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MBPhD Programme

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JAFREE, Daniyal

Entered:

September 2017

Current Position:

(2017/18) PhD Research Year 1

PhD title:

Unravelling the origins of the kidney lymphatics

Principal Supervisor:

Dr David Long, UCL Great Ormond Street Institute of Child Health (Kidney Development and Disease Group, Developmental Biology and Cancer Programme), Faculty of Population Health Sciences

Funding Source:

Child Health Research Charitable Incorporated Organisation and UCL MBPhD Programme

Description of Project:

The field of lymphatic biology has exploded in recent years, given the discovery of specific lymphatic markers, and the generation of new experimental models over the last two decades. The lymphatic vasculature has now been implicated in hypertension, inflammatory diseases, obesity, cancer and beyond. However, the growth and role of lymphatics in the kidney remains a mystery.

We use a combination of novel approaches, including genetic manipulation and advanced imaging strategies, to study the formation of the lymphatics in the kidney. This has implications for vascular biology, as the organ-specific growth and function of lymphatic vessels are just beginning to be understood. Revealing fundamental principles of how the kidney lymphatics is also of benefit to patients, as it provides a basis to study the potential of the lymphatics as a target in chronic kidney disease in children and adults.

Publications:

Peer-reviewed journal articles:

Jafree DJ, Williams AC, Zakrzewska JM (2018) Impact of pain and postoperative complications on patient-reported outcome measures 5 years after microvascular decompression or partial sensory rhizotomy for trigeminal neuralgia. Acta Neurochir (Wien) 160: 125-134, PMID: 29080911

Agha RA, Jafree DJ, Vella-Baldacchino M, Limb C, Kusu-Orkar TE, Millip MC, Fowler AJ (2017) Surveying opinions of 149 registrants to the Research Registry: Awareness of and attitudes towards research registration. Int J Surg 39: 182-187. PMID: 28063975

STARSurg Collaborative (DJ Jafree) (2017) Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study. World J Surg 41: 47-55. PMID: 27766396

Agha R, Fowler AJ, Limb C, Al Omran Y, Sagoo H, Koshy K, Jafree DJ, Anwar MO, McCullogh P, Orgill DP (2016) The First 500 Registrations to the Research Registry®: Advancing Registration of Under-Registered Study Types. Front Surg 3: 50 doi: 10.3389/fsurg.2016.00050. PMID: 27695693

Pidgeon TE, Wellstead G, Sagoo H, Jafree DJ, Fowler AJ, Agha RA (2016) An assessment of the compliance of systematic review articles published in craniofacial surgery with the PRISMA statement guidelines: A systematic review. J Craniomaxillofac Surg 44: 1522-1530. PMID: 27575881

Radenkovic D, Kotecha S, Patel S, Lakhani A, Reimann-Dubbers K, Shah S, Jafree D, Mitrasinovic S, Whitten M (2016) Improving maternal confidence in neonatal care through a checklist intervention. BMJ Qual Improv Rep 5 doi: 10.1136/bmjquality.u210655.w4292. PMID: 27335642

STARSurg Collaborative (DJ Jafree) (2016) Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery. Br J Surg 103: 1158-1172. PMID: 27321766

Agha RA, Fowler AJ, Limb C, Whitehurst K, Coe R, Sagoo H, Jafree DJ, Chandrakumar C, Gundogan B (2016) Impact of the mandatory implementation of reporting guidelines on reporting quality in a surgical journal: A before and after study. Int J Surg 30:169-172. PMID: 27112835

Fowler A, Limb C, Jafree D, Agha R (2017) Describing the first 2000 registrations to the Research Registry®: A study protocol. Int J Surg Protoc 6:11-12. PMID: N/A

Jafree DJ, Koshy K (2017) How to apply to a summer undergraduate research programme. Int J Surg Oncol 2: e25 doi: 10.1097/IJ9.0000000000000029. PMID: 29238757

