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Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.

Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials



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Angelova, P.R., Horrocks, M.H., Klenerman, D., Gandhi, S., Abramov, A.Y., Shchepinov, M.S., 2015. Lipid peroxidation is essential for a-synuclein-induced cell death. J. Neurochem. 133, 582–589. doi:10.1111/jnc.13024

Beavan, M., McNeill, A., Proukakis, C., Hughes, D.A., Mehta, A., Schapira, A.H.V., 2015. Evolution of Prodromal Clinical Markers of Parkinson Disease in a GBA Mutation-Positive Cohort. JAMA Neurol 72, 201–208. doi:10.1001/jamaneurol.2014.2950

Boutoleau-Bretonnière, C., Camuzat, A., Le Ber, I., Bouya-Ahmed, K., Guerreiro, R., Deruet, A.-L., Evrard, C., Bras, J., Lamy, E., Auffray-Calvier, E., Pallardy, A., Hardy, J., Brice, A., Derkinderen, P., Vercelletto, M., 2015. A Phenotype of Atypical Apraxia of Speech in a Family Carrying SQSTM1 Mutation. Journal of Alzheimer’s Disease 43, 625–630. doi:10.3233/JAD-141512.

Bras, J., Alonso, I., Barbot, C., Costa, M.M., Darwent, L., Orme, T., Sequeiros, J., Hardy, J., Coutinho, P., Guerreiro, R., 2015. Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4. The American Journal of Human Genetics 96, 474–479. doi:10.1016/j.ajhg.2015.01.005

Charlesworth, G., Angelova, P.R., Bartolomé-Robledo, F., Ryten, M., Trabzuni, D., Stamelou, M., Abramov, A.Y., Bhatia, K.P., Wood, N.W., 2015. Mutations in HPCA Cause Autosomal-Recessive Primary Isolated Dystonia. The American Journal of Human Genetics 96, 657–665. doi:10.1016/j.ajhg.2015.02.007

Chen, S.W., Drakulic, S., Deas, E., Ouberai, M., Aprile, F.A., Arranz, R., Ness, S., Roodveldt, C., Guilliams, T., De-Genst, E.J., Klenerman, D., Wood, N.W., Knowles, T.P.J., Alfonso, C., Rivas, G., Abramov, A.Y., Valpuesta, J.M., Dobson, C.M., Cremades, N., 2015. Structural characterization of toxic oligomers that are kinetically trapped during a-synuclein fibril formation. Proc. Natl. Acad. Sci. U.S.A. 112, E1994–2003. doi:10.1073/pnas.1421204112

Escott-Price, V., International Parkinson’s Disease Genomics Consortium, Nalls, M.A., Morris, H.R., Lubbe, S., Brice, A., Gasser, T., Heutink, P., Wood, N.W., Hardy, J., Singleton, A.B., Williams, N.M., IPDGC consortium members, 2015. Polygenic risk of Parkinson disease is correlated with disease age at onset. Ann. Neurol. 77, 582–591. doi:10.1002/ana.24335

Ferrari, R., Grassi, M., Salvi, E., Borroni, B., Palluzzi, F., Pepe, D., D’Avila, F., Padovani, A., Archetti, S., Rainero, I., Rubino, E., Pinessi, L., Benussi, L., Binetti, G., Ghidoni, R., Galimberti, D., Scarpini, E., Serpente, M., Rossi, G., Giaccone, G., Tagliavini, F., Nacmias, B., Piaceri, I., Bagnoli, S., Bruni, A.C., Maletta, R.G., Bernardi, L., Postiglione, A., Milan, G., Franceschi, M., Puca, A.A., Novelli, V., Barlassina, C., Glorioso, N., Manunta, P., Singleton, A., Cusi, D., Hardy, J., Momeni, P., 2015. A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia. Neurobiol. Aging 36, 2904.e13–26. doi:10.1016/j.neurobiolaging.2015.06.005

Gegg, M.E., Sweet, L., Wang, B.H., Shihabuddin, L.S., Sardi, S.P., Schapira, A.H.V., 2015. No evidence for substrate accumulation in Parkinson brains with GBA mutations. Mov. Disord. 30, 1085–1089. doi:10.1002/mds.26278

Guerreiro, R., Bras, J., Toombs, J., Heslegrave, A., Hardy, J., Zetterberg, H., 2015. Genetic Variants and Related Biomarkers in Sporadic Alzheimer’s Disease. Curr Genet Med Rep 3, 19–25. doi:10.1007/s40142-014-0062-6

