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Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials

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Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).
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Drosophila fly model - University of Sheffield

Genetic mutations linked to Parkinson's disease

Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...

Autophagy

LRRK2 and autophagy

Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...

Nicholas Wood

(Principal Investigator)

Nick Wood


Prof Nick Wood’s chief interests are the genetic variants which contribute to nervous system function and dysfunction. Over the last few years the laboratory has contributed to the finding of a number of genes which when mutated cause Parkinson's disease and other neurological conditions. Following on from these discoveries he has built a group focussed on understanding the molecular pathogenesis of PD. This involves molecular and cellular biology and live cell imaging. One of the major challenges facing neuroscience is the genetic basis of normal and abnormal function. Over the past few years this lab and colleagues (within and outside UCL) have built a programme of research based around haplotype tagging of the human genome. Currently he is directly involved in 2 genome wide associations studies focussed on two common neurological diseases (Epilepsy and Parkinsons Disease).

Nick qualified in medicine from the University of Birmingham. He went on to take a PhD in Cambridge. He was elected to the Fellowship of the Academy of Medical Science in 2004 and to senior investigator of the NIHR in 2008. He is currently Galton Professor of Genetics, a Consultant Neurologist and neuroscience programme director for UCLH NIHR Biomedical Research Centre (BRC).

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Contact details

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Number of items: 494.

2014

Charlesworth, G; Bhatia, KP; Wood, NW; (2014) No pathogenic GNAL mutations in 192 sporadic and familial cases of cervical dystonia. Mov Disord , 29 (1) pp. 154-155. 10.1002/mds.25713. Green and gold open access
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Damotte, V; Guillot-Noel, L; Patsopoulos, NA; Madireddy, L; El Behi, M; International Multiple Sclerosis Genetics Consortium,; ... Fontaine, B; + view all (2014) A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes Immun 10.1038/gene.2013.70.

Davis, OS; Band, G; Pirinen, M; Haworth, CM; Meaburn, EL; Kovas, Y; ... Spencer, CC; + view all (2014) The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nat Commun , 5 4204 - ?. 10.1038/ncomms5204.

Deas, E; Piipari, K; Machhada, A; Li, A; Gutierrez-Del-Arroyo, A; Withers, DJ; ... Abramov, AY; + view all (2014) PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biol , 4 (5) 140051 - ?. 10.1098/rsob.140051.

Dumontheil, I; Jensen, SK; Wood, NW; Meyer, ML; Lieberman, MD; Blakemore, SJ; (2014) Preliminary investigation of the influence of dopamine regulating genes on social working memory. Soc Neurosci , 9 (5) 1 - 15. 10.1080/17470919.2014.925503. Green and gold open access
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Hersheson, J; Burke, D; Clayton, R; Anderson, G; Jacques, TS; Mills, P; ... Houlden, H; + view all (2014) Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology. Neurology 10.1212/WNL.0000000000000981.

Kara, E; Bras, J; Wood, NW; Hardy, J; Houlden, H; Hernandez, D; ... Bostantjopoulou, S; + view all (2014) Assessment of Parkinson's disease risk loci in Greece. Neurobiology of Aging , 35 (2) 10.1016/j.neurobiolaging.2013.07.011.

Kilford, EJ; Dumontheil, I; Wood, NW; Blakemore, SJ; (2014) Influence of COMT genotype and affective distractors on the processing of self-generated thought. Soc Cogn Affect Neurosci 10.1093/scan/nsu118. Green and gold open access
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Ludtmann, MHR; Angelova, PR; Gandhi, S; Kleneman, D; Devine, M; Wood, NW; Abramov, AY; (2014) Alpha-Synuclein Induces Mitochondrial Dysfunction Leading to a Higher Susceptibility of PTP Opening. In: BIOPHYSICAL JOURNAL. (pp. 590A - 590A).

Macerollo, A; Mencacci, NE; Erro, R; Cordivari, C; Edwards, MJ; Wood, NW; Bhatia, KP; (2014) Screening of mutations in NOL3 in a myoclonic syndromes series. J Neurol , 261 (9) pp. 1830-1831. 10.1007/s00415-014-7463-z. Green and gold open access
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Mencacci, NE; Isaias, IU; Reich, MM; Ganos, C; Plagnol, V; Polke, JM; ... on behalf of the International Parkinson’s Disease Genomics Consortium and UCL-exomes consortium,; + view all (2014) Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain , 137 (9) pp. 2480-2492. 10.1093/brain/awu179. Green and gold open access
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Mencacci, NE; Isaias, IU; Reich, MM; Ganos, C; Plagnol, V; Polke, JM; ... Consortium, U-E; + view all (2014) Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. BRAIN , 137 2480 - 2492. 10.1093/brain/awu179.

Mencacci, NE; Pittman, AM; Isaias, IU; Hardy, J; Klebe, S; Bhatia, KP; Wood, NW; (2014) Reply: Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain 10.1093/brain/awu309.

Nalls, MA; Pankratz, N; Lill, CM; Do, CB; Hernandez, DG; Saad, M; ... Singleton, AB; + view all (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 10.1038/ng.3043.

Narayan, P; Holmström, KM; Kim, DH; Whitcomb, DJ; Wilson, MR; St George-Hyslop, P; ... Klenerman, D; + view all (2014) Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage. Biochemistry 10.1021/bi401606f.

Parkinson, MH; Patel, R; Davagnanam, I; Wood, NW; Giunti, P; (2014) When the penny drops. Pract Neurol 10.1136/practneurol-2014-000859.

Proukakis, C; Shoaee, M; Morris, J; Brier, T; Kara, E; Sheerin, UM; ... Schapira, AH; + view all (2014) Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations. Mov Disord , 29 (8) 060-1064. 10.1002/mds.25883. Green and gold open access
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Psychosis Endophenotypes International Consortium,; Wellcome Trust Case-Control Consortium 2,; Bramon, E; Pirinen, M; Strange, A; Lin, K; ... Spencer, CC; + view all (2014) A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. Biol Psychiatry , 75 (5) 386 - 397. 10.1016/j.biopsych.2013.03.033.

Sheerin, UM; Schneider, SA; Carr, L; Deuschl, G; Hopfner, F; Stamelou, M; ... Bhatia, KP; + view all (2014) ALS2 mutations: Juvenile amyotrophic lateral sclerosis and generalized dystonia. Neurology , 82 (12) 1065-1067 . 10.1212/WNL.0000000000000254. Green and gold open access
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Stamelou, M; Charlesworth, G; Cordivari, C; Schneider, SA; Kaegi, G; Sheerin, U-M; ... Bhatia, KP; + view all (2014) The Phenotypic Spectrum of DYT24 Due to ANO3 Mutations. MOVEMENT DISORDERS , 29 (7) 928 - 934. 10.1002/mds.25802.

Stamelou, M; Charlesworth, G; Cordivari, C; Schneider, SA; Kägi, G; Sheerin, UM; ... Bhatia, KP; + view all (2014) The phenotypic spectrum of DYT24 due to ANO3 mutations. Mov Disord , 29 (7) pp. 928-934. 10.1002/mds.25802. Green and gold open access
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Stroh, PR; Ludtmann, MHR; Wood, NW; Klenerman, D; Gandhi, S; Abramov, AY; (2014) Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death. In: BIOPHYSICAL JOURNAL. (pp. 529A - 529A).

2013

Angeli, A; Mencacci, NE; Duran, R; Aviles-Olmos, I; Kefalopoulou, Z; Candelario, J; ... Foltynie, T; + view all (2013) Genotype and phenotype in Parkinson's disease: Lessons in heterogeneity from deep brain stimulation. Movement Disorders , 28 (10) pp. 1370-1375. 10.1002/mds.25535. Green and gold open access
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Burchell, VS; Nelson, DE; Sanchez-Martinez, A; Delgado-Camprubi, M; Ivatt, RM; Pogson, JH; ... Plun-Favreau, H; + view all (2013) The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci 10.1038/nn.3489.

Charlesworth, G; Bhatia, KP; Wood, NW; (2013) The genetics of dystonia: new twists in an old tale. Brain , 136 (7) 2017 - 2037. 10.1093/brain/awt138. Green and gold open access
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Charlesworth, G; Mohire, MD; Schneider, SA; Stamelou, M; Wood, NW; Bhatia, KP; (2013) Ataxia telangiectasia presenting as dopa-responsive cervical dystonia. Neurology 10.1212/WNL.0b013e3182a55fa2.

Cleeter, MW; Chau, KY; Gluck, C; Mehta, A; Hughes, DA; Duchen, M; ... Schapira, AH; + view all (2013) Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int , 62 (1) 1 - 7. 10.1016/j.neuint.2012.10.010. Gold open access

Cooper-Knock, J; Frolov, A; Highley, JR; Charlesworth, G; Kirby, J; Milano, A; ... Bandmann, O; + view all (2013) C9ORF72 expansions, parkinsonism, and Parkinson disease: A clinicopathologic study. Neurology 10.1212/WNL.0b013e3182a2cc38.

Duran, R; Mencacci, NE; Angeli, AV; Shoai, M; Deas, E; Houlden, H; ... Foltynie, T; + view all (2013) The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease. Movement Disorders , 28 (2) 232 - 236. 10.1002/mds.25248. Green and gold open access
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Hersheson, J; Mencacci, NE; Davis, M; MacDonald, N; Trabzuni, D; Ryten, M; ... Houlden, H; + view all (2013) Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia. Ann Neurol , 73 (4) 546 - 553. 10.1002/ana.23832.

Holmans, P; Moskvina, V; Jones, L; Sharma, M; International Parkinson's Disease Genomics Consortium,; Vedernikov, A; ... Williams, NM; + view all (2013) A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet , 22 (5) 1039 - 1049. 10.1093/hmg/dds492.

Holmström, KM; Marina, N; Baev, AY; Wood, NW; Gourine, AV; Abramov, AY; (2013) Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun , 4 1362 - ?. 10.1038/ncomms2364. Gold open access

Kara, E; Xiromerisiou, G; Spanaki, C; Bozi, M; Koutsis, G; Panas, M; ... Singleton, AB; + view all (2013) Assessment of Parkinson's disease risk loci in Greece. Neurobiol Aging 10.1016/j.neurobiolaging.2013.07.011.

Koutsis, G; Kladi, A; Karadima, G; Houlden, H; Wood, NW; Christodoulou, K; Panas, M; (2013) Friedreich's ataxia and other hereditary ataxias in Greece: An 18-year perspective. J Neurol Sci 10.1016/j.jns.2013.10.012.

Koutsis, G; Pandraud, A; Karadima, G; Panas, M; Reilly, MM; Floroskufi, P; ... Houlden, H; + view all (2013) Mutational analysis of PMP22, EGR2, LITAF and NEFL in Greek Charcot-Marie-Tooth type 1 patients. CLINICAL GENETICS , 83 (4) 388 - 391. 10.1111/j.1399-0004.2012.01910.x.

Koutsis, G; Pandraud, A; Karadima, G; Panas, M; Reilly, MM; Floroskufi, P; ... Houlden, H; + view all (2013) Mutational analysis of PMP22, EGR2, LITAF and NEFL in Greek Charcot-Marie-Tooth type 1 patients. Clin Genet , 83 (4) 388 - 391. 10.1111/j.1399-0004.2012.01910.x.

LeishGEN Consortium,; Wellcome Trust Case Control Consortium 2,; Fakiola, M; Strange, A; Cordell, HJ; Miller, EN; ... Donnelly, P; + view all (2013) Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet , 45 (2) 208 - 213. 10.1038/ng.2518.

Liu, YT; Hersheson, J; Plagnol, V; Fawcett, K; Duberley, KE; Preza, E; ... Houlden, H; + view all (2013) Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation. Journal of Neurology, Neurosurgery & Psychiatry 10.1136/jnnp-2013-306483. Green and gold open access
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Mead, S; Gandhi, S; Beck, J; Caine, D; Gallujipali, D; Carswell, C; ... Collinge, J; + view all (2013) A Novel Prion Disease Presenting with Diarrhea and Autonomic Neuropathy. New England Journal of Medicine , 369 (20) 1904- 1914. 10.1056/NEJMoa1214747. Green open access
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Menon, RP; Nethisinghe, S; Faggiano, S; Vannocci, T; Rezaei, H; Pemble, S; ... Giunti, P; + view all (2013) The role of interruptions in polyQ in the pathology of SCA1. PLOS Genetics , 9 (7) , Article e1003648. 10.1371/journal.pgen.1003648. Green and gold open access
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Ripke, S; O'Dushlaine, C; Chambert, K; Moran, JL; Kähler, AK; Akterin, S; ... Sullivan, PF; + view all (2013) Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 10.1038/ng.2742.

Sheerin, UM; Stamelou, M; Charlesworth, G; Shiner, T; Spacey, S; Valente, EM; ... Bhatia, KP; + view all (2013) Migraine with aura as the predominant phenotype in a family with a PRRT2 mutation. J Neurol , 260 (2) 656 - 660. 10.1007/s00415-012-6747-4.

Trabzuni, D; Ryten, M; Emmett, W; Ramasamy, A; Lackner, KJ; Zeller, T; ... Plagnol, V; + view all (2013) Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 Locus. PLOS ONE , 8 (8) , Article e70724. 10.1371/journal.pone.0070724. Green and gold open access
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Wood-Kaczmar, A; Deas, E; Wood, NW; Abramov, AY; (2013) The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Adv Exp Med Biol , 961 241 - 249. 10.1007/978-1-4614-4756-6_20.

2012

Charlesworth, G; Gandhi, S; Bras, JM; Barker, RA; Burn, DJ; Chinnery, PF; ... Wood, NW; + view all (2012) Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging , 33 (4) 838.e7 - 838.11. 10.1016/j.neurobiolaging.2011.11.001.

Charlesworth, G; Plagnol, V; Holmström, KM; Bras, J; Sheerin, UM; Preza, E; ... Wood, NW; + view all (2012) Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. The American Journal of Human Genetics , 91 (6) 1041 - 1050. 10.1016/j.ajhg.2012.10.024. Green and gold open access
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Cremades, N; Cohen, SI; Deas, E; Abramov, AY; Chen, AY; Orte, A; ... Klenerman, D; + view all (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell , 149 (5) 1048 - 1059. 10.1016/j.cell.2012.03.037.

Fitzgerald, JC; Camprubi, MD; Dunn, L; Wu, HC; Ip, NY; Kruger, R; ... Plun-Favreau, H; + view all (2012) Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function. Cell Death Differ , 19 (2) 257 - 266. 10.1038/cdd.2011.90.

Gandhi, S; Vaarmann, A; Yao, Z; Duchen, MR; Wood, NW; Abramov, AY; (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One , 7 (5) , Article e37564 . 10.1371/journal.pone.0037564. Green and gold open access
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Gardiner, AR; Bhatia, KP; Stamelou, M; Dale, RC; Kurian, MA; Schneider, SA; ... Houlden, H; + view all (2012) PRRT2 gene mutations From paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. NEUROLOGY , 79 (21) 2115 - 2121.

Gardiner, AR; Bhatia, KP; Stamelou, M; Dale, RC; Kurian, MA; Schneider, SA; ... Houlden, H; + view all (2012) PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology , 79 (21) 2115 - 2121. 10.1212/WNL.0b013e3182752c5a.

