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Mammalian Sensory Genetics
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James Cox is a MRC Research Career Development Fellow working within Prof John Wood's Molecular Nociception team at University College London.
Dr Cox graduated from the University of Birmingham in 2001 having studied Medical Science, specialising in cell and molecular biology. Inspired by Dr Tessa Webb to study the genetics of learning disability, Dr Cox joined Dr Lucy Raymond's team at the Dept of Medical Genetics, University of Cambridge and in 2004 completed his Ph.D. in human molecular genetics.
In 2005, he was a founder member of Prof Geoff Woods' University of Cambridge research team, investigating the genetic basis of several human neuronal disorders, including Primary Microcephaly, MORM Syndrome and Channelopathy-associated Insensitivity to Pain.
In order to focus on the genetics of pain, Dr Cox collaborated and then joined Prof John Wood's team at University College London where he identified the gene responsible for Familial Episodic Pain Syndrome. In 2011 Dr Cox, with MRC support, started his own research team and became a Senior Research Fellow at UCL. For further information about current research areas please see the Molecular Nociception webpage http://www.ucl.ac.uk/molecular-nociception-group/.
- 2011-date MRC Research Career Development Fellow, WIBR, UCL
- 2010-2011 Post-doc, WIBR, UCL
- 2009-2010 Post-doc, University of Cambridge
- 2008 Post-doc, UCL
- 2005-2007 Post-doc, University of Cambridge
- 2001-2004 Ph.D., University of Cambridge
- 1998-2001 B. Med. Sc. First Class Honours (Cell and Molecular Biology), University of Birmingham
Quick K, Zhao J, Eijkelkamp N, et al. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol 2012; 2(5):120068
Cox JJ, Willatt L, Homfray T, Woods CG. A SOX9 duplication and familial 46,XX developmental testicular disorder. N Engl J Med 2011;364:91-3.'
Cox JJ, Sheynin J, Shorer Z, et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Hum Mutat 2010;31:E1670-86.
Kremeyer B, Lopera F, Cox JJ et al. A gain-of-function mutation in TRPA1 causes Familial Episodic Pain Syndrome (FEPS). Neuron 2010 66(5):671-80.
Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin DV, McHale DP, Drenth JPH et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci USA 2010 107(11):5148-53.
Jacoby M, Cox JJ, Gayral S, et al. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 2009;41:1027-31.
Further publication information can be viewed at https://iris.ucl.ac.uk/iris/browse/profile?upi=JCOXX25
Research Associate / Fellow