Qualified: MBBS 2008 / MPhil 2006
"Gene Therapy of the scid/scid mouse by homologous recombination"
Dr R Yanez & Dr A Thrasher
Overseas Funding ( Singapore). Additional funding for extension from Samuel Bridge Trust.
Description of Project:
We are exploring the use of gene therapy by homologous recombination, also known as gene targeting, to correct the point mutation responsible for the scid mouse. The use of lentiviral vectors and electroporated constructs of various designs is being tested in cell lines and in vivo.