Prof John N Wood, Molecular Nociception Group

Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK

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Research focus

Selected publications

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Research Focus

The Molecular Nociception Group focuses on genetic approaches to understanding the biology of damage-sensing neurons, somatosensation, pain and touch The past decade has seen a revolution in our understanding of the receptor systems and regulatory pathways that underlie the responses of these specialised cells to the occurrence of tissue damage. This has important implications for human health and disease.

Our group combines recombinant DNA technology, electrophysiology and gene targeting and behavioural approaches to explore the channels, receptors, transcription factors and regulatory pathways that control nociceptor excitability. UCL provides an exciting environment for basic neuroscience and clinical interactions.

We collaborate with research groups in Europe, the United States, Korea, Japan and Australia, using transgenic mouse models, natural products and cloned genes to explore the physiology of pain perception. The systems we study have a broad relevance to understanding how the nervous system works, in terms of synaptic plasticity, responses to environmental stimuli and sensation and behaviour.

Prof. John N Wood is head of the Molecular Nociception Group and a member of the London Pain Consortium.

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Publications

2012

Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachova V, Reeh PW, Lewis RJ, Zimmermann K (2012). Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO JOURNAL, 31(19), 3795 - 3808. doi:10.1038/emboj.2012.207
Farmer C, Cox JJ, Fletcher EV, Woods CG, Wood JN, Schorge S (2012). Splice variants of Na(V)1.7 sodium channels have distinct ? subunit-dependent biophysical properties.. PLoS One, 7(7), e41750 - . doi:10.1371/journal.pone.0041750
Eijkelkamp N, Linley JE, Baker MD, Minett MS, Cregg R, Werdehausen R, Rugiero F, Wood JN (2012). Neurological perspectives on voltage-gated sodium channels.. Brain, 135(Pt 9), 2585 - 2612. doi:10.1093/brain/aws225
Shields SD, Ahn H-S, Yang Y, Han C, Seal RP, Wood JN, Waxman SG, Dib-Hajj SD (2012). Na(v)1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. PAIN, 153(10), 2017 - 2030. doi:10.1016/j.pain.2012.04.022
Wood JN, Eijkelkamp N (2012). Noxious mechanosensation - molecules and circuits.. Curr Opin Pharmacol, 12(1), 4 - 8. doi:10.1016/j.coph.2011.10.013
Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton J, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson G, Freichel M, Flockrzi V, Birnbaumer L, Wood JN (2012). TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biology, 2, - .
Raouf R, Rugiero F, Kiesewetter H, Hatch R, Hummler E, Nassar MA, Wang F, Wood JN (2012). Sodium channels and mammalian sensory mechanotransduction.. Mol Pain, 8, 21 - . doi:10.1186/1744-8069-8-21
Minett MS, Nassar MA, Clark AK, Passmore G, Dickenson AH, Wang F, Malcangio M, Wood JN (2012). Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.. Nat Commun, 3, 791 - . doi:10.1038/ncomms1795
Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A (2012). G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.. Mol Med, 18, 556 - 564. doi:10.2119/molmed.2011.00398
Cho H, Yang YD, Lee J, Lee B, Kim T, Jang Y, Back SK, Na HS, Harfe BD, Wang F, Raouf R, Wood JN, Oh U (2012). The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.. Nat Neurosci, 15(7), 1015 - 1021. doi:10.1038/nn.3111

