Copyright © 2000, Institute for Scientific Information Inc.
(1) TI: Green tea and leukoplakia
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AU: Vaidya_SG, Balentine_D, Blot_W, Bhonsle_RB, Chung_FL,
Chigurupati_K, Gupta_PC, Harris_D, Huvos_AG, Naik_UD, Shah_JP,
Shaha_AR, Vaidya_NS, Vaidya_JS, Yang_CS, Yu_GP, Schantz_SP
JN: AMERICAN JOURNAL OF SURGERY, 1997, Vol.174, No.5, pp.552-555
AB: BACKGROUND: A feasibility chemoprevention trial of green tea
and oral leukoplakia has been conducted. The purpose is to
demonstrate the success and pitfalls of conducting such a
population-based trial within Indian rural villages.
METHODS: Two dosages of green tea were utilized: 3.6 g per day
and 5.4 g per day. Compliance was measured using tea package
counts and by measuring the blood concentration of the active
anticancer compound in green tea, (-)-epigallo-catechin-3-
gallate (EGCG).
RESULTS: Following a 3-year planning period, 13 villages were
visited, and 1,203 tobacco users were interviewed in order to
identify 64 participants suitable for trial inclusion. Of the
subsequently 28 consenting individuals entered, 23 remained on
protocol for the entire 6-month duration, Overall compliance
was excellent, with participants consuming approximately 80% of
prescribed packets.
CONCLUSIONS: These results provide a basis for continuing
international collaborative efforts in conducting population-
based chemoprevention trials against head and neck cancer. (C)
1997 by Excerpta Medics, Inc.