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Understanding the biology of longevity and ageing using a nematode model
A focus of current work in this laboratory is understanding the biological mechanisms that cause pathologies of ageing, and how such pathologies lead to mortality; and how reduced insulin/IGF-1 signalling and dietary restriction suppress ageing and increase lifespan. Other interests include the mechanisms of organismal death, sex differences in the biology of ageing, the role of the microbiome in ageing, evolutionary conservation of mechanisms of ageing, and bioethical implications of ageing research. Funded for our research has been received from the BBSRC, the European Union and the Wellcome Trust.
Research Team
Hannah Chapman, Ph.D. student/research technician, email: hannah.chapman@ucl.ac.uk
Winter 2023/24: Jan 2024, new article in BMC Ecology and Evolution on analysis of colony-level fitness traits in C. elegans (relevant to theory of adaptive death). Recent article in Nature Communications on evidence of semelparous reproductive death in C. elegans. Recent article in GeroScience on improved delivery of anti-ageing drugs using liposomes. For details see publications.
Hear Bruce Zhang talk about the recent helminth infection and inflammageing theory in a Naked Scientists podcast
Updated on
12th March 2024
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SPIM image of a pharynx in a wild-type (N2) C. elegans on day 8 of adulthood (20˚C) where the terminal bulb is infected with RFP labelled E. coli. This will eventually lead to P death, the cause of death of ~40% of senescent wild-type C. elegans (Zhao et al. Nature Communications, 2017). Movie generated by H. Wang. Links Gems Lab Publications | About David Gems | Postgraduate opportunities in Gems lab | IHA main page | Genetics, Evolution and Environment | UCL home page C. elegans Links What is C. elegans | Wormbase | C. elegans Genetics Center | Nematode Net More links NCBI | CEE | Who's Who in Gerontology | Enhancement Technologies | UCL Library | PubMed | Google
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