Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.

Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials


Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).

Drosophila fly model - University of Sheffield

Genetic mutations linked to Parkinson's disease

Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...

Miratul Muqit

(Wellcome Trust Clinician Scientist)

Miratul Muqit

Miratul Muqit graduated MB, ChB (Hons) from the University of Edinburgh (1991-97). He is a former Kennedy Scholar of Harvard University (2000-01) where he undertook postdoctoral studies in Mel Feany’s laboratory making Drosophila models of human neurodegenerative disease. He undertook his PhD as a MRC Clinical Training Fellow at University College London (2001-2004) jointly supervised by David Latchman and Nicholas Wood, where he studied two genes associated with early-onset Parkinson’s disease, parkin (a ubiquitin ligase) and PTEN-induced kinase 1 (PINK1).

In parallel he has trained as a clinical neurologist. He completed general medical training at the Hammersmith Hospital and hospitals affiliated to Imperial College. He then trained as a neurologist at several London hospitals including King’s College Hospital and the National Hospital for Neurology and Neurosurgery at Queen Square. He trained in movement disorders with Andrew Lees and Khailash Bhatia at the National Hospital.

In 2008 he was awarded a Wellcome Trust Intermediate Clinical Fellowship sponsored by Dario Alessi at the MRC Protein Phosphorylation Unit to investigate the molecular signaling pathways of the Parkinson’s disease associated kinases, PINK1 and LRRK2.

Contact details

Lab website

Link to publications

Page last modified on 20 mar 13 17:12