Welcome to Christine Orengo's Group
CATH: protein structures are chopped up into domains and grouped together into superfamilies if there is sufficient evidence that they have diverged from a common ancestor during the process of evolution
In order to understand how different functions evolve, it is often important to consider how combinations of protein domains change over time (PDB 7ahl, structure of a heptameric transmembrane pore)
The CATH website enables users to search and explore relationships between protein sequence, structure and function.
This group is primarily focused on developing computational methods for classifying proteins into evolutionary families. We exploit structural and sequence data to do this and a major interest is in the development of algorithms to recognise very distant relationships.
Evolution of protein families
We are researching the extent to
which functions are conserved across families and in developing better
methods for predicting when and how the functions of relatives change in
We have used our family classification to study the evolution of protein
families and to perform comparative genomics. For example to determine
which families are under or over represented in different organisms or
different environments (e.g. in the metagenomics data).
Prediction of protein function
We have also developed methods for predicting protein associations and functional networks. Our methods for predicting functions and functional networks are being exploited by experimental groups in several EU funded collaborations in which we participate. These groups are researching proteins involved in cancer, angiogenesis, B-cell signalling and differentiation.
We also belong to the London Pain Consortium who are researching chronic pain. We participate in the NIH funded Protein Structure Initiative one of whose aims is to determine the structures of proteins of biological and medical interest.
Page last modified on 12 may 14 11:30