RESEARCH TEAM

Andrea Colli (PI) *

Adult cardiac surgery

Gaetano Burriesci  (Co-Investigator)

Design, development and qualification

Paolo Peruzzo (Research Associate) *

Design and assessment

Francesca M Susin (Collaborator) *

Fluid Mechanics

* University of Padua, Italy

FUNDED BY:

Transcatheter aortic valve replacement (TAVR) procedures represent the treatment of choice for high risk patients. Despite evolving technologies TAVR present commonly paravalvular regurgitation. This severe complication significantly impair long-term survival.

The aim of this proposed project is the development and pre-clinical assessment of a novel device suitable for the post-implant sealing of transcatheter valves, based on an original design concept developed in a collaboration between UCL and the University of Padua, Italy. The device will be positionable percutaneously into the detected gaps between the prosthetic valve and the surrounding tissues, resulting in their occlusion and substantial reduction of paravalvular leakage.  The prosthetic component is being assessed in terms of safety and efficacy by numerical and experimental in vitro and in vivo models.  The device has the potential to make a striking impact on the medium and long-term efficacy of transcatheter valve implantation, and on the expansion of the benefits of this treatment to lower risk patients.

MAIN RELATED PUBLICATIONS

Peruzzo, P., Colli, A., Burriesci, G, Susin, F.M. (2014) Sviluppo di un occlusore innovativo per l’abbattimento del leakage paravalvolare. XXXIV Convegno Nazionale di Idraulica e Costruzioni Idrauliche. Bari, Italy.

Endovascular Device

to Occlude Paravalvular Leakage

improving the efficacy of transcatheter valve implantation

by reducing paravalvular leakage