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Next Journal Club - 20th March

Nat Ageing 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Julio Aguado, Alberto A Amarilla, Atefeh Taherian Fard, Eduardo A Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman K Chaggar, Naphak Modhiran, Cecilia Gómez-Inclán, Ibrahim Javed, Alireza A Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, Pranesh Padmanabhan, Morgan E Freney, Rhys Parry, Julian D J Sng, Ariel Isaacs, Alexander A Khromykh, Guillermo Valenzuela Nieto, Alejandro Rojas-Fernandez, Thomas P Davis, Marco Prinz, Bertram Bengsch, Vadim N Gladyshev, Trent M Woodruff, Jessica C Mar, Daniel Watterson, Ernst J Wolvetang

 

Previous weeks Papers

Nat Commun 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1 Yanxia Huang, Qinyu Peng, Xu Tian, Cancan Chen, Xuanfeng Zhu, Changbai Huang, Zhiting Huo, Yang Liu, Chao Yang, Chao Liu, Ping Zhang

Proc Nail Acad Sci USA. 2023 Nov 28;120(48):e2306374120. doi: 10.1073/pnas.2306374120. Epub 2023 Nov 20. The cyclophilin A-binding loop of the capsid regulates the human TRIM5α sensitivity of nonpandemic HIV-1 Augustin P Twizerimana, Daniel Becker, Shenglin Zhu, Tom Luedde, Holger Gohlke, Carsten Münk

Immunity. 2023 Nov 14;56(11):2492-2507.e10. doi: 10.1016/j.immuni.2023.10.001. Epub 2023 Oct 26. SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Yanfei Hou, Zhimeng Wang, Peiyuan Liu, Xubiao Wei, Zhengyin Zhang, Shilong Fan, Lulu Zhang, Fangping Han, Yikang Song, Ling Chu, Conggang Zhang

Cell Rep. 2023 Jan 31;42(1):112016. doi: 10.1016/j.celrep.2023.112016. Epub 2023 Jan 19. RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer. Hong-Tao Li, H Josh Jang, Krizia Rohena-Rivera, Minmin Liu, Hemant Gujar, Justin Kulchycki, Shuqing Zhao, Sandrin Billet, Xinyi Zhou, Daniel J Weisenberger, Inderbir Gill, Peter A Jones, Neil A Bhowmick, Gangning Liang

Cell 2023 May 11;186(10):2144-2159.e22. doi: 10.1016/j.cell.2023.03.036. Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases. Matae Ahn, Vivian Chih-Wei Chen, Pritisha Rozario, Wei Lun Ng, Pui San Kong, Wan Rong Sia, Adrian Eng Zheng Kang, Qi Su, Lan Huong Nguyen, Feng Zhu, Wharton O Y Chan, Chee Wah Tan, Wan Shoo Cheong, Ying Ying Hey, Randy Foo, Fusheng Guo, Yan Ting Lim, Xin Li, Wan Ni Chia, Radoslaw M Sobota, Nai Yang Fu, Aaron T Irving, Lin-Fa Wang

Nat Microbiol 2023 Nov;8(11):2115-2129. doi: 10.1038/s41564-023-01501-z. Epub 2023 Oct 9. Antiviral responses are shaped by heterogeneity in viral replication dynamics. Lucas J M Bruurs, Micha Müller, Jelle G Schipper, Huib H Rabouw, Sanne Boersma, Frank J M van Kuppeveld, Marvin E Tanenbaum.

Nature 2023 Aug;620(7975):873-880. doi: 10.1038/s41586-023-06401-0. Epub 2023 Aug 9. TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6, Yiqi Zhao, Yongxu Lu, Samuel Richardson, Meghna Sreekumar, Jonas D Albarnaz, Geoffrey L Smith

Nat Immunol. 2022 Sep;23(9):1379-1392. doi: 10.1038/s41590-022-01290-3. Epub 2022 Aug 24. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B. Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti, Francesco Guidi, Francesca Sperati, Sara Vitale, Daniele Macchia, Massimo Spada, Giovanna Schiavoni, Fabrizio Mattei, Adele De Ninno, Luca Businaro, Valeria Lucarini, Laura Bracci, Eleonora Aricò, Giovanna Ziccheddu, Francesco Facchiano, Stefania Rossi, Massimo Sanchez, Alessandra Boe, Mauro Biffoni, Ruggero De Maria, Ilio Vitale, Antonella Sistigu

