publications
from the
[Doctoral (PhD) Theses are listed beneath journal articles]
Selected journal articles:
2013-present
*Shimizu,
T., *Nayar, S.G., Swire, M., Jiang, Y., Grist, M., Kaller, M., Sampaio
Baptista, C., Johansen-Berg, H., Bannerman, D.M., Ogasawara, K.,
Tohyama, K., Li, H. and Richardson, W.D. (2023). Oligodendrocyte
dynamics dicatate cognitive performance outcomes of working memory
training in mice. Nat Commun 14:6499. *equal contributions [PDF] [supplementary info]
Nishiyama, A.*, Shimizu, T.,
Sherafat, A., and Richardson, W.D.* (2021). Lifelong
oligodendrocyte development and plasticity. Seminars
Cell Dev Biol 116, 25-37. # joint senior authors [PDF]
*Jolly, S., *Bazargani, N., Quiroga, A., Attwell, D., Richardson, W.D.**
and Li, H.** (2018). G protein-coupled receptor 37-like
1 modulates
astrocyte glutamate transporters and neuronal NMDA receptors and
is neuroprotective in ischemia. Glia 66, 47-61.
*equivalent contributions **joint
senior authors
[PDF]
Tripathi, R.B., Jackiewicz, M.,
McKenzie, I.A., Kougioumtzidou, E., Grist, M. and Richardson, W.D.
(2017). Remarkable stability of myelinating
oligodendrocytes in mice. Cell Reports 21, 316-323. [PDF]
[supplementary info]
Kougioumtzidou, E., *Shimizu, T., *Hamilton, N.B., *Tohyama,
K., Sprengel, R., Monyer, H., Attwell, D.** and Richardson,
W.D.** (2017). Signalling through AMPA receptors on
oligodendrocyte precursors promotes myelination by enhancing
oligodendrocyte survival. eLife 2017; 6:e28080. doi: 10.7554/eLife.28080
. *equivalent contributions **joint
senior authors [PDF]
*Xiao, L., *Ohayon, D, McKenzie, I.A., Emery, B., Li, H. and Richardson, W.D. (2016). Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat Neurosci 19, 1210-1217 *equal contributions [PDF] [supplementary info]
Crawford,
A.H., Tripathi, R.B., Richardson, W.D.,* and Franklin, R.J.M.* (2016).
The developmental origin of oligodendrocyte lineage cells determines
their response to demyelination and susceptibility to age-related
decline. Cell Reports 15, 761-773. *joint senior authors
[PDF]
Li, H. and
Richardson, W.D. (2016). Evolution of the CNS regulatory
program. Brain Res. 1641, 111-121. [PDF]
Bergles, D.E. and Richardson, W.D. (2015).
Oligodendrocyte development and plasticity. In
Glia; Cold Spring Harbor Laboratory Press (Cold
Spring Harbor) (eds. BA Barres, MR Freeman, B
Stevens) pp139-165. Cold Spring Harb.
Perspect. Biol. In press. [PDF]
*McKenzie, I.A., *Ohayon, D., Li, H., Paes de Faria,
J., Emery, B., Tohyama, K. and Richardson, W.D. (2014). Motor
skills learning requires active central myelination. Science 346,
318-322. *
equal contributions [PDF]
[supplementary
info] Insight article by Long and Corfas (Science
346, 298-299)
Pouwels, P.J.W.,
Vanderver, A., Bernard, G., Wolf,
N.I., Dreha-Kulczewski, S.F., Deoni,
S.C.L., Bertini, E., Kohlschutter, A.,
Richardson, W., ffrench-Constant, C.,
Kohler, W., Rowitch, D. and Barkovich,
A.J. (2014). Hypomyelinating
leukodystrophies: translational
research progress and prospects. Annals
Neurol. 76,
5-19. doi:
10.1002/ana.24194 [PDF]
Paes de Faria, J., Kessaris, N., Andrew, P., Richardson, W.D. and Li, H. (2014). New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development. BMC Neurosci. 15, 12. doi:10.1186/1471-2202-15-12 [PDF] [additional info]
Young, K.M., Psachoulia, K., Tripathi, R.B., Dunn, S.-J., Cossell,
L., Attwell, D., Tohyama, K. and Richardson, W.D.