Gegg, ME; Burke, D; Heales, SJ; Cooper, JM; Hardy, J; Wood, NW; Schapira, AH; (2012) Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol , 72 (3) 455 - 463. 10.1002/ana.23614.

Giunti, P; Houlden, H; Gardner-Thorpe, C; Worth, PF; Johnson, J; Hilton, DA; ... Wood, NW; + view all (2012) Spinocerebellar ataxia type 11. In: UNSPECIFIED (521 - 534).

International Stroke Genetics Consortium (ISGC),; Wellcome Trust Case Control Consortium 2 (WTCCC2),; Bellenguez, C; Bevan, S; Gschwendtner, A; Spencer, CC; ... Markus, HS; + view all (2012) Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet , 44 (3) 328 - 333. 10.1038/ng.1081.

Keller, MF; Saad, M; Bras, J; Bettella, F; Nicolaou, N; Simón-Sánchez, J; ... Wellcome Trust Case Control Consortium 2 (WTCCC2),; + view all (2012) Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet , 21 (22) 4996 - 5009. 10.1093/hmg/dds335.

Kilarski, LL; Pearson, JP; Newsway, V; Majounie, E; Knipe, MD; Misbahuddin, A; ... Morris, HR; + view all (2012) Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. Mov Disord , 27 (12) 1522 - 1529. 10.1002/mds.25132.

Kojovic, M; Sheerin, UM; Rubio-Agusti, I; Saha, A; Bras, J; Gibbons, V; ... Bhatia, KP; + view all (2012) Young-onset parkinsonism due to homozygous duplication of α-synuclein in a consanguineous family. Mov Disord , 27 (14) pp. 1829-1830. 10.1002/mds.25199. Green and gold open access
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Koutsis, G; Karadima, G; Pandraud, A; Sweeney, MG; Paudel, R; Houlden, H; ... Panas, M; + view all (2012) Genetic screening of Greek patients with Huntington’s disease phenocopies identifies an SCA8 expansion. J Neurol , 259 (9) 1874 - 1878. 10.1007/s00415-012-6430-9.

Koutsis, G; Pandraud, A; Polke, JM; Wood, NW; Panas, M; Karadima, G; Houlden, H; (2012) Novel peripheral myelin protein 22 (PMP22) micromutations associated with variable phenotypes in Greek patients with Charcot-Marie-Tooth disease. Brain , 135 (Pt 8) e217 - 6. 10.1093/brain/aws034.

Koutsis, G; Pemble, S; Sweeney, MG; Paudel, R; Wood, NW; Panas, M; ... Houlden, H; + view all (2012) Analysis of spinocerebellar ataxias due to expanded triplet repeats in Greek patients with cerebellar ataxia. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 731 - 731).

Koutsis, G; Pemble, S; Sweeney, MG; Paudel, R; Wood, NW; Panas, M; ... Houlden, H; + view all (2012) Analysis of spinocerebellar ataxias due to expanded triplet repeats in Greek patients with cerebellar ataxia. J Neurol Sci , 318 (1-2) 178 - 180. 10.1016/j.jns.2012.03.019.

Lill, CM; Roehr, JT; McQueen, MB; Kavvoura, FK; Bagade, S; Schjeide, B-MM; ... WTCCC2,; + view all (2012) Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database. PLOS GENETICS , 8 (3) , Article e1002548. 10.1371/journal.pgen.1002548. Green and gold open access
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McNeill, A; Duran, R; Proukakis, C; Bras, J; Hughes, D; Mehta, A; ... Schapira, AH; + view all (2012) Hyposmia and cognitive impairment in Gaucher disease patients and carriers. Mov Disord , 27 (4) 526 - 532. 10.1002/mds.24945.

Mittag, F; Büchel, F; Saad, M; Jahn, A; Schulte, C; Bochdanovits, Z; ... International Parkinson’s Disease Genomics Consortium,; + view all (2012) Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities. Hum Mutat , 33 (12) 1708 - 1718. 10.1002/humu.22161.

Plagnol, V; Curtis, J; Epstein, M; Mok, KY; Stebbings, E; Grigoriadou, S; ... Nejentsev, S; + view all (2012) A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics , 28 (21) 2747 - 2754. 10.1093/bioinformatics/bts526. Gold open access
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Plun-Favreau, H; Burchell, VS; Holmström, KM; Yao, Z; Deas, E; Cain, K; ... Abramov, AY; + view all (2012) HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion. Cell Death and Disease , 3 , Article e335. 10.1038/cddis.2012.77. Green and gold open access
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Proukakis, C; Moore, D; Labrum, R; Wood, NW; Houlden, H; (2012) HEREDITARY SPASTIC PARAPLEGIA CAUSED BY SPASTIN (SPAST, SPG4) MUTATIONS IS FOUND MORE OFTEN IN MALES: REPORT OF NOVEL MUTATIONS FROM ONE CENTRE, AND REVIEW OF PUBLISHED LITERATURE. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY.

Sailer, A; Scholz, SW; Gibbs, JR; Tucci, A; Johnson, JO; Wood, NW; ... Houlden, H; + view all (2012) Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology , 79 (2) 127 - 131. 10.1212/WNL.0b013e31825f048e. Gold open access

Simon-Sanchez, J; Kilarski, LL; Nalls, MA; Martinez, M; Schulte, C; Holmans, P; ... Consor, WTCC; + view all (2012) Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease. PLOS ONE , 7 (3) , Article e28787. 10.1371/journal.pone.0028787. Green and gold open access
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Stamelou, M; Mencacci, NE; Cordivari, C; Batla, A; Wood, NW; Houlden, H; ... Bhatia, KP; + view all (2012) Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency. Neurology , 79 (5) 435 - 441. 10.1212/WNL.0b013e318261714a. Gold open access

Strange, A; Riley, BP; Spencer, CCA; Morris, DW; Pirinen, M; O'Dushlaine, CT; ... Consor, WTCC; + view all (2012) Genome-Wide Association Study Implicates HLA-C*01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia. BIOLOGICAL PSYCHIATRY , 72 (8) 620 - 628. 10.1016/j.biopsych.2012.05.035.

Tsoi, LC; Spain, SL; Knight, J; Ellinghaus, E; Stuart, PE; Capon, F; ... Trembath, RC; + view all (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet , 44 (12) 1341 - 1348. 10.1038/ng.2467.

Tsoi, LC; Spain, SL; Knight, J; Ellinghaus, E; Stuart, PE; Capon, F; ... Trembath, RC; + view all (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet , 44 (12) 1341 - 1348. 10.1038/ng.2467.

Tucci, A; Charlesworth, G; Sheerin, UM; Plagnol, V; Wood, NW; Hardy, J; (2012) Study of the genetic variability in a Parkinson's Disease gene: EIF4G1. Neurosci Lett , 518 (1) 19 - 22. 10.1016/j.neulet.2012.04.033. Green and gold open access
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2011

Abramov, AY; Gegg, M; Grunewald, A; Wood, NW; Klein, C; Schapira, AHV; (2011) Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease. PLOS ONE , 6 (10) , Article e25622. 10.1371/journal.pone.0025622. Green and gold open access
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Deas, E; Plun-Favreau, H; Gandhi, S; Desmond, H; Kjaer, S; Loh, SHY; ... Wood, NW; + view all (2011) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Human Molecular Genetics , 20 (5) pp. 867-879. 10.1093/hmg/ddq526. Green open access
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Deas, E; Wood, NW; Plun-Favreau, H; (2011) Mitophagy and Parkinson's disease: The PINK1-parkin link. BBA-MOL CELL RES , 1813 (4) 623 - 633. 10.1016/j.bbamcr.2010.08.007.

Devine, MJ; Plun-Favreau, H; Wood, NW; (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150.

Evans, DM; Spencer, CCA; Pointon, JJ; Su, Z; Harvey, D; Kochan, G; ... Spondyloarthrit Res Consortium Can,; + view all (2011) Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. NAT GENET , 43 (8) 761 - U67. 10.1038/ng.873.

Ling, H; Polke, JM; Sweeney, MG; Haworth, A; Sandford, CA; Heales, SJR; ... Lees, AJ; + view all (2011) An Intragenic Duplication in Guanosine Triphosphate Cyclohydrolase-1 Gene in a Dopa-Responsive Dystonia Family. MOVEMENT DISORD , 26 (5) 905 - 909. 10.1002/mds.23593.

Nalls, MA; Plagnol, V; Hernandez, DG; Sharma, M; Sheerin, UM; Saad, M; ... Wellcome Trust Case-Control Consor,; + view all (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. LANCET , 377 (9766) 641 - 649. 10.1016/S0140-6736(10)62345-8.

Plagnol, V; Nalls, MA; Bras, JM; Hernandez, DG; Sharma, M; Sheerin, UM; ... WTCCC2,; + view all (2011) A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease. PLoS Genetics , 7 (6) , Article e1002142. 10.1371/journal.pgen.1002142. Green and gold open access
file

Proukakis, C; Moore, D; Labrum, R; Wood, NW; Houlden, H; (2011) Detection of novel mutations and review of published data suggests that hereditary spastic paraplegia caused by spastin (SPAST) mutations is found more often in males. J NEUROL SCI , 306 (1-2) 62 - 65. 10.1016/j.jns.2011.03.043.

Sailer, A; Scholz, SW; Gibbs, JR; Johnson, JO; Wood, NW; Hernandez, D; ... Houlden, H; + view all (2011) EXOME SEQUENCING AS A RAPID AND COST EFFICIENT DIAGNOSTIC METHOD IN NEUROGENETIC DISORDERS. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 552 - 552). WILEY-BLACKWELL

Sawcer, S; Hellenthal, G; Pirinen, M; Spencer, CCA; Patsopoulos, NA; Moutsianas, L; ... Wellcome Trust Case Control Consor,; + view all (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. NATURE , 476 (7359) 214 - 219. 10.1038/nature10251.

Sharma, S; Bandopadhyay, R; Lashley, T; Renton, AEM; Kingsbury, AE; Kumaran, R; ... Holton, JL; + view all (2011) LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study. NEUROPATH APPL NEURO , 37 (7) 777 - 790. 10.1111/j.1365-2990.2011.01187.x.

Spencer, CCA; Plagnol, V; Strange, A; Gardner, M; Paisan-Ruiz, C; Band, G; ... Wellcome Trust Case Control Consor,; + view all (2011) Dissection of the genetics of Parkinson's disease identifies an additional association 5 ' of SNCA and multiple associated haplotypes at 17q21. HUM MOL GENET , 20 (2) 345 - 353. 10.1093/hmg/ddq469.

Yao, Z; Gandhi, S; Burchell, VS; Plun-Favreau, H; Wood, NW; Abramov, AY; (2011) Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci , 124 (Pt 24) 4194 - 4202. 10.1242/jcs.088260. Gold open access

Zhou, KX; Bellenguez, C; Spencer, CCA; Bennett, AJ; Coleman, RL; Tavendale, R; ... MAGIC Investigators,; + view all (2011) Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. NAT GENET , 43 (2) 117 - U57. 10.1038/ng.735.

2010

Alonso-Canovas, A; Katschnig, P; Tucci, A; Carecchio, M; Wood, NW; Edwards, M; ... Bhatia, KP; + view all (2010) Atypical Parkinsonism with Apraxia and Supranuclear Gaze Abnormalities in Type 1 Gaucher Disease. Expanding the Spectrum: Case Report and Literature Review. MOVEMENT DISORD , 25 (10) 1506 - 1509. 10.1002/mds.23109.

Bishop, MW; Chakraborty, S; Matthews, GAC; Dougalis, A; Wood, NW; Festenstein, R; Ungless, MA; (2010) Hyperexcitable Substantia Nigra Dopamine Neurons in PINK1- and HtrA2/Omi-Deficient Mice. J NEUROPHYSIOL , 104 (6) 3009 - 3020. 10.1152/jn.00466.2010.

Burchell, VS; Gandhi, S; Deas, E; Wood, NW; Abramov, AY; Plun-Favreau, H; (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. EXPERT OPIN THER TAR , 14 (5) 497 - 511. 10.1517/14728221003730434.

Burchell, VS; Gandhi, S; Deas, E; Wood, NW; Abramov, AY; Plun-Favreau, H; (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. EXPERT OPIN THER TAR , 14 (4) 369 - 385. 10.1517/14728221003652489.

Gandhi, S; Wood, NW; (2010) Genome-wide association studies: the key to unlocking neurodegeneration? NAT NEUROSCI , 13 (7) 789 - 794. 10.1038/nn.2584.

Heinzen, EL; Radtke, RA; Urban, TJ; Cavalleri, GL; Depondt, C; Need, AC; ... Goldstein, DB; + view all (2010) Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes. The American Journal of Human Genetics , 86 (5) 707 - 718. 10.1016/j.ajhg.2010.03.018. Green and gold open access
file

Kagi, G; Klein, C; Wood, NW; Schneider, SA; Pramstaller, PP; Tadic, V; ... Bhatia, KP; + view all (2010) Nonmotor Symptoms in Parkin Gene-Related Parkinsonism. MOVEMENT DISORD , 25 (9) 1279 - 1284. 10.1002/mds.22897.

Kasperaviciute, D; Catarino, CB; Heinzen, EL; Depondt, C; Cavalleri, GL; Caboclo, LO; ... Sisodiya, SM; + view all (2010) Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. BRAIN , 133 2136 - 2147. 10.1093/brain/awq130.

Mead, S; Gandhi, S; Carswell, C; Ayling, H; Beck, J; Caine, D; ... Collinge, J; + view all (2010) Novel Truncation Mutation of PRNP Causes Chronic Diarrhoea, Sensory Neuropathy and Autonomic Failure Associated with Prion Protein Deposition in the Cerebral Blood Vessels and Small Bowel. PRION , 4 (3) 201 - 202.

Novak, MJU; Tabrizi, SJ; (2010) Huntington's disease. In: UNSPECIFIED (? - ?). B M J PUBLISHING GROUP

Pavese, N; Moore, RY; Scherfler, C; Khan, NL; Hotton, G; Quinn, NP; ... Piccini, P; + view all (2010) In vivo assessment of brain monoamine systems in parkin gene carriers: A PET study. EXP NEUROL , 222 (1) 120 - 124. 10.1016/j.expneurol.2009.12.021.

Plun-Favreau, H; Lewis, PA; Hardy, J; Martins, LM; Wood, NW; (2010) Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genetics , 6 (12) , Article e1001257. 10.1371/journal.pgen.1001257. Green and gold open access
file

Rajakulendran, S; Graves, TD; Labrum, RW; Kotzadimitriou, D; Eunson, L; Davis, MB; ... Schorge, S; + view all (2010) Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy. J PHYSIOL-LONDON , 588 (11) 1905 - 1913. 10.1113/jphysiol.2009.186437.

Sebastian, CL; Roiser, JP; Tan, GCY; Viding, E; Wood, NW; Blakemore, SJ; (2010) Effects of age and MAOA genotype on the neural processing of social rejection. GENES BRAIN BEHAV , 9 (6) 628 - 637. 10.1111/j.1601-183X.2010.00596.x.

Tan, GCY; Doke, TF; Ashburner, J; Wood, NW; Frackowiak, RSJ; (2010) Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. NEUROIMAGE , 53 (3) 1030 - 1042. 10.1016/j.neuroimage.2010.02.018.

