Recent papers
Nieto-Rostro M, Sandhu G, Bauer CS, Jiruska P, Jefferys JGR and Dolphin AC. (2014) Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. Neuroscience 14: 00219-X (in press).
Ferron L, Nieto-Rostro M, Cassidy JS and Dolphin AC (2014) Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density (2014) Nature Communications 5:3628, 1-14 PDF
Alvarez-Laviada A, Kadurin I, Senatore A, Chiesa R and Dolphin AC (2014) The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways. Biochemical Journal 458: 365-374.
Lana B, Schlick B, Martin S, Pratt WS, Page KM, Goncalves L, Rahman W, Dickenson AH, Bauer CS, Dolphin AC. (2014) Differential up-regulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury. Pain 155: 522-533. PDF
Azizan EAB, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Davenport A, Dekkers T, Tops B, Küsters B, Ceral J, Yeo G, Neogi S, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ. (2013) Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nature Genetics (doi: 10.1038/ng.2716).
Kadurin I, Alvarez-Laviada A, Ng SF, Walker-Gray R, D'Arco M, Fadel, MG, Pratt, WS and Dolphin AC. (2012) Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J Biol Chem. 287: 33554-33566. PDF
Hendrich J, Bauer CS and Dolphin AC. (2012) Chronic pregabalin inhibits synaptic transmission between dorsal root ganglion and dorsal horn neurons Channels 6: 1-9 PDF
Senatore A, Colleoni S, Verderio C, Restelli,E, Morini R, Condliffe SB, Bertani I, Mantovani S, , Canovi M, Micotti E, Forloni G, Dolphin AC, Matteoli M, Gobbi M, and Chiesa R. (2012) Mutant prion protein suppresses glutamatergic neurotrasmission in cerebellar granule neurons by impairing membrane delivery of voltage-gated calcium channel a2d-1 subunit. Neuron 74: 300-313.
Hoppa MB, Lana B, Margas, W. Dolphin AC & Ryan TA (2012) α2δ couples calcium channels to neurotransmitter release sites to control release probability. Nature 486: 122-125.
Bannister K, Sikander S, Bauer C.S., Dolphin A.C., Porreca F, Dickenson A.H. (2011) Pregabalin suppresses Spinal Neuronal Hyperexcitability and Visceral Hypersensitivity in the Absence of Peripheral Pathophysiology. Anesthesiology. 115: 144-52.
Waithe D, Ferron L Page KM, Chaggar K and Dolphin AC. (2011) β-subunits promote the expression of CaV2.2 channels by reducing their proteasomal degradation J Biol Chem 286: 9598–9611. PDF
Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC. and Shah, M M. (2011) Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses. Nature Neuroscience 14:478-486
Tran-Van-Minh A and Dolphin AC. (2010) The α2δ ligand gabapentin inhibits the trafficking of the calcium channel subunit α2δ-2 from Rab11-associated recycling endosomes. J Neuroscience 30:12856 –12867 PDF
Davies A, Kadurin I, Alvarez-Laviada A, Douglas L, Bauer CS, Nieto-Rostro M, Pratt, WS and Dolphin AC (2010) The α2δ subunits of voltage-gated calcium channels form functional GPI-anchored proteins Proc Natl Acad Sci U S A 107:1654-1659 PDF SI
Page KM, Heblich F, Margas W, Pratt WS, Nieto-Rostro, Chaggar K, Sandhu, K, Davies A and Dolphin AC (2010). The N-terminus is key to dominant-negative suppression of CaV2 calcium channels: implications for episodic ataxia-2. J. Biol. Chem. 285: 835–844. PDF Supplementary
Walsh C, Davies A, Nieto-Rostro M, Dolphin AC and Kitmitto A.(2009) Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel. Channels 3: 387-92.
Rahman W, Bauer CS, Bannister K, Vonsy J-L, Dolphin AC and Dickenson AH. (2009) Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Molecular Pain 5: 45.
Walsh C, Davies A, Butcher AJ, Dolphin AC and Kitmitto A. (2009) 3D structure of CaV3.1 - comparison with the cardiac L-type voltage-gated calcium channel monomer architecture Journal of Biological Chemistry 284: 22310-2.