2011

Lau J, Minett MS, Zhao J, Dennehy U, Wang F, Wood JN, Bogdanov YD (2011). Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.. Mol Pain, 7, 100 - . doi:10.1186/1744-8069-7-100
Gautron L, Sakata I, Udit S, Zigman JM, Wood JN, Elmquist JK (2011). Genetic Tracing of Nav1.8-Expressing Vagal Afferents in the Mouse. J COMP NEUROL, 519(15), 3085 - 3101. doi:10.1002/cne.22667
Gonzalez-Cano R, Tejada-Giraldez MA, Sanchez-Fernandez C, Torres-Pinedo A, Baeyens JM, Wood JN, Cendan CM (2011). INVOLVEMENT OF TETRODOTOXIN-SENSITIVE SODIUM CHANNELS IN VISCERAL PAIN. BASIC CLIN PHARMACOL, 109, 38 - 38.
Weibel R, Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Matifas A, Reissl D, Filliol D, Wood JN, Maldonado R, Kieffer BL (2011). Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes analgesia. PHARMACOL REP, 63(1), 243 - 243.
Lagerstrom MC, Rogoz K, Abrahamsen B, Lind AL, Olund C, Smith C, Mendez JA, Wallen-Mackenzie A, Wood JN, Kullander K (2011). A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain. P NATL ACAD SCI USA, 108(14), 5789 - 5794. doi:10.1073/pnas.1013602108
Weiss J, Pyrski M, Jacobi E, Bufe B, Willnecker V, Schick B, Zizzari P, Gossage SJ, Greer CA, Leinders-Zufall T, Woods CG, Wood JN, Zufall F (2011). Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.. Nature, 472(7342), 186 - 190. doi:10.1038/nature09975
Moldovan M, Alvarez S, Pinchenko V, Klein D, Nielsen FC, Wood JN, Martini R, Krarup C (2011). Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons. BRAIN, 134, 585 - 601. doi:10.1093/brain/awq336
Liu M, Oh U, Wood JN (2011). From transduction to pain sensation: Defining genes, cells, and circuits. PAIN, 152(3), S16 - S19. doi:10.1016/j.pain.2010.12.018
Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Weibel R, Matifas A, Reiss D, Filliol D, Nassar MA, Wood JN, Maldonado R, Kieffer BL (2011). Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. PAIN, 152(6), 1238 - 1248. doi:10.1016/j.pain.2010.12.031

2010

Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN (2010). Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.. J Neurosci, 30(32), 10860 - 10871. doi:10.1523/JNEUROSCI.1980-10.2010
Raouf R, Quick K, Wood JN (2010). Pain as a channelopathy.. J Clin Invest, 120(11), 3745 - 3752. doi:10.1172/JCI43158
Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, Woods CG, Jones NG, Paterson KJ, Fricker FR, Villegas A, Acosta N, Pineda-Trujillo NG, Ram�rez JD, Zea J, Burley MW, Bedoya G, Bennett DL, Wood JN, Ruiz-Linares A (2010). A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.. Neuron, 66(5), 671 - 680. doi:10.1016/j.neuron.2010.04.030
Zhao J, Yuan G, Cendan CM, Nassar MA, Lagerstr�m MC, Kullander K, Gavazzi I, Wood JN (2010). Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain.. Mol Pain, 6, 77 - . doi:10.1186/1744-8069-6-77
Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A (2010). Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.. J Neurosci, 30(38), 12806 - 12815. doi:10.1523/JNEUROSCI.3142-10.2010
Golden JP, Hoshi M, Nassar MA, Enomoto H, Wood JN, Milbrandt J, Gereau RW, Johnson EM, Jain S (2010). RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors. J NEUROSCI, 30(11), 3983 - 3994. doi:10.1523/JNEUROSCI.5930-09.2010
Lagerstrom MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallen-Mackenzie A, Kullander K (2010). VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch. NEURON, 68(3), 529 - 542. doi:10.1016/j.neuron.2010.09.016
Eijkelkamp N, Heijnen CJ, Willemen HLDM, Deumens R, Joosten EAJ, Kleibeuker W, den Hartog IJM, van Velthoven CTJ, Nijboer C, Nassar MA, Dorn GW, Wood JN, Kavelaars A (2010). GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain. J NEUROSCI, 30(6), 2138 - 2149. doi:10.1523/JNEUROSCI.5752-09.2010
Cregg R, Momin A, Rugiero F, Wood JN, Zhao J (2010). Pain channelopathies.. J Physiol, 588(Pt 11), 1897 - 1904. doi:10.1113/jphysiol.2010.187807
Rugiero F, Drew LJ, Wood JN (2010). Kinetic properties of mechanically activated currents in spinal sensory neurons.. J Physiol, 588(Pt 2), 301 - 314. doi:10.1113/jphysiol.2009.182360
Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LR, de Jong JS, Sternberg MJ, McKenna W, Severs NJ, de Silva R, Wilde AA, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JS (2010). Genetic variation in SCN10A influences cardiac conduction.. Nat Genet, 42(2), 149 - 152. doi:10.1038/ng.516

