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Poster for Autophagy in London public lecture

Public lecture: The autophagy signaling network, c-­‐myc and pathology: don't mess with the cell cycle!

You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...

Link to film: Brain Disease Research - Keeping You You

Video: Brain Disease Research - Keeping You You


Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...

Degenerating Brains public symposium - 13th March 2013

Video: Degenerating Brains public symposium


The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...

Colour-enhanced image of a mitochondrion showing the internal membranes (cristae) and enzyme complexes. Credit Dr David Furness, Wellcome Images.

Mutations in VCP gene implicated in a number of neurodegenerative diseases

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...

Poster for Degenerating brains: new research into Alzheimer's, Parkinson's and Motor Neuron Disease

Public lectures: new research into Alzheimer's, Parkinson's and Motor Neuron Disease

You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.

18.00 Welcome and introduction

18.10 Lectures commence

More...

Video: Parkinson's UK site visit for the Targeting LRRK2 project

1 November 2011

LRRK2 from Tony Cox on Vimeo.

LRRK2 – pronounced lark 2 – is the most common gene associated with Parkinson’s. A mutant form of LRRK2 can cause the death of nerve cells, and blocking this form of LRRK2 from working can prevent this from happening. Before we can use this knowledge to develop treatments we need to fill in the gaps in our understanding of the role LRRK2 plays when it’s healthy, and of the different proteins it interacts with along the way within the nerve cell.

Figuring out how LRRK2 works and how to change this is a promising route to developing novel therapies for the treatment and ultimately cure for Parkinson’s. Although a long way off, we hope that these can ultimately be tested in the clinic to see if we can slow down or alter the progress of the condition.

Patrick Lewis - Lead researcher for the Targeting LRRK2 project

Patrick Lewis' profile

More information (PDF) on the Targeting LRRK2 project

Page last modified on 01 nov 11 14:21