Tucci, A; Nalls, MA; Houlden, H; Revesz, T; Singleton, AB; Wood, NW; ... Paisan-Ruiz, C; + view all (2010) Genetic variability at the PARK16 locus. EUR J HUM GENET , 18 (12) 1356 - 1359. 10.1038/ejhg.2010.125.

Yao, Z; Gandhi, S; Plun-Favreau, H; Wood, NW; Abramov, AY; (2010) PINK1 Deficiency and Mitochondrial Dysfunction in Neurons and Skeletal Myocytes. BIOPHYSICAL JOURNAL , 98 (3) 381A - 381A.

2009

da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; ... Checler, F; + view all (2009) Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. NAT CELL BIOL , 11 (11) 1370 - U255. 10.1038/ncb1981.

Deas, E; Plun-Favreau, H; Wood, NW; (2009) PINK1 function in health and disease. EMBO MOL MED , 1 (3) 152 - 165. 10.1002/emmm.200900024. Gold open access

Gandhi, S; Tabrizi, SJ; Wood, NW; (2009) Neurogenetics. In: Scadding, J and Losseff, N, (eds.) Clinical Neurology. Hodder Arnold

Gandhi, S; Wood-Kaczmar, A; Yao, Z; Plun-Favreau, H; Deas, E; Klupsch, K; ... Abramov, AY; + view all (2009) PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death. MOL CELL , 33 (5) 627 - 638. 10.1016/j.molcel.2009.02.013. Gold open access

Healy, DG; Bressman, S; Dickson, J; Silveira-Moriyama, L; Schneider, SA; Sullivan, SSO; ... Lees, AJ; + view all (2009) Evidence for Pre and Postsynaptic Nigrostriatal Dysfunction in the Fragile X Tremor-Ataxia Syndrome. MOVEMENT DISORD , 24 (8) 1245 - 1247. 10.1002/mds.22267.

Healy, DG; Sullivan, SO; Bonifati, V; Durr, A; Bressman, S; Brice, A; ... Wood, NW; + view all (2009) LRRK2 ASSOCIATED PARKINSON'S DISEASE: CLINICAL FACTORS BASED ON WORLDWIDE EXPERIENCE. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 105 - 106). B M J PUBLISHING GROUP

Kumaran, R; Vandrovcova, J; Luk, C; Sharma, S; Renton, A; Wood, NW; ... Bandopadhyay, R; + view all (2009) Differential DJ-1 gene expression in Parkinson's disease. NEUROBIOL DIS , 36 (2) 393 - 400. 10.1016/j.nbd.2009.08.011.

Lynch, JM; Tate, SK; Kinirons, P; Weale, ME; Cavalleri, GL; Depondt, C; ... Sisodiya, SM; + view all (2009) No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. EPILEPSY RES , 83 (1) 44 - 51. 10.1016/j.eplepsyres.2008.09.003.

Michell, AW; Laura, M; Blake, J; Lunn, MP; Cox, A; Gibbons, VS; ... Reilly, MM; + view all (2009) GJB1 gene mutations in suspected inflammatory demyelinating neuropathies not responding to treatment. J NEUROL NEUROSUR PS , 80 (6) 699 - 700. 10.1136/jnnp.2008.150557.

Moisoi, N; Klupsch, K; Fedele, V; East, P; Sharma, S; Renton, A; ... Martins, LM; + view all (2009) Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. CELL DEATH DIFFER , 16 (3) 449 - 464. 10.1038/cdd.2008.166.

Neumann, J; Bras, J; Deas, E; O'Sullivan, SS; Parkkinen, L; Lachmann, RH; ... Wood, NW; + view all (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. BRAIN , 132 1783 - 1794. 10.1093/brain/awp044. Gold open access

Neumann, J; Parkkinen, L; Bras, J; O'sullivan, SS; Deas, E; Lachmann, H; ... Wood, NW; + view all (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 3 - 3). BLACKWELL PUBLISHING

Paisan-Ruiz, C; Bhatia, KP; Li, A; Hernandez, D; Davis, M; Wood, NW; ... Schneider, SA; + view all (2009) Characterization of PLA2G6 as a Locus for Dystonia-Parkinsonism. ANN NEUROL , 65 (1) 19 - 23. 10.1002/ana.21415.

Pavese, N; Khan, NL; Scherfler, C; Cohen, L; Brooks, DJ; Wood, NW; ... Piccini, P; + view all (2009) Nigrostriatal Dysfunction in Homozygous and Heterozygous Parkin Gene Carriers: An F-18-Dopa PET Progression Study. MOVEMENT DISORD , 24 (15) 2260 - 2266. 10.1002/mds.22817.

Proukakis, C; Moore, D; Labrum, R; Wood, NW; Houlden, H; (2009) A clinical and genetic study of hereditary spastic paraplegia caused by SPAST/SPG4 mutations, including 12 new mutations. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 296 - 296). WILEY-BLACKWELL PUBLISHING, INC

Roiser, JP; de Martino, B; Tan, GCY; Kumaran, D; Seymour, B; Wood, NW; Dolan, RJ; (2009) A Genetically Mediated Bias in Decision Making Driven by Failure of Amygdala Control. J NEUROSCI , 29 (18) 5985 - 5991. 10.1523/JNEUROSCI.0407-09.2009. Gold open access

Segarane, B; Li, A; Paudel, R; Scholz, S; Neumann, J; Lees, A; ... Houlden, H; + view all (2009) GLUCOCEREBROSIDASE MUTATIONS IN 108 NEUROPATHOLOGICALLY CONFIRMED CASES OF MULTIPLE SYSTEM ATROPHY. NEUROLOGY , 72 (13) 1185 - 1186. 10.1212/01.wnl.0000345356.40399.eb. Gold open access

Sharma, S; Bandopadhyay, R; Kingsbury, AE; Lashley, TC; Lees, AJ; Revesz, T; ... Holton, JL; + view all (2009) LRRK2 mRNA and protein expression in Parkinson's disease cases with LRRK2 G2019S mutation. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 27 - 28). BLACKWELL PUBLISHING

Simon-Sanchez, J; Schulte, C; Bras, JM; Sharma, M; Gibbs, JR; Berg, D; ... Gasser, T; + view all (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. NAT GENET , 41 (12) 1308 - U68. 10.1038/ng.487.

Sleiman, PMA; Healy, DG; Muqit, MMK; Yang, YX; Van der Brug, M; Holton, JL; ... Wood, NW; + view all (2009) Characterisation of a novel NR4A2 mutation in Parkinson's disease brain. NEUROSCI LETT , 457 (2) 75 - 79. 10.1016/j.neulet.2009.03.021.

Trender-Gerhard, I; Sweeney, MG; Schwingenschuh, P; Mir, P; Edwards, MJ; Gerhard, A; ... Bhatia, KP; + view all (2009) Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients. J NEUROL NEUROSUR PS , 80 (8) 839 - 845. 10.1136/jnnp.2008.155861.

Vandrovcova, J; Pittman, AM; Malzer, E; Abou-Sleiman, PM; Lees, AJ; Wood, NW; de Silva, R; (2009) Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease. NEUROBIOL AGING , 30 (9) 1477 - 1482. 10.1016/j.neurobiolaging.2007.11.019.

Wood, N; (2009) Cerebellar ataxias and related conditions. In: Clarke, C and Howard, R and Rossor, M and Shorvon, S, (eds.) Neurology: a Queen Square textbook. (629 - 643). Wiley-Blackwell: Chichester.

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, AY; Miljan, EA; Keen, G; ... Wood, NW; + view all (2009) PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons. In: JOURNAL OF NEUROCHEMISTRY. (pp. 301 - 302). WILEY-BLACKWELL PUBLISHING, INC

Yang, YX; Wood, NW; Latchman, DS; (2009) Molecular basis of Parkinson's disease. NEUROREPORT , 20 (2) 150 - 156. 10.1097/WNR.0b013e32831c50df.

Yao, Z; Bandopadhyay, R; Muqit, MMK; Holton, JL; Wood, NW; (2009) Putative LRRK2 (PARK8) substrates: ERM proteins are present in Lewy bodies and are up-regulated in Parkinson's disease brains. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 28 - 28). BLACKWELL PUBLISHING

Yao, Z; Klupsh, K; Hargreaves, I; Downward, J; Heales, S; Revesz, T; ... Wood, NW; + view all (2009) Characterisation of PINK1 knockout mice. In: JOURNAL OF NEUROCHEMISTRY. (pp. 300 - 300). WILEY-BLACKWELL PUBLISHING, INC

Yao, Z; Wood, NW; (2009) Cell Death Pathways in Parkinson's Disease: Role of Mitochondria. ANTIOXID REDOX SIGN , 11 (9) 2135 - 2149. 10.1089/ars.2009.2624.

2008

Gilman, S; Wenning, GK; Low, PA; Brooks, DJ; Mathias, CJ; Trojanowski, JQ; ... Vidailhet, M; + view all (2008) Second consensus statement on the diagnosis of multiple system atrophy. NEUROLOGY , 71 (9) 670 - 676.

Healy, DG; Falchi, M; O'Sullivan, SS; Bonifati, V; Durr, A; Bressman, S; ... Int LRRK2 Consortium,; + view all (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. LANCET NEUROL , 7 (7) 583 - 590. 10.1016/S1474-4422(08)70117-0. Gold open access

Healy, DG; Wood, NW; Schapira, AH; (2008) Test for LRRK2 mutations in patients with Parkinson's disease. Pract Neurol , 8 (6) 381 - 385. 10.1136/jnnp.2008.162420.

Holton, JL; Schneider, SA; Ganesharajah, T; Gandhi, S; Strand, C; Shashidharan, P; ... Revesz, T; + view all (2008) Neuropathology of primary adult-onset dystonia. NEUROLOGY , 70 (9) 695 - 699.

Holton, JL; Schneider, SA; Ganesharajah, T; Gandhi, S; Strand, C; Shashidharan, P; ... Revesz, T; + view all (2008) Neuropathology of primary adult onset non-DYT1 dystonia. In: JOURNAL OF NEUROLOGY. (pp. 98 - 98). DR DIETRICH STEINKOPFF VERLAG

Houlden, H; Johnson, J; Gardner-Thorpe, C; Lashley, T; Hernandez, D; Singleton, AB; ... Wood, NW; + view all (2008) Tau tubulin kinase 2, implicated by tau phosphorylation, contains mutations that segregate with spinocerebellar ataxia type II. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 344 - 344). B M J PUBLISHING GROUP

Houlden, H; Laura, M; Wavrant-De Vrieze, F; Blake, J; Wood, N; Reilly, MM; (2008) Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2. NEUROLOGY , 71 (21) 1660 - 1668. 10.1212/01.wnl.0000319696.14225.67.

Johnson, J; Wood, N; Giunti, P; Houlden, H; (2008) Clinical and genetic analysis of spinocerebellar ataxia type 11. CEREBELLUM , 7 (2) 159 - 164. 10.1007/s12311-008-0022-3.

Kagi, G; Klein, C; Wood, NW; Schneider, SA; Pramstaller, PP; Tadic, V; ... Bhatia, KP; + view all (2008) Non-motor symptoms in parkin gene-related parkinsonism. In: MOVEMENT DISORDERS. (pp. S352 - S352). WILEY-LISS

Lashley, T; Holton, JL; Gray, E; Kirkham, K; O'Sullivan, SS; Hilbig, A; ... Revesz, T; + view all (2008) Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. ACTA NEUROPATHOL , 115 (4) 417 - 425. 10.1007/s00401-007-0336-0.

Lashley, T; Revesz, T; Plant, G; Bandopadhyay, R; Lees, AJ; Frangione, B; ... Holton, JL; + view all (2008) Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease. NEUROPATH APPL NEURO , 34 (5) 492 - 505. 10.1111/j.1365-2990.2008.00935.x. Gold open access

Mortiboys, H; Thomas, KJ; Koopman, WJH; Klaffke, S; Abou-Sleiman, P; Olpin, S; ... Bandmann, O; + view all (2008) Mitochondrial Function and Morphology Are Impaired in parkin-Mutant Fibroblasts. ANN NEUROL , 64 (5) 555 - 565. 10.1002/ana.21492.

Muqit, MMK; Larner, AJ; Sweeney, MG; Sewry, C; Stinton, VJ; Davis, MB; ... Lane, RJM; + view all (2008) Multiple mitochondrial DNA deletions in monozygotic twins with OPMD. J NEUROL NEUROSUR PS , 79 (1) 68 - 71. 10.1136/jnnp.2006.112250.

Paisan-Ruiz, C; Nath, P; Wood, NW; Singleton, A; Houlden, H; (2008) Clinical heterogeneity and genotype-phenotype correlations in hereditary spastic paraplegia because of Spatacsin mutations (SPG11). EUR J NEUROL , 15 (10) 1065 - 1070. 10.1111/j.1468-1331.2008.02247.x.

Pavese, N; Khan, NL; Wood, NW; Quinn, NP; Lees, AJ; Brooks, DJ; Piccini, P; (2008) Nigrostriatal dysfunction in parkin linked parkinsonism and asymptomatic heterozygous carriers: A progressive study with 18-dopa pet. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 341 - 341). B M J PUBLISHING GROUP

Pittman, A; de Silva, R; Lees, AJ; Wood, NW; (2008) Genetics of progressive supranuclear palsy. In: UNSPECIFIED (475 - 485).

Plun-Favreau, H; Gandhi, S; Wood-Kaczmar, A; Deas, E; Yao, Z; Wood, NW; (2008) What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease? MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS , 1147 30 - 36. 10.1196/annals.1427.032.

Schneider, SA; Talelli, P; Cheeran, BJ; Khan, NL; Wood, NW; Rothwell, JC; Bhatia, KP; (2008) Motor Cortical Physiology in Patients and Asymptomatic Carriers of Parkin Gene Mutations. MOVEMENT DISORD , 23 (13) 1812 - 1819. 10.1002/mds.22025.

Silveira-Moriyama, L; Guedes, LC; Kingsbury, A; Ayling, H; Shaw, K; Barbosa, ER; ... Lees, AJ; + view all (2008) Hyposmia in G2019S LRRK2-related parkinsonism - Clinical and pathologic data. NEUROLOGY , 71 (13) 1021 - 1026.

Trender-Gerhard, I; Sweeney, MG; Schwingenschuh, P; Mir, P; Edwards, MJ; Gerhard, A; ... Bhatia, KP; + view all (2008) Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome in 34 patients. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 17 - 17). BLACKWELL PUBLISHING

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, ASY; Miljan, EA; Keen, G; ... Wood, NW; + view all (2008) PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons. PLOS ONE , 3 (6) , Article e2455. 10.1371/journal.pone.0002455. Green and gold open access
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2007

Cavalleri, GL; Walley, NM; Soranzo, N; Mulley, J; Doherty, CP; Kapoor, A; ... Sisodiya, SM; + view all (2007) A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy. EPILEPSIA , 48 (4) 706 - 712. 10.1111/j.1528-1167.2007.00977.x.

Cavalleri, GL; Weale, ME; Shianna, KV; Singh, R; Lynch, JM; Grinton, B; ... Goldstein, DB; + view all (2007) Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. LANCET NEUROL , 6 (11) 970 - 980. 10.1016/Sl474-4422(07)70247-8.

