Rihel Lab

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Publications (rollover for links)


Suppermpool A, Lyons DG, Broom E, Rihel J* (2024). “Sleep pressure modulates single-neuron synapse dynamics in zebrafish”. Nature 629, 639-45. https://doi.org/10.1038/s41586-024-07367-3 *corresponding author

Kroll F, Donnelly J, Özcan GG, Mackay E, and Rihel J* (2024) "Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes". eLife13:RP96839 https://doi.org/10.7554/eLife.96839.1 *corresponding author

Özcan GG, Lim S, Canning T, Tirathdas L, Donnelly J, Kundu T, and Rihel J* (2024). “Genetic and chemical disruption of Amyloid Precursor Protein processing impairs zebrafish sleep maintenance”. iScience 27, 108870.*corresponding author

Kempthorne L, Vaizoglu D, Cammack A, Carcolé M, Suklai P, Muralidharan B, Kroll F, Moens T, Yshii L, Verschoren S, Holbling B, Katona E, Mikheenko A, Coneys R, de Oliveira P, Zhang YJ, Jansen K, Daughrity L, McGown A, Ramesh T, Van Den Bosch L, Rahim A, Petrucelli L, Rihel J, Isaacs A (preprint). “Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo”. BioRxiv, doi: https://doi.org/10.1101/2024.01.26.577366


Benoit E, Lyons DG, and Rihel J* (2023). “Noradrenergic Tone is Not Required for Neuronal Activity-Induced Rebound Sleep in Zebrafish”. J Comp Physiol B. 2023 Jul 22. doi: 10.1007/s00360-023-01504-6. *corresponding author

Barlow IL, Mackay E, Wheater E, Goel A, Lim S, Zimmerman S, Woods I, Prober DA, Rihel J* (2023). “The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation”. eLife 12:RP87521 https://doi.org/10.7554/eLife.87521.2 *corresponding author

Tornini VA, Lee H-J, Miao L, Tang Y, Dube S, Gerson T, Schmidt V, Du K, Kuchroo M, Kroll F, Vejnar CE, Bazzini AA, Krishnaswamy S, Rihel J*, Giraldez AJ* (2023). “linc-wrb and linc-mipep1 encode micropeptides that regulate chromatin accessibility in vertebrate-specific cell types”. eLife *co-corresponding author

Weinshutz Medes H, Neelakantan U, Liu Y, Fitzpatrick SE, Chen T, Wu W, Pruitt A, Jin D, Enriquez KD, Lacadie CM, Li N, Zhao D, Carlson M, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez JM, Eilbott JA, Wyk BV, Rihel J, Papademetris X, Wang Z, Hoffman EJ (2023). "High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways", Cell Reports 42(3):112243   DOI:https://doi.org/10.1016/j.celrep.2023.112243


Tuschl K, White RJ, Trivedi CA, Valdivia LE, Niklaus S, Bianco IH, Dadswell CM, Gonzalez-Mendez R, Sealy IM, Neuhauss SCF, Houart C, Rihel J, Wilson SW, and Busch-Nentwich EM (2022). “Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish”. Disease Models and Mechanisms 15 (6): dmm044594


Kroll F, Powell GT, Ghosh M, Antinucci P, Hearn TJ, Tunbak H, Lim S, Dennis HW, Fernandez JM, Hoffman EJ, Whitmore D, Dreosti E, Wilson SW and Rihel J* (2021). A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. Elife: e59683. *corresponding author


Rihel J (2020). Sleep Across the Animal Kingdom. in Sleep Science, Oxford University Press, pages 15-31

Ozcan GG, Lim S, Leighton PLA, Allison WT, Rihel J* (2020). Sleep is bi-directionally modified by amyloid beta oligomers. Elife Jul 14;9:e53995. doi: 10.7554/eLife.53995 *corresponding author. Paper won Sleep Research Society Young Investigator Award to Dr Ozcan.

Lyons DG and Rihel J* (2020). Sleep circuits and physiology in non-mammalian systems. Current Opinion in Physiology, https://doi.org/10.1016/j.cophys.2020.03.006 *corresponding author

Ghosh M and Rihel J* (2020). Hierarchical compression reveals sub-second to day-long structure in larval zebrafish behaviour. eNeuro, https://doi.org/10.1523/ENEURO.0408-19.2020 *corresponding author

Dreosti E, Hoffman EJ, and Rihel J (2020) Modelling autism spectrum disorders in zebrafish. In: Gerlai RT (ed). Behavioral and Neural Genetics of Zebrafish. San Diego: Elsevier Inc./Academic Press: pp-pp. 451-471.


Shibata-Germanos S, Goodman JR, Grieg A, Trivedi C, Lashley T, Benson BC, Foti SC, Faro A, Castellan R, Correra R, Barber M, Ruhrberg C, Weller RO, Iliff JJ, Hawkins TA, and Rihel J*. (2019) Conservation of a vertebrate meningeal phagocyte with structural and functional characteristics of lymphatic endothelial cells. Acta Neuropathologica, doi:10.1007/s00401-019-02091-z

Reichert S, Pavon Arocas O, Rihel J* (2019). The neuropeptide Galanin is required for homeostatic rebound sleep following increased neuronal activity. Neuron, 104(2):370-384 *corresponding author#


Ashlin TG, Blunsom NJ, Ghosh M, Cockcroft S*, and Rihel J* (2018). Pitpnc1a regulates zebrafish sleep and wake behavior through modulation of Insulin-like Growth Factor signaling. Cell Reports, 24 (6), 1389-1396. *co-corresponding

Rihel J (2018). Copper on the Brain. Nature Chemical Biology, 14(7):638-639.


