UCL Cancer Institute Seminar Series

Dr Parinello and her team are interested in understanding how cell-cell communication within the stem cell microenvironment controls their biology in health and disease, with an emphasis on tissue repair and cancer. The group focus on two regenerative processes: peripheral nerve repair and adult neurogenesis in the subventricular zone of the brain. Our research approach combines cell biology, imaging, siRNA screens, deep sequencing and biochemistry techniques in primary co-cultures and in vivo models. By understanding the cellular and molecular mechanisms that regulate stem cell identity and function, we ultimately hope to identify novel therapeutic strategies for enhancing endogenous regeneration for the treatment of nervous system pathology.

Hosted by: Professor Tariq Enver

The seminar will be followed by a sandwich buffet lunch

Selected Publications

Ottone C., Krusche B., Whitby A., Clements M., Quadrato G., Pitulescu M.E., Adams R.H. and Parrinello S. (2014). Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nature Cell Biology, doi:10.1038/ncb3045, published online 05 October 2014.

Parrinello, S., Napoli, I., Ribeiro, S., Digby, P. W. W., Fedorova, M., Parkinson, D. B., Doddrell, R. D., Nakayama, M., Adams, R. H., & Lloyd, A. C. (2010). EphB signaling directs peripheral nerve regeneration through sox2-dependent schwann cell sorting. Cell, 143(1), 145–155.

Parrinello, S., & Lloyd, A. C. (2009). Neurofibroma development in NF1–insights into tumour initiation. Trends in Cell Biology, 19(8), 395–403.

For further information, view csc.mrc.ac.uk/research-group/cell-interactions-and-cancer

Location

Courtyard Café
UCL Cancer Institute
Paul O'Gorman Building
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.uk

This seminar has been part-sponsored by Merck, the Biomedical Research Centre and Cancer Research UK

Image: Wellcome Images, brain cancer stem cells. 

Image credit: Stephen Pollard