Kinghorn, K.J., Castillo-Quan, J.I., Bartolome, F., Angelova, P.R., Li, L., Pope, S., Cochemé, H.M., Khan, S., Asghari, S., Bhatia, K.P., Hardy, J., Abramov, A.Y., Partridge, L., 2015. Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain 138, 1801–1816. doi:10.1093/brain/awv132

Kovac, S., Angelova, P.R., Holmström, K.M., Zhang, Y., Dinkova-Kostova, A.T., Abramov, A.Y., 2015. Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim. Biophys. Acta 1850, 794–801. doi:10.1016/j.bbagen.2014.11.021

Löhle, M., Hughes, D., Milligan, A., Richfield, L., Reichmann, H., Mehta, A., Schapira, A.H.V., 2015. Clinical prodromes of neurodegeneration in Anderson-Fabry disease. Neurology 84, 1454–1464. doi:10.1212/WNL.0000000000001450

Magdalinou, N.K., Paterson, R.W., Schott, J.M., Fox, N.C., Mummery, C., Blennow, K., Bhatia, K., Morris, H.R., Giunti, P., Warner, T.T., de Silva, R., Lees, A.J., Zetterberg, H., 2015. A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes. J. Neurol. Neurosurg. Psychiatr. doi:10.1136/jnnp-2014-309562

Manzoni, C., Denny, P., Lovering, R.C., Lewis, P.A., 2015. Computational analysis of the LRRK2 interactome. PeerJ 3, e778. doi:10.7717/peerj.778

Mencacci, N.E., Rubio-Agusti, I., Zdebik, A., Asmus, F., Ludtmann, M.H.R., Ryten, M., Plagnol, V., Hauser, A.-K., Bandres-Ciga, S., Bettencourt, C., Forabosco, P., Hughes, D., Soutar, M.M.P., Peall, K., Morris, H.R., Trabzuni, D., Tekman, M., Stanescu, H.C., Kleta, R., Carecchio, M., Zorzi, G., Nardocci, N., Garavaglia, B., Lohmann, E., Weissbach, A., Klein, C., Hardy, J., Pittman, A.M., Foltynie, T., Abramov, A.Y., Gasser, T., Bhatia, K.P., Wood, N.W., 2015. A Missense Mutation in KCTD17 Causes Autosomal Dominant Myoclonus-Dystonia. Am. J. Hum. Genet. 96, 938–947. doi:10.1016/j.ajhg.2015.04.008

Noyce, A.J., Mencacci, N.E., Schrag, A., Bestwick, J.P., Giovannoni, G., Lees, A.J., Hardy, J., 2015. Web-based assessment of Parkinson’s prodromal markers identifies GBA variants. Mov. Disord. doi:10.1002/mds.26249

Schapira, A.H.V., 2015. Glucocerebrosidase and Parkinson disease: Recent advances. Mol. Cell. Neurosci. 66, 37–42. doi:10.1016/j.mcn.2015.03.013

Schottlaender, L.V., Polke, J.M., Ling, H., MacDoanld, N.D., Tucci, A., Nanji, T., Pittman, A., de Silva, R., Holton, J.L., Revesz, T., Sweeney, M.G., Singleton, A.B., Lees, A.J., Bhatia, K.P., Houlden, H., 2015. The analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism. Neurobiology of Aging 36, 1221.e1–1221.e6. doi:10.1016/j.neurobiolaging.2014.08.024

Wallings, R., Manzoni, C., Bandopadhyay, R., 2015. Cellular processes associated with LRRK2 function and dysfunction. FEBS J. 282, 2806–2826. doi:10.1111/febs.13305



Alessi, D.R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y., Kahle, K.T., 2014. The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Sci. Signal. 7, re3–re3. doi:10.1126/scisignal.2005365

Bago, R., Malik, N., Munson, M.J., Prescott, A.R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I.G., Alessi, D.R., 2014. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. Biochemical Journal 463, 413–427. doi:10.1042/BJ20140889

Banerjee, S., Buhrlage, S.J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A.R., Alessi, D.R., Gray, N.S., 2014. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochemical Journal 457, 215–225. doi:10.1042/BJ20131152

Banerjee, S., Zagórska, A., Deak, M., Campbell, D.G., Prescott, A.R., Alessi, D.R., 2014. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1ß(MYPT1) phosphatase complex and the SCF(ßTrCP) E3 ubiquitin ligase. Biochemical Journal 461, 233–245. doi:10.1042/BJ20140408