Giunti, P; Wood, N; (2007) The inherited ataxias. ACNR , 7 (5) 18 - 21.

Heinzen, EL; Yoon, W; Tate, SK; Sen, A; Wood, NW; Sisodiya, SM; Goldstein, DB; (2007) Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. AM J HUM GENET , 80 (5) 876 - 883. 10.1086/516650.

Heinzen, EL; Yoon, W; Weale, ME; Sen, A; Wood, NW; Burke, JR; ... Goldstein, DB; + view all (2007) Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease. GENOME BIOL , 8 (3) , Article R32. 10.1186/gb-2007-8-3-r32.

Houlden, H; Johnson, J; Gardner-Thorpe, C; Lashley, T; Hernandez, D; Worth, P; ... Wood, NW; + view all (2007) Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. NAT GENET , 39 (12) 1434 - 1436. 10.1038/ng.2007.43.

Kasperaviciute, D; Weale, ME; Shianna, KV; Banks, GT; Simpson, CL; Hansen, VK; ... Fisher, EMC; + view all (2007) Large-scale pathways-based association study in amyotrophic lateral sclerosis. BRAIN , 130 2292 - 2301. 10.1093/brain/awm055.

Khan, NL; Bhatt, M; Brooks, DJ; Korlipara, P; Schapira, A; Piccini, P; ... Bhatia, K; + view all (2007) An Indian kindred with reversible dystonia and parkinsonism. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 210 - 210). B M J PUBLISHING GROUP

Limaye, N; Revencu, N; Van Regemorter, N; Garzon, M; Bonduelle, M; Chung, W; ... Vikkula, M; + view all (2007) Novel human pathological mutations. Gene symbol: KRIT1. Disease: cerebral cavernous malformation. Hum Genet , 122 (5) 552 - ?.

McKenzie, M; Liolitsa, D; Akinshina, N; Campanella, M; Sisodiya, S; Hargreaves, I; ... Duchen, MR; + view all (2007) Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. J BIOL CHEM , 282 (51) 36845 - 36852. 10.1074/jbc.M704158200. Gold open access

Plun-Favreau, H; Klupsch, K; Moisoi, N; Gandhi, S; Kjaer, S; Frith, D; ... Downward, J; + view all (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. NAT CELL BIOL , 9 (11) 1243 - U63. 10.1038/ncb1644.

Sisodiya, S; Cross, JH; Blümcke, I; Chadwick, D; Craig, J; Crino, PB; ... Zuberi, S; + view all (2007) Genetics of epilepsy: epilepsy research foundation workshop report. Epileptic Disord , 9 (2) 194 - 236. 10.1684/epd.2007.0107.

van de Leemput, J; Chandran, J; Knight, MA; Holtzclaw, LA; Scholz, S; Cookson, MR; ... Singleton, AB; + view all (2007) Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genetics , 3 (6) , Article e108. 10.1371/journal.pgen.0030108. Green and gold open access
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van de Warrenburg, BPC; Giunti, P; Schneider, SA; Quinn, NP; Wood, NW; Bhatia, KP; (2007) The syndrome of (predominantly cervical) dystonia and cerebellar ataxia: new cases indicate a distinct but heterogeneous entity. J NEUROL NEUROSUR PS , 78 (7) 774 - 775. 10.1136/jnnp.2006.105841.

2006

Abou-Sleiman, PM; Hanna, MG; Wood, NW; (2006) Genetic association studies of complex neurological diseases. J NEUROL NEUROSUR PS , 77 (12) 1302 - 1304. 10.1136/jnnp.2005.082024.

Abou-Sleiman, PM; Muqit, MMK; McDonald, NQ; Yang, YX; Gandhi, S; Healy, DG; ... Wood, NW; + view all (2006) A heterozygous effect for PINK1 mutations in Parkinson's disease? ANN NEUROL , 60 (4) 414 - 419. 10.1002/ana.20960.

Abou-Sleiman, PM; Muqit, MMK; McDonald, NQ; Yang, YX; Gandhi, S; Healy, DG; ... Wood, NW; + view all (2006) A heterozygous effect for PINK1 mutations in Parkinson's disease? ANN NEUROL , 60 (4) 414 - 419. 10.1002/ana.20960.

Abou-Sleiman, PM; Muqit, MMK; Wood, NW; (2006) Expanding insights of mitochondrial dysfunction in Parkinson's disease. NAT REV NEUROSCI , 7 (3) 207 - 219. 10.1038/nrn1868.

Gandhi, S; Muqit, MMK; Abou-Sleiman, PM; Stanyer, L; Hargreaves, I; Heales, S; ... Revesz, T; + view all (2006) PINK1: a novel mitochondrial protein in Parkinson's disease. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 221 - 222). BLACKWELL PUBLISHING

Gandhi, S; Muqit, MMK; Stanyer, L; Healy, DG; Abou-Sleiman, PM; Hargreaves, I; ... Revesz, T; + view all (2006) PINK1 protein in normal human brain and Parkinson's disease. BRAIN , 129 1720 - 1731. 10.1093/brain/awl114.

Graves, TD; Schorge, S; Davies, RA; Wood, NW; Kullmann, DM; Hanna, MG; (2006) The role of the brain P/Q-type calcium channel in human epilepsy. EUR J NEUROL , 13 313 - 313.

Healy, DG; Abou-Sleiman, PM; Ahmadi, KR; Gandhi, S; Muqit, MM; Bhatia, KP; ... Wood, NW; + view all (2006) NR4A2 genetic variation in sporadic Parkinson's disease: A genewide approach. MOVEMENT DISORD , 21 (11) 1960 - 1963. 10.1002/mds.21018.

Healy, DG; Abou-Sleiman, PM; Casas, JP; Ahmadi, KR; Lynch, T; Gandhi, S; ... Wood, NW; + view all (2006) UCHL-1 is not a Parkinson's disease susceptibility gene. ANN NEUROL , 59 (4) 627 - 633. 10.1002/ana.20757.

Hu, MTM; Scherfle, C; Khan, NL; Hajnal, JV; Lees, AJ; Quinn, N; ... Brooks, DJ; + view all (2006) Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease. MOVEMENT DISORD , 21 (3) 299 - 305. 10.1002/mds.20702.

Kinirons, P; Cavalleri, GL; Shahwan, A; Wood, NW; Goldstein, DB; Sisodiya, SM; ... Doherty, CP; + view all (2006) Examining the role of common genetic variation in the gamma 2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs. EPILEPSY RES , 70 (2-3) 229 - 238. 10.1016/j.eplepsyres.2005.05.009.

Kinirons, P; Cavalleri, GL; Shahwan, A; Wood, NW; Goldstein, DB; Sisodiya, SM; ... Doherty, CP; + view all (2006) Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs. Epilepsy Res , 70 (2-3) 229 - 238. 10.1016/j.eplepsyres.2006.05.009.

Kinirons, P; Cavalleri, GL; Singh, R; Shahwan, A; Acheson, JF; Wood, NW; ... Delanty, N; + view all (2006) A pharmacogenetic exploration of vigabatrin-induced visual field constriction. EPILEPSY RES , 70 (2-3) 144 - 152. 10.1016/j.eplepsyres.2006.03.012.

Muqit, MMK; Abou-Sleiman, PM; Saurin, AT; Harvey, K; Gandhi, S; Deas, E; ... Latchman, DS; + view all (2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J NEUROCHEM , 98 (1) 156 - 169. 10.1111/j.1471-4159.2006.03845.x.

Muqit, MMK; Gandhi, S; Wood, NW; (2006) Mitochondria in Parkinson disease - Back in fashion with a little help from genetics. ARCH NEUROL-CHICAGO , 63 (5) 649 - 654.

Ozawa, T; Healy, DG; Abou-Sleiman, PM; Ahmadi, KR; Quinn, N; Lees, AJ; ... European MSA Study Group,; + view all (2006) The alpha-synuclein gene in multiple system atrophy. J NEUROL NEUROSUR PS , 77 (4) 464 - 467. 10.1136/jnnp.2005.073528.

Schmitt, I; Wullner, U; Healy, DG; Wood, NW; Kolsch, H; Henn, R; (2006) The ADH1C stop mutation in multiple system atrophy patients and healthy probands in the United Kingdom and Germany. MOVEMENT DISORD , 21 (11) 2034 - 2034. 10.1002/mds.21082.

Schneider, SA; Mohire, MD; Trender-Gerhard, I; Asmus, F; Sweeney, M; Davis, M; ... Bhatia, KP; + view all (2006) Familial dopa-responsive cervical dystonia. NEUROLOGY , 66 (4) 599 - 601.

Schneider, SA; van de Warrenburg, BPC; Hughes, TD; Davis, M; Sweeney, M; Wood, N; ... Bhatia, KP; + view all (2006) Phenotypic homogeneity of the Huntington disease - like presentation in a SCA17 family. NEUROLOGY , 67 (9) 1701 - 1703.

Sharma, M; Mueller, JC; Zimprich, A; Lichtner, P; Hofer, A; Leitner, P; ... European Consortium Genetic Suscep,; + view all (2006) The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. J MED GENET , 43 (7) 557 - 562. 10.1136/jmg.2005.039149.

Wood, NW; (2006) Pharmacogenetic approaches to neurological disease - Epilepsy as an example. EUR J NEUROL , 13 1 - 1.

Wood-Kaczmar, A; Gandhi, S; Wood, NW; (2006) Understanding the molecular causes of Parkinson's disease. TRENDS MOL MED , 12 (11) 521 - 528. 10.1016/j.molmed.2006.09.007.

2005

Ahmadi, K.R.; Weale, M.E.; Xue, Z.Y.; Soranzo, N.; Yarnall, D.P.; Briley, J.D.; ... Goldstein, D.B.; + view all (2005) A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nature Genetics , 37 (1) pp. 84-89. 10.1038/ng1488.

Ahmadi, KR; Weale, ME; Xue, ZYY; Soranzo, N; Yarnall, DP; Briley, JD; ... Goldstein, DB; + view all (2005) A single-nucleotide polymorphism tagging set for human drug metabolism and transport. NAT GENET , 37 (1) 84 - 89. 10.1038/ng1488.

Bandopadhyay, R; Kingsbury, AE; Muqit, MM; Harvey, K; Reid, AR; Kilford, L; ... Lees, AJ; + view all (2005) Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. NEUROBIOL DIS , 20 (2) 401 - 411. 10.1016/j.nbd.2005.03.021.

Cavalleri, GL; Lynch, JM; Depondt, C; Burley, MW; Wood, NW; Sisodiya, SM; Goldstein, DB; (2005) Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here? BRAIN , 128 1832 - 1840. 10.1093/brain/awh524.

Cavallieri, GL; Kinirons, P; Shahwan, A; McCarthy, M; Doherty, CP; Wood, NW; ... Delanty, N; + view all (2005) Genetic variation in GABAG2 - Lessons to be learned from association studies in two large epilepsy cohorts. In: EPILEPSIA. (pp. 366 - 366). BLACKWELL PUBLISHING

Depondt, C; Cavalleri, GL; Shorvon, SD; Wood, NW; Sisodiya, SM; Goldstein, DB; (2005) Association study of five sodium channel genes in epilepsy and antiepileptic drug response. In: EPILEPSIA. (pp. 90 - 91). BLACKWELL PUBLISHING

Gandhi, S; Abou-Sleiman, PM; Healy, DG; Weale, M; Gilks, W; Ahmadi, K; ... Wood, NW; + view all (2005) Population genetic approaches to neurological disease: Parkinson's disease as an example. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES , 360 (1460) 1573 - 1578. 10.1098/rstb.2005.1687. Gold open access

Gandhi, S; Muqit, M; Ganguly, M; Abou-Sleiman, PM; Wood, NW; Holton, JL; Revesz, T; (2005) PINK1 protein distribution in normal human brain and Parkinson's disease. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 221 - 222). BLACKWELL PUBLISHING LTD

Gandhi, S; Wood, NW; (2005) Molecular pathogenesis of Parkinson's disease. Hum Mol Genet , 14 Spec No. 2 2749 - 2755.

Gandhi, S; Wood, NW; (2005) Molecular pathogenesis of Parkinson's disease. Hum Mol Genet , 14 (18) 2749 - 2755. 10.1093/hmg/ddi308.

Geser, F; Seppi, K; Stampfer-Kountchev, M; Kollensperger, M; Diem, A; Ndayisaba, JP; ... EMSA-SG,; + view all (2005) The European Multiple System Atrophy-Study Group (EMSA-SG). JOURNAL OF NEURAL TRANSMISSION , 112 (12) 1677 - 1686. 10.1007/s00702-005-0328-y.

Gilks, W.P.; Abou-Sleiman, P.M.; Gandhi, S.; Jain, S.; Singleton, A.; Lees, A.J.; ... Wood, N.W.; + view all (2005) A common LRRK2 mutation in idiopathic Parkinson's disease. The Lancet , 365 (9457) pp. 415-416. 10.1016/S0140-6736(05)17830-1.

Gilks, WP; Abou-Sleiman, PM; Gandhi, S; Jain, S; Singleton, A; Lees, AJ; ... Wood, NW; + view all (2005) Common LRRK2 mutation in idiopathic Parkinson's disease. LANCET , 365 (9457) 415 - 416.

Healy, DG; Abou-Sleiman, PM; Quinn, N; Ahmadi, KR; Ozawa, T; Kamm, C; ... European MSA Study Grp,; + view all (2005) UCHL-1 gene in multiple system atrophy: A haplotype tagging approach. MOVEMENT DISORD , 20 (10) 1338 - 1343. 10.1002/mds.20575.

Jain, S; Wood, NW; Healy, DG; (2005) Molecular genetic pathways in Parkinson's disease: a review. CLIN SCI , 109 (4) 355 - 364. 10.1042/CS0050106.

Jain, S; Wood, NW; Healy, DG; (2005) Molecular genetic pathways in Parkinson's disease: a review. Clin Sci (Lond) , 109 (4) 355 - 364. 10.1042/CS20050106.

Kamm, C; Healy, DG; Quinn, NP; Wullner, U; Moller, JC; Schols, L; ... EMSA Study Grp,; + view all (2005) The fragile X tremor ataxia syndrome in the differential diagnosis of multiple system atrophy: data from the EMSA Study Group. BRAIN , 128 1855 - 1860. 10.1093/brain/awh535.

Khan, NL; Giunti, P; Sweeney, MG; Scherfler, C; Brien, MO; Piccini, P; ... Lees, AJ; + view all (2005) Parkinsonism and nigrostriatal dysfunction are associated with spinocerebellar ataxia type 6 (SCA6). MOVEMENT DISORD , 20 (9) 1115 - 1119. 10.1002/mds.20564.

Khan, NL; Horta, W; Eunson, L; Graham, E; Johnson, JO; Chang, S; ... Lees, AJ; + view all (2005) Parkin disease in a Brazilian kindred: Manifesting heterozygotes and clinical follow-up over 10 years. MOVEMENT DISORD , 20 (4) 479 - 484. 10.1002/mds.20335.

Khan, NL; Jain, S; Lynch, JM; Pavese, N; Abou-Sleiman, P; Holton, JL; ... Wood, NW; + view all (2005) Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. BRAIN , 128 2786 - 2796. 10.1093/brain/awh667.