Bauer CS, Nieto-Rostro M, Rahmin W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin, I, Sri Ranjan Y, Fernandez-Alacid L, Millar NS, Dickenson AH, Lujan R and Dolphin AC (2009) The increased trafficking of the calcium channel subunit α2δ -1 to presynaptic terminals in neuropathic pain is inhibited by the α2δ ligand pregabalin. J Neuroscience 29:4076–4088. PDF
Dryssvyannikov A, Page KM, Leroy J, Pratt WS and Dolphin AC. (2009) Determinants of the voltage-dependence of G protein modulation within calcium channel β subunits Pflugers European Journal of Physiology 457:743-56 PDF
Ferron L, Page KM, Davies A, Cox DJ, Leroy J, Waithe D, Butcher AJ, Sellaturay P, Bolsover S, Pratt, WS, Moss FJ and Dolphin AC. (2008) The stargazin-related protein g7 interacts with mRNA binding proteins and regulates the expression and stability of specific mRNAs including CaV2.2. Journal of Neuroscience 28: 10604-10617 PDF
Alix JP, Dolphin AC and Fern R. (2008) Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. Journal of Physiology. 586:4069-4089. PDF
Heblich F, Tran Van Minh A, Hendrich J, Watschinger K and Dolphin AC. (2008) Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin. Channels 2: 4-9. PDF
Hendrich J, Tran Van Minh A, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A and Dolphin AC (2008) Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin. Proc Natl Acad Sci U S A. 105: 3628–3633. PDF
Richards MW, Leroy J, Pratt WS and Dolphin AC. (2007) The HOOK-Domain Between the SH3 and the GK Domains of CaVβ Subunits Contains key Determinants Controlling Calcium Channel Inactivation. Channels 1: 92-101. PDF
Donato R, Page KM, Koch D, Nieto-Rostro M, Foucault I, Davies A, Wilkinson T, Rees M, Edwards FA and Dolphin AC. (2006) The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. Journal of Neuroscience 26:12576-12586. PDF
Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su T-Z, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T and Williams D. (2006) Identification of the α2δ-1 subunit of voltage dependent calcium channels as a novel molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A. 103: 17537-17542. PDF
Davies A, Douglas L, Hendrich, J, Wratten J, Tran-Van-Minh, A, Nieto-Rostro M, Pratt, WS, Saibil, HR and Dolphin AC. (2006) The calcium channel α2δ-2 subunit partitions with CaV2.1 into lipid rafts: implications for function and localization. Journal of Neuroscience 26:8748-8757. PDF
Butcher AJ, Leroy J, Richards MW, Pratt WS and Dolphin AC. (2006) The importance of occupancy rather than affinity of CaVβ subunits for the calcium channel I-II linker in relation to calcium channel function. Journal of Physiology 574: 387-398. PDF
Leroy, J, Butcher, AJ, Richards, M, Davies, A, Nieto-Rostro, M, Pratt, W and Dolphin, AC (2005) Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties Journal of Neuroscience 25:6984-96. PDF
Canti C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards MW, Hendrich J, Douglas L, Page KM, Davies A, Dolphin AC (2005) The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels. Proc Natl Acad Sci U S A. 102: 11230-11235. PDF PDF supporting information
Viard, P., Butcher, A., Halet, G., Davies, A., Nürnberg, B., Heblich F. and Dolphin, A.C. (2004) PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane Nature Neuroscience 7: 939-946. PDF
Page, K.M., Heblich, F., Davies, A. Butcher, A., Bertaso, F., Leroy, J., Pratt, W.S. and Dolphin, A.C. (2004) Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response Journal of Neuroscience 24: 5400-5409 PDF.
Wang, M-C, Collins, R., Ford, R.C., Berrow N. S., Dolphin, A.C and Kitmitto, A. (2004) The 3D structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif J. Biol Chem. 279: 7159-7168. PDF.
Canti, C. and Dolphin, A.C. (2003). CaVβ-subunit-mediated up-regulation of CaV2.2 currents triggered by D2 dopamine receptor activation. Neuropharmacology 45: 814-827. PDF
Moss, F.J., Dolphin, A.C. and Clare, J.J. (2003) Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes BMC Neuroscience 4: 23 PDF.