2009

Rugiero F, Wood JN (2009). The mechanosensitive cell line ND-C does not express functional thermoTRP channels.. Neuropharmacology, 56(8), 1138 - 1146. doi:10.1016/j.neuropharm.2009.03.012
Fricker FR, Zhu N, Abrahamsen B, Nassar MA, Thakur M, Garratt AN, Birchmeier C, McMahon SB, Wood JN, Bennett DLH (2009). SENSORY AXON-DERIVED NEUREGULIN-1 IS REQUIRED FOR AXOGLIAL SIGNALLING AND NORMAL SENSORY FUNCTION BUT NOT FOR LONG TERM AXON MAINTENANCE.
Fricker FR, Zhu N, Tsantoulas C, Abrahamsen B, Nassar MA, Thakur M, Garratt AN, Birchmeier C, McMahon SB, Wood JN, Bennett DLH (2009). Sensory Axon-Derived Neuregulin-1 Is Required for Axoglial Signaling and Normal Sensory Function But Not for Long-Term Axon Maintenance. J NEUROSCI, 29(24), 7667 - 7678. doi:10.1523/JNEUROSCI.6053-08.2009
Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WY, Cheah KS, Yao KM, Wood JN, Okuse K (2009). A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8.. Mol Cell Neurosci, 42(3), 219 - 225. doi:10.1016/j.mcn.2009.07.003
Oh U, Wood JN (2009). Fat location defines sensation. P NATL ACAD SCI USA, 106(44), 18435 - 18436. doi:10.1073/pnas.0910766106
Fricker D, Dinocourt C, Eugene E, Wood JN, Miles R (2009). Pyramidal cells of rodent presubiculum express a tetrodotoxin-insensitive Na+ current (vol 587, pg 4249, 2009). J PHYSIOL-LONDON, 587(23), 5797 - 5797. doi:10.1113/jphysiol.2009.182766

2008

Ostman JA, Nassar MA, Wood JN, Baker MD (2008). GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. The Journal of Physiology, 15(586), 1077 - 1087.
Huang H-L, Cendan C-M, Roza C, Okuse K, Cramer R, Timms JF, Wood JN (2008). Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves. Molecular Pain, 4(33), - .
Momin A, Wood JN (2008). Sensory neuron voltage-gated sodium channels as analgesic drug targets.. Curr Opin Neurobiol, 18(4), 383 - 388. doi:10.1016/j.conb.2008.08.017
Donier E, Rugiero F, Jacob C, Wood JN (2008). Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.. Eur J Neurosci, 28(1), 74 - 86. doi:10.1111/j.1460-9568.2008.06282.x
Abrahamsen B, Zhao J, Asante CO, Cendan CM, Marsh S, Martinez-Barbera JP, Nassar MA, Dickenson AH, Wood JN (2008). The cell and molecular basis of mechanical, cold, and inflammatory pain. Science, 321(5889), 702 - 705.
Foulkes T, Wood JN (2008). Pain Genes. PLOS GENET, 4(7), - . doi:10.1371/journal.pgen.1000086
Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD (2008). Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. NEURON, 58(4), 532 - 545. doi:10.1016/j.neuron.2008.03.006
Ostman JAR, Nassar MA, Wood JN, Baker MD (2008). GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require Na(V)1.9. J PHYSIOL-LONDON, 586(4), 1077 - 1087. doi:10.1113/jphysiol.2007.147942