Agha R, Whitehurst K, Jafree D, Devabalan Y, Koshy K, Gundogan B (2017) How to write a medical CV. Int J Surg Oncol 2: e32 doi: 10.1097/IJ9.0000000000000032. PMID: 29177224

Koshy K, Limb C, Gundogan B, Whitehurst K, Jafree DJ (2017) Reflective practice in health care and how to reflect effectively. Int J Surg Oncol 2: e20 doi: 10.1097/IJ9.0000000000000020. PMID: 29177215

Jafree DJ, Whitehurst K, Rajmohan S (2016) How to approach supervisors for research opportunities. Ann Med Surg 10: 110-112 PMID: 27625784

Fowler AJ, Al Omran Y, Pidgeon TE, Jafree DJ, Agha RA (2016) Response to: Surgical trainee research collaboratives in the UK: An observational study of research activity and publication productivity. Int J Surg 33: 133-135 PMID: 27504847

Conference abstracts:

Jafree DJ, Zakrzewska JM, Venda-Nova C (2017) Patient-completed screening tools have poor diagnostic accuracy for neuropathic orofacial pain in a hospital-based cohort. Eur J Neurol. 24 (S1), 284

Jafree DJ, Nychyk O, Greene N, Copp A, Winyard P (2016) Prenatal Renal Tract Abnormalities in Murine Models of Spina Bifida Overexpressing Grainyhead-Like 2 and Grainyhead-Like 3. J Am Soc Nephrol 27, 388A

Venda Nova, Jafree D, Ghurye S, Awal D, Ghiai A, Leeson R, McMillan R, Zakrzewska J (2016) Utility of screening tools in a facial pain patient cohort. Oral Dis 22, S2

Agha R, Fowler AJ, Limb C, Al Omran Y, Sagoo H, Koshy K, Jafree DJ, Anwar MO, McCullogh P, Orgill DP (2016) Advancing the cause of research registration: the first 500 registrations of the researchregistry.com. Int J Surg 36, S133-137

Pidgeon TE, Wellstead G, Sagoo H, Jafree DJ, Fowler AJ, Agha R (2016) An assessment of the compliance of systematic review articles published in craniofacial surgery with the PRISMA statement guidelines: a systematic review. Int J Surg 36, S139

Agha RA, Fowler AJ, Limb C, Sagoo H, Al Omran Y, Koshy K, Anwar M, Jafree D (2016) Development of a global research registry: improving compliance with the declaration of Helsinki 2013. Brit J Surg 103 (S3), 6-49

Teaching:

 

Awards & Prizes:

Developmental Biology and Cancer Programme Three Minute Thesis Competition winner, 2018 (UCL Great Ormond Street Institute of Child Health)

Certificate of Merit for MBBS Year 4 examinations, 2017 (UCL Medical School)

Travel award for attendance at 3rd European Academy of Neurology Congress, 2017 (UCL Medical Society, Research & Academic Medicine Section)

Dean’s Research Prize, 2017 (UCL Faculty of Medical Sciences)

Travel award for attendance at American Society of Nephrology Kidney Week, 2016 (British Society of Developmental Biology, Company of Biologists)

Oral Presentation Prize, 2016 (European Health Innovation Collaborative)

Dean’s List, 2016 (UCL Faculty of Medical Sciences)

Ken Hobbs’ Prize for highest academic performance in iBSc Surgical Sciences, 2016 (UCL Division of Surgery and Interventional Sciences)

Presentation Prize for highest score in the iBSc Surgical Sciences dissertation defence, 2016 (UCL Division of Surgery and Interventional Sciences)

British Society of Developmental Biology Summer Studentship, 2016 (British Society of Developmental Biology, Company of Biologists)

Be The Change NHS University Champions, 2016 (Be The Change Initiative)

Kidney Research UK Intercalated BSc Scholarship, 2016 (Kidney Research UK)

Oral Presentation Prize, 2015 (AcaMedics National Symposium)

Travel award for attendance at the European Students Conference, 2015 (European Students Conference)

Zurich Biology Undergraduate Summer Studentship, 2015 (University of Zurich)