Drug Discovery
The Drug Discovery Group
Prof. David Selwood
PI: Medicinal Chemistry
Prof. Edith Chan
PI: Computational Drug Design
Dr Valeria Pingitore
Postdoc Fellow
Mr Zuhair Elgaid
PhD Student
Ms Anastasia Patsiarika
PhD Student
Ms Clara Gathmann
Joint PhD Student
Ms Kate Morling
PhD Student
Ms Weitong Cynthia Wang
PhD Student
Mr Mateusz Kaczynski
PhD Student
Mr Oliver Scott
PhD Student
Select publications
- Hurley, MJ, Deacon RMJ, Chan AWE, Baker D, Selwood DL & Cogram P (2022). Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice. Brain. Vol. 145(1): 76-82.
- Radin DP, Caponegro M, Smith G, Moushiaveshi V, Selwood D & Tsirka S (2022). Studies on the function of myeloid-derived Neuropilin-1 in glioma: a focus on tumour hypoxia. FASEB Journal, Vol. 36(51).
- Scott OB, Gu J & Chan AWE (2022). Classification of Protein-Binding Sites Using a Spherical Convolutional Neural Network. Journal of Chemical Information and Modeling. J Chem Inf Model. Vol. 62(22): 5383-5396.
- Selwood DL, Mota F, Yelland T, Hutton JA, Parker J, et al. (2021). Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1. ChemBioChem.
- Gregson A, Thompson K, Tsirka SE & Selwood DL (2019). Emerging small-molecule treatments for multiple sclerosis: focus on B cells. F1000Res, 8.
- Briggs LC, Chan AWE, Davis CA ... Selwood DL, Collins MK, Barrett TE (2017). IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection. J Virol. Vol. 91(23). pii: e01170-17.
- Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI ... Selwood DL (2017). Big conductance calcium-activated potassium channel openers control spasticity without sedation. Br J Pharmacol. Vol. 174(16): 2662-2681.
- Prak K, Kriston-Vizi J, Chan AW, Luft C, Costa JR, Pengo N, Ketteler R. Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members. Biochemistry. Vol. 55(3): 608-17.
- Warne J, Pryce G, Hill JM, Shi X ... Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL (2016). Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis. J Biol Chem. Vol. 291(9): 4356-73.
- Miyauchi JT, Chen D, Choi M, Nissen JC, Shroyer KR, Djordevic S, Zachary IC, Selwood D, Tsirka SE (2016). Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression. Oncotarget. Vol. 7(9): 9801-14.
- Browne L, Lidster K, Al-Izki S, Clutterbuck L, Posada C, Chan AW, Riddall D, Garthwaite J, Baker D, Selwood DL (2014). Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis. J Med Chem. Vol. 57(7): 2942-52. Erratum in: J Med Chem. Vol. 58(8): 3637.
Al-Izki S, Pryce G, Hankey DJ, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C, Chan AWE ... Selwood DL, Baker D (2014). Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis. Brain. 137(Pt 1): 92-108.
Moyes AJ, Khambata RS, Villar I, Bubb KJ ... Selwood DL, Ahluwalia A, Hobbs AJ (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest. Vol. 124(9): 4039-51.
Aldeghi M, Malhotra S, Selwood DL, Chan AW (2014). Two- and three-dimensional rings in drugs. Chem Biol Drug Des. Vol. 83(4): 450-61.
Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL et al. (2013). HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature. Vol. 503(7476): 402-405.
Chan AW, Laskowski RA, Selwood DL (2010). Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites. J Med Chem. Vol. 53(8): 3086-94.
Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL (2007). Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells. Nat Methods. Vol. 4(2):153-9.
Funding and Partnerships
Related programmes
Contact Details
David Selwood | Edith Chan
Wolfson Institute for Biomedical Research
The Cruciform Building
University College London
Gower Street
London WC1E 6BT