: "The use of repetitive TMS in a functional neuroimaging environment to study brain plasticity in humans"
Prof JC Rothwell
ION Funding, Brain Research Trust
Description of Project:
We investigated reorganisation in the motor and attentional networkds during performance of manual tasks following disruption of particular brain areas with rTMS. We found that rTMS could induce lasting changes in synaptic activity, measured with Positron Emission Tomography and functional Magnetic Resonance Imaging, in areas remote but functionally connected to the stimulation site. These occured in the absence of any significant changes in behavioural performance and were thought to constitute a compensatory response in order to maintain function.
Huang,Y.Z., Edwards,M.J., Rounis,E., Bhatia,K.P., & Rothwell,J.C. (2005) Theta burst stimulation of the human motor cortex. Neuron., %20;45, 201-206.
Rounis,E. , Lee,L., Siebner,H.R., Rowe,J.B., Friston,K.J., Rothwell,J.C., & Frackowiak,R.S. (2005) Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex. Neuroimage., 26, 164-176.
Rounis,E. , Stephan,K.E., Lee,L., Siebner,H.R., Pesenti,A., Friston,K.J., Rothwell,J.C., & Frackowiak,R.S. (2006) Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task. J Neurosci., 26, 9629-9638.
Rounis,E. , Yarrow,K., & Rothwell,J.C. (2007) Effects of rTMS conditioning over the fronto-parietal network on motor versus visual attention. J Cogn Neurosci., 19, 513-524.
Lindberg,P.G., Skejo,P.H., Rounis,E., Nagy,Z., Schmitz,C., Wernegren,H., Bring,A., Engardt,M., Forssberg,H., & Borg,J. (2007) Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. Neurorehabil.Neural Repair., 21, 551-560.
Koch,G., Schneider,S., Baumer,T., Franca,M., Munchau,A., Cheeran,B., Fernandez Del,O.M., Cordivari,C., Rounis,E., Caltagirone,C., Bhatia,K., & Rothwell,J.C. (2008) Altered dorsal premotor-motor interhemispheric pathway activity in focal arm dystonia. Mov Disord., .