2007

Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ, Wood JN (2007). High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS ONE, 13(2), e515 - .
Zimmermann K, Leffler A, Babes A, Cendan CM, Carr RW, Kobayashi J, Nau C, Wood JN, Reeh PW (2007). Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature, 14(447), 855 - 858.
Drew LJ, Wood JN (2007). FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli.. Molecular Pain, 6(3), 1 - .
Wood JN (2007). Ion channels in analgesia research.. Handb Exp Pharmacol, (177), 329 - 358.
Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ, Wood JN (2007). High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.. PLoS One, 2(6), e515 - . doi:10.1371/journal.pone.0000515
Foulkes T, Wood JN (2007). Mechanisms of cold pain.. Channels (Austin), 1(3), 154 - 160.
Drew LJ, Rugiero F, Wood JN (2007). Touch. CURR TOP MEMBR, 59, 425 - 465. doi:10.1016/S1063-58223(06)59016-7
Zimmermann K, Leffler A, Babes A, Cendan CM, Carr RW, Kobayashi J, Nau C, Wood JN, Reeh PW (2007). Sensory neuron sodium channel Na(v)1.8 is essential for pain at low temperatures. NATURE, 447(7146), 855 - 858. doi:10.1038/nature05880

2006

Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N, Wood JN, Gardiner RM, Rees M (2006). SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron, 52, 767 - 774. doi:10.1016/j.neuron.2006.10.006
Mathews E, Wood JN, Dickenson AH (2006). Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Molecular Pain, 14(2), 5 - .
Di CA, Drew LJ, Wood JN, Cesare P (2006). Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways.. Proceedings of the National Academy of Sciences of the United States of America, 103(12), 4699 - 4704.
McMahon SB, Wood JN (2006). Increasingly irritable and close to tears: TRPA1 in inflammatory pain. CELL, 124(6), 1123 - 1125. doi:10.1016/j.cell.2006.03.006
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mouldt J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ (2006). mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. P NATL ACAD SCI USA, 103(45), 17030 - 17035. doi:10.1073/pnas.0601819103
Zhao J, Seereeram A, Nassar MA, Levato A, Pezet S, Hathway G, Morenilla-Palao C, Stirling C, Fitzgerald M, McMahon SB, Rios M, Wood JN (2006). Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Molecular and Cellular Neuroscience, 31(3), 539 - 548. doi:10.1016/j.mcn.2005.11.008
Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB, Wood JN (2006). Nerve injury induces robust allodynia and ectopic discharges in Na_v1.3 null mutant mice. Molecular Pain, 2, 33 - . doi:10.1186/1744-8069-2-33
Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG (2006). An SCN9A channelopathy causes congenital inability to experience pain. Nature, 14(444), 894 - 895.
Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH, Wood JN (2006). Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior.. Journal of Neuroscience, 26(41), 10499 - 10507. doi:10.1523/JNEUROSCI.1997-06.2006
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ (2006). muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America, 7(103), 17030 - 17035.
Zhao J, Nassar MA, Gavazzi I, Wood JN (2006). Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis, 44(8), 364 - 371.
Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG (2006). An SCN9A channelopathy causes congenital inability to experience pain. NATURE, 444(7121), 894 - 898. doi:10.1038/nature05413

2005

Donier E, Rugiero F, Okuse K, Wood JN (2005). Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. Journal of Biological Chemistry, 280(46), 38666 - 38672. doi:10.1074/jbc.M505981200
Braz JM, Nassar MA, Wood JN, Basbaum AI (2005). Parallel "pain" pathways arise from subpopulation of primary afferent nociceptor. NEURON, 47(6), 787 - 793. doi:10.1016/j.neuron.2005.08.015
Drew LJ, Wood JN (2005). Worm sensation!. Mol Pain, 1, 8 - . doi:10.1186/1744-8069-1-8
Wood JN, Boorman J (2005). Voltage-gated sodium channel blockers; target validation and therapeutic potential.. Curr Top Med Chem, 5(6), 529 - 537.
Liapi A, Wood JN (2005). Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. European Journal of Neuroscience, 22(4), 825 - 834.
Stirling LC, Forlani G, Baker MD, Wood JN, Matthews EA, Dickenson AH, Nassar MA (2005). Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.. Pain, 113(1), 27 - 36.
Braz JM, Nassar MA, Wood JN, Basbaum AI (2005). Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron, 47(6), 771 - 772.
Maruyama H, Yamamoto M, Matsutomi T Z, T N, Y W, J N O, N (2005). Electrophysiological characterization of the tetrodotoxin-resistant Na(+) channel, Na(v)1.9, in mouse dorsal root ganglion neurons. Pfl�gers Archiv European Journal of Physiology, 449, 76 - 87.
Nassar MA, Levato A, Stirling LC, Wood JN (2005). Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8. Molecular Pain, 1(24), - .
Ahmadi KR, Weale ME, Xue ZYY, Soranzo N, Yarnall DP, Briley JD, Maruyama Y, Kobayashi M, Wood NW, Spurr NK, Burns DK, Roses AD, Saunders AM, Goldstein DB (2005). A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nature Genetics, 37(1), 84 - 89. doi:10.1038/ng1488

