2022 Publications

A 10-year review of TB notifications and mortality trends using a joint point analysis in Zambia - a high TB burden country. (2022) Lungu, P., C. Kasapo, R. Mihova, R. Chimzizi, L. Sikazwe, I. Banda, L. A. Mucheleng'anga, P. Chanda-Kapata, N. Kapata, A. Zumla and P. Mwaba. Int J Infect Dis 124 Suppl 1: S30-S40 https://doi.org/10.1016/j.ijid.2022.03.046

A 24-Week, all-oral regimen for rifampin-resistant tuberculosis. (2022) Nyang'wa, B. T., C. Berry, E. Kazounis, I. Motta, N. Parpieva, Z. Tigay, V. Solodovnikova, I. Liverko, R. Moodliar, M. Dodd, N. Ngubane, M. Rassool, T. D. McHugh, M. Spigelman, D. A. J. Moore, K. Ritmeijer, P. du Cros, K. Fielding and T.-P. S. Collaborators. N Engl J Med 387(25): 2331-2343 https://doi.org/10.1056/NEJMoa2117166

Accuracy of Xpert Ultra for the diagnosis of paediatric tuberculosis in a low TB burden country: a prospective multicentre study. (2022) Aguilera-Alonso, D., G. Solis-Garcia, A. Noguera-Julian, J. Gonzalez-Martin, A. Roman Cobena, F. Baquero-Artigao, C. Toro Rueda, P. Rodriguez-Molino, I. Bloise Sanchez, T. Vallmanya, A. Bernet-Sanchez, L. Minguell Domingo, A. Rubio, J. Saavedra-Lozano, M. J. Ruiz-Serrano, D. Blazquez-Gamero, P. Lopez-Roa, D. Gomez-Pastrana, M. D. Lopez Prieto, E. M. Lopez Medina, A. Gil-Brusola, A. Martin Nalda, A. Soriano-Arandes, T. Tortola, L. Falcon-Neyra, V. Gonzalez Galan, M. Tebruegge and B. Santiago-Garcia. Thorax 77(10): 1023-1029 https://doi.org/10.1136/thorax-2021-218378

Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid. (2022) Bateson, A., J. Ortiz Canseco, T. D. McHugh, A. A. Witney, S. Feuerriegel, M. Merker, T. A. Kohl, C. Utpatel, S. Niemann, S. Andres, K. Kranzer, F. P. Maurer, A. Ghodousi, E. Borroni, D. M. Cirillo, M. Wijkander, J. C. Toro, R. Groenheit, J. Werngren, D. Machado, M. Viveiros, R. M. Warren, F. Sirgel, A. Dippenaar, C. U. Koser, E. Sun and J. Timm. J Antimicrob Chemother 77(6): 1685-1693 https://doi.org/10.1093/jac/dkac070

Ancient DNA confirmation of lepromatous leprosy in a skeleton with concurrent osteosarcoma, excavated from the leprosarium of St. Mary Magdalen in Winchester, Hants. UK. (2022) Cole, G., G. M. Taylor, G. R. Stewart and H. Dawson-Hobbis. Eur J Clin Microbiol Infect Dis https://doi.org/10.1007/s10096-022-04494-5

Applying learning health systems thinking in codeveloping integrated tuberculosis interventions in the contexts of COVID-19. (2022) van Rensburg, A. J., I. Petersen, A. Awotiwon, M. O. Bachmann, R. Curran, J. Murdoch, C. J. Ras and L. Fairall. BMJ Glob Health 7(10) https://doi.org/10.1136/bmjgh-2022-009567

Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? - A review of evidence and the technological landscape. (2022) Hamada, Y., A. Penn-Nicholson, S. Krishnan, D. M. Cirillo, A. Matteelli, R. Wyss, C. M. Denkinger, M. X. Rangaka, M. Ruhwald and S. G. Schumacher. EBioMedicine 82: 104174 https://doi.org/10.1016/j.ebiom.2022.104174

Bacillus Calmette-Guerin skin reaction predicts enhanced mycobacteria-specific T-cell responses in infants: A post hoc analysis of a randomized controlled trial. (2022) Pittet, L. F., N. Fritschi, M. Tebruegge, B. Dutta, S. Donath, N. L. Messina, D. Casalaz, W. A. Hanekom, W. J. Britton, R. Robins-Browne, N. Curtis and N. Ritz. Am J Respir Crit Care Med 205(7): 830-841 https://doi.org/10.1164/rccm.202108-1892OC

Bacterial growth dynamics and pharmacokinetic-pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice. (2022) Muliaditan, M. and O. Della Pasqua. Br J Pharmacol 179(6): 1251-1263 https://doi.org/10.1111/bph.15688

Bedaquiline adherence measured by electronic dose monitoring predicts clinical outcomes in the treatment of patients with multidrug-resistant tuberculosis and HIV/AIDS. (2022) O'Donnell, M. R., N. Padayatchi, A. Wolf, J. Zelnick, A. Daftary, C. Orrell, C. Nimmo, M. Baldwin, R. Boodhram, B. Maharaj, K. R. Amico, K. Naidoo and G. Friedland. J Acquir Immune Defic Syndr 90(3): 325-332 https://doi.org/10.1097/QAI.0000000000002940

Bedaquiline-pretomanid-linezolid regimens for drug-resistant tuberculosis. (2022) Conradie, F., T. R. Bagdasaryan, S. Borisov, P. Howell, L. Mikiashvili, N. Ngubane, A. Samoilova, S. Skornykova, E. Tudor, E. Variava, P. Yablonskiy, D. Everitt, G. H. Wills, E. Sun, M. Olugbosi, E. Egizi, M. Li, A. Holsta, J. Timm, A. Bateson, A. M. Crook, S. M. Fabiane, R. Hunt, T. D. McHugh, C. D. Tweed, S. Foraida, C. M. Mendel, M. Spigelman and T. ZeNix Trial. N Engl J Med 387(9): 810-823 https://doi.org/10.1056/NEJMoa2119430

Bilateral optic neuritis as a first presentation of lymph node tuberculosis. (2022) Keshavan, A., L. McAnena, J. F. Acheson, H. Booth, G. T. Plant and Z. Khaleeli. Pract Neurol 22(1): 51-54 https://doi.org/10.1136/practneurol-2021-003086

Blue skies research is essential for ending the tuberculosis pandemic and advancing a personalized medicine approach for holistic management of respiratory tract infections. (2022) Ntoumi, F., E. Petersen, P. Mwaba, E. Aklillu, S. Mfinanga, D. Yeboah-Manu, M. Maeurer and A. Zumla. Int J Infect Dis 124 Suppl 1: S69-S74 https://doi.org/10.1016/j.ijid.2022.03.012

Bolaamphiphile analogues of 12-bis-THA Cl(2) Are potent antimicrobial therapeutics with distinct mechanisms of action against bacterial, mycobacterial, and fungal pathogens. (2022) Di Blasio, S., M. Clarke, C. K. Hind, M. Asai, L. Laurence, A. Benvenuti, M. Hassan, D. Semenya, D. K. Man, V. Horrocks, G. Manzo, S. Van Der Lith, C. Lam, E. Gentile, C. Annette, J. Bosse, Y. Li, B. Panaretou, P. R. Langford, B. D. Robertson, J. K. W. Lam, J. M. Sutton, M. McArthur and A. J. Mason. mSphere: e0050822 https://doi.org/10.1128/msphere.00508-22

C2-linked alkynyl poly-ethylene glycol (PEG) adenosine conjugates as water-soluble adenosine receptor agonists. (2022) Ferguson, L., N. S. Madieh, A. Vaideanu, A. Schatzlein, J. Festa, H. Singh, G. Wells, S. Bhakta and F. Brucoli. Chem Biol Drug Des https://doi.org/10.1111/cbdd.14128

The cascade of care for latent tuberculosis infection in congregate settings: A national cohort analysis, Korea, 2017-2018. (2022) Min, J., H. W. Kim, H. R. Stagg, M. X. Rangaka, M. Lipman, I. Abubakar, Y. Lee, J. P. Myong, H. Jeong, S. Bae, A. Y. Shin, J. Y. Kang, S. S. Lee, J. S. Park, H. W. Yim and J. S. Kim. Front Med (Lausanne) 9: 927579 https://doi.org/10.3389/fmed.2022.927579