Benitez, B., Jin, S., Guerreiro, R., Graham, R., Lord, J., Harold, D., Sims, R., Lambert, J., Gibbs, J., Bras, J., Sassi, C., Harari, O., Bertelsen, S., Lupton, M., Powell, J., Bellenguez, C., Brown, K., Medway, C., Haddick, P., van der Brug, M., Bhangale, T., Ortmann, W., Behrens, T., Mayeux, R., Pericak-Vance, M., Farrer, L., Schellenberg, G., Haines, J., Turton, J., Braae, A., Barber, I., Fagan, A., Holtzman, D., Morris, J., The 3C Study Group, the EADI consortium, the Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Disease Neuroimaging Initiative (ADNI), the GERAD Consortium, Williams, J., Kauwe, J., Amouyel, P., Morgan, K., Singleton, A., Hardy, J., Goate, A., Cruchaga, C., 2014. Missense variant in TREML2 protects against Alzheimer’s disease. Neurobiol Aging 35, 1510.e19–26.

Berg, D., Postuma, R.B., Bloem, B., Chan, P., Dubois, B., Gasser, T., Goetz, C.G., Halliday, G.M., Hardy, J., Lang, A.E., Litvan, I., Marek, K., Obeso, J., Oertel, W., Olanow, C.W., Poewe, W., Stern, M., Deuschl, G., 2014. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson’s disease. Movement Disorders 29, 454–462. doi:10.1002/mds.25844

Bettencourt, C., Ryten, M., Forabosco, P., Schorge, S., Hersheson, J., Hardy, J., Houlden, H., for the United Kingdom Brain Expression Consortium, 2014. Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia. JAMA Neurology.

Birsa, N., Norkett, R., Wauer, T., Mevissen, T., Wu, H., Foltynie, T., Bhatia, K., Hirst, W., Komander, D., Plun-Favreau, H., Kittler, J., 2014. K27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J Biol Chem.

Bras, J., Guerreiro, R., Darwent, L., Parkkinen, L., Ansorge, O., Escott-Price, V., Hernandez, D.G., Nalls, M.A., Clark, L., Honig, L., Marder, K., van der Flier, W., Lemstra, A., Scheltens, P., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Ortega-Cubero, S., Pastor, P., Ferman, T.J., Graff-Radford, N.R., Ross, O.A., Barber, I., Braae, A., Brown, K., Morgan, K., Maetzler, W., Berg, D., Troakes, C., Al-Sarraj, S., Lashley, T., Compta, Y., Revesz, T., Lees, A., Cairns, N., Halliday, G.M., Mann, D., Pickering-Brown, S., Dickson, D., Singleton, A., Hardy, J., 2014. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies. Human Molecular Genetics. doi:10.1093/hmg/ddu334

Charlesworth, G., Bhatia, K., Wood, N., 2014. No pathogenic GNAL mutations in 192 sporadic and familial cases of cervical dystonia. Mov Disord 29, 154–155.

Civiero, L., Dihanich, S., Lewis, P.A., Greggio, E., 2014. Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains. Chemistry & Biology. doi:10.1016/j.chembiol.2014.05.010

Compta, Y., Parkkinen, L., Kempster, P., Selikhova, M., Lashley, T., Holton, J., Lees, A., Revesz, T., 2014. The significance of a-synuclein, amyloid-ß and tau pathologies in Parkinson’s disease progression and related dementia. Neurodegener Dis 13, 154–156.

Cooper, J.M., Wiklander, P.B.O., Nordin, J.Z., Al-Shawi, R., Wood, M.J., Vithlani, M., Schapira, A.H.V., Simons, J.P., El-Andaloussi, S., Alvarez-Erviti, L., 2014. Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice. Movement Disorders. doi:10.1002/mds.25978

Cruchaga, C., Karch, C., Jin, S., Benitez, B., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A., Cooper, B., Skorupa, T., Carrell, D., Levitch, D., Hsu, S., Choi, J., Ryten, M., UK Brain Expression Consortium (UKBEC), Hardy, J., Ryten, M., Trabzuni, D., Weale, M., Ramasamy, A., Smith, C., Sassi, C., Bras, J., Gibbs, J., Hernandez, D., Lupton, M., Powell, J., Forabosco, P., Ridge, P., Corcoran, C., Tschanz, J., Norton, M., Munger, R., Schmutz, C., Leary, M., Demirci, F., Bamne, M., Wang, X., Lopez, O., Ganguli, M., Medway, C., Turton, J., Lord, J., Braae, A., Barber, I., Brown, K., null, Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P., Hooper, N., Vardy, E., Mann, D., Pickering-Brown, S., Brown, K., Kalsheker, N., Lowe, J., Morgan, K., David Smith, A., Wilcock, G., Warden, D., Holmes, C., Pastor, P., Lorenzo-Betancor, O., Brkanac, Z., Scott, E., Topol, E., Morgan, K., Rogaeva, E., Singleton, A., Hardy, J., Kamboh, M., St George-Hyslop, P., Cairns, N., Morris, J., Kauwe, J., Goate, A., 2014. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease. Nature 505, 550–554.