J Phys Chem B. 2021 Mar 18;125(10):2513-2520. doi: 10.1021/acs.jpcb.0c11068. Epub 2021 Mar 5. Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility. Maria I Freiberger, Peter G Wolynes, Diego U Ferreiro, Monika Fuxreiter

Nature 2023 Apr;616(7957):563-573. doi: 10.1038/s41586-023-05771-9. Epub 2023 Apr 12. Antibodies against endogenous retroviruses promote lung cancer immunotherapy Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T C Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Thomas B K Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M Frankell, Maise Al Bakir, Emilia L Lim, Mark S Hill, Gareth A Wilson, Daniel E Cook, Nicolai J Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw; TRACERx Consortium; CAPTURE Consortium; Crispin T Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward, George Kassiotis

Nature 2023 Jun 23. doi: 10.1038/s41586-023-06343-7. Online ahead of print. Author Correction: A viral biomolecular condensate coordinates assembly of progeny particles. Matthew Charman, Nicholas Grams, Namrata Kumar, Edwin Halko, Joseph M Dybas, Amber Abbott, Krystal K Lum, Daniel Blumenthal, Elene Tsopurashvili, Matthew D Weitzman

Embo J. 2023 Mar 27;e112234. doi: 10.15252/embj.2022112234. Online ahead of print. Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity. Giulia Unali, Giovanni Crivicich, Isabel Pagani, Monah Abou-Alezz, Filippo Folchini, Erika Valeri, Vittoria Matafora, Julie A Reisz, Anna Maria Sole Giordano, Ivan Cuccovillo, Giacomo M Butta, Lorena Donnici, Angelo D'Alessandro, Raffaele De Francesco, Lara Manganaro, Davide Cittaro, Ivan Merelli, Carolina Petrillo, Angela Bachi, Elisa Vicenzi, Anna Kajaste-Rudnitski.

Nat Struct Mol Bio. 2023 Mar;30(3):370-382. doi: 10.1038/s41594-022-00887-4. Epub 2023 Jan 9. HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nadine Renner, Alex Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Böcking, Adolfo Saiardi, Eric O Freed, Leo C James

Nat Commun. 2023 Feb 6;14(1):634. doi: 10.1038/s41467-023-36364-9. Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes. Mayank N K Choudhary, Kara Quaid, Xiaoyun Xing, Heather Schmidt, Ting Wang

Sci Immunol. 2023 Jan 20;8(79):eabp9765. doi: 10.1126/sciimmunol.abp9765. Epub 2023 Jan 20. Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases. Kenta Mosallanejad, Stephanie N Kennedy, Kristin M Bahleda, Kailey M Slavik, Wen Zhou, Apurva A Govande, Dustin C Hancks, Philip J Kranzusch, Jonathan C Kagan

Cell, 2023 Jan 6;S0092-8674(22)01530-6. doi: 10.1016/j.cell.2022.12.017. Online ahead of print. 'Resurrection of endogenous retroviruses during aging reinforces senescence' Xiaoqian Liu, Zunpeng Liu, Zeming Wu, Jie Ren, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Cell Rep. 2022 Mar 15;38(11):110513. doi: 10.1016/j.celrep.2022.110513. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A. Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu, Lei Sun

mbio. 2022 Oct 26;13(5):e0180422. doi: 10.1128/mbio.01804-22. Epub 2022 Oct 3. Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Stephanie M Bester, Daniel Adu-Ampratwum  Arun S Annamalai, Guochao Wei, Lorenzo Briganti, Bridget C Murphy, Reed Haney, James R Fuchs, Mamuka Kvaratskhelia

Science. 2022 Jun 10;376(6598):eabm9506. doi: 10.1126/science.abm9506. Epub 2022 Jun 10. AI-based structure prediction empowers integrative structural analysis of human nuclear pores Shyamal Mosalaganti, Agnieszka Obarska-Kosinska, Marc Siggel, Reiya Taniguchi, Beata Turoňová, Christian E Zimmerli, Katarzyna Buczak, Florian H Schmidt, Erica Margiotta, Marie-Therese Mackmull, Wim J H Hagen, Gerhard Hummer, Jan Kosinski, Martin Beck