Case studies to illustrate good practice in the management of non-tuberculous mycobacterial pulmonary disease. (2022) Tiberi, S., M. C. Lipman and A. Floto. Respir Med Case Rep 38: 101668 https://doi.org/10.1016/j.rmcr.2022.101668

Cell-level spatio-temporal model for a Bacillus Calmette-Guerin-based immunotherapy treatment protocol of superficial bladder cancer. (2022) Lazebnik, T. Cells 11(15) https://doi.org/10.3390/cells11152372

Challenges in defining the functional, non-coding, expressed genome of members of the Mycobacterium tuberculosis complex. (2022) Stiens, J., K. B. Arnvig, S. L. Kendall and I. Nobeli. Mol Microbiol 117(1): 20-31 https://doi.org/10.1111/mmi.14862

Clinical standards for drug-susceptible pulmonary TB. (2022) Akkerman, O. W., R. Duarte, S. Tiberi, H. S. Schaaf, C. Lange, J. W. C. Alffenaar, J. Denholm, A. C. C. Carvalho, M. S. Bolhuis, S. Borisov, J. Bruchfeld, A. M. Cabibbe, J. A. Caminero, I. Carvalho, J. Chakaya, R. Centis, M. P. Dalcomo, D. A. L, M. Dedicoat, K. Dheda, K. E. Dooley, J. Furin, J. M. Garcia-Garcia, N. A. H. van Hest, B. C. de Jong, X. Kurhasani, A. G. Martson, S. Mpagama, M. M. Torrico, E. Nunes, C. W. M. Ong, D. J. Palmero, R. Ruslami, A. M. I. Saktiawati, C. Semuto, D. R. Silva, R. Singla, I. Solovic, S. Srivastava, J. E. M. de Steenwinkel, A. Story, M. G. G. Sturkenboom, M. Tadolini, Z. F. Udwadia, A. R. Verhage, J. P. Zellweger and G. B. Migliori. Int J Tuberc Lung Dis 26(7): 592-604 https://doi.org/10.5588/ijtld.22.0228

Clinical standards for the diagnosis, treatment and prevention of TB infection. (2022) Migliori, G. B., S. J. Wu, A. Matteelli, D. Zenner, D. Goletti, S. Ahmedov, S. Al-Abri, D. M. Allen, M. E. Balcells, A. L. Garcia-Basteiro, E. Cambau, R. E. Chaisson, C. B. E. Chee, M. P. Dalcolmo, J. T. Denholm, C. Erkens, S. Esposito, P. Farnia, J. S. Friedland, S. Graham, Y. Hamada, A. D. Harries, A. W. Kay, A. Kritski, S. Manga, B. J. Marais, D. Menzies, D. Ng, L. Petrone, A. Rendon, D. R. Silva, H. S. Schaaf, A. Skrahina, G. Sotgiu, G. Thwaites, S. Tiberi, N. Tukvadze, J. P. Zellweger, D. A. L, R. Centis and C. W. M. Ong. Int J Tuberc Lung Dis 26(3): 190-205 https://doi.org/10.5588/ijtld.21.0753

Clinical utility of C-reactive protein-based triage for presumptive pulmonary tuberculosis in South African adults. (2023) Calderwood, C. J., B. W. Reeve, T. Mann, Z. Palmer, G. Nyawo, H. Mishra, G. Ndlangalavu, I. Abubakar, M. Noursadeghi, G. Theron and R. K. Gupta. J Infect 86(1): 24-32 https://doi.org/10.1016/j.jinf.2022.10.041

Cognitive impairment in tuberculous meningitis. (2022) Davis, A. G., A. J. Dreyer, C. Albertyn, M. Maxebengula, C. Stek, S. Wasserman, S. Marais, K. Bateman, M. Solms, J. Joska, R. J. Wilkinson and S. Nightingale. Clin Infect Dis https://doi.org/10.1093/cid/ciac831

Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin. (2022) Johnson, R. C., E. Saez-Lopez, E. S. Anagonou, G. G. Kpoton, A. G. Ayelo, R. S. Gnimavo, F. Z. Mignanwande, J. G. Houezo, G. E. Sopoh, J. Addo, L. Orford, G. Vlasakakis, N. Biswas, F. Calderon, O. Della Pasqua, A. Gine-March, Z. Herrador, A. Mendoza-Losana, G. Diez, I. Cruz and S. Ramon-Garcia. Trials 23(1): 559 https://doi.org/10.1186/s13063-022-06473-9

A comparison of vitamin D and cathelicidin (LL-37) levels between patients with active TB and their healthy contacts in a high HIV prevalence setting: a prospective descriptive study. (2022) Lungu, P. S., W. Kilembe, S. Lakhi, T. Sukwa, E. Njelesani, A. I. Zumla and P. Mwaba. Trans R Soc Trop Med Hyg 116(4): 336-343 https://doi.org/10.1093/trstmh/trab126

The contribution of late HIV diagnosis on the occurrence of HIV-associated tuberculosis. (2022) Girardi, E., Y. Caro-Vega, A. Cozzi-Lepri, J. Musaazi, G. Carriquiry, B. Castelnuovo, A. Gori, Y. C. Manabe, J. E. Gotuzzo, A. D'Arminio Monforte, B. Crabtree-Ramirez and C. Mussini. AIDS 36(14): 2005-2013 https://doi.org/10.1097/QAD.0000000000003321

The contribution of late HIV diagnosis on the occurrence of HIV-associated tuberculosis: a 5-year estimate using real-world data. (2022) Girardi, E., Y. Caro-Vega, A. Cozzi-Lepri, J. Musaazi, G. Carriquiry, B. Castelnuovo, A. Gori, Y. C. Manabe, J. E. Gotuzzo, A. D'Arminio Monforte, B. Crabtree-Ramirez and C. Mussini. AIDS https://doi.org/10.1097/QAD.0000000000003321

Cost-effectiveness of a medication event monitoring system for tuberculosis management in Morocco. (2022) Yang, J., H. Y. Kim, S. Park, I. Sentissi, N. Green, B. K. Oh, Y. Kim, K. H. Oh, E. Paek, Y. J. Park, I. H. Oh and S. H. Lee. PLoS One 17(4): e0267292 https://doi.org/10.1371/journal.pone.0267292

Country differences and determinants of yield in programmatic migrant TB screening in four European countries. (2022) Menezes, D., D. Zenner, R. Aldridge, S. R. Anderson, G. de Vries, C. Erkens, V. Marchese, A. Matteeli, M. Muzyamba, J. Nederby-Ohd, J. van Rest, I. Spruijt, J. Were, K. Lonnroth, I. Abubakar and F. Cobelens. Int J Tuberc Lung Dis 26(10): 942-948 https://doi.org/10.5588/ijtld.22.0186

Culture-free enumeration of Mycobacterium tuberculosis in mouse tissues using the molecular bacterial load assay for preclinical drug development. (2022) Evangelopoulos, D., C. M. Shoen, I. Honeyborne, S. Clark, A. Williams, G. V. Mukamolova, M. H. Cynamon and T. D. McHugh. Microorganisms 10(2) https://doi.org/10.3390/microorganisms10020460

Defining discriminatory antibody fingerprints in active and latent tuberculosis. (2022) Nziza, N., D. Cizmeci, L. Davies, E. B. Irvine, W. Jung, B. A. Fenderson, M. de Kock, W. A. Hanekom, K. Franken, C. L. Day, T. H. M. Ottenhoff and G. Alter. Front Immunol 13: 856906 https://doi.org/10.3389/fimmu.2022.856906

Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis. (2022) Nasiri, M. J., M. Zangiabadian, E. Arabpour, S. Amini, F. Khalili, R. Centis, L. D'Ambrosio, J. T. Denholm, H. S. Schaaf, M. van den Boom, X. Kurhasani, M. P. Dalcolmo, S. Al-Abri, J. Chakaya, J. W. Alffenaar, O. Akkerman, D. R. Silva, M. Munoz-Torrico, B. Seaworth, E. Pontali, L. Saderi, S. Tiberi, A. Zumla, G. B. Migliori and G. Sotgiu. Int J Infect Dis 124 Suppl 1(Suppl 1): S90-S103 https://doi.org/10.1016/j.ijid.2022.02.043

