Institute of Immunity and Transplantation


Coagulation & inflammation

Find out about Professor Amit Nathwani's research on coagulation and inflammation.

The primary functions of the coagulation, complement and fibrinolytic systems are to limit blood loss, prevent infection and aid in blood clot clearance/ wound healing, respectively.

The coagulation, complement and fibrinolytic systems are highly interactive and as a result, when one becomes dysregulated, activation of the others are altered and processes such as thrombosis and chronic inflammation can arise.

Patients with impaired thrombin generation also have dysregulated fibrinolysis as demonstrated by the defect in TAFI activation observed in haemophilia A, which contributes to bleeding in certain individuals.

Our group is focused on establishing assays capable of predicting patients at risk of fibrinolytic-induced bleeding, thus allowing for better management of their condition.

In arterial injury causing thrombosis, complement C3a and C5a are strongly correlated whereas they are not correlated in venous thrombosis.

Explaining the discordance of these data is a major focus of our research. Our group aims to characterise the mechanisms of complement activation in thrombosis and devise methods to control inflammation in thrombotic disease.