MBPhD Programme





Current Position:

Qualified 2008

PhD title:

"Cortical oscillations in human motor control"

Principal Supervisor:

Dr P Brown

Funding Source:

Lord Amulree Trust

Description of Project:

The spontaneous or stimulus evoked firing of Neurons is often rhythmic in nature. The primary motor cortex is characterised by oscillatory activity at around 20Hz. This so-called, "beta" rhythm, has been argued to contribute to the bradykinesia and rigidity that characterises Parkinson's disease, since it is grossly exaggerated in the dopamine depleted cortico-basal ganglia system. Using a combination of neurophysiological and signal processing techniques, the aim of this thesis is to test how beta oscillations might alter the functional properties of the motor cortex in Parkinsons's disease and contribute to the symptoms of bradykiesia and rigidity

Gilbertson et. al., (2005). Existing motor state is favoured at the expense of new movement during 13-35 Hz oscillatory synchrony in the human corticospinal system. Journal of Neuroscience 25(34):7771-9.

PubMed-accessible Publications:

Chen,C.C., Litvak,V., Gilbertson,T., Kuhn,A., Lu,C.S., Lee,S.T., Tsai,C.H., Tisch,S., Limousin,P., Hariz,M., & Brown,P. (2007) Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease. Exp.Neurol., 205, 214-221.