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Differences between Biologics and Small Molecules

What’s the difference between Biologics and Small Molecules?

Other than the obvious difference of size, the main difference between these two therapeutic modalities is that while small molecule drugs are chemically derived, biologics are extracted from living organisms. 

Most drugs on the market today will be small molecule compounds manufactured through chemical synthesis. However as our understanding of disease processes increases, we also see biologics targets on the rise, consisting of antibodies, interleukins and vaccines. 

Both modalities involve comprehensive and expensive development measures in order to successfully reach the clinic; but the translational pathways for these drug types differ. Learn more about how to progress your drug discovery project by exploring our Biologics and Small Molecules TIN Roadmaps: