UCL Division of Surgery and Interventional Science


Gastroenterological Intervention Centre (GENIE) 

Head: Prof. Laurence Lovat

The UCL Gastroenterological Intervention Centre (GENIE) works to develop novel, minimally invasive approaches to managing diseases of the oesophagus, stomach and bowel.GENIE pioneered endoscopic therapy for pre-cancerous changes and early cancer of the oesophagus. In particular, the Centre introduced HALO radiofrequency ablation (RFA) for dysplastic (pre-cancerous) Barrett’s oesophagus to the UK and now heads the largest registry of this treatment in Europe. GENIE also develops endoscopic diagnostic and therapeutic tools, including diagnostic imaging, ‘virtual’ biopsy, biomarkers of cancer risk and a whole range of novel therapies. The Centre staff collaborate widely with leading research and patient groups throughout the UK and internationally to develop these new ideas.

Research focus

  • Development of novel endoscopic procedures. 
  • Risk stratification of pre-cancerous conditions and oesophageal cancer.
  • Identification of biomarkers for therapeutic application and diagnosis of GI tract disease.
  • Development of Augmented and Virtual Reality systems for minimally-invasive Colorectal Cancer Surgery
  • Investigation of complex imaging modalities to predict response to chemoradiotherapy
  • The use of fluorescence imaging to guide oncological GI surgery

Clinical Trials

Laboratory Studies

Contact us: l.lovat@ucl.ac.uk