Design and protocol for a cluster randomised trial of enhanced diagnostics for tuberculosis screening among people living with HIV in hospital in Malawi (CASTLE study). (2022) Burke, R. M., S. Nyirenda, H. H. Twabi, M. Nliwasa, E. Joekes, N. Walker, R. Nyirenda, A. Gupta-Wright, K. Fielding, P. MacPherson and E. L. Corbett. PLoS One 17(1): e0261877 https://doi.org/10.1371/journal.pone.0261877

Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: A systematic review and individual participant data meta-analysis. (2022) Dhana, A., Y. Hamada, A. P. Kengne, A. D. Kerkhoff, T. Broger, C. M. Denkinger, M. X. Rangaka, A. Gupta-Wright, K. Fielding, R. Wood, H. Huerga, S. C. M. Rucker, S. Bjerrum, I. S. Johansen, S. S. Thit, M. M. Kyi, J. Hanson, D. A. Barr, G. Meintjes and G. Maartens. J Infect 85(1): 40-48 https://doi.org/10.1016/j.jinf.2022.05.010

The diagnostic performance of novel skin-based in-vivo tests for tuberculosis infection compared with purified protein derivative tuberculin skin tests and blood-based in vitro interferon-gamma release assays: a systematic review and meta-analysis. (2022) Krutikov, M., L. Faust, V. Nikolayevskyy, Y. Hamada, R. K. Gupta, D. Cirillo, A. Mateelli, A. Korobitsyn, C. M. Denkinger and M. X. Rangaka. Lancet Infect Dis 22(2): 250-264 https://doi.org/10.1016/S1473-3099(21)00261-9

Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial. (2022) Turkova, A., H. Waalewijn, M. K. Chan, P. D. J. Bollen, M. F. Bwakura-Dangarembizi, A. R. Kekitiinwa, M. F. Cotton, A. Lugemwa, E. Variava, G. M. Ahimbisibwe, U. Srirompotong, V. Mumbiro, P. Amuge, P. Zuidewind, S. Ali, C. M. Kityo, M. Archary, R. A. Ferrand, A. Violari, D. M. Gibb, D. M. Burger, D. Ford, A. Colbers and O. T. Team. Lancet HIV 9(9): e627-e637 https://doi.org/10.1016/S2352-3018(22)00160-6

Drug resistant TB - latest developments in epidemiology, diagnostics and management. (2022) Tiberi, S., N. Utjesanovic, J. Galvin, R. Centis, L. D'Ambrosio, M. van den Boom, A. Zumla and G. B. Migliori. Int J Infect Dis 124 Suppl 1: S20-S25 https://doi.org/10.1016/j.ijid.2022.03.026

Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-alpha inhibitor initiation in children in Spain. (2023) Calzada-Hernandez, J., J. Anton, J. Martin de Carpi, B. Lopez-Montesinos, I. Calvo, E. Donat, E. Nunez, J. Blasco Alonso, M. J. Mellado, F. Baquero-Artigao, R. Leis, A. M. Vegas-Alvarez, M. Medrano San Ildefonso, M. D. C. Pinedo-Gago, F. J. Eizaguirre, A. Tagarro, M. Camacho-Lovillo, B. Perez-Gorricho, C. Gavilan-Martin, S. Guillen, B. Sevilla-Perez, L. Pena-Quintana, P. Mesa-Del-Castillo, C. Fortuny, M. Tebruegge and A. Noguera-Julian. Eur J Pediatr 182(1): 307-317 https://doi.org/10.1007/s00431-022-04640-3

ECCO topical review on clinicopathological spectrum and differential diagnosis of inflammatory bowel disease. (2022) Feakins, R., J. Torres, P. Borralho-Nunes, J. Burisch, T. Curdia Goncalves, L. De Ridder, A. Driessen, T. Lobaton, L. Menchen, A. Mookhoek, N. Noor, M. Svrcek, V. Villanacci, N. Zidar and M. Tripathi. J Crohns Colitis 16(3): 343-368 https://doi.org/10.1093/ecco-jcc/jjab141

ECG monitoring in STREAM Stage 1: can we identify those at increased risk of QT prolongation? (2022) Hughes, G., H. Bern, C. Y. Chiang, R. L. Goodall, A. J. Nunn, I. D. Rusen and S. K. Meredith. Int J Tuberc Lung Dis 26(11): 1065-1070 https://doi.org/10.5588/ijtld.22.0063

Economic evaluation of shortened, bedaquiline-containing treatment regimens for rifampicin-resistant tuberculosis (STREAM stage 2): A within-trial analysis of a randomised controlled trial. (2023) Rosu, L., J. J. Madan, E. M. Tomeny, M. Muniyandi, J. Nidoi, M. Girma, V. Vilc, P. Bindroo, R. Dhandhukiya, A. K. Bayissa, D. Meressa, G. Narendran, R. Solanki, A. K. Bhatnagar, E. Tudor, B. Kirenga, S. K. Meredith, A. J. Nunn, G. Bronson, I. D. Rusen, S. B. Squire, E. Worrall and S. S. H. E. E. Collaborators. Lancet Glob Health 11(2): e265-e277 https://doi.org/10.1016/S2214-109X(22)00498-3

Effect of dysglycemia on urinary lipid mediator profiles in persons with pulmonary tuberculosis. (2022) Arriaga, M. B., F. Karim, A. T. L. Queiroz, M. Araujo-Pereira, B. Barreto-Duarte, C. Sales, M. S. Moosa, M. Mazibuko, G. L. Milne, F. Maruri, C. H. Serezani, J. R. Koethe, M. C. Figueiredo, A. L. Kritski, M. Cordeiro-Santos, V. C. Rolla, T. R. Sterling, A. Leslie and B. B. Andrade. Front Immunol 13: 919802 https://doi.org/10.3389/fimmu.2022.919802

Elevated IP-10 at the protein and gene level associates with pulmonary TB. (2022) Fisher, K. L., D. Moodley, K. Rajkumar-Bhugeloo, O. O. Baiyegunhi, F. Karim, H. Ndlovu, T. Ndung'u and M. J. Marakalala. Front Cell Infect Microbiol 12: 908144 https://doi.org/10.3389/fcimb.2022.908144

Elevated plasma matrix metalloproteinase 8 associates with sputum culture positivity in pulmonary tuberculosis. (2022) Walker, N. F., F. Karim, M. Y. S. Moosa, S. Moodley, M. Mazibuko, K. Khan, T. R. Sterling, Y. F. van der Heijden, A. D. Grant, P. T. Elkington, A. Pym and A. Leslie. J Infect Dis 226(5): 928-932 https://doi.org/10.1093/infdis/jiac160

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis. (2022) Kloprogge, F., J. Ortiz Canseco, L. Phee, Z. Sadouki, K. Kipper, A. A. Witney, N. Stoker and T. D. McHugh. Sci Rep 12(1): 21429 https://doi.org/10.1038/s41598-022-25827-6

Ending the tuberculosis syndemic: is COVID-19 the (in)convenient scapegoat for poor progress? (2022) Rangaka, M. X., Y. Hamada and I. Abubakar. Lancet Respir Med 10(6): 529-531 https://doi.org/10.1016/S2213-2600(22)00123-0

End-point definition and trial design to advance tuberculosis vaccine development. (2022) Garcia-Basteiro, A. L., R. G. White, D. Tait, A. C. Schmidt, M. X. Rangaka, M. Quaife, E. Nemes, R. Mogg, P. C. Hill, R. C. Harris, W. A. Hanekom, M. Frick, A. Fiore-Gartland, T. Evans, A. F. Dagnew, G. Churchyard, F. Cobelens, M. A. Behr and M. Hatherill. Eur Respir Rev 31(164) https://doi.org/10.1183/16000617.0044-2022

Estimating annual risk of infection with Mycobacterium tuberculosis. (2022) Yates, T. A. and P. Y. Khan. Lancet Infect Dis 22(9): 1276-1277 https://doi.org/10.1016/S1473-3099(22)00454-6