(2013). Oligodendrocyte dynamics
in the healthy adult CNS: evidence for myelin remodelling. Neuron 77,
873-885. [PDF]
[supplementary info]
2008-2012
Philips, T.,
Bento-Abreu, A., Nonneman,
A., Haeck, W., Staats, K., Geelen,
V., Hersmus, N., Kusters, B., Van Den Bosch, L.,
Van Damme, P., Richardson,
W.D. and Robberecht, W.
(2012). Oligodendrocyte
dysfunction in the pathogenesis of amyotrophic lateral
sclerosis. Brain 136, 471-482.
[PDF]
Chikka,
A., Nitarska, J., Grazini, U. and Richardson, W.D.
(2012). Transcription
Factor Positive Regulatory Domain 4 (PRDM4) recruits Protein
Arginine Methyltransferase 5
(PRMT5) to mediate histone arginine methylation and control
neural stem cell proliferation and differentiation. J. Biol. Chem. 287,
42995-43006.
[PDF]
Tsai,
H.-H., Li, H., Fuentealba, L., Molofsky,
A.V., Taveira‑Marques, R., Zhuang, H., Tenney,
A., Murnen, A.T., Fancy, S.P.J.,
Merkle, F., Kessaris,
N., Alvarez-Buylla, A.*,
Richardson, W.D.* and Rowitch,
D.H.* (2012). Regional
astrocyte allocation regulates CNS synaptogenesis and repair. Science 337,
358-362. *
joint senior authors [PDF]
Clarke,
L.E., Young, K.M., Hamilton, N.B., Li, H., Richardson, W.D.
and Attwell, D. (2012). Properties and
fate of oligodendrocyte progenitor cells in the corpus
callosum, motor cortex and piriform cortex of the mouse. J.Neurosci. 32, 8173-8185. [PDF]
Richardson,
W.D., Young, K.M., Tripathi, R.B. and McKenzie, I. (2011). NG2-glia as
multipotent neural stem cells: fact or fantasy? Neuron 70, 661-673. [PDF]
Tripathi,
R.B., Clarke, L.E., Burzomato, V., Anderson, P.N., Kessaris,
N., Attwell, D., and Richardson, W.D. (2011). Dorsally- and
ventrally-derived oligodendrocytes have similar electrical
properties but myelinate preferred tracts. J. Neurosci.31,
6809-6819. [PDF]
Li, H.,
Paes de Faria, J., Andrew, P., Nitarska,
J. and Richardson, W.D. (2011). Phosphorylation regulates
OLIG2 co-factor choice and the motor neuron-oligodendrocyte
fate switch. Neuron 69, 918-929 [PDF]
[suppl info]
Tripathi,
R.B., Rivers, L.E., Jamen, F. Young, K.M. and Richardson, W.D.
(2010). NG2 glia
generate new oligodendrocytes but few astrocytes in a
murine experimental autoimmune encephalomyelitis model of
demyelinating disease. J.
Neurosci. 30,
16383-16390. [PDF]
[suppl info]
Young, K.M., Mitsumori,
T., Pringle, N., Grist, M. and Richardson, W.D. (2010). An Fgfr3‑iCreERT2
transgenic mouse line for studies of neural stem cells
and astrocytes. Glia
58, 943-953. [PDF] [suppl
Fig.S1] [suppl
Fig.S2]
Zawadzka,
M., Rivers, L.E., Fancy, S.P.J., Zhao, C., Tripathi R., Jamen, F., Young, K.M.,
Goncharevich, A., Pohl, H.,
Rizzi, M., Rowitch, D.H., Kessaris, N., Suter, U., Richardson, W.D.* and
Franklin, R.M.J.* (2010). CNS-resident glial
progenitor/stem cells produce Schwann cells as well as
oligodendrocytes during repair of CNS demyelination. Cell Stem Cell
6, 578-590. * joint senior authors
[PDF]
Richardson, W.D. (2009). Oligodendrocyte
Specification. In, Encyclopedia of Neuroscience (Larry
Squire, editor). Elsevier. [PDF]
Psachoulia, K., Jamen, F., Young, K.M. and Richardson, W.D.
(2009). Cell cycle dynamics
of NG2 cells in the postnatal and ageing mouse brain. Neuron Glia Biology 5, 57-67. [PDF]
Li,
H. and Richardson, W.D. (2009).
The evolution of Olig genes and their roles in
myelination. Neuron Glia Biology 4, 129-135. [PDF]
Li,
H., He, Y., Richardson, W.D. and Casacchia,
P. (2009). Two-tier transcriptional
control of oligodendrocyte differentiation. Curr. Opinion Neurobiol. 19, 479-485. [PDF]
Li, H. and Richardson,
W.D. (2009). Genetics meets
epigenetics: HDACs
and Wnt signalling in
oligodendrocyte development and regeneration. Nat. Neurosci. 12, 815-817. (News and Views) [PDF]
Rivers, L.E., Young, K.M., Rizzi, M., Jamen, F., Psachoulia,
K., Wade, A., Kessaris, N. and Richardson, W.D. (2008).
PDGFRA/ NG2-positive glia generate myelinating
oligodendrocytes and piriform projection neurons in adult
mice. Nat. Neurosci. 11, 1392-1401. [PDF]
[suppl info]
Pontecorvi, M.,
Goding, C.R.,
Kessaris, N., Pringle,
N.P. and Richardson, W.D. (2008). Specification
of CNS glia from neural stem cells in the embryonic
neuroepithelium.
Phil. Trans. Royal
Soc. B 363,
71-85. [PDF]
2003-2007
Li, H., Lu, Y., Smith,
H.K. and
Young, K., Fogarty,
M., Kessaris, N. and Richardson, W.D. (2007).
Subventricular zone stem cells are heterogeneous with respect
to their embryonic origins and neurogenic fates in the adult
olfactory bulb. J. Neurosci.
27, 8286-8296.
[PDF]
[suppl
info]
Barrio,
M.G., Taveira-Marques, R., Muruyama,
Y., Yuk., D.‑I., Li, S.,
Wines-Samuelson, M., Shen., J.,
Smith, H.K., Xiang, M., Rowitch, D. and Richardson, W.D.
(2007). A regulatory network involving Foxn4, Mash‑1 and
Delta‑like 4/Notch‑1 generates V2a and V2b spinal
interneurons from a common progenitor pool. Development 134,
3427-3436. [PDF]
Kazakova, N., Li, H., Mora, A.,
Jessen, K., Mirsky, R.,
Kessaris,
N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M. and
Fogarty,
M.,
West,
H.,
Billon,
N., Terrinoni, A., Jolicoeur, C., McCarthy, A.,
Kessaris,
N., Jamen, F., Rubin, L.L., and
Woodruff,
R.F., Fruttiger, M.,
Ivanova, A.,
Agochiya, M., Amoyel, M. and
Pringle,
N.P., Yu, W.-P., Howell, M., Colvin, J.S., Ornitz,
D.M., and
1998-2002
Rowitch,
D.H.,
Lu, Q.R., Kessaris, N., and
Fu, H.,
Qi, Y., Tan, M., Cai, J.,
Takebayashi, H., Nakafuku, M.,
Kessaris,
N., Pringle, N. and Richardson, W.D. (2001). Ventral neurogenesis and the neuron-glial
switch. Neuron 31, 677-680.