Bertaso, F., Ward, R.J., Viard, P., Milligan, G. and Dolphin, A.C. (2003) Mechanism of action of Gq to inhibit Gβg modulation of CaV2.2 calcium channels: probed by the use of receptor-Gα tandems Molecular Pharmacology 63: 832-843 PDF
Wang, M-C., Velarde, G., Ford, R.C., Berrow, N.S., Dolphin, A.C. and Kitmitto, A. (2002) 3D-structure of the skeletal muscle dihydropyridine receptor. J. Mol Biol 323: 85 –98. PDF
Moss, F.J., Viard, P., Davies, A., Bertaso, F., Page, K. M. Graham, A., Cantí, C., Plumpton, M., Plumpton, C., Clare, J. J. and Dolphin A. C. (2002) The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. EMBO Journal 21: 1514-1523. PDF
Brodbeck, J., Davies, A. Balaguero, N., Courtney, J.-M., Canti, C., Meir, A. Moss, F., Page, K. M.., Pratt, W.S., Hunt, S. P., Barclay, J., Rees, M. and Dolphin, A.C. (2002) The ducky mouse mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated a2d-2 protein with abnormal function J. Biol Chem. 277: 7684-7693 PDF
Meir, A. and Dolphin, A.C. (2002) Kinetics and Gβγ modulation of CaV2.2 channels with different auxiliary β subunits Pflügers Archiv 21: 1514-1523 PDF
Raghib, A., Bertaso, F., Davies A., Page K. M., Meir A. Bogdanov, Y. and Dolphin A. C. (2001) Dominant negative synthesis suppression of voltage-gated calcium channel CaV2.2 induced by truncated constructs Journal of Neuroscience 21: 8495 – 8504 PDF
Cantí, C., Davies A, Berrow, N.S., Butcher, A.J., Page K. M and Dolphin, A.C.(2001) Evidence for two concentration-dependent processes for b subunit effects on a1B calcium channels Biophysical Journal 81: 1439-1451 PDF
Barclay, J. Balaguero, N., Mione, M. Ackerman, S.L., Letts, V.A. Canti, C., Brodbeck, J., Meir, A., Page, K.M., Kusumi, K., Perez-Reyes, E. Lander, E.S., Frankel, W.N., Gardiner, R.M., Dolphin, A.C. and Rees, M. (2001) Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. Journal of Neuroscience 21: 6095 -6104 PDF
Scholze, A. Plant, T.D. Dolphin, A.C. and Nürnberg, B. (2001) Functional expression and characterization of a voltage-gated CaV1.3 (a1D) calcium channel subunit from an insulin-secreting cell line Molecular Endocrinology 15: 1211 - 1221 PDF
Bell, D. C., A.J. Butcher, N.S. Berrow, K.M. Page, P.F. Brust, A. Nesterova, K.A. Stauderman, G.R. Seabrook, B. Nürnberg, and A.C. Dolphin. (2001) Biophysical properties, pharmacology and modulation of human, neuronal L-type (a1D, CaV1.3) voltage-dependent calcium currents. Journal of Neurophysiology 85: 816-828 PDF
Canti, C., Bogdanov, Y. and Dolphin, A.C. (2000) Interaction between G proteins and accessory b subunits in the regulation of a1B calcium channels in Xenopus oocytes. Journal of Physiology 527: 419-432 PDF
Stephens, G.J.; Page, K.M.; Bogdanov, Y.; Dolphin, A.C. (2000) The a1B calcium channel amino terminus contributes determinants for b subunit mediated voltage-dependent inactivation properties. Journal of Physiology 525: 377-390. PDF
Meir, A., Bell, D. C., Stephens, G. J., Page, K. M. and Dolphin, A. C. (2000) Calcium channel b subunit promotes voltage-dependent inhibition of a1B by Gbg. Biophysical Journal 79: 731-746 PDF
Bogdanov, Y., Brice, N. L., Canti, C., Page, K. M., Li, M., Volsen S. G. and Dolphin A. C. (2000) Acidic motif responsible for plasma membrane association of the voltage-dependent calcium channel b1b subunit. European Journal of Neuroscience 12: 894-902 PDF
Canti, C., Page, K.M., Stephens, G.J. and Dolphin, A.C. (1999) Identification of residues in the N terminus of a1B critical for inhibition of the voltage-dependent calcium channel by Gbg. Journal of Neuroscience 19: 6855-6864 PDF
Dolphin, A.C., Wyatt, C.N., Richards, J., Beattie, R.E., Craig, P., Lee, J.-H., Cribbs, L.L., Volsen, S.G. and Perez-Reyes, E. (1999) The effect of a2-d and other accessory subunits on expression and properties of the calcium channel a1G. Journal of Physiology 519: 35-45 PDF
Brice, N. L. & Dolphin, A. C. (1999). Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarised cell line. Journal of Physiology 515: 685-694. PDF
Fitzgerald, E. M., Okuse, K., Wood, J. N., Dolphin, A. C. & Moss, S. J. (1999). Cyclic AMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. Journal of Physiology 516: 433-446 PDF
