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chromosome 22q deletion

Parkinson's chromosome deletion linked to other genetic disorders

Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders. More...

Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Marthe Ludtmann

(Research Associate)

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Jump to: 2016 | 2015 | 2014 | 2013 | 2011 | 2009
Number of items: 14.

2016

Angelova, PR; Ludtmann, MH; Horrocks, MH; Negoda, A; Cremades, N; Klenerman, D; Dobson, CM; (2016) Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Journal of Cell Science , 129 (9) pp. 1792-1801. 10.1242/jcs.180737. Green open access
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Deas, E; Cremades, N; Angelova, PR; Ludtmann, MHR; Yao, Z; Chen, S; Horrocks, MH; (2016) Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidants & Redox Signaling , 24 (7) pp. 376-391. 10.1089/ars.2015.6343. Green open access
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Ludtmann, M; Angelova, P; Ninkina, N; Gandhi, S; Buchman, V; Abramov, A; (2016) Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase. The Journal of Neuroscience , 36 (41) pp. 10510-10521. 10.1523/JNEUROSCI.1659-16.2016. Green open access
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2015

Kostic, M; Ludtmann, MHR; Bading, H; Hershfinke, M; Steer, E; Chu, CT; Abramov, AY; (2015) PKA Phosphorylation of NCLX Reverses Mitochondria! Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons. CELL REPORTS , 13 (2) pp. 376-386. 10.1016/j.celrep.2015.08.079.

Mencacci, NE; Rubio-Agusti, I; Zdebik, A; Asmus, F; Ludtmann, MH; Ryten, M; Plagnol, V; (2015) A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia. Am J Hum Genet , 96 (6) pp. 938-947. 10.1016/j.ajhg.2015.04.008. Green open access
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Reeve, AK; Ludtmann, MH; Angelova, PR; Simcox, EM; Horrocks, MH; Klenerman, D; Gandhi, S; (2015) Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death & Disease , 6 (7) , Article e1820. 10.1038/cddis.2015.166. Green open access
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2014

Ludtmann, MH; Otto, GP; Schilde, C; Chen, ZH; Allan, CY; Brace, S; Beesley, PW; (2014) An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci , 127 (Pt 7) pp. 1576-1584. 10.1242/jcs.140939.

Ludtmann, MHR; Angelova, PR; Zhang, Y; Abramov, AY; Dinkova-Kostova, AT; (2014) Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. BIOCHEMICAL JOURNAL , 457 pp. 415-424. 10.1042/BJ20130863.

Neary, MT; Ng, K-E; Ludtmann, MHR; Hall, AR; Piotrowska, I; Ong, S-B; Hausenloy, DJ; (2014) Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY , 74 pp. 340-352. 10.1016/j.yjmcc.2014.06.013.

Stroh, PR; Ludtmann, MHR; Wood, NW; Klenerman, D; Gandhi, S; Abramov, AY; (2014) Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death. In: (Proceedings) 58th Annual Meeting of the Biophysical-Society. (pp. 529A-529A). CELL PRESS

Waheed, A; Ludtmann, MH; Pakes, N; Robery, S; Kuspa, A; Dinh, C; Baines, D; (2014) Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. Br J Pharmacol , 171 (10) pp. 2659-2670. 10.1111/bph.12443. Green open access
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2013

Siddall, HK; Yellon, DM; Ong, SB; Mukherjee, UA; Burke, N; Hall, AR; Angelova, PR; (2013) Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury. PLoS One , 8 (4) , Article e62400. 10.1371/journal.pone.0062400. Green open access
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2011

Ludtmann, MH; Boeckeler, K; Williams, RS; (2011) Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Semin Cell Dev Biol , 22 (1) pp. 105-113. 10.1016/j.semcdb.2010.11.002.

2009

Ludtmann, MH; Rollinson, D; Emery, AM; Walker, AJ; (2009) Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni. Int J Parasitol , 39 (11) pp. 1223-1233. 10.1016/j.ijpara.2009.04.002.

This list was generated on Sun Oct 23 18:54:55 2016 BST.

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