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UCL Great Ormond Street Institute of Child Health

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Experimental and Personalised Medicine

Experimental medicine drives the translation of discoveries from basic science and clinical medicine into benefits for human health. The aim of experimental medicine is to identify mechanisms of pathophysiology or cause of disease and to demonstrate the validity and importance of new discoveries and treatments in patients. In a "From the bench to the bedside and back again" approach, the effective translation of results derived from experimental medicine will ultimately results in later phase clinical research and this in return will generate new hypotheses to be explored in the laboratory.

Personalised Medicine is the next generation of medicine and healthcare research with the potential to provide significant benefits to patients and effect strategic shifts in the way healthcare is delivered in the clinic. Personalised medicine uses an individual's genetic profile to guide decisions made in regard to the prevention, diagnosis, and treatment of a disease. Developing new diagnostic tests and expanding the use of biomarkers enabling the identification of the molecular cause of a disease will ultimately support the development of novel more precisely targeted treatments. It has been estimated that only 30-70% of patients respond positively to drugs. Stratifying in advance groups of patients who have a greater likelihood of responding to a particular therapy or avoiding adverse effects based on their unique genetic and environmental profiles is the aim of personalised (or stratified) medicine.

This section aims to blend together for the first time, experimental medicine with precision medicine approaches to deliver better, more targeted therapies to patients to ensure optimal responses.

Principal Investigators