Cell Host Microbe. 2022 Mar 9;30(3):357-372.e11. doi: 10.1016/j.chom.2022.01.014. Epub 2022 Feb 18. Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Callum Talbot-Cooper, Teodors Pantelejevs, John P Shannon, Christian R Cherry, Marcus T Au, Marko Hyvönen, Heather D Hickman, Geoffrey L Smith

iScience. 2022 Jun 11;25(7):104599. doi: 10.1016/j.isci.2022.104599. eCollection 2022 Jul 15. Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1 Nicolas Vabret, Valérie Najburg , Alexander Solovyov, Ramya Gopal, Christopher McClain, Petr Šulc, Sreekumar Balan, Yannis Rahou, Guillaume Beauclair, Maxime Chazal, Hugo Varet, Rachel Legendre, Odile Sismeiro  8 , Raul Y Sanchez David, Lise Chauveau, Nolwenn Jouvenet, Martin Markowitz, Sylvie van der Werf, Olivier Schwartz, Frédéric Tangy, Nina Bhardwaj, Benjamin D Greenbaum, Anastassia V Komarova

Proc natl Acad Sci USA. 2022 Jan 25;119(4):e2116735119. doi: 10.1073/pnas.2116735119. CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Franziska K Geis, Yosef Sabo, Xiao Chen, Yinglu Li, Chao Lu, Stephen P Goff
 
Nat Chem Bio. 2022 Jun 2. doi: 10.1038/s41589-022-01060-0. Online ahead of print.  A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein
Bhavesh KhatriIshika PramanickSameer Kumar MalladiRaju S RajmaniSahil KumarPritha GhoshNayanika SenguptaR RahisuddinNarender KumarS KumaranRajesh P RingeRaghavan VaradarajanSomnath DuttaJayanta Chatterjee
 

Cell Rep. 2022 Apr 12;39(2):110690. doi: 10.1016/j.celrep.2022.110690. Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Jeffrey R Johnson, David C Crosby, Judd F Hultquist, Andrew P Kurland, Prithy Adhikary, Donna Li, John Marlett, Justine Swann, Ruth Hüttenhain, Erik Verschueren, Tasha L Johnson, Billy W Newton, Michael Shales, Viviana A Simon, Pedro Beltrao, Alan D Frankel, Alexander Marson, Jeffery S Cox, Oliver I Fregoso, John A T Young, Nevan J Krogan

Mol Cell. 2022 Mar 22;S1097-2765(22)00213-1. doi: 10.1016/j.molcel.2022.03.004. Online ahead of print. Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. William Garland, Iris Müller, Mengjun Wu, Manfred Schmid, Katsutoshi Imamura, Leonor Rib, Albin Sandelin, Kristian Helin, Torben Heick Jensen

Nature, 2022 Mar;603(7899):145-151. doi: 10.1038/s41586-022-04421-w. Epub 2022 Jan 19. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Jeremy Di DomizioMuhammet F GulenFanny SaidouneVivek V ThackerAhmad YatimKunal SharmaThéo NassEmmanuella GuenovaMartin SchallerCurdin ConradChristine GoepfertLaurence de LevalChristophe von GarnierSabina BerezowskaAnaëlle DuboisMichel GillietAndrea Ablasser

Nat Microbiol, 2021 Sep;6(9):1211. doi: 10.1038/s41564-021-00960-6.  Author Correction: MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation. Gilberto BetancorJose M Jimenez-GuardeñoSteven LynhamRobin AntrobusHataf KhanAndrew SobalaMatthew D J DicksMichael H Malim

Nature Aging, 2022, SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response. Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto & Eiji Hara

Embo J. 2021 Nov 15;40(22):e108234. doi: 10.15252/embj.2021108234. Epub 2021 Sep 29. DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis Mirjam A BeckHeinz FischerLisa M GrabnerTamara GrofficsMircea WinterSimone TangermannTina MeischelBarbara Zaussinger-Haas, Patrick WagnerCarina FischerChristina FolieJulia ArandChristian SchöferBernard RamsahoyeSabine LaggerGeorg MachatGregor EisenwortStephanie SchneiderAlexandra PodhornikMichael KothmayerUrsula ReichartMartin GlösmannIdo TamirMichael MildnerRaheleh Sheibani-TezerjiLukas KennerPeter PetzelbauerGerda EggerMaria SibiliaAndrea AblasserChristian Seiser

Viruses, volume 12, issue 13. Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein. Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen and Michaela Rumlová

Nat Commun. 2021 Nov 15;12(1):6602. doi: 10.1038/s41467-021-26910-8. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Ji-Seung YooMichihito SasakiSteven X ChoYusuke KasugaBaohui ZhuRyota OudaYasuko OrbaPaul de FigueiredoHirofumi SawaKoichi S Kobayashi

