Selected Publications

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Copeland, CS, TM Wall, RE Sims, SA Neale, E Nisenbaum, HR Parri, TE Salt (2017). Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation. Neuropharmacology 121: 100-110.

Fazio F, Lionetto L, Curto M, Iacovelli L, Copeland CS, Neale SA, Bruno V, Battaglia G, Salt TE, Nicoletti F (2017) Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors. Neuropharmacology, 112: 365-372.

Salt, TE and CS Copeland (2017). Metabotropic Glutamate Receptor Function in Thalamocortical Circuitry. In mGLU Receptors. R. T. Ngomba, G. Di Giovanni, G. Battaglia and F. Nicoletti (eds). Cham, Springer International Publishing: 149-159.

Sathyasaikumar, KV, M Tararina, HQ Wu, SA Neale, F Weisz, TE Salt and R Schwarcz (2017). Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. Neuroscience 367: 85-97.

Weinrich, TW, A Coyne, TE Salt, C Hogg and G Jeffery (2017). Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster. Neurobiology of Aging 60: 34-43.

Chavda S, Luthert PJ, Salt TE  (2016) P2X7R modulation of visually evoked synaptic responses in the retina. Purinergic Signaling 12: 611-625.

Powner MB, Salt TE, Hogg C, Jeffery G (2016) Improving Mitochondrial Function Protects Bumblebees from Neonicotinoid Pesticides. PLoS One. 11(11):e0166531. doi: 10.1371/journal.pone.0166531.

Begum R, Calaza K, Kam JH, Salt TE, Hogg C, Jeffery G (2015) Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster. Biology Letters.  doi: 10.1098/rsbl.2015.0073.

Copeland CS, Neale SA, Salt TE (2015) Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology, 92: 16-24.

Jones HE, Andolina IM, Shipp SD, Adams DL, Cudeiro J, Salt TE, Sillito AM (2015) Figure-ground modulation in awake primate thalamus. Proc Natl Acad Sci (USA), 112: 7085-7090.

Salt TE, Jones HE, Copeland CS, Sillito AM (2014) Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus. Neuropharmacology, 79: 405-411.

Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH (2014) Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Experimental Eye Research 127C: 270-279.

Salt TE, Nizari S, Cordeiro MF,  Russ H, Danysz W (2014) Effect of the Aβ aggregation modulator MRZ-99030 on retinal damage in an animal model of glaucoma. Neurotox Research 26: 440-446.

Liu M, Guo L, Salt TE, Cordeiro MF (2014) Dendritic changes in rat visual pathway associated with experimental ocular hypertension. Current Eye Research, 39: 953-963.

Georgiou AL, Guo L, Cordeiro MF, Salt TE (2014) Electroretinogram and Visual-Evoked Potential Assessment of Retinal and Central Visual Function in a Rat Ocular Hypertension Model of Glaucoma. Current Eye Research, 39: 472-486.

Jones HE, Andolina IM, Grieve KL, Wang W, Salt TE, Cudeiro J, Sillito AM (2013) Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT. Neuroscience, 246:254-264.

Kalinichev M, Rouillier M, Girard F, Royer-Urios I, Bournique B, Finn T, Charvin D, Campo B, Le Poul E, Mutel V, Poli S, Neale SA, Salt TE,  Lütjens R (2013) ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 344: 624-636.

Neale SA, Copeland CS, Uebele VN, Thomson FJ, Salt TE (2013) Modulation of Hippocampal Synaptic Transmission by the Kynurenine Pathway Member Xanthurenic Acid and Other VGLUT Inhibitors. Neuropsychopharmacology, 38:1060-1067.

Copeland CS, Neale SA, Salt TE (2013) Actions of Xanthurenic Acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology, 66: 133-142.

Georgiou AL, Guo L, Cordeiro MF, Salt TE (2012) Changes in the modulation of retinocollicular transmission through group III mGluRs long after an increase in intraocular pressure in a rat model of glaucoma. Visual Neuroscience, 29: 237-246.

Copeland CS, Neale SA, Salt TE (2012) Positive allosteric modulation reveals a specific role for mGlu2 receptors in sensory processing in the thalamus. Journal of Physiology, 590:937-951.