Hanlon, M. R., Berrow, N. S., Dolphin, A. C. & Wallace, B. A. (1999). Modelling of a voltage-dependent Ca2+ channel b subunit as a basis for understanding its functional properties. FEBS Letters. 445: 366-370. PDF
Page, K. M., Canti, C., Stephens, G.J. and Dolphin, A.C. (1998) Identification of the amino terminal of neuronal Ca2+ channel a1 subunits, a1B and a1E, as an essential determinant of G protein modulation Journal of Neuroscience 18: 4815-4824 PDF
Stephens, G.J., Canti, C., Page, K. M. and A.C. Dolphin (1998) Role of domain I in G protein mediated inhibition of calcium channels Journal of Physiology 509: 163-169. PDF
Wyatt CN, Page KM, Berrow NS, Brice NL, Dolphin AC (1998) The effect overexpression of auxiliary calcium channel subunits on native Ca2+ channel currents in undifferentiated NG108-15 cells. Journal of Physiology 510: 347-360 PDF
Allen, T.J., G. Mikala, X-P. Wu and A.C. Dolphin (1998) Effects of 2,3-butanedione monoxime on calcium channels expressed in Xenopus oocytes Journal of Physiology 508: 1-14
Stephens GJ, Brice NL, Berrow NS, Dolphin AC (1998) Facilitation of rabbit a1B calcium channels: involvement of endogenous Gbgamma subunits. Journal of Physiology 509: 15-27 PDF
Meir A, Dolphin AC (1998) Known calcium channel a1 subunits can form low threshold, small conductance channels, with similarities to native T type channels. Neuron 20: 341-351 PDF
Berrow NS, Brice NL, Tedder I, Page K, Dolphin AC (1997) Properties of cloned rat a1A calcium channels transiently expressed in the COS-7 cell line. European Journal of Neuroscience 9: 739-748
Brice NL, Berrow NS, Campbell V, Page KM, Brickley K, Tedder I, Dolphin AC (1997) Importance of the different b subunits in the membrane expression of the a1A and a2 calcium channel subunits: studies using a depolarisation-sensitive a1A antibody. European Journal of Neuroscience 9:749-759
Page KM, Stephens GJ, Berrow NS, Dolphin AC (1997) The intracellular loop between domains I and II of the B type calcium channel confers aspects of G protein sensitivity to the E type calcium channel. Journal of Neuroscience 17:1330-1338. PDF
Recent reviews
Dolphin AC (2012) Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond. Nature Reviews Neuroscience 13 542-555. PDF
Dolphin AC (2010) Age of quantitative proteomics hits voltage-gated calcium channels Proc Natl Acad Sci USA 107: 14941-2. (Commentary).
Bauer CS, Tran Van Minh A, Kadurin I and Dolphin AC (2010) A new look at calcium channel α2δ subunits. Current Opinion in Neurobiology 20:563-71.
Dolphin AC. (2009) Calcium channel diversity: multiple roles of calcium channel subunits. Current Opinion in Neurobiology 19:237-44
Davies A, Hendrich J, Van Minh AT, Wratten J, Douglas L, Dolphin AC (2007) Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels. Trends Pharmacol Sci 28: 220-228.
Dolphin, AC. (2006) A short history of voltage-gated calcium channels. Br J Pharmacol. 147 Suppl 1:S56-62. PDF
Richards MW, Butcher AJ and Dolphin AC (2004) Calcium channel β subunits: structural insights AID our understanding Trends in Pharmacological Sciences 25: 626-632. PDF
Wang MC, Dolphin A, Kitmitto A.(2004) L-type voltage-gated calcium channels: understanding function through structure. FEBS Lett. 564: 245-50. PDF
Dolphin A.C. (2003) G protein modulation of voltage-gated calcium channels Pharmacological Reviews 55: 607-627. PDF
Dolphin, A.C. (2003) Beta subunits of voltage-dependent calcium channels. Journal of Bioenergetics and Biomembranes. 35: 599-620 Calcium channel review issue 35: 599-620. PDF
Canti, C., Davies, A. and Dolphin, A.C. (2003) Calcium channel α2δ subunits: structure, functions and target site for drugs. (Gabapentin review issue) Current Neuropharmacology 1: 209-217. PDF
Dolphin AC (1998) Mechanisms of modulation of voltage-dependent calcium channels by G proteins. Journal of Physiology 506:3-11. PDF
Correspondence on Gender equality in science
Dolphin AC (2006) Gender: missing the prizes that can inspire a career Nature 442 868. PDF
Dolphin AC (2007) The gender issue Biochemist June pp5-7 PDF