Nature 2021 Oct;598(7882):682-687. doi: 10.1038/s41586-021-03994-2. Epub 2021 Oct 20. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements Shang-Min ZhangWesley L CaiXiaoni LiuDurga ThakralJiesi LuoLok Hei ChanMeaghan K McGearyEric SongKim R M BlenmanGoran MicevicShlomit JesselYangyi ZhangMingzhu YinCarmen J BoothLucia B JilaveanuWilliam DamskyMario SznolHarriet M KlugerAkiko IwasakiMarcus W BosenbergQin Yan 

PLoS Pathog 2021 Aug 2;17(8):e1009775. doi: 10.1371/journal.ppat.1009775. eCollection 2021 Aug. Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. Sofia BanchenkoFerdinand KruppChristine GottholdJörg BürgerAndrea GraziadeiFrancis J O'ReillyLudwig SinnOlga Ruda Juri RappsilberChristian M T SpahnThorsten MielkeIan A TaylorDavid Schwefel

Cell 2021 Sep 15;S0092-8674(21)01046-1. doi: 10.1016/j.cell.2021.08.035. Online ahead of print. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion Guilherme Pedreira de Freitas Nader, Sonia Agüera-Gonzalez, Fiona Routet , Matthieu Gratia , Mathieu Maurin, Valeria Cancila , Clotilde Cadart, Andrea Palamidessi, Rodrigo Nalio Ramos, Mabel San Roman, Matteo Gentili, Ayako Yamada, Alice Williart, Catalina Lodillinsky, Emilie Lagoutte, Catherine Villard, Jean-Louis Viovy, Claudio Tripodo, Jérôme Galon, Giorgio Scita, Nicolas Manel, Philippe Chavrier, Matthieu Piel

Cell Rep. 2021 Jan 5;34(1):108586.  doi: 10.1016/j.celrep.2020.108586.  A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA. Hong SunYu HuangShan MeiFengwen XuXiaoman LiuFei ZhaoLijuan YinDi ZhangLiang WeiChao WuShichao MaJianwei WangShan CenChen LiangSiqi HuFei Guo

Science. 2021 Jul 16;373(6552):eabe4832.  doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Senolytics reduce coronavirus-related mortality in old mice. Christina D Camell, Matthew J Yousefzadeh, Yi Zhu, Larissa G P Langhi Prata, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Pengcheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christina L Inman, Kurt O Johnson, Stephanie H Cholensky, Timothy W Carlson, Nathan K LeBrasseur, Sundeep Khosla, M Gerard O'Sullivan, David B Allison, Stephen C Jameson, Alexander Meves, Ming Li  11 , Y S Prakash, Sergio E Chiarella, Sara E Hamilton, Tamara Tchkonia, Laura J Niedernhofer, James L Kirkland, Paul D Robbins.

Nature 2021 Jul;595(7866):309-314. doi: 10.1038/s41586-021-03520-4. Epub 2021 May 5.  Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Gabriel K GriffinJingyi WuArvin Iracheta-VellveJames C PattiJeffrey HsuThomas DavisDeborah Dele-OniPeter P DuAya G HalawiJeffrey J IshizukaSarah Y KimSusan KlaegerNelson H KnudsenBrian C Miller, Tung H NguyenKira E OlanderMalvina PapanastasiouSuzanna RachimiEmily J RobitschekEmily M SchneiderMitchell D YearyMargaret D ZimmerJacob D JaffeSteven A CarrJohn G DoenchW Nicholas HainingKathleen B YatesRobert T MangusoBradley E Bernstein
 

Nat Immunol. 2021 Jul;22(7):820-828. doi: 10.1038/s41590-021-00942-0. Epub 2021 May 11. PMID: 33976430 DOI: 10.1038/s41590-021-00942-0. RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells. Taisho YamadaSeiichi SatoYuki SotoyamaYasuko OrbaHirofumi SawaHajime YamauchiMichihito SasakiAkinori Takaoka

Cell Host Microbe 2021 May 12;29(5):792-805.e6. doi: 10.1016/j.chom.2021.03.001. Epub 2021 Apr 2.
The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
Liane DupontStuart BloorJames C WilliamsonSergio Martínez CuestaRaven ShahAna Teixeira-SilvaAdi NaamatiEdward J D GreenwoodStefan G SarafianosNicholas J MathesonPaul J Lehner
Nat Microbiol. 2021 Apr;6(4):435-444. doi: 10.1038/s41564-021-00868-1. Epub 2021 Mar 1. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Stephanie V RebensburgGuochao WeiRoss C LarueJared LindenbergerAshwanth C FrancisArun S AnnamalaiJames MorrisonNikoloz ShkriabaiSzu-Wei HuangVineet KewalRamaniEric M PoeschlaGregory B MelikyanMamuka Kvaratskhelia
 