2004

Poon WY, Malik-Hall M, Wood JN, Okuse K (2004). Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11. FEBS Letters, 558, 114 - 118.
Drew LJ, Price MP, Wood J (2004). Recent advances in understanding molecular mechanisms of primary afferant activation. Gut, 53, 9 - 12.
Drew LJ, Price MP, Wood J (2004). Acid sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurons. The Journal of Physiology, 556(3), 691 - 710.
(2004). Introduction to the Journal of Neurobiology special issue on noiception. Journal of Neurobiology, 61(1), 1 - 2.
Wood JN, Boorman JP, Okuse K (2004). Voltage gted Sodium channels and pain pathways. Journal of Neurobiology, 61(1), 55 - 71. doi:10.1002/neu.20094
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew LJ, Nassar MA, Okuse K, Seereeram A, Stirling CL, Zhao J (2004). Ion channel activities implicated in pathological pain.. Novartis Found Symp, 261, 32 - 40.
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew L, Nassar MA, Okuse K, Seereeram A, Stirling LC, Zhao J (2004). Mechanisms of hyperalgesia: Regulation of nociceptor activation and excitability.
Wood JN (2004). Recent advances in understanding molecular mechanisms of primary afferent activation.. Gut, 53 Suppl 2, ii9 - i12.
Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN (2004). Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proceedings of the National Academy of Sciences of the United States of America, (101), 12706 - 12711. doi:10.1073/pnas.0404915101
Maruyama H, Yamamoto M, Wood J (2004). Electrophysical characterisation of the tetrodotoxin resistant Na+ channel Na(v)1.9. Pfl�gers Archiv European Journal of Physiology, 449(1), 76 - 87.

2003

Wood JN, Akopian AN (2003). . Issued patent for Nav1.8 as an analgesic drug target ,in US, Japan, Australia CT/GB96/01523P (Publication no WO97/01577) Now issued in US (US6451554).
Roza C, Laird JM, Souslova V, Wood JN, Cervero F (2003). The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. The Journal of Physiology, 550(3), 921 - 926.
Baker MD, Chandra SY, Ding Y, Waxman SG, Wood JN (2003). GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. The Journal of Physiology, 548(2), 373 - 382.
Malik-Hall M, Poon L, Baker M, Wood JN, Okuse K (2003). Sensory neuron proteins interact with the intracellular domains of sodium channel Nav1.8. Molecular Brain Research, 110(2), 298 - 304.
Malik-Hall M, Wood JN, Okuse K (2003). Voltage-gated sodium channels. In Moss SJ, Henley J (Ed.), Receptor and Ion Channel Traficking (pp. 3 - 28). : Oxford University Press.
Djouhri L, Fang X, Okuse K, Wood JN, Berry CM, Lawson S (2003). The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. The Journal of Physiology, 550(3), 739 - 752.
Weale ME, Depondt C, Macdonald SJ, Smith A, Lai PS, Shorvon SD, Wood NW, Goldstein DB (2003). Selection and evaluation of tagging SNPs in the neuronal sodium channel gene SCN1A: Implications for linkage disequilibrium gene mapping. The American Journal of Human Genetics, 73(3), 551 - 565. doi:10.1086/378098