Khan, NL; Scherfler, C; Graham, E; Bhatia, KP; Quinn, N; Lees, AJ; ... Piccini, P; + view all (2005) Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation. NEUROLOGY , 64 (1) 134 - 136.

Liolitsa, D; McKenzie, M; Hargreaves, I; Heales, S; Land, J; Sisodiya, SM; ... Hanna, MG; + view all (2005) MELAS, a young-onset stroke disorder associated with a homoplasmic ND5 mitochondrial DNA mutation. EUR J NEUROL , 12 158 - 159.

Martinez, M; Brice, A; Vaughan, JR; Zimprich, A; Breteler, MMB; Meco, G; ... French Parkinson's Disease,; + view all (2005) Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease. AM J MED GENET B , 136B (1) 72 - 74. 10.1002/ajmg.b.30196.

Morris, HR; Wood, NW; Lees, AJ; (2005) Progressive supranuclear palsy (Steele-Richardson-Olszewski disease). In: Morris, H, (ed.) Neurology update: reviews for continuing professional development. (185 - 196). Radcliffe Publishing: Oxford.

Ozawa, T; Paviour, D; Quinn, NP; Lees, AJ; Josephs, KA; Healy, DG; ... Revesz, T; + view all (2005) The spectrum of pathological involvement of multiple system atrophy (MSA): clinicopathological correlations. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 244 - 244). BLACKWELL PUBLISHING LTD

Pittman, AM; Myers, AJ; Abou-Sleiman, P; Fung, HC; Kaleem, M; Marlowe, L; ... de Silva, R; + view all (2005) Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J MED GENET , 42 (11) 837 - 846. 10.1136/jmg.2005.031377. Gold open access

Prestel, J; Sharma, M; Leitner, P; Zimprich, A; Vaughan, JR; Durr, A; ... GSPD,; + view all (2005) PARK11 is not linked with Parkinson's disease in European families. EUR J HUM GENET , 13 (2) 193 - 197. 10.1038/sj.ejhg.5201317.

Sisodiya, S; Soranzo, N; Wood, NW; Goldstein, DB; (2005) Association of genetic loci: replication or not, that is the question. Neurology , 64 (11) 1989 - ?.

Stumpf, MPH; Goldstein, DB; Wood, NW; (2005) Introduction: genetic variation and human health. PHILOS T R SOC B , 360 (1460) 1539 - 1541. 10.1098/rstb.2005.1694.

Tate, SK; Depondt, C; Sisodiya, SM; Cavalleri, GL; Schorge, S; Soranzo, N; ... Goldstein, DB; + view all (2005) Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. P NATL ACAD SCI USA , 102 (15) 5507 - 5512. 10.1073/pnas.0407346102. Gold open access

Wood, NW; Healy, DG; Depondt, C; Abou-Sleiman, PM; (2005) Commentary on "A genome wide linkage disequilibrium screen in Parkinson's disease" By Foltynie et al. in J Neurol (2005)252:597-602. J NEUROL , 252 (5) 603 - 604. 10.1007/s00415-005-0707-1.

2004

Abou-Sleiman, PM; Healy, DG; Wood, NW; (2004) Causes of Parkinson's disease: genetics of DJ-1. CELL TISSUE RES , 318 (1) 185 - 188. 10.1007/s00441-004-0922-6.

Abou-Sleiman, PM; Healy, DG; Wood, NW; (2004) Genetic approaches to solving common diseases. J NEUROL , 251 (10) 1169 - 1172. 10.1007/s00415-004-0518-9.

Ansorge, O; Giunti, P; Michalik, A; Van Broeckhoven, C; Harding, B; Wood, N; Scaravilli, F; (2004) Ataxin-7 aggregation and ubiquitination in infantile SCA7 with 180 CAG repeats. ANN NEUROL , 56 (3) 448 - 452.

Bandopadhyay, R; Kingsbury, AE; Cookson, MR; Reid, AR; Evans, IM; Hope, AD; ... Lees, AJ; + view all (2004) The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. BRAIN , 127 420 - 430. 10.1093/brain/awh054.

Beck, J.A.; Poulter, M.; Campbell, T.A.; Uphill, J.B.; Adamson, G.; Geddes, J.F.; ... Tabrizi, S.J.; + view all (2004) Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. Human Molecular Genetics , 13 (12) pp. 1219-1224. 10.1093/hmg/ddh134.

Beck, JA; Poulter, M; Campbell, T; Uphill, JB; Adamson, G; Geddes, JF; ... Tabrizi, SJ; + view all (2004) Nuclear somatic mosaicism in sporadic early-onset Alzheimer's disease. In: NEUROBIOLOGY OF AGING. (pp. S54 - S54). ELSEVIER SCIENCE INC

Beck, JA; Poulter, M; Campbell, TA; Uphill, JB; Adamson, G; Geddes, JF; ... Tabrizi, SJ; + view all (2004) Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. HUM MOL GENET , 13 (12) 1219 - 1224. 10.1093/hmg/ddh134.

Depondt, C; Cavalleri, G; Weale, ME; Burly, MW; Cock, H; Shorvon, SD; ... Goldstein, DB; + view all (2004) Common variation in the SCN1A gene is a risk factor for common forms of epilepsy associated with febrile seizures. In: EPILEPSIA. (pp. 120 - 120). BLACKWELL PUBLISHING INC

Depondt, C; Cock, HR; Healy, DG; Burley, MW; Weinshenker, D; Wood, NW; ... Sisodiya, SM; + view all (2004) The -1021C -> T DBH gene variant is not associated with epilepsy or antiepileptic drug response. NEUROLOGY , 63 (8) 1497 - 1499.

Everett, CM; Wood, NW; (2004) Trinucleotide repeats and neurodegenerative disease. BRAIN , 127 2385 - 2405. 10.1093/brain/awh278.

Healy, DG; Abou-Sleiman, PM; Ahmadi, KR; Muqit, MMK; Bhatia, KP; Quinn, NP; ... Wood, NW; + view all (2004) The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism. ANN NEUROL , 56 (3) 329 - 335.

Healy, DG; Abou-Sleiman, PM; Gibson, JM; Ross, OA; Jain, S; Gandhi, S; ... Lynch, T; + view all (2004) PINK1 (PARK6) associated Parkinson disease in Ireland. NEUROLOGY , 63 (8) 1486 - 1488.

Healy, DG; Abou-Sleiman, PM; Gibson, JM; Ross, OA; Jain, S; Gandhi, S; ... Lynch, T; + view all (2004) PINK1 (PARK6) associated Parkinson disease in Ireland. Neurology , 63 (8) 1486 - 1488.

Healy, DG; Abou-Sleiman, PM; Goldstein, DB; Wood, NW; (2004) Population genetics for target identification. Drug Discov Today Technol , 1 (1) 69 - 74. 10.1016/j.ddtec.2004.08.012.

Healy, DG; Abou-Sleiman, PM; Lees, AJ; Casas, JP; Quinn, N; Bhatia, K; ... Wood, NW; + view all (2004) Tau gene and Parkinson's disease: a case-control study and meta-analysis. J NEUROL NEUROSUR PS , 75 (7) 962 - 965. 10.1136/jnnp.2003.026203.

Healy, DG; Abou-Sleiman, PM; Ozawa, T; Lees, AJ; Bhatia, K; Ahmadi, KR; ... Wood, NW; + view all (2004) A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. ANN NEUROL , 55 (3) 443 - 446.

Healy, DG; Abou-Sleiman, PM; Valente, EM; Gilks, WP; Bhatia, K; Quinn, N; ... Wood, NW; + view all (2004) DJ-1 mutations in Parkinson's disease. J NEUROL NEUROSUR PS , 75 (1) 144 - 145.

Healy, DG; Abou-Sleiman, PM; Wood, NW; (2004) PINK, PANK, or PARK? A clinicians' guide to familial parkinsonism. LANCET NEUROL , 3 (11) 652 - 662.

Healy, DG; Abou-Sleiman, PM; Wood, NW; (2004) Genetic causes of Parkinson's disease: UCHL-1. CELL TISSUE RES , 318 (1) 189 - 194. 10.1007/s00441-004-0917-3.

Healy, DG; Wood, NW; (2004) Clinical picture of bilateral vestibular schwannomas, sudden bilateral hearing loss, and aviation. NEUROLOGY , 63 (5) 933 - 933.

Houlden, H; Girard, M; Cockerell, C; Ingram, D; Wood, NW; Goossens, M; ... Reilly, MM; + view all (2004) Connexin 32 promoter P2 mutations: A mechanism of peripheral nerve dysfunction. ANN NEUROL , 56 (5) 730 - 734. 10.1002/ana.20267.

Khan, NL; Katzenschlager, R; Watt, H; Bhatia, KP; Wood, NW; Quinn, N; Lees, AJ; (2004) Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease. NEUROLOGY , 62 (7) 1224 - 1226.

Lee, MJ; Stephenson, D; Groves, M; Sweeney, M; Davis, M; An, SF; ... Reilly, M; + view all (2004) Sensory deprivation is associated with a mutation in the rat chaperonin delta subunit. In: GENETICAL RESEARCH. (pp. 120 - 120). CAMBRIDGE UNIV PRESS

MacCormac, LP; Muqit, MMK; Faulkes, DJ; Wood, NW; Latchman, DS; (2004) Reduction in endogenous parkin levels renders glial cells sensitive to both caspase-dependent and caspase-independent cell death. EUR J NEUROSCI , 20 (8) 2038 - 2048. 10.1111/j.1460-9568.2004.03659.x.

Mantuano, E; Veneziano, L; Spadaro, M; Giunti, P; Guida, S; Leggio, MG; ... Frontali, M; + view all (2004) Clusters of non-truncating mutations of P/Q type Ca2+ channel subunit Ca(v)2.1 causing episodic ataxia 2. J MED GENET , 41 (6) , Article e82. 10.1136/jmg.2003.015396.

Martinez, M; Brice, A; Vaughan, JR; Zimprich, A; Breteler, MMB; Meco, G; ... European Consortium Genetic Susc,; + view all (2004) Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease. J MED GENET , 41 (12) 900 - 907. 10.1136/jmg.2004.022632.

Morris, HR; Steele, JC; Crook, R; Wavrant-De Vrieze, F; Onstead-Cardinale, L; Gwinn-Hardy, K; ... Perez-Tur, J; + view all (2004) Genome-wide analysis of the Parkinsonism-dementia complex of Guam. ARCH NEUROL-CHICAGO , 61 (12) 1889 - 1897.

Muqit, MMK; Davidson, SM; Smith, MDP; MacCormac, LP; Kahns, S; Jensen, PH; ... Latchman, DS; + view all (2004) Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival. HUM MOL GENET , 13 (1) 117 - 135. 10.1093/hmg/ddh012.

Myers, AJ; Pittman, A; Duckworth, J; Fung, P; Evans, J; Evans, W; ... Hardy, JA; + view all (2004) Investigation of the microtubule associated protein tau locus. In: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. (pp. 16 - 16). WILEY-LISS

Ozawa, T; Paviour, D; Quinn, NP; Josephs, KA; Sangha, H; Kilford, L; ... Revesz, T; + view all (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. BRAIN , 127 2657 - 2671. 10.1093/brain/awh303.

Ozawa, T.; Paviour, D.; Quinn, N.P.; Josephs, K.A.; Sangha, D.; Kilford, L.; ... Revesz, T.; + view all (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain , 127 (12) pp. 2657-2671. 10.1093/brain/awh303.

Paisan-Ruiz, C; Jain, S; Evans, EW; Gilks, WP; Simon, J; van der Brug, M; ... Singleton, AB; + view all (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. NEURON , 44 (4) 595 - 600.

Pittman, A.M.; Myers, A.J.; Duckworth, J.; Bryden, L.; Hanson, M.; Abou-Sleiman, P.; ... de Silva, R.; + view all (2004) The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human Molecular Genetics , 13 (12) pp. 1267-1274. 10.1093/hmg/ddh138.

Pittman, AM; Myers, AJ; Duckworth, J; Bryden, L; Hanson, M; Abou-Sleiman, P; ... de Silva, R; + view all (2004) The structure of the tau haplotype in controls and in progressive supranuclear palsy. HUM MOL GENET , 13 (12) 1267 - 1274. 10.1093/hmg/ddh138.

Scherfler, C; Khan, NL; Pavese, N; Eunson, L; Graham, E; Lees, AJ; ... Piccini, PP; + view all (2004) Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. BRAIN , 127 1332 - 1342. 10.1093/brain/awh150.

Sinha, KK; Worth, PF; Jha, DK; Sinha, S; Stinton, VJ; Davis, MB; ... Bhatia, KP; + view all (2004) Autosomal dominant cerebellar ataxia: SCA2 is the most frequent mutation in eastern India. J NEUROL NEUROSUR PS , 75 (3) 448 - 452. 10.1136/jnnp.2002.004895.

Soranzo, N; Cavalleri, GL; Weale, ME; Wood, NW; Depondt, C; Marguerie, R; ... Goldstein, DB; + view all (2004) Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. GENOME RES , 14 (7) 1333 - 1344.

Soranzo, N.; Cavalleri, G.L.; Weale, M.E.; Wood, N.W.; Depondt, C.; Marguerie, R.; ... Goldstein, D.B.; + view all (2004) Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Genome Research , 14 (7) pp. 1333-1344. 10.1101/gr.1965304. Green open access
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Tabrizi, SJ; Beck, JA; Poulter, M; Campbell, T; Uphill, JB; Adamson, G; ... Collinge, J; + view all (2004) Somatic mosaicism in sporadic early-onset Alzheimer's disease. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 1216 - 1216). B M J PUBLISHING GROUP

Valente, EM; Abou-Sleiman, PM; Caputo, V; Muqit, MMK; Gispert, S; Ali, Z; ... Wood, NW; + view all (2004) PARK6 linked Parkinson's disease is caused by mutations in a mitochondrial protein kinase. JOURNAL OF NEUROLOGY , 251 50 - 50.

Valente, EM; Abou-Sleiman, PM; Caputo, V; Muqit, MMK; Harvey, K; Gispert, S; ... Wood, NW; + view all (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. SCIENCE , 304 (5674) 1158 - 1160. 10.1126/science.1096284.

Valente, EM; Abou-Sleiman, PM; Caputo, V; Muqit, MMK; Harvey, K; Gispert, S; ... Wood, NW; + view all (2004) Identification of PINK1, the first mitochondrial gene causing Parkinson's disease. EUR J NEUROL , 11 366 - 367.

Wilkinson, PA; Crosby, AH; Turner, C; Bradley, LJ; Ginsberg, L; Wood, NW; ... Warner, TT; + view all (2004) A clinical, genetic and biochemical study of SPG7 mutations in hereditary spastic paraplegia. BRAIN , 127 973 - 980. 10.1093/brain/awh125.

