CANCELLED: UK DRI at UCL Seminar: Felipe Aedo-Jury

The decision has been made to cancel this seminar to reduce the transmission risk of the coronavirus disease (COVID-19).  Apologies to all those that wished to attend.

Spatio-temporal dynamics of cortical slow wave activity in health and disease unveiled by optical methods and fast line fMRI scanning.

Slow-oscillation-associated slow wave state (SWS) represents a default cortical state occurring for e.g. during deep sleep and anesthesia. It is characterized by the generation of traveling waves of neuronal activity1,2. These waves are impaired in neurodegenerative diseases such as Alzheimer’s disease3. Therefore, translational neuroscience requires to characterize the spatiotemporal properties of the SWS to better understand functional cortical network architecture and neuronal excitability in health and disease. In this talk, I will show how combining optical methods with non-invasive fast line fMRI scanning in anesthetized rodents, we can interrogate the spatio-temporal dynamics of persistent and slow wave states. Finally, I hypothesize how we can adapt these experimental protocols to use fMRI as non-invasive tool in the early detection of neurological conditions.