2002

Wood JN, Akopian AN, Baker MD, Ding Y, Geoghegan F, Nassar M, Malik-Hall M, Okuse K, Poon L, Ravenall S, Sukumaran M, Souslova V (2002). Sodium channels in primary sensory neurons: relationship to pain states. , , - .
Malik-Hall M, Wood J, Okuse K, Henley J (2002). Voltage-gated Sodium channels in Receptor and Ion Channel Traficking. In (Ed.), (pp. 3 - 28). : Oxford University Press.
Laird JMA, Souslova V, Wood JN, Cervero F (2002). Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J NEUROSCI, 22(19), 8352 - 8356.
Drew L, Wood J, Cesare P (2002). Distinct mechanosensitive properties of capsaicin-sensitive and insensitive sensory neurons. Journal of Neuroscience, 22(12), - .
Okuse K, Malik-Hall M, Baker MD, Poon L, Kong H, Chao M, Wood J (2002). Annexin 2 light chain regulates sensory neuron-specific sodium channel expression. Nature, 417, 653 - 656. doi:10.1038/nature00781
Baker MD, Chandra SY, Wood JN (2002). Up-regulation of Na+ current attributed to Na(v)1.9 (NaN) changes firing properties of small diameter sensory neurones.
Ravenall S, Gavazzi I, Wood JN, Akopian AN (2002). A peripheral nervous system actin-binding protein regulates neurite outgrowth. European Journal of Neuroscience, 15(2), 281 - 290.

2001

Wood JN (2001). The primary nociceptor: special functions, special receptors. In Devor M (Ed.), (pp. 1 - 16). : IASP.
Dziadulewicz EK, Walpole CS, Snell CR, Wrigglesworth R, Hughes GA, Beattie D, Wood JN, Beech MM, Coote PR (2001). Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold. Bioorganic and Medicinal Chemistry Letters, 11(5), 705 - 709.
Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Netter YB, Noda M, Tamkun MM, Waxman SG, Wood JN, Catterall WA (2001). Nomenclature of voltage-gated sodium channels. Neuron, 28, 365 - 368.
Kerr BJ, Souslova V, McMahon SB, Wood JN (2001). A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. NeuroReport, 12(14), 3077 - 3080.
Wood JN, Baker MD (2001). Voltage-gated sodium channels. Current Opinion in Pharmacology, 1, 17 - 21.
Baker MD, Wood JN (2001). Involvement of sodium channels in pain pathways. Trends in Pharmacological Sciences, 22, 27 - 31.
Sukumaran M, Waxman SG, Wood JN, Pachnis V (2001). Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c-ret, directs lac Z (beta-galactosidase) expression in developing somatosensory system. Developmental Dynamics, 222(3), 389 - 402.
Wood JN (2001). Sodium channels in primary sensory neurons; relationship to pain states (in "Sodium Channels and neuronal excitability", eds.Waxman, S.G.). Novartis Foundation Symposium, 241, - .
Souslova V, Cesare P, Ding YN, Akoplan AN, Stanfa L, Suzuki R, Carpenter K, Nebenius-Oosthuizen D, Smith AJH, Kidd EJ, Wood JN (2001). Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X(3) (vol 407, pg 1015, 2000). NATURE, 409(6821), 743 - +.

