Perioperative Inflammation as Triggering Origin of Metastasis Development, 1st edition 2017
31 July 2017
A book on breast cancer with several important connections to University College London has just been published by Springer/Nature. The topic is an exploration of events that occur after surgery to remove a primary breast malignancy. It is proposed that metastatic relapses in the first 3 years post surgery are initiated during the week post surgery due to systemic inflammation.
It is also proposed that such metastatic initiation is amplified 100 fold during that post surgery week. (Based on the writings of Galen and Celsus, this effect was known 2000 years ago but somehow became overlooked.) It needs to be confirmed but based on a retrospective study, an inexpensive and non-toxic NSAID administered perioperatively can prevent these early relapses. It is suggested that this would be most effective in sub-Saharan Africa due to the biology of the disease there. A clinical trial is proposed in Nigeria. While it is only in the talking phase, a paired trial in Denmark is also considered.
Eleven chapters on various aspects of this topic are written by authors from a variety of countries. The Editor is Michael W. Retsky (Staff at Harvard TH Chan School of Public Health and honorary faculty at Division of Surgery & Interventional Science, UCL.) Co-editor is Romano Demicheli (Milan National Cancer Center). Chapters are written by Retsky and Demicheli, Jayant S. Vaidya (Professor of Surgery and Oncology, Division of Surgery & Interventional Science, UCL) and Michael Baum (retired Prof. of Surgery, UCL.).
The book can be purchased via the following link: https://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Dstripbooks&field-keywords=retsky+demicheli&rh=n%3A283155%2Ck%3Aretsky+demicheli