Lythgoe MF, Alexander DC (2012) A viable isolated tissue system: A tool for detailed MR measurements and controlled perturbation in physiologically stable tissue. Magnetic Resonance in Medicine:1–8. PDF
  • Treiber CD, Salzer MC, Riegler J, Edelman N, Sugar C, Breuss M, Pichler P, Cadiou H, Saunders M, Lythgoe M, Shaw J, Keays DA (2012) Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons. Nature 484:367–370. PDF
  • Wells JA, Siow B, Lythgoe MF, Thomas DL (2012) The importance of RF bandwidth for effective tagging in pulsed arterial spin labeling MRI at 9.4T. NMR in Biomedicine. PDF
  • Duffy BA, Choy M, Riegler J, Wells JA, Anthony DC, Scott RC, Lythgoe MF (2012) Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent. NeuroImage 60:1149–1155. PDF
  • Panagiotaki E, Schneider T, Siow B, Hall MG, Lythgoe MF, Alexander DC (2012) Compartment models of the diffusion MR signal in brain white matter: a taxonomy and comparison. NeuroImage 59:2241–2254. PDF
  • Siow B, Drobnjak I, Chatterjee A, Lythgoe MF, Alexander DC (2012) Estimation of pore size in a microstructure phantom using the optimised gradient waveform diffusion weighted NMR sequence. Journal of Magnetic Resonance 214:51–60. PDF
  • Thayyil S, De Vita E, Sebire NJ, Bainbridge A, Thomas D, Gunny R, Chong K, Lythgoe MF, Golay X, Robertson NJ, Cady EB, Taylor AM (2012) Post-mortem cerebral magnetic resonance imaging T1 and T2 in fetuses, newborns and infants. European Journal of Radiology 81:e232–e238. PDF
  • Totonelli G, Maghsoudlou P, Garriboli M, Riegler J, Orlando G, Burns AJ, Sebire NJ, Smith VV, Fishman JM, Ghionzoli M, Turmaine M, Birchall MA, Atala A, Soker S, Lythgoe MF, Seifalian A, Pierro A, Eaton S, De Coppi P (2012) A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration. Biomaterials 33:3401–3410. PDF

Selected Publications 2011

  • Boult JKR, Walker-Samuel S, Jamin Y, Leiper JM, Whitley GSJ, Robinson SP (2011) Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas. The Journal of Pathology 225:344–352. PDF
  • Burrell JS, Walker-Samuel S, Baker LCJ, Boult JKR, Ryan AJ, Waterton JC, Halliday J, Robinson SP (2011) Investigating Temporal Fluctuations in Tumor Vasculature With Combined Carbogen and Ultrasmall Superparamagnetic Iron Oxide Particle (CUSPIO) Imaging. Magnetic Resonance in Medicine 66:227–234. PDF
  • Bollini S, Cheung KK, Riegler J, Dong X, Smart N, Ghionzoli M, Loukogeorgakis SP, Maghsoudlou P, Dubé KN, Riley PR, Lythgoe MF, De Coppi P (2011) Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem Cells and Development 20:1985–1994. PDF
  • Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN, Ghionzoli M, Cheung KK, Cabrelle A, O’Mahoney PR, Cozzi E, Sartore S, Tinker A, Lythgoe MF, De Coppi P (2011) In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells. Stem Cell Reviews and Reports 7:364–380. PDF
  • Cleary JO, Modat M, Norris FC, Price AN, Jayakody SA, Martinez-Barbera JP, Greene NDE, Hawkes DJ, Ordidge RJ, Scambler PJ, Ourselin S, Lythgoe MF (2011) Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping. NeuroImage 54:769–778. PDF
  • Cleary JO, Wiseman FK, Norris FC, Price AN, Choy M, Tybulewicz VLJ, Ordidge RJ, Brandner S, Fisher EMC, Lythgoe MF (2011) Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. NeuroImage 56:974–983. PDF
  • Lim SY, Hausenloy DJ, Arjun S, Price AN, Davidson SM, Lythgoe MF, Yellon DM (2011) Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure. Journal of Cellular and Molecular Medicine 15:2443–2451. PDF
  • Price AN, Cheung KK, Lim SY, Yellon DM, Hausenloy DJ, Lythgoe MF (2011) Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T. Journal of Cardiovascular Magnetic Resonance 13:44. PDF
  • Riegler J, Lau KD, Garcia-Prieto A, Price AN, Richards T, Pankhurst QA, Lythgoe MF (2011) Magnetic cell delivery for peripheral arterial disease: A theoretical framework. Medical Physics 38:3932–3943. PDF
  • Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature 474:640–644. PDF
  • Walker-Samuel S, Orton M, Boult JKR, Robinson SP (2011) Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing. Magnetic Resonance in Medicine 65:438–447. PDF
  • Walker-Samuel S, Peter Johnson S, Pedley B, Lythgoe MF, Golay X (2011) Extracranial measurements of amide proton transfer using exchange-modulated point-resolved spectroscopy (EXPRESS). NMR in Biomedicine PDF

