UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
- Research Groups
- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...
Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
(Former Research Associate)
Mitochondrial Morphology and distribution. Apoptosis, autophagy and mitochondrial electron transport chain function in relation to Parkinson’s Disease.
|Link to Publications|
|Osellame, LD; Rahim, AA; Hargreaves, IP; Gegg, ME; Richard-Londt, A; Brandner, S; ... Duchen, MR; + view all Osellame, LD; Rahim, AA; Hargreaves, IP; Gegg, ME; Richard-Londt, A; Brandner, S; Waddington, SN; Schapira, AH; Duchen, MR; - view fewer (2013) Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease. Cell Metabolism , 17 (6) pp. 941-953. 10.1016/j.cmet.2013.04.014. |
|Osellame, LD; Blacker, TS; Duchen, MR; (2012) Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab , 26 (6) 711 - 723. 10.1016/j.beem.2012.05.003. |
|Osellame, LD; Rahim, A; Gegg, ME; Waddington, S; Schapira, AHV; Duchen, MR; (2012) Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S79 - S80). |
|Palmer, CS; Osellame, LD; Laine, D; Koutsopoulos, OS; Frazier, AE; Ryan, MT; (2011) MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO REP , 12 (6) 565 - 573. 10.1038/embor.2011.54. |
|Palmer, CS; Osellame, LD; Stojanovski, D; Ryan, MT; (2011) The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery. CELL SIGNAL , 23 (10) 1534 - 1545. 10.1016/j.cellsig.2011.05.021. |
|Osellame, LD; Koutsopoulos, OS; Laine, D; Frazier, AE; Ryan, MT; (2008) MiD51 and MiD49: New mediators of mammalian mitochondrial distribution. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S57 - S57). ELSEVIER SCIENCE BV |
|Koutsopoulos, OS; Laine, D; Osellame, L; Chudakov, DM; Parton, RG; Frazier, AE; Ryan, MT; Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. Biochim Biophys Acta , 1803 (5) 564 - 574. 10.1016/j.bbamcr.2010.03.006. |
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