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The articles in this blog will focus on the main barriers to translational research and how to overcome these.

Early Career Innovators: A Biologics Therapeutic Target for Huntington’s Disease, Biologics TIN

In the second interview as part of the new Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks, Dr Anais Cassaignau highlights her Biologics TIN Pilot Data Fund awarded project “Developing an scFv binder against nascent huntingtin” and presents some advice for future applicants.

Please provide an overview of your Biologics project.

Early Career Innovators: Treating Diabetes with a Function-Blocking Antibody, Biologics TIN

In the first interview as part of the new Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks, Dr Giulia De Rossi highlights her Biologics TIN Pilot Data Fund awarded project “LRG1 antibody for diabetic macular oedema” and presents some advice for future applicants.

Please provide an overview of your Biologics project. 

The Development of Gene Therapy for Infantile Neuroaxonal Dystrophy

Dr Ahad Rahim is an Associate Professor of Translational Neuroscience and Associate Director of Research at the UCL School of Pharmacy. Dr Rahim’s group works on the development of novel therapies for neurodegenerative diseases and recently at the end of 2019, received an MRC DPFS grant of £654,904 to develop gene therapy for infantile neuroaxonal dystrophy (INAD).

Please provide an overview of infantile neuroaxonal dystrophy (INAD) and the need to develop a new therapy.

How to get millions in support of your funding bid

Written by Terry Emery and Linda von Neree

You may be thinking £’s, $’s or even €’s? We’re thinking people – although one may very well lead to the other.

In rough statistics there are:

Using Immersive Virtual Reality to Increase levels of Self-Compassion in Patients with Depression

Dr John King and Professor Chris Brewin have recently gained an NIHR i4i Mental Health Challenge Award (an award to develop an innovative technological solution to which will improve the care pathway and outcomes of patients experiencing mental ill-health) for their translational research project, “Treating depression with self-compassion in virtual reality”. In this interview, they discuss the motivation behind their work and provide an overview of the project which they will be starting this autumn.

Early Small Molecule Research: Following Industry Standards to Advance Drug Discovery

Motivated by an unmet medical need, you’ve identified a mechanism that may play a fundamental role in a medical condition that is currently poorly treated. You want to look at possible drug molecules that could modulate the mechanism to see how it might affect this condition – but how do you take this from an idea to a promising starting point for a new drug treatment?

Breaking Down Barriers in Translational Research

Welcome to the UCL Translational Research Office (TRO) Blog!

The articles in this blog will focus on the main challenges in or barriers to translational research – and how to overcome these in order to achieve successful translation into benefits for patients.

We will also be talking to some of the PI’s working on translational projects with the support of the UCL TRO, to demonstrate the scope of translational work taking place at University College London.

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