Selected references to studies of PCA

Articles available to download

Crutch, S. J., Schott, J. M., Rabinovici, G. D., Boeve, B. F., Cappa, S. F., Dickerson, B. C., Dubois, B., et al. (2012). Shining a light on posterior cortical atrophy. Alzheimer’s & dementia : the journal of the Alzheimer's Association, 1–3. Download this paper as a PDF.

Golden H.L., Nicholas J.M., Yong K.X., Downey L.E., Schott J.M., Mummery C.J., Crutch S.J., Warren J.D. (2015). Auditory spatial processing in Alzheimer's disease. Brain, 138(1), 189-202. Download this paper as a PDF.

Sebastian J Crutch, Manja Lehmann, Jonathan M Schott, Gil D Rabinovici, Martin N Rossor, Nick C Fox. (2012). Posterior cortical atrophy. Lancet Neurology 2012;11:170-78. Download this paper as a PDF.

Shakespeare, T., Ryan, N. S., Petrushkin, H., & Crutch, S. J. (2012). Identifying cortical visual dysfunction in posterior cortical atrophy. Optometry in Practice, 13(4), 159–162. Download this paper as a PDF.

Shakespeare, T.J., Yong, K.X.X., Foxe, D., Hodges, J., Crutch, S.J. (2014). Pronounced Impairment of Everyday Skills and Self-Care in Posterior Cortical Atrophy. Epub ahead of print. Download this paper as a PDF.

Solomons, H. (2005). Vision and dementia: Ocular effects and examination, Optometry Today, 25-28. View PDF online

Yong K.X., Shakespeare T.J., Cash D., Henley S.M., Warren J.D., Crutch S.J. (2014). (Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. Cortex 57, 92-106. Download this paper as a PDF.

Yong K.X.X., Shakespeare T.J., Cash D., Henley S.M., Nicholas J.M., Ridgway G.R., Golden H.L., Warrington E.K., Carton A.M., Kaski D., Schott J.M., Warren J.D., Crutch S.J. (2014). Prominent effects and neural correlates of visual crowding in a neurodegenerative disease population. Brain, 137(12), 3284-99. Download this paper as a PDF.

2015

Golden H.L., Nicholas J.M., Yong K.X., Downey L.E., Schott J.M., Mummery C.J., Crutch S.J., Warren J.D. (2015). Auditory spatial processing in Alzheimer's disease. Brain, 138(1), 189-202. Download this paper as a PDF.

2014

Shakespeare, T.J., Yong, K.X.X., Foxe, D., Hodges, J., Crutch, S.J. (2014). Pronounced Impairment of Everyday Skills and Self-Care in Posterior Cortical Atrophy. Epub ahead of print. Download this paper as a PDF.

Yong K.X., Shakespeare T.J., Cash D., Henley S.M., Warren J.D., Crutch S.J. (2014). (Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. Cortex 57, 92-106. Download this paper as a PDF.

Yong K.X.X., Shakespeare T.J., Cash D., Henley S.M., Nicholas J.M., Ridgway G.R., Golden H.L., Warrington E.K., Carton A.M., Kaski D., Schott J.M., Warren J.D., Crutch S.J. (2014). Prominent effects and neural correlates of visual crowding in a neurodegenerative disease population. Brain, 137(12), 3284-99. Download this paper as a PDF.

2013

Crutch, S. J., Lehmann, M., Warren, J. D., & Rohrer, J. D. (2013). The language profile of posterior cortical atrophy. Journal of neurology, neurosurgery, and psychiatry, 84(4), 460–6. Pubmed PMID: 23138762

Everhart, D. E., Highsmith, J. M., & Davis, C. E. (2012). Posterior cortical atrophy: a case study of Benson’s syndrome that initially presented as anxiety disorder. Applied neuropsychology. Adult, 19(3), 229–36. Pubmed PMID: 23373609.

Lehmann, M., Ghosh, P. M., Madison, C., Laforce, R., Corbetta-Rastelli, C., Weiner, M. W., Greicius, M. D., et al. (2013). Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease. Brain : a journal of neurology, 136(Pt 3), 844–58. Pubmed PMID: 23358601.

Ruis, C., Van den Berg, E., Van Zandvoort, M. J. E., Boshuisen, K., & Frijns, C. J. M. (2012). Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report. Applied neuropsychology. Adult, 19(2), 153–7. Pubmed PMID: 23373584

Witoonpanich, P., Omar, R., Ryan, N., Shakespeare, T., Yong, K., Crutch, S. J., Rossor, M., et al. (2012). Olfactory function in posterior cortical atrophy. Alzheimer’s & Dementia, 8(4), P553. PubMed PMID: 23435114.