2000

Wood JN, Akopian AN, Cesare P, Ding YN, Garcia R, Heath M, Liapi A, Malik-Hall M, Nassar M, Okuse K, Ravenall S, Rufian O, Souslova V, Sukumaran M (2000). The primary nociceptor: Special functions, special receptors.
Wood JN (2000). Genetic approaches to pain mechanisms. J PHYSIOL-LONDON, 526, 6S - 6S.
Wood JN (2000). Genetic approaches to pain therapy. American Journal of Physiology, 278, - .
Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB (2000). Potent analgesic effects of GDNF in neuropathic pain states. Science, 290, 124 - 127.
Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Netter YB, Noda M, Tamkun MM, Waxman SG, Wood JN, Caterall WA (2000). Nomenclature of voltage-gated sodium channels. Neuron, 28, 365 - 368.
Ding Y, Cesare P, Drew L, Nikitaki D, Wood JN (2000). ATP, P2X receptors and pain pathways. Journal of the Autonomic Nervous System, 81, 289 - 294.
Souslova V, Cesare P, Ding Y, Akopian AN, Stanfa L, Suzuki R, Carpenter K, Dickenson AH, Boyce S, Hill R, Nebenius-Oosthuizen D, Smith AH, Kidd EJ, Wood JN (2000). Warm coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature, 407, 1015 - 1017.
(2000). Molecular Basis of Pain Induction.
Wood JN (2000). Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. II. Genetic approaches to pain therapy.. Am J Physiol Gastrointest Liver Physiol, 278(4), G507 - G512.
Wood JN, Heath MJ (2000). Molecules that specify modality: mechanisms of nociception.. J Pain, 1(3 Suppl), 19 - 25.
Cesare P, Souslova V, Akopian A, Rufian O, Wood JN (2000). Fast inactivating responses to ATP are lost in dorsal root ganglion neurons isolated from P2X3 knock-out mice. J PHYSIOL-LONDON, 523, 10P - 11P.
Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, Waxman SG (2000). Novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type spinal sensory neurons. J PHYSIOL-LONDON, 523, 161P - 161P.
Wood JN (2000). Gene ablation studies of nociceptive neurons. J PHYSIOL-LONDON, 523, 10S - 10S.
Wood JN (2000). Molecular biology of nociceptor Na channels. BRIT J PHARMACOL, 129, - .
Akopian AN, Chen CC, Ding Y, Cesare P, Wood JN (2000). A new member of the acid-sensing ion channel family. NeuroReport, 11, 2217 - 2222.

1999

Waxman SG, Wood JN (1999). Sodium channels: from mechanisms to medicines?. Brain Research Bulletin, 50(5), 309 - 310.
Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure N, Smith A, Kerr BJ, Wood JN (1999). The tetrodotoxin-resistant sodium channel SNS plays a specialised role in pain pathways. Nature Neuroscience, 2, 541 - 548.
Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, Hill R, Stanfa LC, Dickenson AH, Wood JN (1999). The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nature Neuroscience, , 541 - 548.
Fitzgerald E, Okuse K, Dolphin A, Wood JN, Moss S (1999). Cyclic AMP-dependent phosphorylation of the Tetrodotoxin-resistant voltage-dependent sodium channel, SNS. The Journal of Physiology, 516, 433 - 446.
Akopian AN, Okuse K, Souslova V, England S, Ogata N, Wood JN (1999). Trans-splicing of a voltage-gated sodium channel is regulated by Nerve Growth Factor. FEBS Letters, 445(1), 177 - 182.
Wood JN, Perl ER (1999). Pain.. Curr Opin Genet Dev, 9(3), 328 - 332.
Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, Waxman SG (1999). A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensor neurons. Journal of Neuroscience, 19(24), - .
Wood JN, Perl ER (1999). Pain. CURR OPIN GENET DEV, 9(3), 328 - 332.
Fitzgerald EM, Okuse K, Wood JN, Dolphin AC, Moss SJ (1999). cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. The Journal of Physiology, 516(2), 433 - 446.
Wood JN, Perl ER (1999). The molecular basis of pain induction. Current Opinion in Genetics and Development, 9, 328 - 332.

1998

England S, Chen CC, Akopian AN, Wood JN (1998). Properties of a rat, sensory neurone-specific, proton-gated ion channel. J PHYSIOL-LONDON, 509P, 34P - 35P.
Georgiades P, Wood JN, Brickell PM (1998). RXR-gamma gene expression is developmentally regulated in the embryonic rodent peripheral nervous system. Anatomy and Embryology, 197, 477 - 484.
Chen CC, England S, Akopian AN, Wood JN (1998). A sensory neuron-specific proton-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America, 95, 10240 - 10245.