Estimating the contribution of transmission in primary healthcare clinics to community-wide TB disease incidence, and the impact of infection prevention and control interventions, in KwaZulu-Natal, South Africa. (2022) McCreesh, N., A. S. Karat, I. Govender, K. Baisley, K. Diaconu, T. A. Yates, R. M. Houben, K. Kielmann, A. D. Grant and R. White. BMJ Glob Health 7(4) https://doi.org/10.1136/bmjgh-2021-007136

Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial. (2022) Rangaka, M. X., Y. Hamada, T. Duong, H. Bern, J. Calvert, M. Francis, A. L. Clarke, A. Ghanouni, C. Layton, V. Hack, E. Owen-Powell, J. Surey, K. Sanders, H. L. Booth, A. Crook, C. Griffiths, R. Horne, H. Kunst, M. Lipman, M. Mandelbaum, P. J. White, D. Zenner and I. Abubakar. BMJ Open 12(9): e057717 https://doi.org/10.1136/bmjopen-2021-057717

Evaluation of host protein biomarkers by ELISA From whole lysed peripheral blood for development of diagnostic tests for active tuberculosis. (2022) Garlant, H. N., K. Ellappan, M. Hewitt, P. Perumal, S. Pekeleke, N. Wand, J. Southern, S. V. Kumar, H. Belgode, I. Abubakar, S. Sinha, S. Vasan, N. M. Joseph and K. E. Kempsell. Front Immunol 13: 854327 https://doi.org/10.3389/fimmu.2022.854327

Evaluation of SARS-CoV-2 diagnostics and risk factors associated with SARS-CoV-2 infection in Zambia. (2022) Tembo, J., N. F. Egbe, K. Maluzi, K. Mulonga, M. Chilufya, N. Kapata, V. Mukonka, E. Simulundu, A. Zumla, S. Fwoloshi, L. Mulenga, S. R. Pallerla, T. P. Velavan and M. Bates. Int J Infect Dis 120: 150-157 https://doi.org/10.1016/j.ijid.2022.04.017

Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial. (2022) Goodall, R. L., S. K. Meredith, A. J. Nunn, A. Bayissa, A. K. Bhatnagar, G. Bronson, C. Y. Chiang, F. Conradie, M. Gurumurthy, B. Kirenga, N. Kiria, D. Meressa, R. Moodliar, G. Narendran, N. Ngubane, M. Rassool, K. Sanders, R. Solanki, S. B. Squire, G. Torrea, B. Tsogt, E. Tudor, A. Van Deun, I. D. Rusen and S. s. collaborators. Lancet 400(10366): 1858-1868 https://doi.org/10.1016/S0140-6736(22)02078-5

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A feasibility study evaluating the uptake, effectiveness and acceptability of routine screening of pregnant migrants for latent tuberculosis infection in antenatal care: a research protocol. (2022) Rahman, A., S. Thangaratinam, A. Copas, D. Zenner, P. J. White, C. Griffiths, I. Abubakar, C. McCourt and H. Kunst. BMJ Open 12(4): e058734 https://doi.org/10.1136/bmjopen-2021-058734

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Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990-2019: results from the Global Burden of Disease Study 2019. (2022) Collaborators, G. T. Lancet Infect Dis 22(2): 222-241 https://doi.org/10.1016/s1473-3099(21)00449-7

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High burden of childhood tuberculosis in migrants: a retrospective cohort study from the Thailand-Myanmar border. (2022) Carroll, A., B. Maung Maung, W. P. P. Htun, W. Watthanaworawit, M. Vincenti-Delmas, C. Smith, P. Sonnenberg and F. Nosten. BMC Infect Dis 22(1): 608 https://doi.org/10.1186/s12879-022-07569-y

The historical evolution of ocular tuberculosis: Past, present, and future. (2022) Betzler, B. K., D. V. Gunasekeran, J. Kempen, J. R. Smith, P. McCluskey, Q. D. Nguyen, C. Pavesio, V. Gupta and R. Agrawal. Ocul Immunol Inflamm 30(3): 593-599 https://doi.org/10.1080/09273948.2021.1992446

Host, technical, and environmental factors affecting QuantiFERON-TB Gold In-Tube performance in children below 5 years of age. (2022) Velasco-Arnaiz, E., M. Batllori, M. Monsonis, A. Valls, M. Rios-Barnes, S. Simo-Nebot, A. Gamell, C. Fortuny, M. Tebruegge and A. Noguera-Julian. Sci Rep 12(1): 19908 https://doi.org/10.1038/s41598-022-24433-w

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The impact, effectiveness and outcomes of targeted screening thresholds for programmatic latent TB infection testing in HIV: cohort study results. (2022) White, H. A., R. F. Baggaley, H. Okhai, H. Patel, I. Stephenson, C. Bodimeade, M. J. Wiselka and M. Pareeka. AIDS https://doi.org/10.1097/QAD.0000000000003364

The impact, effectiveness and outcomes of targeted screening thresholds for programmatic latent tuberculosis infection testing in HIV. (2022) White, H. A., R. F. Baggaley, H. Okhai, H. Patel, I. Stephenson, C. Bodimeade, M. J. Wiselka and M. Pareek. AIDS 36(14): 2035-2044 https://doi.org/10.1097/QAD.0000000000003364

Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses. (2022) Martin-Hughes, R., L. Vu, N. Cheikh, S. L. Kelly, N. Fraser-Hurt, Z. Shubber, I. Manhiça, K. Mbendera, B. Girma, I. Pambudi, J. Ríos, A. Elmira, P. Harimurti, R. Hafez, J. N. B. Garcia, T. Palmer, A. Roberts, M. Gorgens and D. Wilson. PLOS Global Public Health 2(3): e0000219 https://doi.org/10.1371/journal.pgph.0000219

Improving access to affordable quality-assured inhaled medicines in low- and middle-income countries. (2022) Stolbrink, M., M. J. Chinouya, S. Jayasooriya, R. Nightingale, L. Evans-Hill, K. Allan, H. Allen, J. Balen, T. Beacon, K. Bissell, J. Chakaya, C. Y. Chiang, M. Cohen, G. Devereux, A. El Sony, D. M. G. Halpin, J. R. Hurst, C. Kiprop, A. Lawson, C. Mace, A. Makhanu, P. Makokha, R. Masekela, H. Meme, E. M. Khoo, R. Nantanda, S. Pasternak, C. Perrin, H. Reddel, S. Rylance, P. Schweikert, C. Were, S. Williams, T. Winders, A. Yorgancioglu, G. B. Marks and K. Mortimer. Int J Tuberc Lung Dis 26(11): 1023-1032 https://doi.org/10.5588/ijtld.22.0270

Improving healthcare for patients with HIV, tuberculosis and hepatitis C in eastern Europe: a review of current challenges and important next steps. (2022) Kraef, C., A. Bentzon, A. Skrahina, A. Mocroft, L. Peters, J. D. Lundgren, N. Chkhartishvili, D. Podlekareva and O. Kirk. HIV Med 23(1): 48-59 https://doi.org/10.1111/hiv.13163

Incidental Tuberculosis in sudden, unexpected, and violent deaths in the community Lusaka, Zambia - A descriptive forensic post-mortem examination study. (2022) Mucheleng'anga, L. A., C. M. Himwaze, V. Telendiy, S. Simumba, J. Soko, N. Kayonde, B. Mulenga, A. Hamukale, A. L. Shibemba, P. S. Lungu, J. Tembo, M. Bates, P. Chanda-Kapata, P. Mwaba, N. Kapata, F. Ntoumi and A. Zumla. Int J Infect Dis 124 Suppl 1: S75-S81 https://doi.org/10.1016/j.ijid.2022.03.005

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. (2022) Martinez, L., O. Cords, Q. Liu, C. Acuna-Villaorduna, M. Bonnet, G. J. Fox, A. C. C. Carvalho, P. C. Chan, J. Croda, P. C. Hill, E. Lopez-Varela, S. Donkor, K. Fielding, S. M. Graham, M. A. Espinal, B. Kampmann, A. Reingold, H. Huerga, J. A. Villalba, L. Grandjean, G. Sotgiu, U. Egere, S. Singh, L. Zhu, C. Lienhardt, J. T. Denholm, J. A. Seddon, C. C. Whalen, A. L. Garcia-Basteiro, R. Triasih, C. Chen, J. Singh, L. M. Huang, S. Sharma, D. Hannoun, H. Del Corral, A. M. Mandalakas, L. L. Malone, D. L. Ling, A. Kritski, C. M. Stein, R. Vashishtha, F. Boulahbal, C. T. Fang, W. H. Boom, E. M. Netto, A. C. Lemos, A. C. Hesseling, A. Kay, E. C. Jones-Lopez, C. R. Horsburgh, C. Lange and J. R. Andrews. Lancet Glob Health 10(9): e1307-e1316 https://doi.org/10.1016/S2214-109X(22)00283-2