Salt TE, Jones HE, Andolina IM, Copeland CS, Clements JT, Knoflach F, Sillito AM (2012) Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator. Neuropharmacology, 62:1695-1699.

Jones HE, Andolina IM, Ahmed B, Shipp SD, Clements JT, Grieve KL, Cudeiro J, Salt TE, Sillito AM (2012) Differential feedback modulation of center and surround mechanisms in parvocellular cells in the visual thalamus. Journal of Neuroscience, 32:15946-51.

Ngomba RT, Santolini I, Salt TE, Ferraguti F, Battaglia G, Nicoletti F, van Luijtelaar G (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52:1211-1222.

Liu M, Duggan J, Salt TE, Cordeiro MF (2011) Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions. Experimental Eye Research, 92:244-250.

Georgiou AL, Guo L, Cordeiro MF, Salt TE (2010) Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma. Neurobiology of Disease, 39:344-351.

Cordeiro MF, Guo L, Coxon KM, Duggan J, Nizari S, Normando EM, Sensi SL, Sillito AM, Fitzke FW, Salt TE, Moss SE (2010) Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo. Cell Death and Disease 1, e3; doi:10.1038/cddis.2009.3.

Maione S, Cristino L, Migliozzi AL, Georgiou AL, Starowicz K, Salt TE, Di Marzo V (2009) TRPV1 channels control synaptic plasticity in the developing superior colliculus. Journal of Physiology, 587:2521-2535.

Guo L, Salt TE, Luong V, Wood N, Cheung W, Maass A, Ferrari G, Russo-Marie F, Sillito AM, Cheetham ME, Moss SE, Fitzke FW, Cordeiro MF (2007) Targeting amyloid-beta in glaucoma treatment. Proc Natl Acad Sci (USA),104(33):13444-9.

Neale SA, Salt TE (2006) Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor. Journal of Physiology, 577:659-669.

MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, Swaroop A, Sowden JC, Ali RR (2006) Retinal repair by transplantation of photoreceptor precursors. Nature, 444:203-207.

Wang W, Jones HE, Andolina IM, Salt TE, Sillito AM (2006) Functional alignment of feedback effects from visual cortex to thalamus. Nature Neuroscience, 9:1330-1336.

Guo L, Salt TE, Maass A, Luong V, Moss SE, Fitzke FW, Cordeiro MF (2006) Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Investigative Ophthalmolology & Visual Science, 47:626-633.

Salt TE, Cordeiro MF (2006) Glutamate excitotoxicity in glaucoma: throwing the baby out with the bathwater?Eye, 20:730-731.

Turner JP, Sauve Y, Varela-Rodriguez C, Lund RD, Salt TE (2005) Recruitment of local excitatory circuits in the superior colliculus following deafferentation and the regeneration of retinocollicular inputs. European Journal of Neuroscience, 22:1643-1654.

Lacey CJ, Pothecary CA, Salt TE (2005) Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development. Neuropharmacology, 49:26-34.

Pothecary CA, Thompson H, Salt TE (2005) Changes in glutamate receptor function in synaptic input to the superficial superior colliculus with aging and retinal degeneration in the Royal College of Surgeons (RCS) rat. Neurobiology of Aging, 26:965-972.

Thompson H, Neale SA, Salt TE (2004) Activation of Group II and Group III metabotropic glutamate receptors by endogenous ligand(s) and the modulation of synaptic transmission in the supercial superior colliculus. Neuropharmacology, 47:822-832.

Mize RR, Salt TE (2004) Contribution of GABAergic inhibition to synaptic responses and LTD early in postnatal development in the rat superior colliculus. European Journal of Neuroscience 20:1331-1340.

Schlichtenbrede FC, Smith AJ, Bainbridge JW, Thrasher AJ, Salt TE, Ali RR (2004) Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy. Molecular & Cellular Neuroscience 25:103-110.

Do KQ, Benz B, Binns KE, Eaton SA, Salt TE (2004) Release of homocysteic acid from rat thalamus following stimulation of somatosensory afferents in vivo: feasibility of glial participation in synaptic transmission. Neuroscience 124:387-93.

Turner JP, Salt TE (2003) Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro. Neuroscience 122:459-469.

