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chromosome 22q deletion

Parkinson's chromosome deletion linked to other genetic disorders

Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders. More...

Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
More...

Patrick A Lewis

(Principal Investigator and Parkinson`s UK Research Fellow)

Patrick Lewis


I studied biochemistry at the University of Manchester, undertaking a year of research at the Mayo Clinic in Florida as part of this during which I investigated cellular dysfunction linked to mutations in the amyloid precursor protein and presenilin 1 associated with familial Alzheimer's disease. I then moved to the MRC Prion Unit at UCL, where I carried out graduate studies into the molecular mechanisms of scrapie gaining my PhD in 2005. From 2005 to 2007 I was visiting fellow in the Laboratory of Neurogenetics at the National Institute of Aging in Bethesda, mentored by Mark Cookson. It was here that I first started working on LRRK2, a protein which has been the object of my affections ever since. I returned to UCL in 2007 as a Brain Research Trust senior research fellow in the Department of Molecular Neuroscience and have continued my research into the basis of Parkinson's disease linked to mutations in LRRK2. I am currently a Parkinson's UK research fellow.

Laboratory webpage

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Number of items: 74.

2017

Cogo, S; Greggio, E; Lewis, PA; (2017) Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors. EXPERT OPINION ON THERAPEUTIC TARGETS , 21 (8) pp. 751-753. 10.1080/14728222.2017.1342968.

Ferrari, R; Lovering, RC; Hardy, J; Lewis, PA; Manzoni, C; (2017) Weighted Protein Interaction Network Analysis of Frontotemporal Dementia. Journal of Proteome Research , 16 (2) pp. 999-1013. 10.1021/acs.jproteome.6b00934.

Manzoni, C; Ferrari, R; Hardy, J; Lovering, RC; Bandopadhyay, R; Lewis, PA; (2017) Protein network analysis of FTD and PD: pathways and candidate genes for sporadic disease. Presented at: 118th Meeting of the British-Neuropathological-Society, Royal Coll Phys, London, ENGLAND.

Manzoni, C; Lewis, PA; (2017) LRRK2 and Autophagy. Adv Neurobiol , 14 pp. 89-105. 10.1007/978-3-319-49969-7_5.

Murthy, MN; Blauwendraat, C; UKBEC, ; Guelfi, S; IPDGC, ; Hardy, J; Lewis, PA; (2017) Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3. Neurogenetics 10.1007/s10048-017-0514-8. Green open access
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Noyce, AJ; Kia, DA; Hemani, G; Nicolas, A; Price, TR; De Pablo-Fernandez, E; Haycock, PC; ... Wood, NW; + view all (2017) Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Medicine , 14 (6) , Article e1002314. 10.1371/journal.pmed.1002314. Green open access
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2016

Kara, E; Tucci, A; Manzoni, C; Lynch, DS; Elpidorou, M; Bettencourt, C; Chelban, V; ... Houlden, H; + view all (2016) Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain , 139 (7) pp. 1904-1918. 10.1093/brain/aww111. Green open access
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Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Acevedo Arozena, A; Adachi, H; ... Zughaier, SM; + view all (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy , 12 (1) pp. 1-222. 10.1080/15548627.2015.1100356.

Lubbe, SJ; Escott-Price, V; Gibbs, JR; Nalls, MA; Bras, J; Price, TR; Nicolas, A; ... for International Parkinson’s Disease Genomics Consortium, .; + view all (2016) Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. Human Molecular Genetics , 25 (24) pp. 5483-5489. 10.1093/hmg/ddw348. Green open access
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Manzoni, C; Kia, DA; Vandrovcova, J; Hardy, J; Wood, NW; Lewis, PA; Ferrari, R; (2016) Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences. Brief Bioinform 10.1093/bib/bbw114.

Manzoni, C; Mamais, A; Roosen, DA; Dihanich, S; Soutar, MPM; Plun-Favreau, H; Bandopadhyay, R; ... Lewis, PA; + view all (2016) mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Scientific Reports , 6 , Article 35106. 10.1038/srep35106. Green open access
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2015

Civiero, L; Cirnaru, MD; Beilina, A; Rodella, U; Russo, I; Belluzzi, E; Lobbestael, E; ... Greggio, E; + view all (2015) Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. JOURNAL OF NEUROCHEMISTRY , 135 (6) pp. 1242-1256. 10.1111/jnc.13369.