Wood, N; Muqit, M; (2004) Identification of PINK1 (PARK6), the first mitochondrial gene causing Parkinson's disease. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 1220 - 1220). B M J PUBLISHING GROUP

2003

Abou-Sleiman, PM; Healy, DG; Ahmadi, K; Goldstein, DB; Wood, NW; (2003) Population genetic approaches to Parkinsons disease. In: AMERICAN JOURNAL OF HUMAN GENETICS. (pp. 541 - 541). UNIV CHICAGO PRESS

Abou-Sleiman, PM; Healy, DG; Quinn, N; Lees, AJ; Wood, NW; (2003) The role of pathogenic DJ-1 mutations in Parkinson's disease. ANN NEUROL , 54 (3) 283 - 286. 10.1002/ana.10675.

de Silva, R; Hope, A; Pittman, A; Weale, ME; Morris, HR; Wood, NW; Lees, AJ; (2003) Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy. NEUROLOGY , 61 (3) 407 - 409.

de Silva, R; Lashley, T; Gibb, G; Hanger, D; Hope, A; Reid, A; ... Lees, A; + view all (2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. NEUROPATH APPL NEURO , 29 (3) 288 - 302.

Edwards, M; Wood, N; Bhatia, K; (2003) Unusual phenotypes in DYT1 dystonia: A report of five cases and a review of the literature. MOVEMENT DISORD , 18 (6) 706 - 711. 10.1002/mds.10411.

Edwards, M; Wood, N; Bhatia, K; (2003) Unusual phenotypes in DYT1 dystonia: A report of five cases and a review of the literature. Movement Disorders , 18 (6) 706 - 711.

Edwards, MJ; Huang, YZ; Wood, NW; Rothwell, JC; Bhatia, KP; (2003) Different patterns of electrophysiological deficits in manifesting and non-manifesting carriers of the DYT1 gene mutation. BRAIN , 126 2074 - 2080. 10.1093/brain/awg209.

Goldstein, D.B.; Ahmadi, K.R.; Weale, M.E.; Wood, N.W.; (2003) Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends in Genetics , 19 (11) pp. 615-622. 10.1016/j.tig.2003.09.006.

Goldstein, DB; Ahmadi, KR; Weale, ME; Wood, NW; (2003) Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. TRENDS GENET , 19 (11) 615 - 622. 10.1016/j.tig.2003.09.006.

Hadjivassiliou, M; Grunewald, R; Sharrack, B; Sanders, D; Lobo, A; Williamson, C; ... Davies-Jones, A; + view all (2003) Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. BRAIN , 126 685 - 691. 10.1093/brain/awg050.

Khan, NL; Graham, E; Critchley, P; Schrag, AE; Wood, NW; Lees, AJ; ... Quinn, N; + view all (2003) Parkin disease: a phenotypic study of a large case series. BRAIN , 126 1279 - 1292. 10.1093/brain/awg142.

Khan, NL; Wood, NW; Bhatia, KP; (2003) Autosomal recessive, DYT2-like primary torsion dystonia - A new family. NEUROLOGY , 61 (12) 1801 - 1803.

Kuoppamaki, M; Giunti, P; Quinn, N; Wood, NW; Bhatia, KP; (2003) Slowly progressive cerebellar ataxia and cervical dystonia: Clinical presentation of a new form of spinocerebellar ataxia? MOVEMENT DISORD , 18 (2) 200 - 206. 10.1002/mds.10308.

Lee, M.-J.; Stephenson, D.A.; Groves, M.J.; Sweeney, M.G.; Davis, M.B.; An, S.-F.; ... Reilly, M.M.; + view all (2003) Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene. Human Molecular Genetics , 12 (15) pp. 1917-1925. 10.1093/hmg/ddg198.

Lee, MJ; Stephenson, DA; Groves, MJ; Sweeney, MG; Davis, MB; An, SF; ... Reilly, MM; + view all (2003) Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4) gene. HUM MOL GENET , 12 (15) 1917 - 1925. 10.1093/hmg/ddg198.

Lohmann, E; Periquet, M; Bonifati, V; Wood, NW; De Michele, G; Bonnet, AM; ... European Consortium Genetic Suscep,; + view all (2003) How much phenotypic variation can be attributed to parkin genotype? ANN NEUROL , 54 (2) 176 - 185. 10.1002/ana.10613.

Morris, HR; Osaki, Y; Holton, J; Lees, AJ; Wood, NW; Revesz, T; Quinn, N; (2003) Tau exon 10 +16 mutation FTDP-17 presenting clinically as sporadic young onset PSP. NEUROLOGY , 61 (1) 102 - 104.

Periquet, M; Latouche, M; Lohmann, E; Rawal, N; De Michele, G; Ricard, S; ... European Consortium Genetic Suscep,; + view all (2003) Parkin mutations are frequent in patients with isolated early-onset parkinsonism. BRAIN , 126 1271 - 1278. 10.1093/brain/awg136.

Sibbing, D; Trender-Gerhardt, I; Wood, NW; Oertel, WH; Bhatia, KP; Bandmann, O; (2003) The promoter region of the Menkes gene ATP7A is not altered in focal or generalized dystonia. ANN NEUROL , 53 (2) 278 - 279. 10.1002/ana.10436.

Siddiqui, A; Kerb, R; Weale, ME; Brinkmann, U; Smith, A; Goldstein, DB; ... Sisodiya, SM; + view all (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. NEW ENGL J MED , 348 (15) 1442 - 1448.

Weale, ME; Depondt, C; Macdonald, SJ; Smith, A; Lai, PS; Shorvon, SD; ... Goldstein, DB; + view all (2003) Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: Implications for linkage-disequilibrium gene mapping. AM J HUM GENET , 73 (3) 551 - 565.

Wilkinson, PA; Crosby, AH; Turner, C; Patel, H; Wood, NW; Schapira, AH; Warner, TT; (2003) A clinical and genetic study of SPG5A linked autosomal recessive hereditary spastic paraplegia. NEUROLOGY , 61 (2) 235 - 238.

Wood, N; (2003) Principles of genetic counselling. In: EPILEPSIA. (pp. 9 - 9). BLACKWELL PUBLISHING INC

Wood, NW; (2003) Ataxic disorders. In: Warrell, DA and Cox, TM and Firth, JD and Benz, EJ, (eds.) Oxford Textbook of Medicine. (1068 - 1074). Oxford University Press: Oxford.

Wood, NW; (2003) Neurogenetics. In: Warrell, DA and Cox, TM and Firth, JD and Benz, EJ, (eds.) Oxford Textbook of Medicine. (945 - 952). Oxford University Press: Oxford.

Wood, NW; (2003) Neurogenetics. In: Fowler, TJ and Scadding, JW, (eds.) Clinical neurology. (119 - 129). Arnold: London.

Worth, PF; Wood, NW; (2003) A systematic and structured approach to the investigation of ataxia. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 1166 - 1166). BRITISH MED JOURNAL PUBL GROUP

2002

Asmus, F; Zimprich, A; du Montcel, ST; Kabus, C; Deuschl, G; Kupsch, A; ... Gasser, T; + view all (2002) Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype. ANN NEUROL , 52 (4) 489 - 492. 10.1002/ana.10325.

Bajaj, NPS; Waldman, A; Orrell, R; Wood, NW; Bhatia, KP; (2002) Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging. J NEUROL NEUROSUR PS , 72 (5) 635 - 638.

Bandmann, O; Wood, NW; (2002) Dopa-responsive dystonia -- the story so far. Neuropediatrics , 33 (1) 1 - 5.

de Silva, R; Hardy, J; Crook, J; Khan, N; Graham, EA; Morris, CM; ... Lees, AJ; + view all (2002) The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. NEUROSCI LETT , 330 (2) 201 - 203.

Dobson-Stone, C; Danek, A; Rampoldi, L; Hardie, RJ; Chalmers, RM; Wood, NW; ... Monaco, AP; + view all (2002) Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis. EUR J HUM GENET , 10 (11) 773 - +. 10.1038/sj/ejhg.5200866.

Eunson, L; Khan, NL; Quinn, N; Bhatia, K; Wood, NW; Davis, MB; (2002) Novel parkin mutations in early-onset parkinsonism. In: JOURNAL OF MEDICAL GENETICS. (pp. S71 - S71). BRITISH MED JOURNAL PUBL GROUP

Everett, CM; Saveliev, A; Webster, Z; Wood, NW; Festenstein, R; (2002) The molecular basis for aberrant gene regulation in Friedreich's ataxia. J NEUROL NEUROSUR PS , 73 (2) 225 - 225.

Gabriel, CM; Gregson, NA; Wood, NW; Hughes, RAC; (2002) Immunological study of hereditary motor and sensory neuropathy type 1 a (HMSN1 a). J NEUROL NEUROSUR PS , 72 (2) 230 - 235.

Goldstein, DB; Ramachandran, V; Wood, N; Shorvon, S; (2002) Pharmacogenomics of neurological disorders. In: Pharmacogenomics: The search for Individualised Therapies.

Hafezparast, M; Ahmad-Annuar, A; Wood, NW; Tabrizi, SJ; Fisher, EMC; (2002) Mouse models for neurological disease. LANCET NEUROL , 1 (4) 215 - 224.

Hanna, MG; Wood, NW; (2002) Running a neurogenetic clinic. J NEUROL NEUROSUR PS , 73 2 - 4.

Houlden, H; Roper, H; Willis, T; Schenone, A; Di Battista, C; Wood, NW; Reilly, M; (2002) Giant axonal neuropathy is caused by mutations in the gigaxonin gene: Clinical, genetic, and pathological characterisation of three families. J NEUROL NEUROSUR PS , 73 (2) 225 - 225.

Houlden, H; Smith, S; de Carvalho, M; Blake, J; Mathias, C; Wood, NW; Reilly, MM; (2002) Clinical and genetic characterization of families with triple A (Allgrove) syndrome. BRAIN , 125 2681 - 2690.

Houlden, H; Smith, S; de Carvalho, M; Mathias, C; Blake, J; Wood, NW; Reilly, M; (2002) Clinical and genetic characterisation of families with triple a (Allgrove) syndrome. J NEUROL NEUROSUR PS , 73 (2) 225 - 225.

Janssen, JC; Warrington, EK; Morris, HR; Lantos, P; Brown, J; Revesz, T; ... Rossor, MN; + view all (2002) Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation. NEUROLOGY , 58 (8) 1161 - 1168.

Jarman, PR; Wood, NW; (2002) Genetics of movement disorders and ataxia. Journal of Neurology, Neurosurgery and Psychiatry , 73 (Suppl.2) II22 - II26.

Jarman, PR; Wood, NW; (2002) Genetics of movement disorders and ataxia. J NEUROL NEUROSUR PS , 73 22 - 26.

Khan, N; Valente, EM; Brooks, DJ; Piccini, P; Bhatia, KP; Quinn, NP; Wood, NW; (2002) The genetic basis and phenotypic variability in early onset parkinsonism. J NEUROL NEUROSUR PS , 73 (2) 213 - 213.

Khan, NL; Brooks, DJ; Pavese, N; Sweeney, MG; Wood, NW; Lees, AJ; Piccini, P; (2002) Progression of nigrostriatal dysfunction in a parkin kindred: an [F-18] dopa PET and clinical study. BRAIN , 125 2248 - 2256.

Khan, NL; Brooks, DJ; Pavese, N; Wood, NW; Lees, AJ; Piccini, P; (2002) Progression of nigrostriatal dysfunction in a parkin kindred: An F-18-dopa PET and clinical study. J NEUROL NEUROSUR PS , 72 (1) 134 - 134.

Khan, NL; Valente, EM; Bentivoglio, AR; Wood, NW; Albanese, A; Brooks, DJ; Piccini, P; (2002) Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: An F-18-dopa PET study. ANN NEUROL , 52 (6) 849 - 853. 10.1002/ana.10417.

Kinton, L; Johnson, MR; Smith, SJM; Farrell, F; Stevens, J; Rance, JB; ... Sander, JWA; + view all (2002) Partial epilepsy with pericentral spikes: A new familial epilepsy syndrome with evidence for linkage to chromosome 4p15. ANN NEUROL , 51 (6) 740 - 749. 10.1002/ana.10221.

Lee, MJ; Huang, YC; Sweeney, MG; Wood, NW; Reilly, MM; Yip, PK; (2002) Mutation of the sterol 27-hydroxylase gene (CYP27A1) in a Taiwanese family with cerebrotendinous xanthomatosis. J NEUROL , 249 (9) 1311 - 1312. 10.1007/s00415-002-0762-9.

Lee, MJ; Nelson, I; Houlden, H; Sweeney, MG; Hilton-Jones, D; Blake, J; ... Reilly, MM; + view all (2002) Six novel connexin32 (GJB1) mutations in X-linked Charcot-Marie-Tooth disease. J NEUROL NEUROSUR PS , 73 (3) 304 - 306.

McCabe, DJH; Wood, NW; Ryan, F; Hanna, MG; Connolly, S; Moore, DP; ... Murphy, RP; + view all (2002) Intrafamilial phenotypic variability in Friedreich ataxia associated with a G130V mutation in the FRDA gene. ARCH NEUROL-CHICAGO , 59 (2) 296 - 300.

Misbahuddin, A; Placzek, MR; Chaudhuri, KR; Wood, NW; Bhatia, KP; Warner, TT; (2002) A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. NEUROLOGY , 58 (1) 124 - 126.

Morris, H.R.; Gibb, G.; Katzenschlager, R.; Wood, N.W.; Hanger, D.P.; Strand, C.; ... Revesz, T.; + view all (2002) Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy. Brain , 125 (5) pp. 969-975. 10.1093/brain/awf109.

Morris, HR; Baker, M; Yasojima, K; Houlden, H; Khan, MN; Wood, NW; ... Hutton, M; + view all (2002) Analysis of tau haplotypes in Pick's disease. NEUROLOGY , 59 (3) 443 - 445.

Morris, HR; Gibb, G; Katzenschlager, R; Wood, NW; Hanger, DP; Strand, C; ... Revesz, T; + view all (2002) Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy. BRAIN , 125 969 - 975.

Morris, HR; Katzenschlager, R; Janssen, JC; Brown, JM; Ozansoy, M; Quinn, N; ... Lees, AJ; + view all (2002) Sequence analysis of tau in familial and sporadic progressive supranuclear palsy. J NEUROL NEUROSUR PS , 72 (3) 388 - 390.

Nicholl, DJ; Vaughan, JR; Khan, NL; Ho, SL; Aldous, DEW; Lincoln, S; ... Wood, NW; + view all (2002) Two large British kindreds with familial Parkinson's disease: A clinico-pathological and genetic study. BRAIN , 125 44 - 57.

Pang, JT; Giunti, P; Chamberlain, S; An, SF; Vitaliani, R; Scaravilli, T; ... Ansorge, O; + view all (2002) Neuronal intranuclear inclusions in SCA2: a genetic, morphological and immunohistochemical study of two cases. BRAIN , 125 656 - 663.

Siddiqui, A; Davis, M; Dixon, PH; Johnson, M; Koepp, M; Shorvon, SD; ... Wood, NW; + view all (2002) Mapping the disease locus in a large kindred with generalised epilepsy. J NEUROL NEUROSUR PS , 72 (1) 141 - 142.

Siddiqui, A; Johnson, M; Dixon, M; Koepp, M; Shorvon, SD; Sander, JWA; ... Wood, NW; + view all (2002) A novel locus on chromosome 2p 14-21 in a British family with generalised epilepsy and febrile seizures. J NEUROL NEUROSUR PS , 73 (2) 224 - 224.