Selected Publications 2010

  • Walker-Samuel S, Orton M, McPhail LD, Boult JKR, Box G, Eccles SA, Robinson SP (2010) Bayesian estimation of changes in transverse relaxation rates. Magnetic Resonance in Medicine 64:914–921. PDF
  • Abi-Nader KN, Mehta V, Wigley V, Filippi E, Tezcan B, Boyd M, Peebles DM, David AL (2010) Doppler ultrasonography for the noninvasive measurement of uterine artery volume blood flow through gestation in the pregnant sheep. Reproductive Sciences 17:13–19. PDF
  • Choy M, Cheung KK, Thomas DL, Gadian DG, Lythgoe MF, Scott RC (2010) Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model. Epilepsy Research 88:221–230. PDF
  • Choy M, Wells JA, Thomas DL, Gadian DG, Scott RC, Lythgoe MF (2010) Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. Experimental Neurology 225:196–201. PDF
  • Lovell MJ, Yasin M, Lee KL, Cheung KK, Shintani Y, Collino M, Sivarajah A, Leung K-yi, Takahashi K, Kapoor A, Yaqoob MM, Suzuki K, Lythgoe MF, Martin J, Munroe PB, Thiemermann C, Mathur A (2010) Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway. Atherosclerosis 213:67–76. PDF
  • Martinelli J, Balali-Mood B, Panizzo R, Lythgoe MF, White AJP, Ferretti P, Steinke JHG, Vilar R (2010) Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies. Dalton Transactions 39:10056–10067. PDF
  • Panagiotaki E, Hall MG, Zhang H, Siow B, Lythgoe MF, Alexander DC (2010) High-fidelity meshes from tissue samples for diffusion MRI simulations. Lecture Notes in Computer Science 6362:404–411. PDF
  • Riegler J, Cheung KK, Man YF, Cleary JO, Price AN, Lythgoe MF (2010) Comparison of segmentation methods for MRI measurement of cardiac function in rats. Journal of Magnetic Resonance Imaging 32:869–877. PDF
  • Riegler J, Wells JA, Kyrtatos PG, Price AN, Pankhurst QA, Lythgoe MF (2010) Targeted magnetic delivery and tracking of cells using a magnetic resonance imaging system. Biomaterials 31:5366–5371. PDF
  • Vigor KL, Kyrtatos PG, Minogue S, Al-Jamal KT, Kogelberg H, Tolner B, Kostarelos K, Begent RH, Pankhurst QA, Lythgoe MF, Chester KA (2010) Nanoparticles functionalised with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells. Biomaterials 31:1307–1315. PDF
  • van der Weerd L, Tariq Akbar M, Aron Badin R, Valentim LM, Thomas DL, Wells DJ, Latchman DS, Gadian DG, Lythgoe MF, de Belleroche JS (2010) Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 30:849–856. PDF
  • Wells JA, Lythgoe MF, Gadian DG, Ordidge RJ, Thomas DL (2010) In vivo Hadamard encoded continuous arterial spin labeling (H-CASL). Magnetic Resonance in Medicine 63:1111–1118. PDF
  • Wells JA, Thomas DL, King MD, Connelly A, Lythgoe MF, Calamante F (2010) Reduction of errors in ASL cerebral perfusion and arterial transit time maps using image de-noising. Magnetic Resonance in Medicine 64:715–724. PDF

