UCL Division of Surgery and Interventional Science



We seek to investigate approaches to risk assessment, causes of complications after major surgery and ways to reduce the likelihood of them occurring.

We collaborate widely with leading research, Royal College and patient partners throughout the UK and internationally to develop these new ideas, working closely with the UCL Bloomsbury Institute of Intensive Care.


Lead: Professor Ramani Moonesinghe

The aim of the group is to use measurement to improve the quality of perioperative healthcare. The work undertaken by the group predominantly focuses on the following areas:

  • Risk stratification
    Understanding and improving methods to predict adverse outcomes (complications and mortality) after major non-cardiac surgery.
  • Innovation in measurement
    Development and validation of measures for assessing outcome from major surgery: encompassing complications and patient-reported outcome
  • Improvement Science
    Using measurement to improve quality of care; dissemination of learning for quality improvement

The advice the group gives is based upon the results of research and audit studies looking at risk adjustment and outcome measures a parallel program of process evaluation and implementation testing conducted in partnership with clinicians. The aim is to achieve this in a timely, pragmatic and rigorous manner.

Staff are predominantly NHS clinicians but also have an academic input from DAHR and a partnership with the National Institute for Academic Anaesthesia’s Health Services Research Centre (NIAA-HSRC) who are based at the Royal College of Anaesthetists.

Translational Research Centre

Lead: Dr Dan Martin

Our team is involved with a number of novel studies that aim to broaden our understanding of the cellular processes that may determine perioperative outcomes. We have particular interests in redox homeostasis and influence of oxygen on biological pathways. We are currently funded via the National Institute for Academic Anaesthesia, British Journal of Anaesthesia, Royal Free Charity and UCLH-UCL NIHR BRC. One of our key collaborations is with the dept at the University of Cambridge.

UCL-UCLH POM Clinical Trials Group

Lead: Dr Sam Bampoe

The Centre for Perioperative Medicine Trials Group is dedicated to the design and delivery of local, national and international collaborative clinical trials in surgery, anaesthesia and perioperative medicine. Our UCL and UCLH team of clinicians and researchers are leading the delivery of a number of locally designed NIHR portfolio studies including X-MINS, X-LAB and SPACE. Our aim is to work closely and collaboratively with partners to deliver world-class perioperative research, focused on improving outcomes and experiences for surgical patients. Clinical trials in development include studies of postoperative cognitive dysfunction in the elderly and perioperative anaemia and iron therapy in a number of different surgical populations.