Binns KE, Turner JP, Salt TE (2003) Kainate receptor (GluR5)-mediated disinhibition of responses in rat ventrobasal thalamus allows a novel sensory processing mechanism. Journal of Physiology 551:525-537.

Salt TE (2002) Glutamate receptor functions in sensory relay in the thalamus. Philosophical Transactions of The Royal Society B 357: 1759-1766.

Pothecary CA, Jane DE, Salt TE (2002) Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG. Neuropharmacology 43: 231-234.

Do KQ, Grima G, Benz B, Salt TE (2002) Glial-Neuronal Transfer of Arginine and S-Nitrosothiols in Nitric Oxide Transmission. Ann NY Acad Sci 962: 81-92.

Cirone J, Pothecary CA, Turner JP, Salt TE (2002) Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat. Journal of Physiology 541:895-903.

Cirone J, Sharp C, Jeffery G, Salt TE (2002) Distribution of metabotropic glutamate receptors in the superior colliculus of the adult rat, ferret and cat. Neuroscience 109:779-786.

Salt TE (2001) Metabotropic glutamate (mGlu) receptors and nociceptive processing. Drug Development Research, 54:129-139.

Spooren WPJM; Gasparini F; Salt TE; Kuhn R; (2001) Novel allosteric antagonists shed light on mGluR5 receptors and CNS disorders. Trends in Pharmacological Sciences, 22: 331-337.

Cirone J; Salt TE; (2001) Group II and III metabotropic glutamate (mGlu) receptors contribute to different aspects of visual response processing in the superior colliculus. Journal of Physiology, 534: 169-178.

Binns KE; Salt TE; (2001) Actions of the systemically active metabotropic glutamate antagonist MPEP on sensory responses of thalamic neurones.  Neuropharmacology, 40: 639-644.

Salt TE; Zhang H; Mayer B; Benz B; Binns KE; Do KQ; (2000) Novel mode of nitric oxide neurotransmission mediated via S-nitroso-cysteinyl-glycine. European Journal of Neuroscience, 12: 3919-3925.

Turner JP; Salt TE; (2000) Synaptic activation of the Group I metabotropic glutamate receptor mGlu1 on the thalamocortical neurons of the rat dorsal lateral geniculate nucleus in vitro. Neuroscience, 100: 495-507.

Salt TE; Binns KE; (2000) Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-D-aspartate  receptor-mediated responses and nociceptive sensory responses of rat thalamic neurones.  Neuroscience, 100: 375-380.

Binns KE; Salt TE; (2000) The functional influence of nicotinic cholinergic receptors on the visual responses of neurones in the superficial superior colliculus. Visual Neuroscience, 17: 283-289.

Cirone J; Salt TE; (2000) Physiological role of group III metabotropic glutamate receptors in visually responsive neurons of the rat superficial superior colliculus. European Journal of Neuroscience, 12: 847-855.

Turner JP; Salt TE; (1999) Group III metabotropic glutamate receptors control corticothalamic synaptic transmission in the rat thalamus in vitro. Journal of Physiology, 519: 481-491.

Salt TE; Turner JP; Kingston AE; (1999) Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo. Neuropharmacology, 38: 1505-1510.

Salt TE; Binns KE; Turner JP; Gasparini F; Kuhn R; ( 1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. British Journal of Pharmacology, 127: 1057-1059.

Shaw PJ; Charles SL; Salt TE; (1999) Actions of 8-Bromo-cyclic-GMP on neurones in the rat thalamus in vivo and in vitro. Brain Research, 833: 272-277

Binns KE; Turner JP;Salt TE; (1999) Visual experience alters the molecular profile of NMDA-receptor-mediated sensory transmission. European Journal of Neuroscience, 11: 1101 -1104

Binns KE; Salt TE; (1998) Experience-dependent changes in the importance of N-methyl-D- aspartate (NMDA) receptors for visual transmission in superior colliculus. Developmental Brain Research, 110: 241-248

Turner JP; Salt TE; (1998) Characterization of sensory and corticothalamic excitatory inputs to rat thalamocortical neurones in vitro. Journal of Physiology, 510: 829-843

Salt TE; Turner JP; (1998) Modulation of sensory inhibition in the ventrobasal thalamus via activation of Group II metabotropic glutamate receptors (mGluRs) by 2R,4R-APDC. Experimental Brain Research, 121: 181-185

