MBPhD Programme


BRICOGNE, Christopher Charles


July 2011

Current Position: 

Qualified 2017

PhD title: 

Plasma membrane dynamics regulating the PD-1 : PD-L1 pathway

Principal Supervisor: 

Professor Mary Collins, Cancer Institute

Funding Source: 

Rosetrees Charitable Trust and MRC DTG

Description of Project:



Liechtenstein T, Perez-Janices N, Bricogne C, Lanna A, Dufait I, Goyvaerts C, Laranga R, Padella A, Arce F, Baratchian M, Ramirez N, Lopez N, Kochan G, Blanco-Luquin I, Guerrero-Setas D, Breckpot K, Escors D. Immune modulation by genetic modification of dendritic cells with lentiviral vectors. Virus Res. 2013 Sep;176(1-2):1-15. doi: 10.1016/j.virusres.2013.05.007.

Dufait I, Liechtenstein T, Lanna A, Bricogne C, Laranga R, Padella A, Breckpot K, Escors D. Retroviral and lentiviral vectors for the induction of immunological tolerance. Scientifica (Cairo). 2012 Dec;2012. doi:pii: 694137.

Liechtenstein T, Dufait I, Bricogne C, Lanna A, Pen J, Breckpot K, Escors D. PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell
Differentiation Signal. J Clin Cell Immunol. 2012 Oct 30;S12. doi:pii: 006.

Escors D, Bricogne C, Arce F, Kochan G, Karwacz K. On the Mechanism of T cell receptor down-modulation and its physiological significance. J Biosci Med. 2011 Jan;1(1). doi:pii: 2011.5.

Karwacz K, Arce F, Bricogne C, Kochan G, Escors D. PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy. Oncoimmunology. 2012 Jan 1;1(1):86-88.

Karwacz K, Bricogne C, MacDonald D, Arce F, Bennett CL, Collins M, Escors D. PD-L1 co-stimulation contributes to ligand-induced T cell receptor
down-modulation on CD8+ T cells. EMBO Mol Med. 2011 Oct;3(10):581-92. doi: 10.1002/emmm.201100165. Epub 2011 Aug 10. PubMed PMID: 21739608;


UCL MSc Cancer - Lecturer and exam marker

Awards & Prizes:

UCL Bogue Research Fellowship - 5 months visiting fellowship to UT Southwestern, Dallas, TX, USA.