[PDF]
Tekki-Kessaris,
N.,
Woodruff, R., Hall, A.C., Gaffield,
W., Kimura, S., Stiles, C.D., Rowitch, D.H., and
van Heyningen, P., Calver, A.R. and
Richardson, W.D. (2001). Control of
progenitor cell number by mitogen supply-and-demand.
Current Biology 11, 232-241. [PDF]
Woodruff,
R.H., Tekki-Kessaris, N., Stiles, C.D., Rowitch, D.H. and
Fruttiger,
M., Calver, A.R. and Richardson, W.D. (2000). PDGF
is constitutively secreted from neuronal cell bodies but not
from axons. Current Biology 10, 1283-1286. [PDF]
Sun,
T., Jayatilake, D., Ataliotis, P., Afink,
G.B., Nister, M.,
Fruttiger,
M., Karlsson, L., Hall, A.C., Abramsson, A., Calver, A.R., Bostrom, H., Willetts,
K., Bertold, C.-H.,
Heath, J.K., Betsholtz, C. and
Sun,
T., Pringle, N.P., Hardy, A.,
Pringle,
N.P., Guthrie, S., Lumsden, A.,
and Richardson, W.D. (1998). Dorsal spinal cord
neuroepithelium generates astrocytes but not oligodendrocytes.
Neuron 20, 883-893. [PDF]
Calver,
A.R., Hall, A.C., Yu, W-P., Walsh.
F.S., Heath, J.K., Betsholtz, C.
and
1990-1997
Pringle,
N.P.,
Nadon, N.L., Rhode, D.,
Hall,
A.C., Giese, N.A. and
Fruttiger,
M.., Calver, A.R., Kruger, W., Mudhar, H.S., Michalovich,
D., Takakura, N., Nishikawa,
S.-I. and
Pringle,
N.P., Yu, W.-P., Guthrie, S., Roelink, H., Lumsden,
A., Peterson, A.C. and
Yu,
W.-P., Collarini,
E.J., Pringle, N.P. and
Ninkina,
N.N., Stevens, G.E.M., Wood, J.S., and
Mudhar,
H.S., Pollock, R.A., Wang, C., Stiles, C., and
Pringle,
N.P., and Richardson, W.D. (1993). A singularity of PDGF alpha
receptor expression in the dorsoventral
axis of the neural tube may define the origin of the
oligodendrocyte lineage. Development 117,
525-533. [PDF]
Barres,
B.A., Hart, I.K., Coles, H.S.R., Burne,
J.F., Voyvodic, J.T., Richardson,
W.D. and Raff, M.C. (1992).
Cell death and control of cell survival in the
oligodendrocyte lineage.
Cell 70, 31-46. [PDF]
Pringle,
N.P., Mudhar, H.S., Collarini, E.J. and Richardson, W.D.
(1992). PDGF receptors in the rat CNS: during late
neurogenesis, PDGF alpha-receptor expression seems to be
restricted to glial cells of the oligodendrocyte lineage. Development 115, 535-551.
[PDF]
1980-1989
Pringle,
N.,
Collarini, E.J., Mosley, M.J., Heldin, C.‑H., Westermark, B and Richardson,
W.D. (1989). PDGF
A chain homodimers drive proliferation of bipotential (O-2A)
glial progenitor cells in the developing rat optic nerve. EMBO J. 8, 1049-1056. [PDF]
Richardson, W.D., Pringle, N.P., Mosley, M.J., Westermark, B. and Dubois-Dalcq, M. (1988). A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 53, 300-310. [PDF]
Richardson, W.D. and
Westphal, H. (1981). A cascade of adenovirus early
functions is required for expression of adeno-associated
virus. Cell, 27, 133-141. [PDF]
Doctoral (PhD) Theses:
Lawrence M.J. Best (2020). "Magnetic resonance imaging of mouse models of de- and dys-myelination." Doctoral Thesis, University College London.
