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Simon Kolstoe B.Sc. B.A. M.A. Ph.D.

I have recently moved from University College London to take up a tenure-tracked position at the University of Portsmouth.
Please click here to see my new departmental webpage.

Research Publications:

Mikolajek, H., Kolstoe, S.E., Pye, V., Mangione, P.P., Pepys, M.B. and Wood, S.P. (2011) Structural Basis of Ligand Specificity in the Human Pentraxins, C-reactive Protein and Serum Amyloid P component. J. Mol. Recognit. 24:371-377

Kolstoe, S.E.,
Mangione, P.P., Bellotti, V., Taylor, G.W., Tennent, G.A, Deroo, S., Morrison, A.J., Cobb, A.J.A., Coyne, A., McCammon, M.G., Warner, T.D., Mitchell, J., Gill, R, Smith, M.D., Ley, S.V., Robinson, C.V., Wood, S.P. and Pepys, M.B. (2010) Trapping of Novel Palindromic Ligands within Native Transthyretin prevents Amyloid Formation. Proc. Natl. Acad. Sci. USA 107(47):20483-8

Kolstoe, S.E., Basil R., Bellotti, V., Wang, N. Robinson, C., Crutch, S., Keir, G., Kukkastenvehmas, R., Gallimore, J., Hutchinson, W., Hawkins, P., Wood, S., Rossor, M., Pepys, M. (2009) Molecular dissection of Alzheimer disease neuropathology by depletion of serum amyloid P component. Proc. Natl. Acad. Sci. USA, 106(18):7619-23

Gill, R., Kolstoe, S.E., Mohammed, F., D-Bass, A.A., Cooper, J.B., Wood, S.P. and Shoolingin-Jordan, P.M. (2009) The structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria. Biochem. J. 420(1):17-25

Pepys, M.B., Hirschfield, G.M., Tennent, G.A., Gallimore, R.J., Kahan, M.C., Bellotti, V., Hawkins, P.N., Myers, R.M., Smith, M.D., Polara, A., Cobb, A., Ley, S.V., Aquilina, A., Robinson, C., Sharif, I., Gray, G.A., Sabin, C.A., Jenvey, M.C., Kolstoe, S.E., Thompson, D. and Wood, S.P. (2006) Targeting C-reactive protein for treatment of cardiovascular disease Nature 440:1217-1221.


Kolstoe, S.E. (2005) Ligand Binding to Pentraxins. Ph.D. Thesis, University of Southampton.

Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S.E., Wood, S.P. and Hawkins, P.N. (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417:254-25

Invited Publications:

Kolstoe, S.E. (2011) BOOK REVIEW - Debating Darwin. Two debates: Is Darwinism true and does it matter? Science and Christian Belief 23(1):83-84

Kolstoe S. and Wood S.P. (2010) Serum Amyloid P component. Chapter 26, Protein Misfolding Disease: Current and emerging Principles and Therapies ed. M. Ramirez-Alvarado, J. Kelly and C. Dobson, John Wiley & Sons Inc., New Jersey.

Kolstoe, S.E. and Wood, S.P. (2010) Drug Targets for Amyloidosis. Biochem. Soc. T. 38(2):466-470

Kolstoe S.E., Morrison, A.J., Cobb, A.J.A., Coyne A., Gill, R., Smith, M.D., Ley, S.V., Wood, S.P. and Pepys, M.B.(2010) Targeting transthyretin - X-ray crystallography and rational drug design. Amyloid 17(S1):102.

Kolstoe S.E. (2010) BOOK REVIEW - Evolutionary Creation: A Christian approach to Evolution by Denis O. Lamoureux. Science and Christian Belief 22(1):97-98

Kolstoe, S.E. and Wood S.P. (2004) Perspectives for Drug Intervention in Amyloid Disease. Current Drug Targets 5(2):151-158.


Pepys Mark; Ley Steven Victor; Morrison Angus John; Bellotti Vittorio; Wood Stephen; Kolstoe Simon; Smith Martin (2009-04-02) Compound and Use thereof in the treatment of Amyloidosis. Patent number: WO2009040405 (A1)

Acknowledgements in other publications:

Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB. (2010) Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature 468(7320):93-7

Pal, M. (2010) Protein mis-folding and human disease. Ph.D. Thesis, University of Southampton.

Ruckerl, R. (2010) Determinants of the acute phase protein CRP in myocardial infarction survivors: The role of co-morbidities and environmental factors, S. Roderer Verlag, Regensburg.

Gardnera, Q.A., Younasa, H., Rashida, N., Wright, J.N. and Akhtara, M. (2009) Inventory of ‘slow exchanging’ hydrogen atoms in human proinsulin and its derivatives: Observations on the mass spectrometric analysis of deuterio-proteins in D2O. Biochemica et Biophysica Acta (BBA) 1794(8):1224-33

Mikolajek, H. (2008) Ligand Binding to Pentraxins. Ph.D. Thesis, University of Southampton.

Casas J.P., Shah T., Hingorani A.D., Danesh J., Pepys M.B. (2008) C-reactive protein and coronary heart disease: a critical review. J Intern Med. 264(4):295-314.

Jenvey, M.C. (2008) Structure led drug design for the pentraxins. Ph.D. Thesis, University of Southampton.

PDB depositions:



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