Nat MicroBiol. 2021 Apr;6(4):467-478. doi: 10.1038/s41564-021-00884-1. Epub 2021 Mar 16. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. GuanQun LiuJung-Hyun LeeZachary M ParkerDhiraj AcharyaJessica J ChiangMichiel van GentWilliam RiedlMeredith E Davis-GardnerEffi WiesCindy ChiangMichaela U Gack

Cell. 2021 Feb 18;184(4):1032-1046.e18. doi: 10.1016/j.cell.2021.01.025. Epub 2021 Feb 10. Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Vojtech ZilaErica MargiottaBeata TuroňováThorsten G MüllerChristian E ZimmerliSimone MatteiMatteo AllegrettiKathleen BörnerJona RadaBarbara MüllerMarina LusicHans-Georg KräusslichMartin Beck
 
Science. 2021 Mar 19;371(6535):eabc5386. doi: 10.1126/science.abc5386. Epub 2021 Feb 4. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Tuo LiTuozhi HuangMingjian DuXiang ChenFenghe DuJunyao RenZhijian J Chen
 
Cell Host Microb. 2021 Mar 10;29(3):489-502.e8. doi: 10.1016/j.chom.2021.01.015. Epub 2021 Jan 29. Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. Jing-Wen LinChao TangHan-Cheng WeiBaowen DuChuan ChenMinjin WangYongzhao ZhouMing-Xia YuLu ChengSuvi KuivanenNatacha S OgandoLev LevanovYuancun ZhaoChang-Ling LiRan ZhouZhidan LiYiming ZhangKe SunChengdi WangLi ChenXia XiaoXiuran ZhengSha-Sha ChenZhen ZhouRuirui YangDan ZhangMengying XuJunwei SongDanrui WangYupeng LiShiKun LeiWanqin ZengQingxin YangPing HeYaoyao ZhangLifang ZhouLing CaoFeng LuoHuayi LiuLiping WangFei YeMing ZhangMengjiao LiWei FanXinqiong LiKaiju LiBowen KeJiannan XuHuiping YangShusen HeMing PanYichen YanYi ZhaLingyu JiangChangxiu YuYingfen LiuZhiyong XuQingfeng LiYongmei JiangJiufeng SunWei HongHongping WeiGuangwen LuOlli VapalahtiYunzi LuoYuquan WeiThomas ConnorWenjie TanEric J SnijderTeemu SmuraWeimin LiJia GengBinwu YingLu Chen.
 
medRxiv. 2021 Jan 10;2021.01.04.21249236. doi: 10.1101/2021.01.04.21249236. Preprint. Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality. Julio SilvaCarolina LucasMaria SundaramBenjamin IsraelowPatrick WongJon KleinMaria TokuyamaPeiwen LuArvind VenkataramanFeimei LiuTianyang MaoJi Eun OhAnnsea ParkArnau Casanovas-MassanaChantal B F VogelsCatherine M MuenkerJoseph ZellJohn B FournierMelissa CampbellMichael ChiorazziEdwin Ruiz FuentesMary PetroneChaney C KalinichIsabel M OttAnnie WatkinsAdam J MooreMaura I NakahataNathan D GrubaughShelli FarhadianCharles Dela CruzAlbert KoWade L SchulzAaron M RingShuangge MaSaad OmerAnne L WyllieAkiko Iwasaki
 
Science. 2020 Oct 9;370(6513):eabc8420. doi: 10.1126/science.abc8420. Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Devin E ChristensenBarbie K Ganser-PornillosJarrod S JohnsonOwen PornillosWesley I Sundquist
 

Nat Commun. 2020 Nov 3;11(1):5387. doi: 10.1038/s41467-020-19170-5.. The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s. Hale Tunbak, Rocio Enriquez-Gasca, Christopher H C Tie, Poppy A Gould, Petra Mlcochova Ravindra K Gupta Liane Fernandes James Holt, Annemarthe G van der Veen, Evangelos Giampazolias, Kathleen H Burns, Pierre V Maillard, Helen M Rowe

Nat Commun. 2020 Oct 2;11(1):4940. doi: 10.1038/s41467-020-18761-6. TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control. Christopher H DouseIva A TchasovnikarovaRichard T TimmsAnna V ProtasioMarta SeczynskaDaniil M PrigozhinAnna AlbeckaJane WagstaffJames C WilliamsonStefan M V FreundPaul J LehnerYorgo Modis

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