Kiely, AP; Ling, H; Asi, YT; Kara, E; Proukakis, C; Schapira, AH; Morris, HR; ... Holton, JL; + view all (2015) Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. In: BIOMED CENTRAL LTD

Kiely, AP; Ling, H; Asi, YT; Kara, E; Proukakis, C; Schapira, AH; Morris, HR; ... Holton, JL; + view all (2015) Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular Neurodegeneration , 10 , Article 41. 10.1186/s13024-015-0038-3. Green open access
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Manzoni, C; Denny, P; Lovering, RC; Lewis, PA; (2015) Computational analysis of the LRRK2 interactome. PeerJ , 3 , Article e778. 10.7717/peerj.778. Green open access
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van der Brug, MP; Singleton, A; Gasser, T; Lewis, PA; (2015) Parkinson's disease: From human genetics to clinical trials. SCIENCE TRANSLATIONAL MEDICINE , 7 (305) 10.1126/scitranslmed.aaa8280.

2014

Civiero, L; Dihanich, S; Lewis, PA; Greggio, E; (2014) Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains. CHEMISTRY & BIOLOGY , 21 (7) pp. 809-818. 10.1016/j.chembiol.2014.05.010.

Dihanich, S; Civiero, L; Manzoni, C; Mamais, A; Bandopadhyay, R; Greggio, E; Lewis, PA; (2014) GTP binding controls complex formation by the human ROCO protein MASL1. FEBS J , 281 (1) pp. 261-274. 10.1111/febs.12593. Green open access
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Mamais, A; Chia, R; Beilina, A; Hauser, DN; Hall, C; Lewis, PA; Cookson, MR; (2014) Arsenite Stress Downregulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2) Promoting Self-Association and Cellular Redistribution. J Biol Chem , 289 (31) pp. 21386-21400. 10.1074/jbc.M113.528463. Green open access
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Schulte, EC; Ellwanger, DC; Dihanich, S; Manzoni, C; Stangl, K; Schormair, B; Graf, E; ... Winkelmann, J; + view all (2014) Rare variants in LRRK1 and Parkinson's disease. NEUROGENETICS , 15 (1) pp. 49-57. 10.1007/s10048-013-0383-8.

Tsika, E; Glauser, L; Moser, R; Fiser, A; Daniel, G; Sheerin, UM; Lees, A; ... Moore, DJ; + view all (2014) Parkinson's Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration. Hum Mol Genet , 23 (17) pp. 4621-4638. 10.1093/hmg/ddu178. Green open access
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2013

Burchell, VS; Nelson, DE; Sanchez-Martinez, A; Delgado-Camprubi, M; Ivatt, RM; Pogson, JH; Randle, SJ; ... Plun-Favreau, H; + view all (2013) The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. NATURE NEUROSCIENCE , 16 (9) 1257-U135. 10.1038/nn.3489.

Burchell, VS; Nelson, DE; Sanchez-Martinez, A; Delgado-Camprubi, M; Ivatt, RM; Pogson, JH; Randle, SJ; ... Plun-Favreau, H; + view all (2013) The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nature Neuroscience , 16 (9) pp. 1257-1265. 10.1038/nn.3489.

Kara, E; Lewis, PA; Ling, H; Proukakis, C; Houlden, H; Hardy, J; (2013) α-Synuclein mutations cluster around a putative protein loop. Neuroscience Letters , 546 pp. 67-70. 10.1016/j.neulet.2013.04.058.

