Sainsbury Wellcome Centre for Neural Circuits and Behaviour



Emerging Neuroscientist Seminar Series: Sabine Krabbe

Start: Oct 4, 2018 1:00:00 PM
End: Oct 4, 2018 2:00:00 PM

Talk Title: Disinhibitory amygdala microcircuits for aversive learning

Abstract: Learning and memory are fundamental neuronal processes that areessential for behavioural adaptations driven by unexpected positive or negativeexperiences in an ever-changing environment. While the functional role and plasticity mechanisms ofprojection neurons during associative learning have been extensively studied, to date, little is known about the contributions of local interneurons. Using fear conditioning as a model system, we combine deep brain calcium imaging and optogenetic manipulations in freely behaving mice to study the functional contribution of amygdala interneuron subtypes to associative learning. We find that interactions between distinct inhibitory interneurons can gate behaviourally relevant, salient stimuli to instruct plastic changes in neighbouring excitatory amygdala projection neurons. Furthermore, responses of distinct interneurons are highly plastic and shift from the instructive to the predictive cue upon memory formation. This novel form of adaptive disinhibitory gating allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific learning, thereby ensuring appropriate behavioural adaptations to salient events.

Joint Symposium by NEUReka! and the Sainsbury Wellcome Centre

Start: Oct 12, 2018 1:00:00 PM
End: Oct 12, 2018 6:00:00 PM

What is the quantum of neural computation?

This October the Centre for Developmental Neurobiology's NEUReka! team and the Sainsbury Wellcome Centre will be hosting their second joint symposium, this year entitled: From synapses to behaviour: what is the quantum of neural computation?