Salt TE; Turner JP; (1998) Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel mGluR1-selective antagonist S-2-methyl-4-carboxy-phenylglycine (LY367385). Neuroscience, 85:655-658

Binns KE; Salt TE; (1998) Developmental changes in NMDA receptor mediated visual activity in the rat superior colliculus. Experimental Brain Research, 120: 335-344

Binns KE; Salt TE; (1997) Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus. Journal of Physiology, 504: 629-639

Shaw PJ; Salt TE; (1997) Modulation of sensory and excitatory amino acid responses by nitric oxide donors and glutathione in the ventrobasal thalamus of the rat.European Journal of Neuroscience, 9: 1507-1513

Binns KE; Salt TE; (1997) Post eye-opening maturation of visual receptive field diameters in the superior colliculus of normal- and dark-reared rats. Developmental Brain Research, 99: 263-266.

Jeffery G; Sharp C; Malitschek B; Salt TE; Kuhn R; Knopfel T; (1996) Cellular localisation of metabotropic glutamate receptors in the mammalian optic nerve: A mechanism for axon-glia communication. Brain Research, 741: 75-81.

Salt TE; Eaton SA; Turner JP; (1996) Characterisation of the metabotropic glutamate receptors (mGluRs) which modulate GABA-mediated inhibition in the ventrobasal thalamus. Neurochemistry International, 29: 317-322.

Do KQ; Benz B; Grima G; GutteckAmsler U; Kluge I; Salt TE; (1996) Nitric oxide precursor arginine and S-nitrosoglutathione in synaptic and glial function. Neurochemistry International, 29: 213-224.

Binns KE; Salt TE; (1996) Corticofugal influences on visual responses in cat superior colliculus: The role of NMDA receptors. Visual Neuroscience, 13:683-694.

Eaton SA; Salt TE; (1996) Role of NMDA and metabotropic glutamate receptors in cortico-thalamic excitatory post-synaptic potentials in vivo. Neuroscience, 73:1-5.

Salt TE; Eaton SA; (1996) Functions of ionotropic and metabotropic glutamate receptors in sensory transmission in the mammalian thalamus. Progress in Neurobiology, 48:55-72.

Binns KE; Salt TE; (1996) The importance of NMDA receptors for multi-modal integration in the deep layers of the cat superior colliculus. Journal of Neurophysiology, 75:920-930.

Salt TE; Eaton SA; (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65:5-13.

Salt TE; Eaton SA; (1995) Modulation of sensory neurone excitatory and inhibitory responses in the ventrobasal thalamus by activation of metabotropic excitatory amino acid receptors. Neuropharmacology 34: 1043-1051.

Salt TE; Meier CL; Seno N; Krucker T; Herrling PL; (1995) Thalamo-cortical and cortico-cortical excitatory postsynaptic potentials mediated by excitatory amino acid receptors in the cat motor cortex in vivo. Neuroscience 64:433-442.

Binns KE; Salt TE; (1995) Excitatory amino acid receptors modulate habituation of the response to visual stimulation in the cat superior colliculus. Visual Neuroscience 12:563-571.

Binns KE; Salt TE; (1994) Excitatory amino acid receptors participate in synaptic transmission of visual responses in the superficial layers of the cat superior colliculus. European Journal of Neuroscience 6: 161-169.

Do KQ; Binns KE; Salt TE; (1994) Release of the nitric oxide precursor, arginine, from the thalamus upon sensory afferent stimulation, and its effect on thalamic neurons in vivo. Neuroscience 60: 581-586.

Salt TE; Eaton SA; (1994) The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: studies with novel phenylglycine antagonists. Neurochemistry International 24:451-458.

Eaton SA; Birse EF; Wharton B; Sunter DC; Udvarhelyi PM; Watkins JC;Salt TE; (1993) Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors. European Journal of Neuroscience 5: 186-189.

Roberts WA; Eaton SA; Salt TE; (1992) Widely distributed GABA-mediated afferent inhibition processes within the ventrobasal thalamus of rat and their possible relevance to pathological pain states and somatotopic plasticity. Experimental Brain Research 89:363-372.  

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