Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...
Prof Nick Wood’s chief interests are the genetic variants which contribute to nervous system function and dysfunction. Over the last few years the laboratory has contributed to the finding of a number of genes which when mutated cause Parkinson's disease and other neurological conditions. Following on from these discoveries he has built a group focussed on understanding the molecular pathogenesis of PD. This involves molecular and cellular biology and live cell imaging. One of the major challenges facing neuroscience is the genetic basis of normal and abnormal function. Over the past few years this lab and colleagues (within and outside UCL) have built a programme of research based around haplotype tagging of the human genome. Currently he is directly involved in 2 genome wide associations studies focussed on two common neurological diseases (Epilepsy and Parkinsons Disease).
Nick qualified in medicine from the University of Birmingham. He went on to take a PhD in Cambridge. He was elected to the Fellowship of the Academy of Medical Science in 2004 and to senior investigator of the NIHR in 2008. He is currently Galton Professor of Genetics, a Consultant Neurologist and neuroscience programme director for UCLH NIHR Biomedical Research Centre (BRC).esearcherID
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