Yong, KX, Warren, JD, Warrington, EK, Crutch, SJ. Intact reading in patients with profound early visual dysfunction. Cortex. Epub ahead of print. Pubmed PMID: 23578749.

2012

Sebastian J Crutch, Manja Lehmann, Jonathan M Schott, Gil D Rabinovici, Martin N Rossor, Nick C Fox. Posterior cortical atrophy. Lancet Neurology 2012;11:170-78. Download this paper as a PDF.

Andrade K, Kas A, Valabrègue R, Samri D, Sarazin M, Habert MO, Dubois B, Bartolomeo P. Visuospatial deficits in posterior cortical atrophy: structural and functional correlates. J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):860-3. Epub 2012 May 29. PubMed PMID: 22645257.

Dorothée G, Bottlaender M, Moukari E, de Souza LC, Maroy R, Corlier F, Colliot O, Chupin M, Lamari F, Lehéricy S, Dubois B, Sarazin M, Aucouturier P. Distinct Patterns of Antiamyloid-β Antibodies in Typical and Atypical Alzheimer DiseaseDistinct Patterns of Anti-Aβ Antibodies and AD. Arch Neurol. 2012 Jun 18:1-5. doi: 10.1001/archneurol.2012.604. [Epub ahead of print] PubMed PMID: 22710357.

Kennedy J, Lehmann M, Sokolska MJ, Archer H, Warrington EK, Fox NC, Crutch SJ. Visualizing the emergence of posterior cortical atrophy. Neurocase. 2012 Jun;18(3):248-57. Epub 2011 Oct 25. PubMed PMID: 22026812.

Andrade K, Kas A, Samri D, Sarazin M, Dubois B, Habert MO, Bartolomeo P. Visuospatial deficits and hemispheric perfusion asymmetries in posterior cortical atrophy. Cortex. 2012 Mar 23. [Epub ahead of print] PubMed PMID: 22513341.

Lehmann M, Barnes J, Ridgway GR, Ryan NS, Warrington EK, Crutch SJ, Fox NC. Global gray matter changes in posterior cortical atrophy: A serial imaging study. Alzheimers Dement. 2012 Feb 23. [Epub ahead of print] PubMed PMID: 22365384.

Migliaccio R, Agosta F, Scola E, Magnani G, Cappa SF, Pagani E, Canu E, Comi G, Falini A, Gorno-Tempini ML, Bartolomeo P, Filippi M. Ventral and dorsal visual streams in posterior cortical atrophy: A DT MRI study. Neurobiol Aging. 2012 Jan 23. [Epub ahead of print] PubMed PMID: 22277261.

2011

Pelak VS, Smyth SF, Boyer PJ, Filley CM. Computerized visual field defects in posterior cortical atrophy. Neurology. 2011 Dec 13;77(24):2119-22. Epub 2011 Nov 30. PubMed PMID: 22131540.

Koedam EL, Lehmann M, van der Flier WM, Scheltens P, Pijnenburg YA, Fox N, Barkhof F, Wattjes MP. Visual assessment of posterior atrophy development of a MRI rating scale. Eur Radiol. 2011 Dec;21(12):2618-25. Epub 2011 Jul 31. PubMed PMID: 21805370; PubMed Central PMCID: PMC3217148.

Formaglio M, Costes N, Seguin J, Tholance Y, Le Bars D, Roullet-Solignac I, Mercier B, Krolak-Salmon P, Vighetto A. In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings. J Neurol. 2011 Oct;258(10):1841-51. Epub 2011 Apr 10. PubMed PMID: 21479849.

Lehmann M, Barnes J, Ridgway GR, Wattam-Bell J, Warrington EK, Fox NC, Crutch SJ. Basic visual function and cortical thickness patterns in posterior cortical atrophy. Cereb Cortex. 2011 Sep;21(9):2122-32. Epub 2011 Feb 10. PubMed PMID: 21310781.

Lehmann M, Crutch SJ, Ridgway GR, Ridha BH, Barnes J, Warrington EK, Rossor MN, Fox NC. Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease. Neurobiol Aging. 2011 Aug;32(8):1466-76. Epub 2009 Sep 25. PubMed PMID: 19781814.

de Souza LC, Corlier F, Habert MO, Uspenskaya O, Maroy R, Lamari F, Chupin M, Lehéricy S, Colliot O, Hahn-Barma V, Samri D, Dubois B, Bottlaender M, Sarazin M. Similar amyloid-β burden in posterior cortical atrophy and Alzheimer's disease. Brain. 2011 Jul;134(Pt 7):2036-43. PubMed PMID: 21705422.

