Mark Swindells teaching on the antibodies workshop
Course Lectures
An introduction to the natural role of antibodies in the adaptive immune response
An introduction to the genetics of antibody diversity and class switching
A detailed view of antibody structure and structural variability
An explanation of why antibodies make good lab reagents, diagnostics and drugs
How antibodies are used as drugs
The problems of using antibodies as in vivo drugs (size and immunogenicity) and routes to solve these (chimerics, humanization and 'fully human' antibodies).
New developments in antibody formats
Examples of the production and use of antibodies as therapeutics
Methods to model the structure of antibodies and how these differ from normal comparative homology modelling
An introduction to intellectual property (and patents in particular) and how this applies to antibody-based drugs
An analysis of biopharmaceutical court cases related to infringement and equivalence, sufficiency, novelty, inventive step and industrial application
Course Workshops
Course workshops will offer hands-on experience in:
Exploring the abYsis database and workbench
Analysing antibody sequences
Standard numbering of antibody sequences
Understanding antibody structure
Exploration of unusual sequence features and mapping these to structure
Opportunities
Discussions and Q&A sessions - an opportunity for you to ask questions and for the lecturers to help you with your particular needs.
A reception party on the first evening - opportunities to network
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