UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
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- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...
(Former Research Associate)
Mitochondrial Morphology and distribution. Apoptosis, autophagy and mitochondrial electron transport chain function in relation to Parkinson’s Disease.
|Link to Publications|
|Osellame, LD; Rahim, AA; Hargreaves, IP; Gegg, ME; Richard-Londt, A; Brandner, S; ... Duchen, MR; + view all Osellame, LD; Rahim, AA; Hargreaves, IP; Gegg, ME; Richard-Londt, A; Brandner, S; Waddington, SN; Schapira, AH; Duchen, MR; - view fewer (2013) Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease. Cell Metabolism , 17 (6) pp. 941-953. 10.1016/j.cmet.2013.04.014. |
|Osellame, LD; Blacker, TS; Duchen, MR; (2012) Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab , 26 (6) 711 - 723. 10.1016/j.beem.2012.05.003. |
|Osellame, LD; Rahim, A; Gegg, ME; Waddington, S; Schapira, AHV; Duchen, MR; (2012) Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S79 - S80). |
|Palmer, CS; Osellame, LD; Laine, D; Koutsopoulos, OS; Frazier, AE; Ryan, MT; (2011) MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO REP , 12 (6) 565 - 573. 10.1038/embor.2011.54. |
|Palmer, CS; Osellame, LD; Stojanovski, D; Ryan, MT; (2011) The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery. CELL SIGNAL , 23 (10) 1534 - 1545. 10.1016/j.cellsig.2011.05.021. |
|Osellame, LD; Koutsopoulos, OS; Laine, D; Frazier, AE; Ryan, MT; (2008) MiD51 and MiD49: New mediators of mammalian mitochondrial distribution. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S57 - S57). ELSEVIER SCIENCE BV |
|Koutsopoulos, OS; Laine, D; Osellame, L; Chudakov, DM; Parton, RG; Frazier, AE; Ryan, MT; Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. Biochim Biophys Acta , 1803 (5) 564 - 574. 10.1016/j.bbamcr.2010.03.006. |
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