A A A
Feed icon

News

Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
More...

Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials

More...

Mike Devine

(Former MRC Clinical Research Fellow)

I am an MRC-funded clinical research fellow and trainee in neurology. My interest is in understanding the mechanisms that underpin neurodegeneration, and currently I am using iPS cell models of Parkinson's disease to study the impact of genetic mutations that cause familial Parkinson's disease on human dopaminergic neurons. The overall aim of this work is to help shed light on the biological processes that occur in neurodegeneration, in order to help start to make mechanistic treatments that can change the course of the disease process.

Contact details

Link to publications

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2008 | 2007
Number of items: 16.

2015

Reyes, JF; Olsson, TT; Lamberts, JT; Devine, MJ; Kunath, T; Brundin, P; (2015) A cell culture model for monitoring α-synuclein cell-to-cell transfer. Neurobiol Dis , 77 266 - 275. 10.1016/j.nbd.2014.07.003.

2014

Devine, MJ; Bentley, P; Jones, B; Hotton, G; Greenwood, RJ; Jenkins, IH; Joyce, EM; (2014) The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis. J Neurol , 261 (3) pp. 600-603. 10.1007/s00415-014-7242-x.

Ludtmann, MHR; Angelova, PR; Gandhi, S; Kleneman, D; Devine, M; Wood, NW; Abramov, AY; (2014) Alpha-Synuclein Induces Mitochondrial Dysfunction Leading to a Higher Susceptibility of PTP Opening. Presented at: UNSPECIFIED.

2013

Manzoni, C; Mamais, A; Dihanich, S; McGoldrick, P; Devine, MJ; Zerle, J; Kara, E; (2013) Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun , 441 (4) pp. 862-866. 10.1016/j.bbrc.2013.10.159.

2012

Devine, MJ; (2012) Proteasomal inhibition as a treatment strategy for Parkinson's disease: the impact of α-synuclein on Nurr1. J Neurosci , 32 (46) 16071 - 16073. 10.1523/JNEUROSCI.4224-12.2012.

Devine, MJ; (2012) Patient-derived cell models of Parkinson’s disease. Doctoral thesis, UCL (University College London). Green open access
file

Wray, S; Self, M; NINDS Parkinson's Disease iPSC Consortium, ; NINDS Huntington's Disease iPSC Consortium, ; NINDS ALS iPSC Consortium, ; Lewis, PA; Taanman, JW; (2012) Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLOS One , 7 (8) , Article e43099. 10.1371/journal.pone.0043099. Green open access
file

2011

Devine, M; Bentley, P; Jones, B; Jenkins, H; Malhotra, P; (2011) PERSISTENT PSYCHOSIS IN THREE SUSCEPTIBLE INDIVIDUALS WITH RIGHT INFERIOR FRONTAL LOBE STROKE. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 420 - 420). WILEY-BLACKWELL

Devine, MJ; Gwinn, K; Singleton, A; Hardy, J; (2011) Parkinson's Disease and alpha-Synuclein Expression. MOVEMENT DISORD , 26 (12) 2160 - 2168. 10.1002/mds.23948.

Devine, MJ; Kaganovich, A; Ryten, M; Mamais, A; Trabzuni, D; Manzoni, C; McGoldrick, P; (2011) Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 6 (7) , Article e22489. 10.1371/journal.pone.0022489. Green open access
file

Devine, MJ; Plun-Favreau, H; Wood, NW; (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150.

Devine, MJ; Ryten, M; Vodicka, P; Thomson, AJ; Burdon, T; Houlden, H; Cavaleri, F; (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. NAT COMMUN , 2 , Article 440. 10.1038/ncomms1453. Gold open access

Gwinn, K; Devine, MJ; Jin, LW; Johnson, J; Bird, T; Muenter, M; Waters, C; (2011) Clinical Features, with Video Documentation, of the Original Familial Lewy Body Parkinsonism Caused By alpha-Synuclein Triplication (Iowa Kindred). MOVEMENT DISORD , 26 (11) 2134 - 2136. 10.1002/mds.23776.

2008

Devine, MJ; Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x.

Devine, MJ; Wilkinson, PA; Doherty, JF; Jarman, PR; (2008) Neuroschistosomiasis presenting as brainstem encephalitis. NEUROLOGY , 70 (23) 2262 - 2264.

2007

Devine, MJ; Duncan, JS; (2007) Development of psychogenic non-epileptic seizures in response to auditory hallucinations. SEIZURE-EUR J EPILEP , 16 (8) 717 - 721. 10.1016/j.seizure.2007.06.001.

This list was generated on Sun Sep 27 11:33:28 2015 BST.

Page last modified on 18 mar 13 12:12