Spacey, SD; Szczygielski, BI; McRory, JE; Wali, GM; Wood, NW; Snutch, TP; (2002) Mutation analysis of the sodium/hydrogen exchanger gene (NHE5) in familial paroxysmal kinesigenic dyskinesia. J NEURAL TRANSM , 109 (9) 1189 - 1194. 10.1007/s00702-002-0750-3.

Spacey, SD; Valente, EM; Wali, GM; Warner, TT; Jarman, PR; Schapira, AHV; ... Wood, NW; + view all (2002) Genetic and clinical heterogeneity in paroxysmal kinesigenic dyskinesia: Evidence for a third EKD gene. MOVEMENT DISORD , 17 (4) 717 - 725. 10.1002/mds.10126.

Valente, EM; Brancati, F; Caputo, V; Graham, EA; Davis, MB; Ferraris, A; ... European Consortium Genetic Suscep,; + view all (2002) PARK6 is a common cause of familial parkinsonism. NEUROLOGICAL SCIENCES , 23 S117 - S118.

Valente, EM; Brancati, F; Ferraris, A; Graham, EA; Davis, MB; Breteler, MMB; ... European Consortium Genetic Suscep,; + view all (2002) PARK6-linked parkinsonism occurs in several European families. ANN NEUROL , 51 (1) 14 - 18. 10.1002/ana.10053.

Warren, JD; Mummery, CJ; Al-Din, AS; Brown, P; Wood, NW; (2002) Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike? MOVEMENT DISORD , 17 (3) 563 - 567. 10.1002/mds.10122.

West, A; Periquet, M; Lincoln, S; Lucking, CB; Nicholl, D; Bonifati, V; ... European Consortium Genetic Suscep,; + view all (2002) Complex relationship between parkin mutations and Parkinson disease. AM J MED GENET , 114 (5) 584 - 591. 10.1002/ajmg.10525.

2001

Bandopadhyay, R; de Silva, R; Khan, N; Graham, E; Vaughan, J; Engelender, S; ... Lees, A; + view all (2001) No pathogenic mutations in the synphilin-1 gene in Parkinson's disease. NEUROSCI LETT , 307 (2) 125 - 127.

Bird, TD; Jarvik, GP; Wood, NW; (2001) Genetic association studies - Genes in search of diseases. NEUROLOGY , 57 (7) 1153 - 1154.

Bonifati, V; De Michele, G; Lucking, CB; Durr, A; Fabrizio, E; Ambrosio, G; ... European Consortium Genetic Suscep,; + view all (2001) The parkin gene and its phenotype. NEUROLOGICAL SCIENCES , 22 (1) 51 - 52.

Davenport, WJ; Siegel, AM; Dichgans, J; Drigo, P; Mammi, I; Pereda, P; ... Rouleau, GA; + view all (2001) CCM1 gene mutations in families segregating cerebral cavernous malformations. NEUROLOGY , 56 (4) 540 - 543.

de Silva, R; Weiler, M; Morris, HR; Martin, ER; Wood, NW; Lees, AJ; (2001) Strong association of a novel Tau promoter haplotype in progressive supranuclear palsy. NEUROSCI LETT , 311 (3) 145 - 148.

Frangione, B; Revesz, T; Vidal, R; Holton, J; Lashley, T; Houlden, H; ... Ghiso, J; + view all (2001) Familial cerebral amyloid angiopathy related to stroke and dementia. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS , 8 36 - 42.

Gaspar, C; Lopes-Cendes, I; Hayes, S; Goto, J; Arvidsson, K; Dias, A; ... Rouleau, GA; + view all (2001) Ancestral origins of the Machado-Joseph disease mutation: A worldwide haplotype study. AM J HUM GENET , 68 (2) 523 - 528.

Gasser, T; Dichgans, M; Finsterer, J; Hausmanowa-Petrusewicz, I; Jurkat-Rott, K; Klopstock, T; ... EFNS Task Force on Molecular Diagnosis of Neurologic Disorders,; + view all (2001) EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. Second of two parts. Eur J Neurol , 8 (5) 407 - 424.

Gasser, T; Dichgans, M; Finsterer, J; Hausmanowa-Petrusewicz, I; Jurkat-Rott, K; Klopstock, T; ... EFNS Task Force on Molecular Diagnosis of Neurologic Disorders,; + view all (2001) EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. First of two parts. Eur J Neurol , 8 (4) 299 - 314.

Ghiso, J; Revesz, T; Holton, J; Rostagno, A; Lashley, T; Houlden, H; ... Frangione, B; + view all (2001) Review - Chromosome 13 dementia syndromes as models of neurodegeneration. AMYLOID , 8 (4) 277 - 284.

Ghiso, JA; Holton, J; Miravalle, L; Calero, M; Lashley, T; Vidal, R; ... Frangione, B; + view all (2001) Systemic amyloid deposits in familial British dementia. J BIOL CHEM , 276 (47) 43909 - 43914. Gold open access

Holton, JL; Ghiso, J; Lashley, T; Rostagno, A; Guerin, CJ; Gibb, G; ... Revesz, T; + view all (2001) Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia. AM J PATHOL , 158 (2) 515 - 526.

Houlden, H; Baker, M; Morris, HR; MacDonald, N; Pickering-Brown, S; Adamson, J; ... Hutton, M; + view all (2001) Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. NEUROLOGY , 56 (12) 1702 - 1706.

Houlden, H; King, RHM; Hashemi-Nejad, A; Wood, NW; Mathias, CJ; Reilly, M; Thomas, PK; (2001) A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V. ANN NEUROL , 49 (4) 521 - 525.

Houlden, H; King, RHM; Wood, NW; Thomas, PK; Reilly, MM; (2001) Mutations in the 5 ' region of the myotubularin-related protein 2 (MTMR2) gene in autosomal recessive hereditary neuropathy with focally folded myelin. BRAIN , 124 907 - 915.

Houlden, H.; King, R.H.M.; Wood, N.W.; Thomas, P.K.; Reilly, M.M.; (2001) Mutations in the 5' region of the myotubularin-related protein 2 (MTMR2) gene in autosomal recessive hereditary neuropathy with focally folded myelin. Brain , 124 (5) pp. 907-915. 10.1093/brain/124.5.907.

Khan, N; Graham, E; Dixon, P; Morris, C; Mander, A; Clayton, D; ... de Silva, R; + view all (2001) Parkinson's disease is not associated with combined alpha-synuclein/apolipoprotein E susceptibility genotype. ANN NEUROL , 49 (5) 665 - 668.

McEntagart, M; Norton, N; Williams, H; Teare, MD; Dunstan, M; Baker, P; ... Rahman, N; + view all (2001) Localization of the gene for distal hereditary motor neuronopathy VII (dHMN-VII) to chromosome 2q14. AM J HUM GENET , 68 (5) 1270 - 1276.

McEntagart, M.; Norton, N.; Williams, H.; Teare, M.D.; Dunstan, M.; Baker, P.; ... Rahman, N.; + view all (2001) Localization of the gene for distal hereditary motor neuronopathy VII (dHMN-VII) to chromosome 2q14. The American Journal of Human Genetics , 68 (5) pp. 1270-1276. 10.1086/320122.

Mead, SH; Proukakis, C; Wood, N; Crosby, AH; Plant, GT; Warner, TT; (2001) A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. J NEUROL NEUROSUR PS , 71 (6) 788 - 791.

Morris, HR; Al-Sarraj, S; Schwab, C; Gwinn-Hardy, K; Perez-Tur, J; Wood, NW; ... Steele, JC; + view all (2001) A clinical and pathological study of motor neurone disease on Guam. BRAIN , 124 2215 - 2222.

Morris, HR; Khan, MN; Janssen, JC; Brown, JM; Perez-Tur, J; Baker, M; ... Rossor, MN; + view all (2001) The genetic and pathological classification of familial frontotemporal dementia. ARCH NEUROL-CHICAGO , 58 (11) 1813 - 1816.

Morris, HR; Schrag, A; Nath, U; Burn, D; Quinn, NP; Daniel, S; ... Lees, AJ; + view all (2001) Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy. NEUROSCI LETT , 312 (2) 118 - 120.

Nardocci, N; Fernandez-Alvarez, E; Wood, NW; Spacey, SD; Richter, A; (2001) The paroxysmal dyskinesias. In: Guerrini, R and Aicardi, J and Andermann, F and Hallett, M, (eds.) Epilepsy and movement disorders. (125 - 139). Cambridge University Press: Cambridge.

Nath, U; Ben-Shlomo, Y; Thomson, RG; Morris, HR; Wood, NW; Lees, AJ; Burn, DJ; (2001) The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK. BRAIN , 124 1438 - 1449.

Patel, H; Hart, PE; Warner, T; Allen, I; Phillimore, HE; Silver, JR; ... Crosby, AH; + view all (2001) Silver syndrome is not linked to any of the previously established autosomal dominant hereditary spastic paraplegia loci. AM J MED GENET , 102 (1) 68 - 72.

Periquet, M; Lucking, CB; Vaughan, JR; Bonifati, V; Durr, A; De Michele, G; ... European Consortium Genetic Suscep,; + view all (2001) Origin of the mutations in the parkin gene in europe: Exon rearrangements are independent recurrent events, whereas point mutations may result from founder effects. AM J HUM GENET , 68 (3) 617 - 626.

Placzek, MR; Misbahuddin, A; Chaudhuri, KR; Wood, NW; Bhatia, KP; Warner, TT; (2001) Cervical dystonia is associated with a polymorphism in the dopamine (D5) receptor gene. J NEUROL NEUROSUR PS , 71 (2) 262 - 264.

Rampoldi, L; Dobson-Stone, C; Rubio, JP; Danek, A; Chalmers, RM; Wood, NW; ... Monaco, AP; + view all (2001) A conserved sorting-associated protein is mutant in chorea- acanthocytosis. Nature Genetics , 28 (2) 119 - 120.

Reilly, MM; Lee, MJ; Sweeney, MG; Stephenson, D; Davis, M; Groves, M; ... Scaravilli, F; + view all (2001) Genetic analysis of the mutilated foot (mf) rat: an animal model for human hereditary sensory neuropathy. AM J HUM GENET , 69 (4) 501 - 501.

Sheen, VL; Dixon, PH; Fox, JW; Hong, SE; Kinton, L; Sisodiya, SM; ... Walsh, CA; + view all (2001) Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. HUM MOL GENET , 10 (17) 1775 - 1783.

Valente, EM; Bentivoglio, AR; Cassetta, E; Dixon, PH; Davis, MB; Ferraris, A; ... Albanese, A; + view all (2001) DYT13, a novel primary torsion dystonia locus, maps to chromosome 1p36.13-36.32 in an Italian family with cranial cervical or upper limb onset. ANN NEUROL , 49 (3) 362 - 366.

Valente, EM; Bentivoglio, AR; Cassetta, E; Dixon, PH; Davis, MB; Ferraris, A; ... Albanese, A; + view all (2001) Identification of a novel primary torsion dystonia loons (DYT13) on chromosome 1p36 in an Italian family with cranial-cervical or upper limb onset. NEUROLOGICAL SCIENCES , 22 (1) 95 - 96.

Valente, EM; Bentivoglio, AR; Dixon, PH; Ferraris, A; Ialongo, T; Frontali, M; ... Wood, NW; + view all (2001) Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. AM J HUM GENET , 68 (4) 895 - 900.

Valente, EM; Brancati, F; Ferraris, A; Bentivoglio, AR; Bonifati, V; Vaughan, J; ... European Consortium Genet Suscepti,; + view all (2001) PARK6 is a major locus in early-onset parkinsonism. AM J HUM GENET , 69 (4) 500 - 500.

Vaughan, JR; Davis, MB; Wood, NW; (2001) Genetics of Parkinsonism: a review. ANN HUM GENET , 65 111 - 126.

Wood, NW; Kinton, L; Hanna, MG; (2001) Genetics of the overlap between epilepsy and movement disorders. In: Guerrini, R and Aicardi, J and Andermann, F and Hallett, M, (eds.) Epilepsy and movement disorders. (451 - 464). Cambridge University Press: Cambridge.

Worth, PF; Wood, NW; (2001) Spinocerebellar ataxia type 12 is rare in the United Kingdom. NEUROLOGY , 56 (3) 419 - 420.

Worth, PF; Wood, NW; (2001) Genotype to phenotype in the spinocerebellar ataxias. In: Malcom, S and Goodship, J, (eds.) Genotype to phenotype. (165 - 187). Bios Scientific Publishers

2000

Bandmann, O; Vaughan, JR; Holmans, P; Marsden, CD; Wood, NW; (2000) Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease. MOVEMENT DISORD , 15 (1) 30 - 35.

de Silva, HA; Khan, NL; Wood, NW; (2000) The genetics of Parkinson's disease. CURR OPIN GENET DEV , 10 (3) 292 - 298.

Houlden, H; Baker, M; McGowan, E; Lewis, P; Hutton, M; Crook, R; ... Revesz, T; + view all (2000) Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. ANN NEUROL , 48 (5) 806 - 808.

Jarman, PR; Bhatia, KP; Davie, C; Heales, SJR; Turjanski, N; Taylor-Robinson, SD; ... Wood, NW; + view all (2000) Paroxysmal dystonic choreoathetosis: Clinical features and investigation of pathophysiology in a large family. MOVEMENT DISORD , 15 (4) 648 - 657.

Lodi, R; Schapira, AHV; Manners, D; Styles, P; Wood, NW; Taylor, DJ; Warner, TT; (2000) Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy. ANN NEUROL , 48 (1) 72 - 76.

Lucking, CB; Durr, A; Bonifati, V; Vaughan, J; De Michele, G; Gasser, T; ... French Parkinsons Dis Genetics Stu,; + view all (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. NEW ENGL J MED , 342 (21) 1560 - 1567.

Morris, HR; Vaughan, JR; Datta, SR; Bandopadhyay, R; de Silva, HAR; Schrag, A; ... Wood, NW; + view all (2000) Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE. NEUROLOGY , 55 (12) 1918 - 1920.

Munchau, A; Valente, EM; Davis, MB; Stinton, V; Wood, NW; Quinn, NP; Bhatia, KP; (2000) A Yorkshire family with adult-onset cranio-cervical primary torsion dystonia. MOVEMENT DISORD , 15 (5) 954 - 959.

Munchau, A; Valente, EM; Shahidi, GA; Eunson, LH; Hanna, RG; Quinn, NP; ... Bhatia, KP; + view all (2000) A new family with paroxysmal exercise induced dystonia and migraine: a clinical and genetic study. J NEUROL NEUROSUR PS , 68 (5) 609 - 614.

Spauschus, A; Rea, R; Eunson, L; Wood, NW; Hanna, MG; Kullmann, DM; (2000) Functional characterisation of mutant Kv1.1 subunits from two families with episodic ataxia type 1. J PHYSIOL-LONDON , 523 156P - 157P.

Valente, EM; Spacey, SD; Wali, GM; Bhatia, KP; Dixon, PH; Wood, NW; Davis, MB; (2000) A second paroxysmal kinesigenic choreoathetosis locus (EKD2) mapping on 16q13-q22.1 indicates a family of genes which give rise to paroxysmal disorders on human chromosome 16. BRAIN , 123 2040 - 2045.