Kara, E; Lewis, PA; Ling, H; Proukakis, C; Houlden, H; Hardy, J; (2013) α-Synuclein mutations cluster around a putative protein loop. Neurosci Lett , 546 67 - 70. 10.1016/j.neulet.2013.04.058. Green open access
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Kiely, AP; Asi, YT; Kara, E; Limousin, P; Ling, H; Lewis, P; Proukakis, C; ... Holton, JL; + view all (2013) α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica , 125 (5) 753 - 769. 10.1007/s00401-013-1096-7. Green open access
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Kiely, AP; Asi, YT; Ling, H; Lees, AJ; Hardy, J; Revesz, T; Holton, JL; ... Quinn, N; + view all (2013) A-synucleinopathy associated with G51D SNCA mutation: A link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica , 125 (5) 753 - 769. 10.1007/s00401-013-1096-7. Green open access
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Mamais, A; Raja, M; Manzoni, C; Dihanich, S; Lees, A; Moore, D; Lewis, PA; (2013) Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases. Neurobiol Dis , 58 pp. 183-190. 10.1016/j.nbd.2013.05.017. Green open access
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Manzoni, C; Lewis, PA; (2013) Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. The FASEB Journal , 27 (9) 3424 - 3429. 10.1096/fj.12-223842. Green open access
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Manzoni, C; Mamais, A; Dihanich, S; Abeti, R; Soutar, MP; Plun-Favreau, H; Giunti, P; ... Lewis, PA; + view all (2013) Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim Biophys Acta , 1833 (12) pp. 2900-2910. 10.1016/j.bbamcr.2013.07.020. Green open access
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Manzoni, C; Mamais, A; Dihanich, S; McGoldrick, P; Devine, MJ; Zerle, J; Kara, E; ... Lewis, PA; + view all (2013) Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochemical and Biophysical Research Communications , 441 (4) pp. 862-866. 10.1016/j.bbrc.2013.10.159. Green open access
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Manzoni, C; Mamais, A; Dihanich, S; Tooze, S; Bandopadhyay, R; Lewis, PA; (2013) LRRK2 regulates autophagy. In: (Proceedings) 114th Meeting of the British-Neuropathological-Society / Symposium on Advances in Motor Neuron Diseases. (pp. p. 10). WILEY-BLACKWELL

Paisan-Ruiz, C; Lewis, PA; Singleton, AB; (2013) LRRK2: Cause, Risk, and Mechanism. JOURNAL OF PARKINSONS DISEASE , 3 (2) pp. 85-103. 10.3233/JPD-130192.

Trabzuni, D; Ryten, M; Emmett, W; Ramasamy, A; Lackner, KJ; Zeller, T; Walker, R; ... Plagnol, V; + view all (2013) Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 Locus. PLOS ONE , 8 (8) , Article e70724. 10.1371/journal.pone.0070724. Green open access
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2012

Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; McGoldrick, P; ... Lewis, PA; + view all (2012) Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 7 (1) , Article e22489. 10.1371/annotation/c12e4f9e-5aae-424b-a69f-fddf16976dc5. Green open access
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Jebelli, JD; Dihanich, S; Civiero, L; Manzoni, C; Greggio, E; Lewis, PA; (2012) GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. SCIENTIFIC REPORTS , 2 (ARTN 695) 10.1038/srep00695. Gold open access

Lewis, PA; (2012) Assaying the Kinase Activity of LRRK2 in vitro. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (59) 10.3791/3495. Gold open access

Lewis, PA; (2012) James Parkinson: The Man Behind the Shaking Palsy. JOURNAL OF PARKINSONS DISEASE , 2 (3) pp. 181-187. 10.3233/JPD-2012-012108.

Lewis, PA; Alessi, DR; (2012) Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease. BIOCHEMICAL SOCIETY TRANSACTIONS , 40 pp. 1039-1041. 10.1042/BST20120178.

Lewis, PA; Cookson, MR; (2012) Gene expression in the Parkinson's disease brain. BRAIN RESEARCH BULLETIN , 88 (4) pp. 302-312. 10.1016/j.brainresbull.2011.11.016.

Lewis, PA; Manzoni, C; (2012) LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? SCIENCE SIGNALING , 5 (207) 10.1126/scisignal.2002680.

Patani, R; Lewis, PA; Trabzuni, D; Puddifoot, CA; Wyllie, DJA; Walker, R; Smith, C; ... Ryten, M; + view all (2012) Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. JOURNAL OF NEUROCHEMISTRY , 122 (4) pp. 738-751. 10.1111/j.1471-4159.2012.07825.x.

