The calcium channel α2δ-1 subunit is involved in neuropathic pain, and is also the target of the drug gabapentin
We wish to
investigate further the properties of this subunit, which we have recently
found is a GPI-anchored protein.
Two projects are offered.
1.Calcium imaging and immunocytochemistry
Are there differences in calcium handling between neurons from wild type and α2δ-1 knockout mice
2 Biochemistry/molecular biology/imaging
Expression of wild-type and mutated α2δ-1 subunits in neurons to examine their role in trafficking