1997

Souslova V, Fox M, Wood JN, Akopian AN (1997). Cloning and characterisation of a Mouse Sensory Neuron Tetrodotoxin-resistant Voltage-Gated Sodium Channel Gene, Scn10a. Genomics, 41, 201 - 209.
Wood JN, Docherty RJ (1997). Chemical activation of sensory neurons. , , - .
Souslova V, Ravenall S, Fox M, Wells D, Wood JN, Akopian AN (1997). Structure and Chromosomal Mapping of The Mouse P2X3 Gene. Gene, 195(1), 101 - 111.
Sivilotti L, Okuse K, Akopian AN, Moss S, Wood JN (1997). A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channnel SNS. Federation of European Biochemical Societies Letters, 409(1), 49 - 52.
Kress M, Vyklicky L, Krylova O, Wood JN, Averbeck B, Reeh PW (1997). Non-steroidal anti-flammatory drugs block capsaicin-evoked ion fluxes. Nature Medicine, , - .
Akopian AN, Okuse K, Souslova V, England S, Sivilotti L, Wood JN (1997). Nerve Growth Factor induced trans-splicing of the SNS sodium channel. Molecular Cell, , - .
Okuse K, Akopian AN, Souslova V, Sivilotti L, Dolphin AC, Wood JN (1997). Sensory neuron voltage-gated sodium channels and nociception. In Borsook D (Ed.), Molecular Neurobiology of Pain (pp. 239 - 257). : IASP Press.
Krylova O, Chen CC, Akopian AN, Souslova V, Okuse K, Abson S, Ravenall S, Wood JN (1997). Ligand-gated ion channels of sensory neurons; from purines to peppers. , , - .
King B, Chen CC, Akopian AN, Burnstock G, Wood JN (1997). A role for calcineurin in the desensitization of the P2X₃ receptor. NeuroReport, 8, 1099 - 1102.
Akopian AN, Souslova V, Sivilotti L, Wood JN (1997). Structure and distribution of a broadly-expressed atypical sodium channel. Federation of European Biochemical Societies Letters, 400, 183 - 187.
Okuse K, Chaplan SR, McMahon S, Luo ZD, Calcutt NA, Scott BP, Akopian AN, Wood JN (1997). Regualtion of expression of the sensory neuron specific sodium channel SNS in inflammatory and neuropathic pain. MOL CELL NEUROSCIENCE, 10, 196 - 207.

1996

Begbie JL, Wood JN, Anderson PN, Latchman DS (1996). Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.. Neurosci Lett, 207(3), 183 - 186.
Burnstock G, Wood JN (1996). Purinergic receptors: their role in nociception and primary afferent neurotransmission.. Curr Opin Neurobiol, 6(4), 526 - 532.
Wood JN (1996). No pain, some gain. NAT GENET, 13(4), 382 - 383.
Akopian AN, Abson NC, Wood JN (1996). Molecular genetic approaches to nociceptor development and function. TRENDS NEUROSCI, 19(6), 240 - 246.
Akopian AN, Sivilotti L, Wood JN (1996). A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature, 379, 257 - 262.

1995

Kendall G, Brar-Rai A, Ensor E, Winter J, Wood JN, Latchman DS (1995). Nerve growth factor induces the Oct-2 transcription factor in sensory neurons with the kinetics of an immediate-early gene.. J Neurosci Res, 40(2), 169 - 176. doi:10.1002/jnr.490400205
Chen CC, Akopian AN, Sivilotti LG, Colquhoun D, Burnstock G, Wood JN (1995). A P2X purinoceptor expressed by a subset of sensory neurons. Nature, 377, 428 - 428. doi:10.1038/377428a0

1993

WOOD JN, COOTE PR, NINKINA NN, LATCHMAN DS (1993). NGF-REGULABLE OCT-2 ISOFORMS IN RAT DRG NEURONS DEFINED BY SPECIFIC ANTISERA. J CELL BIOCHEM, , 212 - 212.