Wray, S; Self, M; NINDS Parkinson's Disease iPSC Consortium, ; NINDS Huntington's Disease iPSC Consortium, ; NINDS ALS iPSC Consortium, ; Lewis, PA; Taanman, JW; ... Hardy, J; + view all (2012) Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLOS One , 7 (8) , Article e43099. 10.1371/journal.pone.0043099. Green open access
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2011

Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; McGoldrick, P; ... Lewis, PA; + view all (2011) Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 6 (7) , Article e22489. 10.1371/journal.pone.0022489. Green open access
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Devine, MJ; Ryten, M; Vodicka, P; Thomson, AJ; Burdon, T; Houlden, H; Cavaleri, F; ... Kunath, T; + view all (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. NAT COMMUN , 2 , Article 440. 10.1038/ncomms1453. Gold open access

2010

Plun-Favreau, H; Lewis, PA; Hardy, J; Martins, LM; Wood, NW; (2010) Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genetics , 6 (12) , Article e1001257. 10.1371/journal.pgen.1001257. Green open access
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Wray, S; Lewis, PA; (2010) A tangled web - tau and sporadic Parkinson's disease. Front Psychiatry , 1 150-. 10.3389/fpsyt.2010.00150.

2009

Hardy, J; Lewis, P; Revesz, T; Lees, A; Paisan-Ruiz, C; (2009) The genetics of Parkinson's syndromes: a critical review. CURR OPIN GENET DEV , 19 (3) 254 - 265. 10.1016/j.gde.2009.03.008.

Lewis, PA; (2009) The function of ROCO proteins in health and disease. BIOL CELL , 101 (3) 183 - 191. 10.1042/BC20080053.

Li, YC; Dunn, L; Greggio, E; Krumm, B; Jackson, GS; Cookson, MR; Lewis, PA; (2009) The R1441C mutation alters the folding properties of the ROC domain of LRRK2. BBA-MOL BASIS DIS , 1792 (12) 1194 - 1197. 10.1016/j.bbadis.2009.09.010.

2008

Camargos, S; Scholz, S; Simon-Sanchez, J; Paisan-Ruiz, C; Lewis, P; Hernandez, D; Ding, J; ... Singleton, AB; + view all (2008) DYT16, a novel young-onset dystonia-parkinson ism disorder: identification of a segregating mutation in the stress-response protein PRKRA. LANCET NEUROL , 7 (3) 207 - 215. 10.1016/S1474-4422(08)70022-X.

Camargos, S; Scholz, S; Simón-Sánchez, J; Paisán-Ruiz, C; Lewis, P; Hernandez, D; Ding, J; ... Singleton, AB; + view all (2008) DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. The Lancet Neurology , 7 (3) pp. 207-215. 10.1016/S1474-4422(08)70022-X.

Cookson, MR; Greggio, E; Lewis, P; (2008) The Role of LRRK2 Kinase Activity in Cellular PD Models. In: Parkinson's Disease. (pp. 423-431).

Cookson, MR; Hardy, J; Lewis, PA; (2008) Genetic Neuropathology of Parkinson's Disease. INT J CLIN EXP PATHO , 1 (3) 217 - 231. Gold open access

Deng, JP; Lewis, PA; Greggio, E; Sluch, E; Beilina, A; Cookson, MR; (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. P NATL ACAD SCI USA , 105 (5) 1499 - 1504. 10.1073/pnas.0709098105.

Devine, MJ; Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x.

Greggio, E; Zambrano, I; Kaganovich, A; Beilina, A; Taymans, J-M; Daniëls, V; Lewis, P; ... Cookson, MR; + view all (2008) The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem , 283 (24) pp. 16906-16914. 10.1074/jbc.M708718200.

Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease. FEBS J , 275 (23) 5747 - 5747. 10.1111/j.1742-4658.2008.06706.x.

2007

Chandran, J; Lewis, P; (2007) Mad fly disease. J Neurosci , 27 (5) pp. 971-972.

Greggio, E; Lewis, PA; van der Brug, MP; Ahmad, R; Kaganovich, A; Ding, JH; Beilina, A; ... Cookson, MR; + view all (2007) Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. J NEUROCHEM , 102 (1) 93 - 102. 10.1111/j.1471-4159.2007.04523.x.