Seguin J, Formaglio M, Perret-Liaudet A, Quadrio I, Tholance Y, Rouaud O, Thomas-Anterion C, Croisile B, Mollion H, Moreaud O, Salzmann M, Dorey A, Bataillard M, Coste MH, Vighetto A, Krolak-Salmon P. CSF biomarkers in posterior cortical atrophy. Neurology. 2011 May 24;76(21):1782-8. Epub 2011 Apr 27. PubMed PMID: 21525425.

Rosenbloom MH, Alkalay A, Agarwal N, Baker SL, O'Neil JP, Janabi M, Yen IV, Growdon M, Jang J, Madison C, Mormino EC, Rosen HJ, Gorno-Tempini ML, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD. Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution. Neurology. 2011 May 24;76(21):1789-96. Epub 2011 Apr 27. PubMed PMID: 21525424; PubMed Central PMCID: PMC3100124.

Kas A, de Souza LC, Samri D, Bartolomeo P, Lacomblez L, Kalafat M, Migliaccio R, Thiebaut de Schotten M, Cohen L, Dubois B, Habert MO, Sarazin M. Neural correlates of cognitive impairment in posterior cortical atrophy. Brain. 2011 May;134(Pt 5):1464-78. Epub 2011 Apr 7. PubMed PMID: 21478188.

2010

Crutch SJ, Lehmann M, Gorgoraptis N, Kaski D, Ryan N, Husain M, Warrington EK. Abnormal visual phenomena in posterior cortical atrophy. Neurocase 2010; 2:1-18.

Roca M, Gleichgerrcht E, Torralva T, Manes F. Cognitive rehabilitation in posterior cortical atrophy. Neuropsychological Rehabilitation 2010. 20(4):528-540.

2009

Crutch SJ, Warrington EK. The relationship between visual crowding and letter confusability: towards an understanding of dyslexia in posterior cortical atrophy. Journal of Cognitive Neuropsychology 2009; 26(5):471-498.

Duning T, Warnecke T, Mohammadi S et al. Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging. Journal of Neurology, Neurosurgery and Psychiatry 2009; 80: 432-436.

Lehmann M, Crutch SJ, Ridgway GR et al. Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease. Neurobiology of Aging 2009. doi:10.1016/j.neurobiolaging.2009.08.017.

Neiberg MN. Optometric perspective of Alzheimer’s Disease. J Behav Optom 2009; 20:3-6.

2008

Tenovuo O, Kemppainen N, Aalto S et al. Posterior Cortical Atrophy: A Rare Form of Dementia with in vivo Evidence of Amyloid-beta Accumulation. Journal of Alzheimers Disease 2008; 15: 351-355.

2007

Alladi S, Xuereb J, Bak T, Nestor P, Knibb J, Patterson K, Hodges JR. Focal cortical presentations of Alzheimer's disease. Brain 2007; 130: 2636-2645.

Crutch SJ, Warrington EK. Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading. Cognitive Neuropsychology 2007; 24: 843-866.

Snowden JS, Stopford CL, Julien CL et al. Cognitive phenotypes in Alzheimer's disease and genetic risk. Cortex 2007; 43: 835-845.

Stopford CL, Snowden JS, Thompson JC, Neary D. Distinct memory profiles in Alzheimer's disease. Cortex 2007; 43: 846-857.

Whitwell JL, Jack CR, Kantarci K et al. Imaging correlates of posterior cortical atrophy. Neurobiology of Aging 2007; 28: 1051-1061.

2006

Josephs KA, Whitwell JL, Boeve BF et al. Visual hallucinations in posterior cortical atrophy. Archives of Neurology 2006; 63: 1427-1432.

McMonagle P, Deering F, Berliner Y, Kertesz A. The cognitive profile of posterior cortical atrophy. Neurology 2006; 66: 331-338.

Schott JM, Ridha BH, Crutch SJ et al. Apolipoprotein E genotype modifies the phenotype of Alzheimer disease. Archives of Neurology 2006; 63: 155-156.

Tang-Wai D, Mapstone M. What are we seeing? Is posterior cortical atrophy just Alzheimer disease? Neurology 2006; 66: 300-301.

