Sainsbury Wellcome Centre for Neural Circuits and Behaviour



SWC Seminar: Linda Wilbrecht, Associate Professor, UC Berkeley

Start: Feb 27, 2019 12:00:00 PM
End: Feb 27, 2019 1:00:00 PM

Talk Title: Testing the role of basal ganglia cell types and circuits in flexible choice behavior

Abstract:  The basal ganglia are believed to play a key role in reward-based decision  making, particularly in the selection of rewarded actions and suppression of undesired actions. I will discuss recent optogenetic and chemogenetic manipulation experiments that inform our understanding of how activity in striatal spiny projection neurons contributes to choice. 

SWC Semina: Dr Nuo Li, Baylor College of Medicine

Start: Mar 28, 2019 12:00:00 PM
End: Mar 28, 2019 1:00:00 PM

Host: Tom Mrsic-Flogel, Director

Talk Title: Neural mechanisms of volitional movement

The brain plans volitional movements before they are executed. Persistent and ramping activity in frontal cortex anticipates specific movements. This preparatory activity is the neural correlate of a motor plan that instructs future movements. Preparatory activity is distributed across multiple brain regions, but it is unclear which brain areas are involved and how this activity is mediated. My lab studies how neural circuits support preparatory activity and how preparatory activity triggers movement. I will discuss our progress in delineating a distributed motor planning circuit in the mouse.


Start: Apr 8, 2019 1:00:00 PM
End: Apr 9, 2019 7:00:00 PM

In the 1940’s Kenneth Craik postulated that thought serves to model, or parallels, reality much as a computing device does. This idea, that the brain functions by developing a generative model of the environment, is nearly as old as neuroscience. This workshop aims to take stock of current progress and future directions in this field. We will do this by bringing together experts who are investigating neural implementations of predictive processing, inspired by both experimental and theoretical data, across different brain systems. We hope to foster discussions, identify avenues for future research and inspire cross disciplinary collaborations.