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chromosome 22q deletion

Parkinson's chromosome deletion linked to other genetic disorders

Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders. More...

Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.

Mike Devine

(Former MRC Clinical Research Fellow)

I am an MRC-funded clinical research fellow and trainee in neurology. My interest is in understanding the mechanisms that underpin neurodegeneration, and currently I am using iPS cell models of Parkinson's disease to study the impact of genetic mutations that cause familial Parkinson's disease on human dopaminergic neurons. The overall aim of this work is to help shed light on the biological processes that occur in neurodegeneration, in order to help start to make mechanistic treatments that can change the course of the disease process.

Contact details

Link to publications

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Number of items: 22.


Deas, E; Cremades, N; Angelova, PR; Ludtmann, MHR; Yao, Z; Chen, S; Horrocks, MH; (2016) Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidants & Redox Signaling , 24 (7) pp. 376-391. 10.1089/ars.2015.6343. Green open access

Devine, MJ; Birsa, N; Kittler, JT; (2016) Miro sculpts mitochondrial dynamics in neuronal health and disease. NEUROBIOLOGY OF DISEASE , 90 pp. 27-34. 10.1016/j.nbd.2015.12.008.

Devine, MJ; Norkett, R; Kittler, JT; (2016) DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity. J Physiol , 594 (19) pp. 5459-5469. 10.1113/JP272187.

Horrocks, MH; Lee, SF; Gandhi, S; Magdalinou, NK; Chen, SW; Devine, MJ; Tosatto, L; (2016) Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids. ACS CHEMICAL NEUROSCIENCE , 7 (3) pp. 399-406. 10.1021/acschemneuro.5b00324.


Holmqvist, S; Brouwer, M; Djelloul, M; Diaz, AG; Devine, MJ; Hammarberg, A; Fog, K; (2015) Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors. STEM CELL RESEARCH , 15 (1) pp. 203-220. 10.1016/j.scr.2015.05.014.

Reyes, JF; Olsson, TT; Lamberts, JT; Devine, MJ; Kunath, T; Brundin, P; (2015) A cell culture model for monitoring alpha-synuclein cell-to-cell transfer. NEUROBIOLOGY OF DISEASE , 77 pp. 266-275. 10.1016/j.nbd.2014.07.003.

Sposito, T; Preza, E; Mahoney, CJ; Setó-Salvia, N; Ryan, NS; Morris, HR; Arber, C; (2015) Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Human Molecular Genetics , 24 (18) pp. 5260-5269. 10.1093/hmg/ddv246. Green open access


Devine, MJ; Bentley, P; Jones, B; Hotton, G; Greenwood, RJ; Jenkins, IH; Joyce, EM; (2014) The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis. JOURNAL OF NEUROLOGY , 261 (3) pp. 600-603. 10.1007/s00415-014-7242-x.

Ludtmann, MHR; Angelova, PR; Gandhi, S; Kleneman, D; Devine, M; Wood, NW; Abramov, AY; (2014) Alpha-Synuclein Induces Mitochondrial Dysfunction Leading to a Higher Susceptibility of PTP Opening. In: (Proceedings) 58th Annual Meeting of the Biophysical-Society. (pp. 590A-590A). CELL PRESS


Manzoni, C; Mamais, A; Dihanich, S; McGoldrick, P; Devine, MJ; Zerle, J; Kara, E; (2013) Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochemical and Biophysical Research Communications , 441 (4) pp. 862-866. 10.1016/j.bbrc.2013.10.159. Green open access


Devine, MJ; (2012) Proteasomal Inhibition as a Treatment Strategy for Parkinson's Disease: The Impact of alpha-Synuclein on Nurr1. JOURNAL OF NEUROSCIENCE , 32 (46) pp. 16071-16073. 10.1523/JNEUROSCI.4224-12.2012.

Devine, MJ; (2012) Patient-derived cell models of Parkinson’s disease. Doctoral thesis, UCL (University College London). Green open access

Wray, S; Self, M; NINDS Parkinson's Disease iPSC Consortium, ; NINDS Huntington's Disease iPSC Consortium, ; NINDS ALS iPSC Consortium, ; Lewis, PA; Taanman, JW; (2012) Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLOS One , 7 (8) , Article e43099. 10.1371/journal.pone.0043099. Green open access



Devine, MJ; Gwinn, K; Singleton, A; Hardy, J; (2011) Parkinson's Disease and alpha-Synuclein Expression. MOVEMENT DISORD , 26 (12) 2160 - 2168. 10.1002/mds.23948.

Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; McGoldrick, P; (2011) Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 6 (7) , Article e22489. 10.1371/journal.pone.0022489. Green open access

Devine, MJ; Plun-Favreau, H; Wood, NW; (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150.

Devine, MJ; Ryten, M; Vodicka, P; Thomson, AJ; Burdon, T; Houlden, H; Cavaleri, F; (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. NAT COMMUN , 2 , Article 440. 10.1038/ncomms1453. Gold open access

Gwinn, K; Devine, MJ; Jin, LW; Johnson, J; Bird, T; Muenter, M; Waters, C; (2011) Clinical Features, with Video Documentation, of the Original Familial Lewy Body Parkinsonism Caused By alpha-Synuclein Triplication (Iowa Kindred). MOVEMENT DISORD , 26 (11) 2134 - 2136. 10.1002/mds.23776.


Devine, MJ; Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x.

Devine, MJ; Wilkinson, PA; Doherty, JF; Jarman, PR; (2008) Neuroschistosomiasis presenting as brainstem encephalitis. NEUROLOGY , 70 (23) 2262 - 2264.


Devine, MJ; Duncan, JS; (2007) Development of psychogenic non-epileptic seizures in response to auditory hallucinations. SEIZURE-EUR J EPILEP , 16 (8) 717 - 721. 10.1016/j.seizure.2007.06.001.

This list was generated on Sun Oct 23 16:39:14 2016 BST.

Page last modified on 18 mar 13 12:12