MBPhD Programme





Current Position:

PhD awarded 2008

PhD title:

Antigen Identification in Paraneoplastic and Post-Infectious Neurological Disorders

Principal Supervisor:

Dr J Rees

Funding Source:

Int Journal of Path

Description of Project:

"The Identification and Purification of neuronal proteins Associated with Paraneoplastic Neurological Syndromes"

PubMed-accessible Publications:

Church,A.J., Dale,R.C., Cardoso,F., Candler,P.M., Chapman,M.D., Allen,M.L., Klein,N.J., Lees,A.J., & Giovannoni,G. (2003) CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? J.Neuroimmunol., 136, 149-153.

Candler,P.M . & Dale,R.C. (2004) Three cases of central nervous system complications associated with Mycoplasma pneumoniae. Pediatr.Neurol., 31, 133-138.

Candler,P.M ., Hart,P.E., Barnett,M., Weil,R., & Rees,J.H. (2004) A follow up study of patients with paraneoplastic neurological disease in the United Kingdom. J.Neurol.Neurosurg.Psychiatry., 75, 1411-1415.

Chapman,M.D., Hartley,J.C., Furrows,S.J., Ridgeway,G.L., Thompson,E.J., Church,A.J., Candler,P.M., & Giovannoni,G. (2005) Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis. Eur.Neurol., 53, 81-83.

Martino,D., Branson,J.A., Church,A.J., Candler,P.M., Livrea,P., Giovannoni,G., & Dale,R.C. (2005) Soluble adhesion molecules in acute disseminated encephalomyelitis. Pediatr.Neurol., 33, 255-258

Candler,P.M ., Dale,R.C., Griffin,S., Church,A.J., Wait,R., Chapman,M.D., Keir,G., Giovannoni,G., & Rees,J.H. (2006) Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. J.Neurol.Neurosurg.Psychiatry., 77, 507-512.

Dale,R.C., Candler,P.M., Church,A.J., Wait,R., Pocock,J.M., & Giovannoni,G. (2006) Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease. J.Neuroimmunol., 172, 187-197.

Dale,R.C., Church,A.J., Candler,P.M., Chapman,M., Martino,D., & Giovannoni,G. (2006) Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology., 66, 1612.

Chapman,M.D., Thompson,E.J., Candler,P.M., Dale,R.C., Church,A.J., & Giovannoni,G. (2007) Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblotting. J Neuroimmunol., 185, 130-135.