Infective Native Extracranial Carotid Artery Aneurysms: A Systematic Review. (2022) Hanger, M. and D. M. Baker. Ann Vasc Surg https://doi.org/10.1016/j.avsg.2022.11.028

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial. (2022) Maitre, T., M. Bonnet, A. Calmy, M. Raberahona, R. A. Rakotoarivelo, N. Rakotosamimanana, J. Ambrosioni, J. M. Miro, P. Debeaudrap, C. Muzoora, A. Davis, G. Meintjes, S. Wasserman, R. Wilkinson, S. Eholie, F. E. Nogbou, M. C. Calvo-Cortes, C. Chazallon, V. Machault, X. Anglaret and F. Bonnet. Trials 23(1): 928 https://doi.org/10.1186/s13063-022-06772-1

"It's too hard" - the management of latent TB in under-served populations in the UK: a qualitative study. (2022) Gray, A. T., J. Surey, H. Esmail, A. Story and M. Harris. BMC Health Serv Res 22(1): 1464 https://doi.org/10.1186/s12913-022-08855-w

Investigating neutrophil cell death in TB pathogenesis. (2021) Fisher, K. L., K. Rajkumar-Bhugeloo, D. Moodley, T. Mpotje, D. Ramsuran, T. Ndung'u and M. J. Marakalala. Gates Open Res 5: 175 https://doi.org/10.12688/gatesopenres.13472.2

Keeping up with the guidelines: design changes to the STREAM stage 2 randomised controlled non-inferiority trial for rifampicin-resistant tuberculosis. (2022) Goodall, R. L., K. Sanders, G. Bronson, M. Gurumurthy, G. Torrea, S. Meredith, A. Nunn, I. D. Rusen and S. T. Team. Trials 23(1): 474 https://doi.org/10.1186/s13063-022-06397-4

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Latent tuberculosis screening and treatment in HIV: highly acceptable in a prospective cohort study. (2022) White, H. A., H. Okhai, A. Sahota, J. Maltby, I. Stephenson, H. Patel, P. M. Hefford, M. J. Wiselka and M. Pareek. ERJ Open Res 8(2) https://doi.org/10.1183/23120541.00442-2021

Milk and meat consumption patterns and the potential risk of zoonotic disease transmission among urban and peri-urban dairy farmers in Ethiopia. (2022) Deneke, T. T., A. Bekele, H. L. Moore, T. Mamo, G. Almaw, G. A. Mekonnen, A. Mihret, R. Tschopp, L. Yeheyis, C. Hodge, J. L. N. Wood, S. Berg and E. consortium. BMC Public Health 22(1): 222 https://doi.org/10.1186/s12889-022-12665-4

Mind the gap - Managing tuberculosis across the disease spectrum. (2022) Esmail, H., L. Macpherson, A. K. Coussens and R. Houben. EBioMedicine 78: 103928 https://doi.org/10.1016/j.ebiom.2022.103928

A multi-centre observational study of HIV, tuberculosis and risk of chronic lung disease in urban West Africa. (2022) Fink, D. L., D. A. Oladele, A. J. Slack, O. Odubela, T. Musari-Martins, A. Okechukwu, K. Adetayo, S. Opaneye, R. Abubakar, A. David, J. Cai, S. Quaderi, I. Abubakar, O. Ezechi, J. R. Hurst, M. Lipman and B. Salako. AIDS 36(14): 1987-1995 https://doi.org/10.1097/QAD.0000000000003360

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. (2022) Gideon, H. P., T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, 2nd, A. A. Tu, T. M. Gierahn, J. M. Peters, F. F. Hopkins, J. R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Y. Phuah, H. J. Borish, P. Maiello, A. G. White, C. G. Winchell, S. K. Nyquist, S. K. C. Ganchua, A. Myers, K. V. Patel, C. L. Ameel, C. T. Cochran, S. Ibrahim, J. A. Tomko, L. J. Frye, J. M. Rosenberg, A. Shih, M. Chao, E. Klein, C. A. Scanga, J. Ordovas-Montanes, B. Berger, J. T. Mattila, R. Madansein, J. C. Love, P. L. Lin, A. Leslie, S. M. Behar, B. Bryson, J. L. Flynn, S. M. Fortune and A. K. Shalek. Immunity 55(5): 827-846 e810 https://doi.org/10.1016/j.immuni.2022.04.004

Mycobacterium tuberculosis senses host Interferon-gamma via the membrane protein MmpL10. (2022) Ahmed, M., J. Mackenzie, L. Tezera, R. Krause, B. Truebody, D. Garay-Baquero, A. Vallejo, K. Govender, J. Adamson, H. Fisher, J. W. Essex, S. Mansour, P. Elkington, A. J. C. Steyn and A. Leslie. Commun Biol 5(1): 1317 https://doi.org/10.1038/s42003-022-04265-0

Mycobactin analogues with excellent pharmacokinetic profile demonstrate potent antitubercular specific activity and exceptional efflux pump inhibition. (2022) Shyam, M., H. Verma, G. Bhattacharje, P. Mukherjee, S. Singh, S. Kamilya, P. Jalani, S. Das, A. Dasgupta, A. Mondal, A. K. Das, A. Singh, F. Brucoli, C. Bagneris, R. Dickman, V. N. Basavanakatti, P. Naresh Babu, V. Sankaran, A. Dev, B. N. Sinha, S. Bhakta and V. Jayaprakash. J Med Chem 65(1): 234-256 https://doi.org/10.1021/acs.jmedchem.1c01349

Mycotic internal carotid artery pseudoaneurysm secondary to Mycobacterium tuberculosis. (2022) Lui, D. H., S. Patel, R. Khurram, M. Joffe, J. Constantinou and D. Baker. J Vasc Surg Cases Innov Tech 8(2): 251-255 https://doi.org/10.1016/j.jvscit.2022.02.012

National tuberculosis spending efficiency and its associated factors in 121 low-income and middle-income countries, 2010-19: a data envelopment and stochastic frontier analysis. (2022) Abou Jaoude, G. J., I. Garcia Baena, P. Nguhiu, A. Siroka, T. Palmer, L. Gosce, K. Allel, E. Sinanovic, J. Skordis and H. Haghparast-Bidgoli. Lancet Glob Health 10(5): e649-e660 https://doi.org/10.1016/S2214-109X(22)00085-7

No implication of HIV coinfection on the plasma exposure to rifampicin, pyrazinamide, and ethambutol in tuberculosis patients. (2022) Nardotto, G. H. B., V. R. Bollela, A. Rocha, O. Della Pasqua and V. L. Lanchote. Clin Transl Sci 15(2): 514-523 https://doi.org/10.1111/cts.13169

Optimising tuberculosis care for refugees affected by armed conflicts. (2022) Castro, K. G., L. Ditiu, S. Sahu, F. Ntoumi, S. Tiberi, C. M. O'Kane, O. Akkerman, K. Manika, P. Mwaba, L. Davies Forsman, E. Petersen, E. Aklillu, E. I. Azhar, D. M. Cirillo, G. B. Migliori, A. Abbara and A. Zumla. Lancet Respir Med 10(6): 533-536 https://doi.org/10.1016/S2213-2600(22)00104-7

Outcomes of a residential respite service for homeless people with tuberculosis in London, UK: a cross-sectional study. (2022) Crosby, L., D. Lewer, Y. Appleby, C. Anderson, A. Hayward and A. Story. Perspect Public Health: 17579139221093544 https://doi.org/10.1177/17579139221093544

Paediatric TB care in the United Kingdom. (2022) Duret, A., F. Olgemoeller, L. Ferreras-Antolin, E. Whittaker and J. M. Cohen. Int J Tuberc Lung Dis 26(9): 814-819 https://doi.org/10.5588/ijtld.21.0581