Selected Publications 2009

  • Badin RA, Modo M, Cheetham M, Thomas DL, Gadian DG, Latchman DS, Lythgoe MF (2009) Protective effect of post-ischaemic viral delivery of heat shock proteins in vivo. Journal of Cerebral Blood Flow and Metabolism 29:254–263. PDF
  • Cleary JO, Price AN, Thomas DL, Scambler PJ, Kyriakopoulou V, McCue K, Schneider JE, Ordidge RJ, Lythgoe MF (2009) Cardiac phenotyping in ex vivo murine embryos using μMRI. NMR in Biomedicine 22:857–866. PDF
  • Iwata S, Iwata O, Olson L, Kapetanakis A, Kato T, Evans S, Araki Y, Kakuma T, Matsuishi T, Setterwall F, Lagercrantz H, Robertson NJ (2009) Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a “phase changing material” mattress in a newborn piglet model. Archives of Disease in Childhood 94:387–391. PDF
  • Judkewitz B, Rizzi M, Kitamura K, Häusser M (2009) Targeted single-cell electroporation of mammalian neurons in vivo. Nature Protocols 4:862–869. PDF
  • Kyrtatos PG, Lehtolainen P, Junemann-Ramirez M, Garcia-Prieto A, Price AN, Martin JF, Gadian DG, Pankhurst QA, Lythgoe MF (2009) Magnetic tagging increases delivery of circulating progenitors in vascular injury. JACC: Cardiovascular Interventions 2:794–802. PDF
  • Laufer J, Zhang E, Raivich G, Beard P (2009) Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner. Applied Optics 48:D299–D306. PDF
  • Loebinger MR, Kyrtatos PG, Turmaine M, Price AN, Pankhurst Q, Lythgoe MF, Janes SM (2009) Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Research 69:8862–8867. PDF
  • Panagiotaki E, Fonteijn H, Siow B, Hall MG, Price A, Lythgoe MF, Alexander DC (2009) Two-compartment models of the diffusion MR signal in brain white matter. Lecture Notes in Computer Science 5761:329–336. PDF
  • Panizzo RA, Kyrtatos PG, Price AN, Gadian DG, Ferretti P, Lythgoe MF (2009) In vivo magnetic resonance imaging of endogenous neuroblasts labelled with a ferumoxide-polycation complex. NeuroImage 44:1239–1246. PDF
  • Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM (2009) Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374:467–475. PDF
  • Watt AJ, Cuntz H, Mori M, Nusser Z, Sjöström PJ, Häusser M (2009) Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity. Nature Neuroscience 12:463–473. PDF
  • Wells JA, Lythgoe MF, Choy M, Gadian DG, Ordidge RJ, Thomas DL (2009) Characterizing the origin of the arterial spin labelling signal in MRI using a multiecho acquisition approach. Journal of Cerebral Blood Flow and Metabolism 29:1836–1845. PDF
  • Zhang EZ, Laufer JG, Pedley RB, Beard PC (2009) In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy. Physics in Medicine and Biology 54:1035–1046. PDF

Selected Publications 2008

  • Cady EB, Iwata O, Bainbridge A, Wyatt JS, Robertson NJ (2008) Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. Journal of Neurochemistry 107:1027–1035. PDF
  • David AL, Torondel B, Zachary I, Wigley V, Nader KA, Mehta V, Buckley SMK, Cook T, Boyd M, Rodeck CH, Martin J, Peebles DM (2008) Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep. Gene Therapy 15:1344–1350. PDF
  • Iwata O, Iwata S, Bainbridge A, De Vita E, Matsuishi T, Cady EB, Robertson NJ (2008) Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome. Brain 131:2220–2226. PDF
  • Kitamura K, Judkewitz B, Kano M, Denk W, Häusser M (2008) Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nature Methods 5:61–67. PDF

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