Deas, E., Piipari, K., Machhada, A., Li, A., Gutierrez-del-Arroyo, A., Withers, D.J., Wood, N.W., Abramov, A.Y., 2014. PINK1 deficiency in ß-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biology 4. doi:10.1098/rsob.140051

Delos Heros, P., Alessi, D.R., Gourlay, R., Campbell, D.G., Deak, M., Macartney, T.J., Kahle, K.T., Zhang, J., 2014. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(-) co-transporters. Biochemical Journal 458, 559–573. doi:10.1042/BJ20131478

Ferrari, R., Ryten, M., Simone, R., Trabzuni, D., Nicolaou, N., Hondhamuni, G., Ramasamy, A., Vandrovcova, J., Weale, M.E., Lees, A.J., Momeni, P., Hardy, J., de Silva, R., 2014. Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy. Neurobiology of Aging 35, 1514.e1–1514.e12. doi:10.1016/j.neurobiolaging.2014.01.010

Godena, V.K., Brookes-Hocking, N., Moller, A., Shaw, G., Oswald, M., Sancho, R.M., Miller, C.C.J., Whitworth, A.J., De Vos, K.J., 2014. Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nat Commun 5.

Gómez-Sánchez, R., Gegg, M., Bravo-San Pedro, J., Niso-Santano, M., Alvarez-Erviti, L., Pizarro-Estrella, E., Gutiérrez-Martín, Y., Alvarez-Barrientos, A., Fuentes, J., González-Polo, R., Schapira, A., 2014. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis.

Guerreiro, R., Brás, J., Hardy, J., Singleton, A., 2014. Next generation sequencing techniques in neurological diseases: redefining clinical and molecular associations. Human Molecular Genetics. doi:10.1093/hmg/ddu203

Guerreiro, R., Brás, J., Wojtas, A., Rademakers, R., Hardy, J., Graff-Radford, N., 2014. A nonsense mutation in PRNP associated with clinical Alzheimer’s disease. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2014.05.013

Guerreiro, R., Hardy, J., 2014. Genetics of Alzheimer’s Disease. Neurotherapeutics 11, 732–737. doi:10.1007/s13311-014-0295-9

Houde, V.P., Ritorto, M.S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, K., Alessi, D.R., 2014. Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochemical Journal 458, 41–56. doi:10.1042/BJ20131324

Ivatt, R.M., Sanchez-Martinez, A., Godena, V.K., Brown, S., Ziviani, E., Whitworth, A.J., 2014. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proceedings of the National Academy of Sciences of the United States of America 111, 8494–8499. doi:10.1073/pnas.1321207111

Ivatt, R.M., Whitworth, A.J., 2014. SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease. Autophagy 10, 1476–1477. doi:10.4161/auto.29642

Ivatt, R.M., Whitworth, A.J., 2014. The many faces of mitophagy. EMBO Reports 15, 5–6. doi:10.1002/embr.201338224

Jansen, R.L.M., Brogan, B., Whitworth, A.J., Okello, E.J., 2014. Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson’s Disease Model. Phytotherapy Research 28, 1789–1795. doi:10.1002/ptr.5199

Johnson, J., Pioro, E., Boehringer, A., Chia, R., Feit, H., Renton, A., Pliner, H., Abramzon, Y., Marangi, G., Winborn, B., Gibbs, J., Nalls, M., Morgan, S., Shoai, M., Hardy, J., Pittman, A., Orrell, R., Malaspina, A., Sidle, K., Fratta, P., Harms, M., Baloh, R., Pestronk, A., Weihl, C., Rogaeva, E., Zinman, L., Drory, V., Borghero, G., Mora, G., Calvo, A., Rothstein, J., null, Drepper, C., Sendtner, M., Singleton, A., Taylor, J., Cookson, M., Restagno, G., Sabatelli, M., Bowser, R., Chiò, A., Traynor, B., 2014. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci 17, 664–666.