Singh C, Rihel J, and Prober DA (2017). Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current Biology, doi.org/10.1016/j.cub.2017.11.018

Shams S, Rihel J, Ortiz JG, and Gerlai R (2017). The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium. Neuroscience and Biobehavioral Reviews Sep 5. pii: S0149-7634(17)30071-4. doi: 10.1016/j.neubiorev.2017.09.002

Chen S, Reichert S, Singh C, Oikonomou G, Rihel J*, and Prober DA* (2017). Light-dependent regulation of sleep/wake states by prokineticin 2 in zebrafish. Neuron. http://dx.doi.org/10.1016/j.neuron.2017.06.001. *co-corresponding

van Lessen M, Shibata-Germanos S, van Impel A, Hawkins TA, Rihel J, and Schulte-Merker S (2017). Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. eLife DOI: http://dx.doi.org/10.7554/eLife.25932

Barlow IL and Rihel J (2017). Zebrafish sleep: from geneZZZ to neuronZZZ. Current Opinion in Neurobiology, 10.1016/j.conb.2017.02.009


Naumann E, Fitzgerald JE, Dunn TW, Rihel J, Sompolinsky H, and Engert F (2016). From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response. Cell, 167(4):947-960.

Tuschl, K., Meyer, E., Valdivia, L.E., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C.Y., Simpson, M.A., Chong, W.K., Jacques, T.S., et al. (2016). Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun 7, 11601.

Chiu CN*, Rihel J*, Lee DA, Singh C, Mosser EA, Chen S, Sapin S, Engle J, Niles BJ, Montz CJ, Chakravarthy S, Salehi-Ashtiani K, Vidal M, Schier AF, Prober DA. (2016) A zebrafish genetic screen identifies neuromedin U as a regulator of sleep/wake states.  Neuron 89(4):842-856. *co-first author

Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJF, Wilson SW, Rihel J*, State MW*, Giraldez AJ* (2016). Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron DOI:http://dx.doi.org/10.1016/j.neuron.2015.12.039 *co-corresponding


Davies WIL, Tamai TK, Zheng L, Fu JK, Rihel J, Foster RG, Whitmore D, and Hankins MW. (2015). An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome Research 25:1-4.

Rihel J* and Bendor D. (2015). Flies Sleep on It, or Fuhgeddaboudit! Cell 161, 1498–1500.

Rihel J* and Ghosh M. (2015). Zebrafish. In Drug Discovery and Evaluation: Pharmacological Assays, F.J. Hock, ed. (Springer Berlin Heidelberg), pp. 1–102.


O'Leary LA (2014). Orexin and melanin-concentrating hormone neurons: a hypothalamic interface for sleep and feeding regulation. Bioscience Horizons, 7: hzu008, doi:10.1093/biohorizons/hzu008. Supervisor: Rihel J

Ozcan GG and Rihel J* (2014). A Drosophila Circuit feels the (Sleep) Pressure. Neuron, 81(4):720-22.


Rihel J*, and Schier AF (2013).  Sites of action of sleep and wake drugs: insights from model organisms.  Current Opinion in Neurobiology, 23(5):831-40.


Rihel J*, and Schier AF (2012).  Behavioral screening for neuroactive drugs in zebrafish.  Developmental Neurobiology, 72(3):373-385.


Rihel J*, Prober DA, and Schier AF (2010).  Chapter 11--Monitoring sleep and arousal in zebrafish. Methods in Cell Biology, 100:281-294.  

Rihel J*, Prober DA*, Arvanites A, Lam K, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, and Schier AF (2010).  Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.  Science, 327(5963):348-51.
*equal contribution

Emran F, Rihel J, Adolph AR, Dowling JE (2010).  Larval zebrafish lose vision at night. PNAS, 107(13): 6034-6039.


Prober DA, Zimmerman S, Myers BR, McDermott BM Jr., Kim SH, Caron S, Rihel J, Solnica-Krezel L, Julius D, Hudspeth AJ, and Schier AF (2008).  Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.   J Neuroscience, 28(40):10102-10.

Emran F, Rihel J, and Dowling, JE (2008).  A behavioral assay to measure responsiveness of zebrafish to changes in light intensities.  J of Visualized Experiments, 19, October 3, 2008.


Emran F, Rihel J, Adolph AR, Wong KY, Kraves S, and Dowling JE (2007).  OFF ganglion cells cannot drive the optokinetic reflex in zebrafish. PNAS, 104(48): 19126-19131.


Prober D, Rihel J, Onah AA, Sung RJ, Schier AF (2006).  Hypocretin/orexin overexpression generates a zebrafish genetic model of insomnia.  J Neuroscience, 26(51):13400-13410.

Giraldez, AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier, AF (2006).  Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science, 312(5770):75-9.


Tietjen I, Rihel J, Dulac CG (2005).  Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium.  International Journal of Developmental Biology, 49(2-3):201-7.


Tietjen I*, Rihel JM*, Cao Y*, Koentges G, Zakhary L, Dulac C (2003).  Single cell transcriptional analysis of neuronal progenitors.  Neuron, 38:161-175.              
* equal contribution


Bao S*, Rihel J*, Bjes E, Price JL (2001).  The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.  J Neuroscience, 21(18):7117-71.
* equal contribution