UK Parkinson's Disease Consortium - UKPDC
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Video: Parkinson's and the Genetic Revolution: From Genes to Treatments
Dr Patrick Lewis of
University College London and Dr Flaviano Giorgini of the University of
Leicester, discuss how their work on genetics is helping us develop treatments for Parkinson's.
More...
Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Video: Brain Disease Research - Keeping You You
Have you ever wondered how scientists research the brain?
Have you wondered who digs through that beautiful mass of grey matter between
our ears to understand how it works and why it stops working? Meet the
Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this
team of scientists from around the globe investigates Alzheimer's, Parkinson's
and Motor Neuron Diseases. The team is on the hunt for understanding and
treatments for brain diseases. More...
Video: Degenerating Brains public symposium
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
Mutations in VCP gene implicated in a number of neurodegenerative diseases
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
- UK Parkinson's Disease Consortium (UKPDC) is a group of world-leading genetic, biochemical, clinical and other scientific researchers who possess complementary expertise, technology and other resources to identify and tackle the causes of Parkinson’s disease (PD).
- Parkinson's disease is a common, disabling and currently incurable neurodegenerative condition that affects over 2% of people over the age of 75.
- There has been tremendous progress in recent years in understanding better the possible causes of Parkinson's disease.
- This has been principally driven by genetic discoveries of the genes/molecules that determine a higher risk factor for developing Parkinson's disease.
- We now have the opportunity to harness these discoveries into a more complete understanding of neurodegeneration (cell death) and dysfunction in this disease and to fully characterise the common clinical traits so that Parkinson's disease treatment can be realised.
We have three main goals:
- To undertake comprehensive genetic analysis of a large number of well characterised Parkinson's disease patients to identify rare variants and novel genes that cause and predispose to the disease.
- To understand the biochemistry of existing and novel causative Parkinson's disease gene products, and their pathways, to describe the regulation and function of these proteins.
- To collate the clinical traits of a large group of at-risk patients and to define the early Parkinson's disease symptoms, so that disease modifying treatments could be administered as early as possible.
- This research should yield crucial new knowledge of the pathways leading to neurodegeneration and shed insight into the causation of Parkinson's disease.
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Page last modified on 02 may 13 16:51