https://discovery.ucl.ac.uk/id/eprint/10110160/
Palma
Iannarelli (2017). "Oligodendrocyte population
dynamics and plasticity probed by genetic manipulation in
mice." Doctoral Thesis, University College London
https://discovery.ucl.ac.uk/id/eprint/1460297/
Eleni Kougioumtzidou (2015). "Regulation of
oligodendrocyte development by neuron-glial electrical
interactions." Doctoral Thesis, University
College London
https://discovery.ucl.ac.uk/id/eprint/1461417/
Alexander Sinclair-Wilson (2015). " Phosphorylation of
Olig2 and the control of stem cell fate choice in the
developing spinal cord." Doctoral Thesis, University
College London
https://discovery.ucl.ac.uk/id/eprint/1472153/
Raquel
Taveira-Marques (2011). "Fate-mapping neural stem
cells in the mouse ventral neural tube by Cre-lox
transgenesis." Doctoral Thesis, University College
London.
http://discovery.ucl.ac.uk/1333991/
Konstantina
(Nada) Psachoulia (2010). "NG2 cells in adult
neural plasticity." Doctoral
Thesis,
Leanne E. Rivers (2009).
"Oligodendrocyte progenitors and their role in adult neural
cell genesis." Doctoral Thesis, University College
London.
Nina A.L. Callard (2008). "Time-lapse studies
of neural precursor cell divisions in vitro." Doctoral
Thesis, University of London.
http://discovery.ucl.ac.uk/1446305/
http://discovery.ucl.ac.uk/1445704/
Matthew
H. Fogarty (2005). "Fate-mapping
the mouse neural tube by Cre-loxP
transgenesis." Doctoral Thesis, University of London.
https://discovery.ucl.ac.uk/id/eprint/10098508/
Paul van Heyningen (2000). "Control of glial
progenitor cell number in the developing central nervous
system." Doctoral Thesis, University College London
https://discovery.ucl.ac.uk/id/eprint/10098392/
Andrew R. Calver (1999). "Oligodendrocyte
population dynamics: insights from transgenic mice."
Doctoral Thesis, University College London.
https://discovery.ucl.ac.uk/id/eprint/10108341/
Anita C. Hall (1999). "Platelet-derived
growth factor and its alpha-receptor subunit in
oligodendrocyte development." Doctoral Thesis,
University College London.
https://discovery.ucl.ac.uk/id/eprint/10108497/
Tao Sun (1999). "Function and regulation of
platelet-derived growth factor receptor alpha during
development." Doctoral Thesis, University College
London.
https://discovery.ucl.ac.uk/id/eprint/10101288/
Wei-Ping Yu (1995). "Glial cell lineages in
the developing central nervous system." Doctoral
Thesis, University College London.
https://discovery.ucl.ac.uk/id/eprint/10101106/
Georgina E.M. Stevens (1994). "POU-domain
transcription factors in the developing rat nervous
system." Doctoral Thesis, University College London.
Hardeep Singh Mudhar (1994). "Platelet-derived
growth factor and its receptors in retinal
development." Doctoral Thesis, University College
London.
https://discovery.ucl.ac.uk/id/eprint/10103031/
Nigel P. Pringle (1992). "Platelet-derived
growth factor and its receptors in the developing rat
central nervous system." Doctoral Thesis, University
College London.
https://discovery.ucl.ac.uk/id/eprint/10121013/
Richard A. Pollock (1992). "Investigations
into the function of structural isoforms of the
platelet-derived growth factor A-chain." Doctoral
Thesis, University College London.
https://discovery.ucl.ac.uk/id/eprint/10121852/
Colin A. Hodgkinson (1990). "Studies on the
expression and functional activities of bacteriophage T7 RNA
polymerase and vaccinia virus guanylyltransferase in
mammalian cells." Doctoral Thesis, University College
London.
https://discovery.ucl.ac.uk/id/eprint/10111506/
![[suppl info]](Fig%2520S1%2520Li%2520et%2520al%25202007.jpg){kind=link}
![[suppl info]](Fig%2520S1%2520Young%2520et%2520al%25202007.jpg){kind=link}