Weiler, M; de Silva, HAR; Morris, H; Wood, NW; Lees, AJ; (2000) Strong association of novel tau promoter polymorphisms with progressive supranuclear palsy. AM J HUM GENET , 67 (4) 193 - 193.

Wilson, CJ; Wood, NW; Leonard, JV; Surtees, R; Rahman, S; (2000) Mitochondrial DNA point mutation T9176C in Leigh syndrome. J CHILD NEUROL , 15 (12) 830 - 833.

Wood, NW; Harding, AE; (2000) Ataxic disorders. In: Bradley, WG and Daroff, RB and Fenichel, GM and Marsden, CD, (eds.) Neurology in clinical practice: volume 1. Principles of diagnosis and management. (309 - 317). Butterworth Heinemann: Oxford.

Wood, NW; Harding, AE; (2000) Cerebellar and spinocerebellar disorders. In: Bradley, WG and Daroff, RB and Fenichel, GM and Marsden, CD, (eds.) Neurology in clinical practice: volume 2. The neurological disorders. (1931 - 1951). Butterworth Heinemann: Oxford.

Worth, PF; Houlden, H; Giunti, P; Davis, MB; Wood, NW; (2000) Large, expanded repeats in SCA8 are not confined to patients with cerebellar ataxia. NAT GENET , 24 (3) 214 - 215.

Zhang, J; Hattori, N; Leroy, E; Morris, HR; Kubo, SI; Kobayashi, T; ... Mizuno, Y; + view all (2000) Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease. PARKINSONISM RELAT D , 6 (4) 195 - 197.

1999

Abbas, N; Lucking, CB; Ricard, S; Durr, A; Bonifati, V; De Michele, G; ... European Consortium Genetic Susceptibility Park,; + view all (1999) A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. HUM MOL GENET , 8 (4) 567 - 574.

Andrews, TC; Weeks, RA; Turjanski, N; Gunn, RN; Watkins, LHA; Sahakian, B; ... Brooks, DJ; + view all (1999) Huntington's disease progression PET and clinical observations. BRAIN , 122 2353 - 2363.

Bandmann, O; Vaughan, J; Holmans, PA; Marsden, CD; Wood, NW; (1999) Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2. In: UNSPECIFIED (199 - 204).

Chalmers, RM; Andreae, L; Wood, NW; Raj, RVKD; Casey, ATH; (1999) Familial hydrocephalus. J NEUROL NEUROSUR PS , 67 (3) 410 - 411.

Clark, KM; Taylor, RW; Johnson, MA; Chinnery, PF; Chrzanowska-Lightowlers, ZMA; Andrews, RM; ... Turnbull, DM; + view all (1999) An mtDNA mutation in the initiation codon of the cytochrome C oxidase subunit II gene results in lower levels of the protein and a mitochondrial encephalomyopathy. AMERICAN JOURNAL OF HUMAN GENETICS , 64 (5) 1330 - 1339. 10.1086/302361.

Dixon, PH; Stinton, VJ; Humphray, SJ; Hammond, S; Howard, PJ; Dunham, I; ... Davis, MB; + view all (1999) Physical and EST mapping on chromosome 9: Candidate Genes for the geniospasm (GSM1) locus. AM J HUM GENET , 65 (4) A224 - A224.

Dixon, PH; Stinton, VJ; Humphray, SJ; Hammond, S; Howard, PJ; Dunham, I; ... Davis, MB; + view all (1999) Physical and EST mapping on chromosome 9: Candidate Genes for the geniospasm (GSM1) locus. The American Journal of Human Genetics , 65 1241 - ?.

Elliott, PM; Hanna, MG; Ward, SA; Chinnery, PF; Turnbull, DM; Wood, NW; McKenna, WJ; (1999) Diagnostic utility of metabolic exercise testing in a patient with cardiovascular disease. HEART , 81 (4) 441 - 443.

Eunson, LH; Davis, MB; Wood, NW; Hanna, MG; (1999) The national DNA-based diagnostic service for periodic paralyses. J MED GENET , 36 S63 - S63.

Eunson, LH; Jouvenceau, A; Ramesh, V; Zuberi, SM; Nairne, A; Hyman, N; ... Hanna, MG; + view all (1999) New mutations in the voltage-gated calcium channel gene CACNA1A in british families with episodic ataxia type 2. AM J HUM GENET , 65 (4) A293 - A293.

Flowers, JM; Leigh, PN; Davies, AM; Ninkina, NN; Buchman, VL; Vaughan, J; ... Powell, JF; + view all (1999) Mutations in the gene encoding human persyn are not associated with amyotrophic lateral sclerosis or familial Parkinson's disease. Neuroscience Letters , 274 (1) 21 - 24.

Giunti, P; Stevanin, G; Worth, PF; David, G; Brice, A; Wood, NW; (1999) Molecular and clinical study of 18 families with ADCA type II: Evidence for genetic heterogeneity and De Novo mutation. AM J HUM GENET , 64 (6) 1594 - 1603.

Harhangi, BS; Farrer, MJ; Lincoln, S; Bonifati, V; Meco, G; De Michele, G; ... Breteler, MMB; + view all (1999) The lle93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease. NEUROSCI LETT , 270 (1) 1 - 4.

Jarman, P; Wood, N; (1999) Parkinson's disease genetics comes of age - Knowledge about genes in familial parkinsonism helps elucidate idiopathic disease. BRIT MED J , 318 (7199) 1641 - 1642.

Jarman, PR; del Grosso, N; Valente, EM; Leube, B; Cassetta, E; Bentivoglio, AR; ... Nygaard, TG; + view all (1999) Primary torsion dystonia: the search for genes is not over. J NEUROL NEUROSUR PS , 67 (3) 395 - 397.

Khan, NL; Wood, NW; (1999) Prader-Willi and Angelman syndromes: update on genetic mechanisms and diagnostic complexities. Curr Opin Neurol , 12 (2) 149 - 154.

Lincoln, S; Vaughan, J; Wood, N; Baker, M; Adamson, J; Gwinn-Hardy, K; ... Farrer, M; + view all (1999) Low frequency of pathogenic mutations in the ubiquitin carboxyterminal hydrolase gene in familial Parkinson's disease. NEUROREPORT , 10 (2) 427 - 429.

Marques, W; Hanna, MG; Marques, SR; Sweeney, MG; Thomas, PK; Wood, NW; (1999) Phenotypic variation of a new P0 mutation in genetically identical twins. J NEUROL , 246 (7) 596 - 599.

Marques, W; Sweeney, MG; Wood, NW; Wroe, SJ; Marques, W; (1999) Central nervous system involvement in a novel connexin 32 mutation affecting identical twins. J NEUROL NEUROSUR PS , 66 (6) 803 - 804.

Morris, HR; Baker, M; Lees, AJ; Hutton, M; Hardy, J; Wood, NW; (1999) Further analysis of the association of tau with progressive supranuclear palsy. AM J HUM GENET , 65 (4) A462 - A462.

Morris, HR; Baker, M; Lees, AJ; Hutton, M; Hardy, J; Wood, NW; (1999) Further analysis of the association of tau with progressive supranuclear palsy. The American Journal of Human Genetics , 65 2621 - ?.

Morris, HR; Janssen, JC; Bandmann, O; Daniel, SE; Rossor, MN; Lees, AJ; Wood, NW; (1999) The tau gene A0 polymorphism in progressive supranuclear palsy and related neurodegenerative diseases. J NEUROL NEUROSUR PS , 66 (5) 665 - 667.

Morris, HR; Lees, AJ; Wood, NW; (1999) Neurofibrillary tangle parkinsonian disorders - Tau pathology and tau genetics. MOVEMENT DISORD , 14 (5) 731 - 736.

Morris, HR; Perez-Tur, J; Janssen, JC; Brown, J; Lees, AJ; Wood, NW; ... Rossor, MN; + view all (1999) Mutation in the tau exon 10 splice site region in familiar frontotemporal dementia. ANN NEUROL , 45 (2) 270 - 271.

Morris, HR; Wood, NW; Lees, AJ; (1999) Progressive supranuclear palsy (Steele-Richardson-Olszewski disease). POSTGRAD MED J , 75 (888) 579 - 584.

Pulkes, T; Eunson, L; Patterson, V; Siddiqui, A; Wood, NW; Nelson, IP; ... Hanna, MG; + view all (1999) The mitochondrial DNA G13513A transition in ND5 is associated with a LHON/MELAS overlap syndrome and may be a frequent cause of MELAS. ANN NEUROL , 46 (6) 916 - 919.

Robinson, R; McCarthy, GT; Bandmann, O; Dobbie, M; Surtees, R; Wood, NW; (1999) GTP cyclohydrolase deficiency; intrafamilial variation in clinical phenotype, including levodopa responsiveness. J NEUROL NEUROSUR PS , 66 (1) 86 - 89.

Robinson, RO; McCarthy, GT; Bandmann, O; Dobbie, M; Surtees, R; Wood, NW; (1999) GTP cyclohydrolase deficiency: intrafamilial variation in phenotype, including levadopa responsiveness. Journal of Neurology, Neurosurgery and Psychiatry , 66 86 - 89.

Rojo, A; Pernaute, RS; Fontan, A; Ruiz, PG; Honnorat, J; Lynch, T; ... de Yebenes, JG; + view all (1999) Clinical genetics of familial progressive supranuclear palsy. BRAIN , 122 1233 - 1245.

Spacey, SD; Wood, NW; (1999) The genetics of Parkinson's disease. CURR OPIN NEUROL , 12 (4) 427 - 432.

Sweeney, MG; Giunti, P; Stinton, VJ; Worth, PF; Hanna, MG; Wood, NW; Davis, MB; (1999) Population genetics of the SCA6 locus in British families with ADCA. AM J HUM GENET , 65 (4) A400 - A400.

Valente, EM; Povey, S; Warner, TT; Wood, NW; Davis, MB; (1999) Detailed haplotype analysis in Ashkenazi Jewish and non-Jewish British dystonic patients carrying the GAG deletion in the DYT1 gene: evidence for a limited number of founder mutations. ANN HUM GENET , 63 1 - 8.

Valente, EM; Povey, S; Warner, TT; Wood, NW; Davis, MB; (1999) Detailed haplotype analysis in Ashkenazi Jews and non-Jewish British dystonic patients carrying the GAG deletion in the DYT1 gene: evidence of two new founder mutations. Annals of Human Genetics , 63 1 - 8.

Valente, EM; Wood, NW; Davis, MB; Povey, S; Warner, TT; (1999) Detailed haplotype analysis in Ashkenazi Jewish and non-Jewish British dystonic patients carrying the GAG deletion in the DYT1 gene: Evidence for a limited number of founder mutations. Annals of Human Genetics , 63 (1) 1 - 8. 10.1017/S0003480099007265.

Vaughan, JR; Farrer, M; De Michele, G; Volpe, G; Hardy, J; Wood, NW; (1999) Further evidence for a chromosome 4p haplotype segregating with Parkinson's disease in an independent Italian kindred. AM J HUM GENET , 65 (4) A496 - A496.

Worth, PF; Dunne, E; Nemeth, AH; Wood, NW; (1999) Autosomal dominant cerebellar ataxia type III: No evidence for a large pathological CAG repeat expansion in the SCA 11 gene. AM J HUM GENET , 65 (4) A499 - A499.

Worth, PF; Giunti, P; Gardner-Thorpe, C; Dixon, PH; Davis, MB; Wood, NW; (1999) Autosomal dominant cerebellar ataxia type III: Linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3. AM J HUM GENET , 65 (2) 420 - 426.

Zuberi, SM; Eunson, LH; Spauschus, A; De Silva, R; Tolmie, J; Wood, NW; ... Hanna, MG; + view all (1999) A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. BRAIN , 122 817 - 825.

1998

Bandmann, O; Marsden, CD; Wood, NW; (1998) Genetic aspects of Parkinson's disease. MOVEMENT DISORD , 13 (2) 203 - 211.

Bandmann, O; Marsden, CD; Wood, NW; (1998) Atypical presentations of dopa-responsive dystonia. Adv Neurol , 78 283 - 290.

Bandmann, O; Valente, EM; Holmans, P; Surtees, RAH; Walters, JH; Wevers, RA; ... Wood, NW; + view all (1998) Dopa-responsive dystonia: A clinical and molecular genetic study. ANN NEUROL , 44 (4) 649 - 656.

Bandmann, O; Wood, NW; (1998) Acetylator genotype and Parkinson's disease - Reply. LANCET , 351 (9096) 142 - 142.

Giunti, P; Sabbadini, G; Sweeney, MG; Davis, MB; Veneziano, L; Mantuano, E; ... Wood, NW; + view all (1998) The role of the SCA2 trinucleotide repeat expansion in 89 autosomal dominant cerebellar ataxia families - Frequency, clinical and genetic correlates. BRAIN , 121 459 - 467.

Hanna, MG; Davis, MB; Sweeney, MG; Noursadeghi, M; Ellis, CJ; Elliot, P; ... Marsden, CD; + view all (1998) Generalized chorea in two patients harboring the Friedreich's ataxia gene trinucleotide repeat expansion. MOVEMENT DISORD , 13 (2) 339 - 340.

Hanna, MG; Nelson, IP; Morgan-Hughes, JA; Wood, NW; (1998) MELAS: a new disease associated mitochondrial DNA mutation and evidence for further genetic heterogeneity. J NEUROL NEUROSUR PS , 65 (4) 512 - 517.

Hanna, MG; Nelson, IP; Rahman, S; Lane, RJM; Land, J; Heales, S; ... Wood, NW; + view all (1998) Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA. AM J HUM GENET , 63 (1) 29 - 36.

Hanna, MG; Stewart, J; Schapira, AHV; Wood, NW; Morgan-Hughes, JA; Murray, NMF; (1998) Salbutamol treatment in a patient with hyperkalaemic periodic paralysis due to a mutation in the skeletal muscle sodium channel gene (SCN4A). J NEUROL NEUROSUR PS , 65 (2) 248 - 250.

Hanna, MG; Wood, N; Kullmann, DM; (1998) Ion channels and neurological disease: DNA based diagnosis is now possible, and ion channels may be important in common paroxysmal disorders. J NEUROL NEUROSUR PS , 65 (4) 427 - 431.

Kapoor, R; Miller, DH; Jones, SJ; Plant, GT; Brusa, A; Gass, A; ... McDonald, WI; + view all (1998) Effects of intravenous methylprednisolone on outcome in MRI-based prognostic subgroups in acute optic neuritis. NEUROLOGY , 50 (1) 230 - 237.

Lamont, PJ; Surtees, R; Woodward, CE; Leonard, JV; Wood, NW; Harding, AE; (1998) Clinical and laboratory findings in referrals for mitochondrial DNA analysis. ARCH DIS CHILD , 79 (1) 22 - 27.

Lopes, J; Ravise, N; Vandenberghe, A; Palau, F; Ionasescu, V; Mayer, M; ... LeGuern, E; + view all (1998) Fine mapping of de novo CMT1A and HNPP rearrangements within CMT1A-REPs evidences two distinct sex-dependent mechanisms and candidate sequences involved in recombination. HUM MOL GENET , 7 (1) 141 - 148.

Lucking, CB; Abbas, N; Durr, A; Bonifati, V; Bonnet, AM; de Broucker, T; ... French Parkinsons Dis Genetics Study Grp,; + view all