Hoe, H-S; Cooper, MJ; Burns, MP; Lewis, PA; van der Brug, M; Chakraborty, G; Cartagena, CM; ... Rebeck, GW; + view all (2007) The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. J Neurosci , 27 (40) pp. 10895-10905. 10.1523/JNEUROSCI.3135-07.2007.

Lewis, P.A.; Critchley, H.D.; Rotshtein, P.; Dolan, R.J.; (2007) Neural correlates of processing valence and arousal in affective words. Cerebral Cortex , 17 (3) pp. 742-748. 10.1093/cercor/bhk024. Green open access
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Lewis, PA; Greggio, E; Beilina, A; Jain, S; Baker, A; Cookson, MR; (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem Biophys Res Commun , 357 (3) pp. 668-671. 10.1016/j.bbrc.2007.04.006.

2006

Greggio, E; Jain, S; Kingsbury, A; Bandopadhyay, R; Lewis, P; Kaganovich, A; van der Brug, MP; ... Cookson, MR; + view all (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. NEUROBIOL DIS , 23 (2) 329 - 341. 10.1016/j.nbd.2006.04.001.

Lewis, PA; Properzi, F; Prodromidou, K; Clarke, AR; Collinge, J; Jackson, GS; (2006) Removal of the glycosylphosphatidylinositol anchor from PrPSc by cathepsin D does not reduce prion infectivity. BIOCHEM J , 395 443 - 448. 10.1042/BJ20051677. Gold open access

Lewis, PA; Tattum, MH; Jones, S; Bhelt, D; Batchelor, M; Clarke, AR; Collinge, J; (2006) Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation. J GEN VIROL , 87 2443 - 2449. 10.1099/vir.0.81630-0.

2002

Amtul, Z; Lewis, PA; Piper, S; Crook, R; Baker, M; Findlay, K; Singleton, A; ... Golde, TE; + view all (2002) A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiol Dis , 9 (2) pp. 269-273. 10.1006/nbdi.2001.0473.

Tang-Wai, D; Lewis, P; Boeve, B; Hutton, M; Golde, T; Baker, M; Hardy, J; ... Petersen, R; + view all (2002) Familial frontotemporal dementia associated with a novel presenilin-1 mutation. Dement Geriatr Cogn Disord , 14 (1) pp. 13-21.

2001

Lewis, PA; Piper, S; Baker, M; Onstead, L; Murphy, MP; Hardy, J; Wang, R; ... Golde, TE; + view all (2001) Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochim Biophys Acta , 1537 (1) pp. 58-62.

Mudher, A; Chapman, S; Richardson, J; Asuni, A; Gibb, G; Pollard, C; Killick, R; ... Lovestone, S; + view all (2001) Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neurosci , 21 (14) pp. 4987-4995.

2000

Houlden, H; Baker, M; McGowan, E; Lewis, P; Hutton, M; Crook, R; Wood, NW; ... Revesz, T; + view all (2000) Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. ANN NEUROL , 48 (5) 806 - 808.

Lewis, PA; Perez-Tur, J; Golde, TE; Hardy, J; (2000) The presenilin 1 C92S mutation increases abeta 42 production. Biochem Biophys Res Commun , 277 (1) pp. 261-263. 10.1006/bbrc.2000.3646.

McLendon, C; Xin, T; Ziani-Cherif, C; Murphy, MP; Findlay, KA; Lewis, PA; Pinnix, I; ... Golde, TE; + view all (2000) Cell-free assays for gamma-secretase activity. FASEB J , 14 (15) pp. 2383-2386. 10.1096/fj.00-0286fje.

Murphy, MP; Uljon, SN; Fraser, PE; Fauq, A; Lookingbill, HA; Findlay, KA; Smith, TE; ... Golde, TE; + view all (2000) Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. J Biol Chem , 275 (34) pp. 26277-26284. 10.1074/jbc.M002812200. Gold open access

This list was generated on Sun Sep 17 07:33:10 2017 BST.

Page last modified on 10 jan 14 16:23