The paradox of immune checkpoint inhibition reactivating tuberculosis. (2022) Ahmed, M., L. B. Tezera, P. T. Elkington and A. J. Leslie. Eur Respir J https://doi.org/10.1183/13993003.02512-2021

Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria. (2022) Daza-Cajigal, V., A. S. Albuquerque, D. F. Young, M. J. Ciancanelli, D. Moulding, I. Angulo, V. Jeanne-Julien, J. Rosain, E. Minskaia, J. L. Casanova, S. Boisson-Dupuis, J. Bustamante, R. E. Randall, T. D. McHugh, A. J. Thrasher and S. O. Burns. Front Immunol 13: 888427 https://doi.org/10.3389/fimmu.2022.888427

Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study. (2022) Soler-Garcia, A., A. Gamell, T. Perez-Porcuna, A. Soriano-Arandes, B. Santiago, T. Tortola, M. J. Ruiz-Serrano, J. J. Korta Murua, M. Bustillo-Alonso, M. I. Garrote-Llanos, P. Rodriguez-Molino, A. I. Piqueras, A. Tagarro, M. Monsonis, M. Tebruegge, A. Noguera-Julian and Q. F.-P. S. G. o. t. S. P. T. R. Network. Thorax 77(12): 1193-1201 https://doi.org/10.1136/thoraxjnl-2021-217592

Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study. (2022) Buonsenso, D., A. Noguera-Julian, R. Moroni, A. Hernandez-Bartolome, N. Fritschi, L. Lancella, L. Cursi, A. Soler-Garcia, R. Kruger, C. Feiterna-Sperling, M. Sali, A. Lo Vecchio, S. Scarano, A. Hernanz Lobo, M. Espiau, A. Soriano-Arandes, B. S. Cetin, F. Brinkmann, I. Ozere, F. Baquero-Artigao, M. Tsolia, T. Milheiro Silva, M. Bustillo-Alonso, A. Martin Nalda, M. Mancini, A. Starshinova, N. Ritz, S. Velizarova, L. Ferreras-Antolin, F. Gotzinger, O. Bilogortseva, V. Chechenyeva, M. Tebruegge, B. Santiago-Garcia and Q. F. T. P. s. g. ptbnet. Thorax https://doi.org/10.1136/thorax-2022-218929

Pharmacokinetics of first-line drugs in children with tuberculosis, using World Health Organization-recommended weight band doses and formulations. (2022) Chabala, C., A. Turkova, A. C. Hesseling, K. M. Zimba, M. van der Zalm, M. Kapasa, M. Palmer, M. Chirehwa, L. Wiesner, E. Wobudeya, A. Kinikar, V. Mave, S. Hissar, L. Choo, K. LeBeau, V. Mulenga, R. Aarnoutse, D. Gibb and H. McIlleron. Clin Infect Dis 74(10): 1767-1775 https://doi.org/10.1093/cid/ciab725

A phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis (The LASER-TBM Trial). (2022) Davis, A. G., S. Wasserman, C. Stek, M. Maxebengula, C. J. Liang, S. Stegmann, S. Koekemoer, A. Jackson, Y. Kadernani, M. Bremer, R. Daroowala, S. Aziz, R. Goliath, L. L. Sai, T. Sihoyiya, P. Denti, R. P. Lai, T. Crede, J. Naude, P. Szymanski, Y. Vallie, I. A. Banderker, M. S. Moosa, P. Raubenheimer, S. Candy, C. Offiah, G. Wahl, I. Vorster, G. Maartens, J. Black, G. Meintjes and R. J. Wilkinson. Clin Infect Dis https://doi.org/10.1093/cid/ciac932

The pitfalls of mining for QuantiFERON Gold in severely ill patients with COVID-19. (2022) Cortes, M. P., C. S. Schultz, S. Isha, J. E. Sinclair, S. Bhakta, K. L. Kunze, P. W. Johnson, J. B. Cowart, R. E. Carter, P. M. Franco, D. K. Sanghavi and A. Roy. Mayo Clin Proc Innov Qual Outcomes 6(5): 409-419 https://doi.org/10.1016/j.mayocpiqo.2022.06.004

Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with HIV. (2022) Singer, S. N., O. C. Ndumnego, R. S. Kim, T. Ndung'u, K. Anastos, A. French, G. Churchyard, E. Paramithiothis, V. O. Kasprowicz and J. M. Achkar. EBioMedicine 75: 103787 https://doi.org/10.1016/j.ebiom.2021.103787

Pre-clinical tools for predicting drug efficacy in treatment of tuberculosis. (2022) Margaryan, H., D. D. Evangelopoulos, L. Muraro Wildner and T. D. McHugh. Microorganisms 10(3) https://doi.org/10.3390/microorganisms10030514

Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: Implications for dose selection. (2022) Muliaditan, M., D. Teutonico, F. Ortega-Muro, S. Ferrer and O. Della Pasqua. Eur J Pharm Sci 173: 106163 https://doi.org/10.1016/j.ejps.2022.106163

Pregnancy-related tuberculous meningitis and immune reconstitution inflammatory syndrome: A case series and systematic review. (2022) Pastick, K. A., E. Kagimu, J. Dobbin, K. Ssebambulidde, J. Gakuru, J. Milln, B. Nakabuye, D. B. Meya, D. R. Boulware, F. V. Cresswell and N. C. Bahr. Open Forum Infect Dis 9(10): ofac513 https://doi.org/10.1093/ofid/ofac513

Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers. (2022) Kumbargere Nagraj, S., P. Eachempati, M. Paisi, M. Nasser, G. Sivaramakrishnan, T. Francis and J. H. Verbeek. Cochrane Database Syst Rev 8(8): CD013826 https://doi.org/10.1002/14651858.CD013826.pub2

Prevalence of Mycobacterium tuberculosis in sputum and reported symptoms among clinic attendees compared with a community survey in rural South Africa. (2022) Govender, I., A. S. Karat, S. Olivier, K. Baisley, P. Beckwith, N. Dayi, J. Dreyer, D. Gareta, R. Gunda, K. Kielmann, O. Koole, N. Mhlongo, T. Modise, S. Moodley, X. Mpofana, T. Ndung'u, D. Pillay, M. J. Siedner, T. Smit, A. Surujdeen, E. B. Wong and A. D. Grant. Clin Infect Dis 75(2): 314-322 https://doi.org/10.1093/cid/ciab970

Pyrimidine derivatives with antitubercular activity. (2023) Finger, V., M. Kufa, O. Soukup, D. Castagnolo, J. Roh and J. Korabecny. Eur J Med Chem 246: 114946 https://doi.org/10.1016/j.ejmech.2022.114946

QT prolongation in the STREAM Stage 1 Trial. (2022) Hughes, G., H. Bern, C. Y. Chiang, R. L. Goodall, A. J. Nunn, I. D. Rusen and S. K. Meredith. Int J Tuberc Lung Dis 26(4): 334-340 https://doi.org/10.5588/ijtld.21.0403

Rapid molecular tests for tuberculosis and tuberculosis drug resistance: a qualitative evidence synthesis of recipient and provider views. (2022) Engel, N., E. A. Ochodo, P. W. Karanja, B. M. Schmidt, R. Janssen, K. R. Steingart and S. Oliver. Cochrane Database Syst Rev 4(4): CD014877 https://doi.org/10.1002/14651858.CD014877.pub2

Rare mycobacteria and HIV in children: Two case reports. (2022) Johnson, S. M., C. Pinera, E. Whittaker, N. Kirkhope, O. M. Kon, G. Satta, M. E. Balcells and C. Foster. Clin Drug Investig 42(6): 541-547 https://doi.org/10.1007/s40261-022-01153-7

Relevance of genomic diversity of Mycobacterium tuberculosis complex in Africa. (2022) Osei-Wusu, S., I. D. Otchere, P. Asare, F. Ntoumi, A. Zumla, A. Asante-Poku and D. Yeboah-Manu. Int J Infect Dis 124 Suppl 1: S47-S49 https://doi.org/10.1016/j.ijid.2022.03.016

Repairing boundaries along pathways to tuberculosis case detection: a qualitative synthesis of intervention designs. (2022) van Wyk, S. S., N. Medley, T. Young and S. Oliver. Health Res Policy Syst 20(1): 7 https://doi.org/10.1186/s12961-021-00811-0