2005

Charles RF, Hillis AE. Posterior cortical atrophy: clinical presentation and cognitive deficits compared to Alzheimer's disease. Behavioral Neurology 2005; 16: 15-23.

Solomons, H. (2005). Vision and dementia: Ocular effects and examination,Optometry Today, 25-28. View PDF online

2004

Lee AG, Martin CO. Neuro-ophthalmic Findings in the Visual Variant of Alzheimer’s Disease. Ophthalmology 2004;111(2):376-380.

Renner JA, Burns JM, Hou CE et al. Progressive posterior cortical dysfunction: a clinicopathologic series. Neurology 2004; 63: 1175-1180.

Tang-Wai DF, Graff-Radford NR, Boeve BF et al. Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology 2004; 63: 1168-1174.

Yoshida T, Shiga K, Yoshikawa K et al. White matter loss in the splenium of the corpus callosum in a case of posterior cortical atrophy: A diffusion tensor imaging study. European Neurology 2004; 52: 77-81.

2003

Nestor PJ, Caine D, Fryer TD et al. The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET. Journal of Neurology, Neurosurgery and Psychiatry 2003; 74: 1521-1529.

Tang-Wai DF, Josephs KA, Boeve BF et al. Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease". Journal of Neurology, Neurosurgery and Psychiatry 2003; 74: 389.

Tang-Wai DF, Josephs KA, Boeve BF et al. Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. Neurology 2003; 61: 1134-1135.

2002

Mendez MF, Ghajarania M, Perryman KM. Posterior cortical atrophy: Clinical characteristics and differences compared to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 2002; 14: 33-40.

2001

Chan D, Crutch SJ, Warrington EK. A disorder of colour perception associated with abnormal colour after-images: a defect of the primary visual cortex. Journal of Neurology, Neurosurgery and Psychiatry 2001; 71: 515-517.

Goethals M, Santens P. Posterior cortical atrophy. Two case reports and a review of the literature. Clinical Neurology and Neurosurgery 2001; 103: 115-119.

2000

Galton CJ, Patterson K, Xuereb JH, Hodges JR. Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain 2000; 123: 484-498.

1999

Aharon-Peretz J, Israel O, Goldsher D, Peretz A. Posterior cortical atrophy variants of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 1999; 10: 483-487.

1997

Hof PR, Vogt BA, Bouras C, Morrison JH. Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways. Vision Research 1997; 37: 3609-3625.

Stark ME, Grafman J, Fertig E. A restricted 'spotlight' of attention in visual object recognition. Neuropsychologia 1997; 35: 1233-1249.

1996

Della Sala S, Spinnler H, Trivelli C. Slowly progressive impairment of spatial exploration and visual perception. Neurocase 1996; 2: 299-323.

Pietrini P, Furey ML, Graff-Radford N et al. Preferential metabolic involvement of visual cortical areas in a subtype of Alzheimer's disease: Clinical implications. American Journal of Psychiatry 1996; 153: 1261-1268.

Ross SJ, Graham N, Stuart Green L et al. Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 1996; 61: 388-395.

1994

Victoroff J, Ross GW, Benson DF et al. Posterior Cortical Atrophy - Neuropathologic Correlations. Archives of Neurology 1994; 51: 269-274.

1993

Levine DN, Lee JM, Fisher CM. The visual variant of Alzheimer's disease: a clinicopathologic case study. Neurology 1993; 43: 305-313.

1991

Freedman L, Selchen DH, Black SE et al. Posterior cortical dementia with alexia: neurobehavioural, MRI, and PET findings. Journal of Neurology, Neurosurgery and Psychiatry 1991; 54: 443-448.

1990

Hof PR, Bouras C, Constantinidis J, Morrison JH. Selective disconnection of specific visual association pathways in cases of Alzheimer's disease presenting with Balint's syndrome. Journal of Neuropathology and Experimental Neurology 1990; 49: 168-184.

1989

Hof PR, Bouras C, Constantinidis J, Morrison JH. Balint's syndrome in Alzheimer's disease: specific disruption of the occipito-parietal visual pathway. Brain Research 1989; 493: 368-375.

1988

Benson F, Davis J, Snyder BD. Posterior Cortical atrophy. Archives of Neurology 1988; 45: 789-793.

1986

De Renzi E. Slowly progressive visual agnosia or apraxia without dementia. Cortex 1986; 22: 171-180.

1985

Cogan DG. Visual Disturbances with Focal Progressive Dementing Disease. American Journal of Ophthalmology 1985; 100: 68-72.