Three month PhD rotation

The calcium channel α2δ-1 subunit is involved in neuropathic pain, and is also the target of the drug gabapentin

We wish to investigate further the properties of this subunit, which we have recently found is a GPI-anchored protein.

 

Two projects are offered.

 

1.Calcium imaging and immunocytochemistry

Are there differences in calcium handling between neurons from wild type and α2δ-1 knockout mice

 

2 Biochemistry/molecular biology/imaging

Expression of wild-type and mutated α2δ-1 subunits in neurons to examine their role in trafficking