Rethinking intercurrent events in defining estimands for tuberculosis trials. (2022) Pham, T. M., C. D. Tweed, J. R. Carpenter, B. C. Kahan, A. J. Nunn, A. M. Crook, H. Esmail, R. Goodall, P. P. Phillips and I. R. White. Clin Trials 19(5): 522-533 https://doi.org/10.1177/17407745221103853

Rifampicin resistance and mortality in patients hospitalised with HIV-associated tuberculosis. (2022) Spies, R., C. Schutz, A. Ward, A. Balfour, M. Shey, M. Nicol, R. Burton, B. Sossen, R. Wilkinson, D. Barr and G. Meintjes. South Afr J HIV Med 23(1): 1396 https://doi.org/10.4102/sajhivmed.v23i1.1396

Risk for development of active tuberculosis in patients with chronic airway disease-a systematic review of evidence. (2022) Hamada, Y., C. J. Fong, A. Copas, J. R. Hurst and M. X. Rangaka. Trans R Soc Trop Med Hyg 116(5): 390-398 https://doi.org/10.1093/trstmh/trab122

Shorter treatment for nonsevere tuberculosis in African and Indian children. (2022) Turkova, A., G. H. Wills, E. Wobudeya, C. Chabala, M. Palmer, A. Kinikar, S. Hissar, L. Choo, P. Musoke, V. Mulenga, V. Mave, B. Joseph, K. LeBeau, M. J. Thomason, R. B. Mboizi, M. Kapasa, M. M. van der Zalm, P. Raichur, P. K. Bhavani, H. McIlleron, A. M. Demers, R. Aarnoutse, J. Love-Koh, J. A. Seddon, S. B. Welch, S. M. Graham, A. C. Hesseling, D. M. Gibb, A. M. Crook and S. T. Team. N Engl J Med 386(10): 911-922 https://doi.org/10.1056/NEJMoa2104535

Shorter Treatment for Tuberculosis in Children. Reply. (2022) Turkova, A., M. Palmer and D. M. Gibb. N Engl J Med 386(25): 2439-2440 https://doi.org/10.1056/NEJMc2204561

Small contracted bladders posing bigger problems: Etiology, presentation, and management and a short review of literature. (2022) Panwar, V. K., J. M. Tosh, A. Mittal, T. A. Narain, A. K. Mandal and H. S. Talwar. J Family Med Prim Care 11(5): 2246-2251 https://doi.org/10.4103/jfmpc.jfmpc_1926_21

Structural adjustment programmes and infectious disease mortality. (2022) Nosrati, E., J. B. Dowd, M. Marmot and L. P. King. PLoS One 17(7): e0270344 https://doi.org/10.1371/journal.pone.0270344

Subretinal abscess: Causative pathogens, clinical features and management. (2022) Gallo, B., I. Testi and C. Pavesio. J Ophthalmic Inflamm Infect 12(1): 40 https://doi.org/10.1186/s12348-022-00315-0

Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors. (2022) Alshabani, L. A., A. Kumar, S. J. Willcocks, G. Srithiran, S. Bhakta, D. F. Estrada and C. Simons. RSC Med Chem 13(11): 1350-1360 https://doi.org/10.1039/d2md00155a

A systematic review of tuberculosis detection and prevention studies in prisons. (2022) Haeusler, I. L., A. Torres-Ortiz and L. Grandjean. Glob Public Health 17(2): 194-209 https://doi.org/10.1080/17441692.2020.1864753

TB preventive treatment among pregnant women with HIV. (2022) DeAtley, T., Y. Hamada, A. Baddeley, P. Werner, A. Kanchar, M. Zignol and M. X. Rangaka. Int J Tuberc Lung Dis 26(8): 727-732 https://doi.org/10.5588/ijtld.21.0477

TB-PRACTECAL: Study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis. (2022) Berry, C., P. du Cros, K. Fielding, S. Gajewski, E. Kazounis, T. D. McHugh, C. Merle, I. Motta, D. A. J. Moore and B. T. Nyang'wa. Trials 23(1): 484 https://doi.org/10.1186/s13063-022-06331-8

Towards accurate point-of-care tests for tuberculosis in children. (2022) Vaezipour, N., N. Fritschi, N. Brasier, S. Belard, J. Dominguez, M. Tebruegge, D. Portevin and N. Ritz. Pathogens 11(3) https://doi.org/10.3390/pathogens11030327

Treatment and outcome in children with tuberculous meningitis: A multicenter Pediatric Tuberculosis Network European Trials Group study. (2022) Thee, S., R. Basu Roy, D. Blazquez-Gamero, L. Falcon-Neyra, O. Neth, A. Noguera-Julian, C. Lillo, L. Galli, E. Venturini, D. Buonsenso, F. Gotzinger, N. Martinez-Alier, S. Velizarova, F. Brinkmann, S. B. Welch, M. Tsolia, B. Santiago-Garcia, R. Schilling, M. Tebruegge, R. Kruger and T. B. M. S. G. ptbnet. Clin Infect Dis 75(3): 372-381 https://doi.org/10.1093/cid/ciab982

Tuberculosis drug discovery: challenges and new horizons. (2022) Fernandes, G. F. S., A. M. Thompson, D. Castagnolo, W. A. Denny and J. L. Dos Santos. J Med Chem 65(11): 7489-7531 https://doi.org/10.1021/acs.jmedchem.2c00227

Tuberculosis following two-dose SARS-CoV-2 vaccination with messenger RNA vaccine (BNT162b2) and inactivated virus vaccine (CoronaVac). (2022) Li, X., K. Peng, F. W. T. Cheng, D. C. L. Lam, C. L. Cheung, C. S. L. Chui, F. T. T. Lai, E. Y. F. Wan, C. K. H. Wong, T. Ma, S. H. H. Yum, E. W. Y. Chan, J. D. Huang, C. S. Lau, M. S. M. Ip and I. C. K. Wong. J Infect https://doi.org/10.1016/j.jinf.2022.12.016

Tuberculosis incidence in country of origin is a key determinant of the risk of active tuberculosis in people living with HIV: Data from a 30-year observational cohort study. (2022) White, H. A., H. Okhai, P. Kirwan, S. H. Rafeeq, H. Dillon, P. Hefford, M. J. Wiselka and M. Pareek. HIV Med 23(6): 650-660 https://doi.org/10.1111/hiv.13222

Tuberculosis prevalence: beyond the tip of the iceberg. (2022) Houben, R., H. Esmail, F. Cobelens, C. M. L. Williams and A. K. Coussens. Lancet Respir Med 10(6): 537-539 https://doi.org/10.1016/S2213-2600(22)00184-9

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis. (2022) Dhana, A., Y. Hamada, A. P. Kengne, A. D. Kerkhoff, M. X. Rangaka, T. Kredo, A. Baddeley, C. Miller, S. Singh, Y. Hanifa, A. D. Grant, K. Fielding, D. Affolabi, C. S. Merle, A. P. Wachinou, C. Yoon, A. Cattamanchi, C. J. Hoffmann, N. Martinson, E. T. Mbu, M. S. Sander, T. T. Balcha, S. Skogmar, B. W. P. Reeve, G. Theron, G. Ndlangalavu, S. Modi, J. Cavanaugh, S. Swindells, R. E. Chaisson, F. Ahmad Khan, A. A. Howard, R. Wood, S. S. Thit, M. M. Kyi, J. Hanson, P. K. Drain, A. E. Shapiro, T. Kufa, G. Churchyard, D. T. Nguyen, E. A. Graviss, S. Bjerrum, I. S. Johansen, J. K. Gersh, D. J. Horne, S. M. LaCourse, H. A. A. Al-Darraji, A. Kamarulzaman, R. R. Kempker, N. Tukvadze, D. A. Barr, G. Meintjes and G. Maartens. Lancet Infect Dis 22(4): 507-518 https://doi.org/10.1016/S1473-3099(21)00387-X

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis. (2022) Dhana, A., Y. Hamada, A. P. Kengne, A. D. Kerkhoff, M. X. Rangaka, T. Kredo, A. Baddeley, C. Miller, A. Gupta-Wright, K. Fielding, R. Wood, H. Huerga, S. C. M. Rucker, C. Heidebrecht, D. Wilson, S. Bjerrum, I. S. Johansen, S. S. Thit, M. M. Kyi, J. Hanson, D. A. Barr, G. Meintjes and G. Maartens. Lancet HIV 9(4): e233-e241 https://doi.org/10.1016/S2352-3018(22)00002-9