Kara, E., Kiely, A.P., Proukakis, C., Giffin, N., Love, S., Hehir, J., Rantell, K., Pandraud, A., Hernandez, D.G., Nacheva, E., Pittman, A.M., Nalls, M.A., Singleton, A.B., Revesz, T., Bhatia, K.P., Quinn, N., Hardy, J., Holton, J.L., Houlden, H., 2014. A 6.4 Mb duplication of the a-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations. JAMA Neurol 71, 1162–1171. doi:10.1001/jamaneurol.2014.994

Kara, E., Xiromerisiou, G., Spanaki, C., Bozi, M., Koutsis, G., Panas, M., Dardiotis, E., Ralli, S., Bras, J., Letson, C., Edsall, C., Pliner, H., Arepalli, S., Kalinderi, K., Fidani, L., Bostantjopoulou, S., Keller, M., Wood, N., Hardy, J., Houlden, H., Stefanis, L., Plaitakis, A., Hernandez, D., Hadjigeorgiou, G., Nalls, M., Singleton, A., 2014. Assessment of Parkinson’s disease risk loci in Greece. Neurobiol Aging 35, 442.e9–442.e16.

Karran, E., Hardy, J., 2014. A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease. Annals of Neurology. doi:10.1002/ana.24188

Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C.J., Peggie, M., Macartney, T., Woodroof, H.I., Alessi, D.R., Pedrioli, P.G.A., Muqit, M.M.K., 2014. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Open Biology 4, 130213. doi:10.1098/rsob.130213

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D.G., Ritorto, M.S., Hofmann, K., Alessi, D.R., Knebel, A., Trost, M., Muqit, M.M.K., 2014. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochemical Journal 460, 127–139.

Kefalopoulou, Z., Politis, M., Piccini, P., Mencacci, N., Bhatia, K., Jahanshahi, M., Widner, H., Rehncrona, S., Brundin, P., Björklund, A., Lindvall, O., Limousin, P., Quinn, N., Foltynie, T., 2014. Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease: Two Case Reports. JAMA Neurol 71, 83–87.

Kilford, E.J., Dumontheil, I., Wood, N.W., Blakemore, S.-J., 2014. Influence of COMT genotype and affective distractors on the processing of self-generated thought. Social Cognitive and Affective Neuroscience. doi:10.1093/scan/nsu118

Le Ber, I., De Septenville, A., Guerreiro, R., Bras, J., Camuzat, A., Caroppo, P., Lattante, S., Couarch, P., Kabashi, E., Bouya-Ahmed, K., Dubois, B., Brice, A., 2014. Homozygous TREM2 mutation in a family with atypical frontotemporal dementia. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2014.04.010

Ling, H., Kara, E., Revesz, T., Lees, A., Plant, G., Martino, D., Houlden, H., Hardy, J., Holton, J., 2014. Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer. Acta Neuropathol Commun 2, 24.

Ludtmann, M., Angelova, P., Zhang, Y., Abramov, A., Dinkova-Kostova, A., 2014. Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. Biochem J 457, 415–424.

Mamais, A., Chia, R., Beilina, A., Hauser, D.N., Hall, C., Lewis, P.A., Cookson, M.R., Bandopadhyay, R., 2014. Arsenite Stress Downregulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2) Promoting Self-Association and Cellular Redistribution. Journal of Biological Chemistry. doi:10.1074/jbc.M113.528463

McNeill, A., Magalhaes, J., Shen, C., Chau, K., Hughes, D., Mehta, A., Foltynie, T., Cooper, J., Abramov, A., Gegg, M., Schapira, A., 2014. Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain.

Mencacci, N.E., Isaias, I.U., Reich, M.M., Ganos, C., Plagnol, V., Polke, J.M., Bras, J., Hersheson, J., Stamelou, M., Pittman, A.M., Noyce, A.J., Mok, K.Y., Opladen, T., Kunstmann, E., Hodecker, S., Münchau, A., Volkmann, J., Samnick, S., Sidle, K., Nanji, T., Sweeney, M.G., Houlden, H., Batla, A., Zecchinelli, A.L., Pezzoli, G., Marotta, G., Lees, A., Alegria, P., Krack, P., Cormier-Dequaire, F., Lesage, S., Brice, A., Heutink, P., Gasser, T., Lubbe, S.J., Morris, H.R., Taba, P., Koks, S., Majounie, E., Raphael Gibbs, J., Singleton, A., Hardy, J., Klebe, S., Bhatia, K.P., Wood, N.W., 2014. Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers. Brain. doi:10.1093/brain/awu179.

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