UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
- Research Groups
- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...
Dr Laura Osellame tells us about her recent paper in Cell Metabolism about Mitochondrial dysfunction linked to loss of an enzyme called GBA: Gaucher Disease (GD) is a rare inherited disease, belonging to the family of lysosomal storage disorders. Mutations in the gene glucocerebrosidase (GBA) are responsible for the disease and can increase susceptibility to Parkinson’s disease (PD). Genetic studies undertaken at UCL and other hospitals around the world suggest that mutations in GBA are the most common genetic risk factor currently known for PD. More...
First author Adamantios Mamais tells us about his recent publication in Neurobiology of Disease: At the Queen Square Brain Bank (part of the UCL Institute of Neurology) we hold a large collection of post-mortem human brain tissue from patients with neurodegenerative diseases including Parkinson’s disease (PD); a debilitating neurological disorder that affects the central nervous system. In the United States alone about 50,000 new cases are reported every year. The main symptoms include tremor, slow movement, rigid limbs and a shuffling gait while these worsen with time. More...
(Former MRC Clinical Research Fellow)
I am an MRC-funded clinical research fellow and trainee in neurology. My interest is in understanding the mechanisms that underpin neurodegeneration, and currently I am using iPS cell models of Parkinson's disease to study the impact of genetic mutations that cause familial Parkinson's disease on human dopaminergic neurons. The overall aim of this work is to help shed light on the biological processes that occur in neurodegeneration, in order to help start to make mechanistic treatments that can change the course of the disease process.
|Toot, S; Hoe, J; Ledgerd, R; Burnell, K; Devine, M; Orrell, M; (2013) Causes of crises and appropriate interventions: the views of people with dementia, carers and healthcare professionals. Aging Ment Health , 17 (3) 328 - 335. 10.1080/13607863.2012.732037. |
|Devine, MJ; (2012) Patient-derived cell models of Parkinson’s disease. Doctoral thesis, UCL (University College London). |
|Devine, M; Bentley, P; Jones, B; Jenkins, H; Malhotra, P; (2011) PERSISTENT PSYCHOSIS IN THREE SUSCEPTIBLE INDIVIDUALS WITH RIGHT INFERIOR FRONTAL LOBE STROKE. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 420 - 420). WILEY-BLACKWELL |
|Devine, MJ; Gwinn, K; Singleton, A; Hardy, J; (2011) Parkinson's Disease and alpha-Synuclein Expression. MOVEMENT DISORD , 26 (12) 2160 - 2168. 10.1002/mds.23948. |
|Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; ... Lewis, PA; + view all Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; McGoldrick, P; Chan, D; Dillman, A; Zerle, J; Horan, S; Taanman, JW; Hardy, J; Marti-Masso, JF; Healy, D; Schapira, AH; Wolozin, B; Bandopadhyay, R; Cookson, MR; van der Brug, MP; Lewis, PA; - view fewer (2011) Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 6 (7) , Article e22489. 10.1371/journal.pone.0022489. |
|Devine, MJ; Plun-Favreau, H; Wood, NW; (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150. |
|Devine, MJ; Ryten, M; Vodicka, P; Thomson, AJ; Burdon, T; Houlden, H; ... Kunath, T; + view all Devine, MJ; Ryten, M; Vodicka, P; Thomson, AJ; Burdon, T; Houlden, H; Cavaleri, F; Nagano, M; Drummond, NJ; Taanman, JW; Schapira, AH; Gwinn, K; Hardy, J; Lewis, PA; Kunath, T; - view fewer (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. NAT COMMUN , 2 , Article 440. 10.1038/ncomms1453. |
|Gwinn, K; Devine, MJ; Jin, LW; Johnson, J; Bird, T; Muenter, M; ... Singleton, A; + view all Gwinn, K; Devine, MJ; Jin, LW; Johnson, J; Bird, T; Muenter, M; Waters, C; Adler, CH; Caselli, R; Houlden, H; Lopez, G; Singleton, A; Hardy, J; Singleton, A; - view fewer (2011) Clinical Features, with Video Documentation, of the Original Familial Lewy Body Parkinsonism Caused By alpha-Synuclein Triplication (Iowa Kindred). MOVEMENT DISORD , 26 (11) 2134 - 2136. 10.1002/mds.23776. |
|Devine, MJ; Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x. |
|Devine, MJ; Wilkinson, PA; Doherty, JF; Jarman, PR; (2008) Neuroschistosomiasis presenting as brainstem encephalitis. NEUROLOGY , 70 (23) 2262 - 2264. |
|Devine, ME; Fonseca, JAS; Walker, RWH; Sikdar, T; Stevens, T; Walker, Z; (2007) Cerebral white matter changes and rate of progression of dementia during cholinesterase inhibitor treatment: a retrospective cohort study. INT J GERIATR PSYCH , 22 (11) 1120 - 1126. 10.1002/gps.1799. |
|Devine, MJ; Duncan, JS; (2007) Development of psychogenic non-epileptic seizures in response to auditory hallucinations. SEIZURE-EUR J EPILEP , 16 (8) 717 - 721. 10.1016/j.seizure.2007.06.001. |
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