DAF-2 receptor structure and mutations

Image: DAF-2 receptor

Homology model of C. elegans DAF-2 insulin/IGF-1 receptor showing positions of mutant lesions of different allele classes. Green = class 1, red = class 2, black= non-conditional alleles. Purple: Residues predicted to bind to insulin-like ligands. Blue: Receptor tyrosine kinase active site.

From D.S. Patel, A. Garza-Garcia, M. Nanji, J.J. McElwee, D. Ackerman, P.C. Driscoll, D. Gems. 'Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.' Genetics (2008) 178: 931-946. (download pdf file)

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