Tuberculosis surveillance in Romania among vulnerable risk groups between 2015 and 2017. (2022) Munteanu, I., N. Cioran, R. van Hest, I. Abubakar, A. Story, D. Chiotan, G. de Vries and B. Mahler. Ther Clin Risk Manag 18: 439-446 https://doi.org/10.2147/TCRM.S347748

Tuberculosis, HIV/AIDS and malaria health services in sub-Saharan Africa - A situation analysis of the disruptions and impact of the COVID-19 pandemic. (2022) Chanda-Kapata, P., F. Ntoumi, N. Kapata, P. Lungu, L. A. Mucheleng'anga, J. Chakaya, J. Tembo, C. Himwaze, R. Ansumana, D. Asogun, S. Mfinanga, P. Nyasulu, P. Mwaba, D. Yeboah-Manu, A. Zumla and J. B. Nachega. Int J Infect Dis 124 Suppl 1: S41-S46 https://doi.org/10.1016/j.ijid.2022.03.033

The two extremes of Hansen's disease-Different manifestations of leprosy and their biological consequences in an Avar Age (late 7th century CE) osteoarchaeological series of the Duna-Tisza Interfluve (Kiskundorozsma-Daruhalom-dulo II, Hungary). (2022) Spekker, O., B. Tihanyi, L. Kis, O. A. Varadi, H. D. Donoghue, D. E. Minnikin, C. Szalontai, T. Vida, G. Palfi, A. Marcsik and E. Molnar. PLoS One 17(6): e0265416 https://doi.org/10.1371/journal.pone.0265416

Understanding the tuberculosis granuloma: the matrix revolutions. (2022) Elkington, P., M. E. Polak, M. T. Reichmann and A. Leslie. Trends Mol Med 28(2): 143-154 https://doi.org/10.1016/j.molmed.2021.11.004

An unusual case of tuberculous spondylodiscitis in a patient with multiple neck masses. (2022) Said, A., R. Balachandar and N. van Vucht. BJR Case Rep 8(3): 20210079 https://doi.org/10.1259/bjrcr.20210079

Urine tuberculosis diagnostics in patients with advanced HIV. (2022) Nel, J. and A. Gupta-Wright. AIDS 36(6): 897-898 https://doi.org/10.1097/QAD.0000000000003178

Utility of esophageal ultrasound-guided biopsy of mediastinal lymph nodes in diagnosis of childhood tuberculosis. (2022) Cohen, J. M., M. Banks, O. M. Kon and S. Eisen. Pediatr Infect Dis J 41(5): e246-e248 https://doi.org/10.1097/INF.0000000000003498

Variation in initial health assessment of unaccompanied asylum-seeking children: a cross-sectional survey across England. (2022) Nezafat Maldonado, B., A. J. Armitage and B. Williams. BMJ Paediatr Open 6(1) https://doi.org/10.1136/bmjpo-2022-001435

The war in Ukraine and potential consequences for the TB epidemic in Europe. (2022) Sotgiu, G., I. Solovic, D. Zenner, S. Tiberi, K. Manika, C. Celan, J. Chorostowska-Wynimko, A. Zumla and G. B. Migliori. Int J Tuberc Lung Dis 26(5): 470-471 https://doi.org/10.5588/ijtld.22.0162

The WHO Global Tuberculosis 2021 Report - Not so good news and turning the tide back to End TB. (2022) Chakaya, J., E. Petersen, R. Nantanda, B. N. Mungai, G. B. Migliori, F. Amanullah, P. Lungu, F. Ntoumi, N. Kumarasamy, M. Maeurer and A. Zumla. Int J Infect Dis 124 Suppl 1: S26-S29 https://doi.org/10.1016/j.ijid.2022.03.011

Whole genome sequencing and prediction of antimicrobial susceptibilities in non-tuberculous mycobacteria. (2022) Solanki, P., M. Lipman, T. D. McHugh and G. Satta. Front Microbiol 13: 1044515 https://doi.org/10.3389/fmicb.2022.1044515

Why has the incidence of tuberculosis not reduced in London during the COVID-19 pandemic? (2022) Lewer, D., R. Mulchandani, A. Roche, C. Cosgrove and C. Anderson. Lancet Respir Med 10(3): 231-233 https://doi.org/10.1016/S2213-2600(22)00012-1

World TB Day 2022: Revamping and reshaping global TB control programs by advancing lessons learnt from the COVID-19 pandemic. (2022) Petersen, E., S. Al-Abri, J. Chakaya, D. Goletti, L. Parolina, C. Wejse, L. A. Mucheleng'anga, S. A. Khalili, D. Yeboah-Manu, P. Chanda-Kapata, M. J. Nasiri, P. S. Lungu, M. Maeurer, S. Tiberi, F. Ntoumi, G. Battista-Migliori and A. Zumla. Int J Infect Dis 124 Suppl 1: S1-S3 https://doi.org/10.1016/j.ijid.2022.02.057

World Tuberculosis Day 2022: Aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis. (2022) Ntoumi, F., J. B. Nachega, E. Aklillu, J. Chakaya, I. Felker, F. Amanullah, D. Yeboah-Manu, K. G. Castro and A. Zumla. Lancet Infect Dis 22(4): 442-444 https://doi.org/10.1016/S1473-3099(22)00142-6

Other Outputs

Report of the technical consultation on innovative clinical trial designs for evaluating new TB preventive treatments. Virtual meeting, 15-17 September 2021 (published 2022). https://www.who.int/publications/i/item/9789240047150. The World Health Organization (WHO) Global Tuberculosis Programme, in collaboration with University College London and other partners, convened a virtual technical consultation from 15 to 17 September 2021 that focused on innovative clinical trial designs that could be used for evaluating new tuberculosis (TB) preventive treatments (TPTs). The objectives of the meeting were to identify and summarize challenges in designing future TPT trials and to explore innovative designs that could facilitate advances in biomedical TB preventive interventions and would complement similar developments in other fields relevant to TB prevention. Discussions were organized in four main sessions: Session 1: Models of delivery; Session 2: Estimating the benefits and harms of TPT; Session 3: Trial design and analytical approaches; Session 4: Trial populations. Yohhei Hamada and Molebogeng (Lele) Rangaka, both from the Institute for Global Health and the Medical Research Council (MRC) Clinical Trials Unit at University College London (UCL), drafted the concept note and helped organize the meeting. Elena Pallari and Genevieve Wills, both also from the MRC Clinical Trials Unit at UCL, served as meeting rapporteurs. Others involved from UCL included Angela Crook, David Dunn, Becky Turner and Ian White (MRC Clinical Trials Unit at UCL).

WHO consolidated guidelines on tuberculosis: module 3: diagnosis: tests for TB infection. https://www.who.int/publications/i/item/9789240056084. The systematic review team was led by Molebogeng (Lele) Rangaka (UCL), and the team included Yohhei Hamada, Lara Goscé, Finna Parkinson and Ting Ting Wang from UCL.

Workshop and resources: Oxford Nanopore sequencing for tuberculosis. https://pandora.tghn.org/training/oxford-nanopore-sequencing-tuberculosis/. This workshop took place 22-25th August 2022 at the National Institute for Medical Research (NIMR) at Muhimbili, Dar es Salaam, Tanzania. It was jointly run by UCL and NIMR. The aim of the workshop was to provide theoretical and practical training for all of the steps in the tuberculosis Oxford Nanopore Technologies (ONT) sequencing pipeline, from CTAB DNA extraction, DNA quantification best practice, library preparation and setting up a sequencing run, and analysing sequencing data. The workshop was run using a combination of theoretical, laboratory and bioinformatic sessions, with discussion and Q&A sessions throughout the workshop. The website includes links to the presentations and workshop handbook, how to set up a sequencing laboratory (aimed at resource constrained laboratories), how to learn sequencing bioinformatics, and tutorial videos on ONT sequencing.  The UCL team were Linzy Elton and Sylvia Rofael from the UCL Centre for Clinical Microbiology.

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