PROTAC & AUTAC Opportunity for UCL researchers

The Small Molecules TIN has purchased a stock of molecules suitable for modification into functional PROTACs, and a stock of AUTAC4, which are available to UCL researchers for free.

PROTACs/AUTACs are a new technology that chemically knocks-out a protein of interest by directing it to the Proteasome or to Autophagy. They are particularly useful for cell biology and in-vivo studies.

The Small Molecules TIN has purchased a stock of molecules suitable for modification into functional PROTACs. It has also purchased a stock of AUTAC4 (HY-W073762-Autophagy Ligand and HY-128837-Nutlin carboxylic acid, a mitophagy enhancer) that does not require further chemistry. An overview of the design and use of PROTACs was recently published in Nature Reviews Drug Development https://doi.org/10.1038/s41573-021-00245-x

These molecules are being made freely available to interested research groups across UCL, and we anticipate that many labs around UCL will be interested in the potential for these molecules in research.

If you would like to take advantage of this opportunity to obtain a PROTAC or AUTAC for your research, please complete this expression of interest form.

Obtain a PROTAC or AUTAC for your research

For more information, please contact the Small Molecules TIN coordinator Helen Cooksley (h.cooksley@ucl.ac.uk).